LOCUS       NM_001378923            4257 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens natriuretic peptide receptor 2 (NPR2), transcript
            variant 2, mRNA.
ACCESSION   NM_001378923 XM_005251478
VERSION     NM_001378923.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4257)
  AUTHORS   Chen,H., Zhang,S., Sun,Y., Chen,J., Yuan,K., Zhang,Y., Yang,X.,
            Lin,X. and Chen,R.
  TITLE     Novel pathogenic NPR2 variants in short stature patients and the
            therapeutic response to rhGH
  JOURNAL   Orphanet J Rare Dis 18 (1), 221 (2023)
   PUBMED   37501190
  REMARK    GeneRIF: Novel pathogenic NPR2 variants in short stature patients
            and the therapeutic response to rhGH.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4257)
  AUTHORS   Zhu,J., Meng,R., Zhao,H., Cai,L., Wen,X., Zeng,W., Luo,Y. and Qi,H.
  TITLE     Identification of Diagnostic Variants in FGFR2 and NPR2 Genes in a
            Chinese Family Affected by Crouzon Syndrome and Acromesomelic
            Dysplasia, Type Maroteaux
  JOURNAL   DNA Cell Biol 41 (11), 996-1006 (2022)
   PUBMED   36322898
  REMARK    GeneRIF: Identification of Diagnostic Variants in FGFR2 and NPR2
            Genes in a Chinese Family Affected by Crouzon Syndrome and
            Acromesomelic Dysplasia, Type Maroteaux.
REFERENCE   3  (bases 1 to 4257)
  AUTHORS   Stavber,L., Gaia,M.J., Hovnik,T., Jenko Bizjan,B., Debeljak,M.,
            Kovac,J., Omladic,J.S., Battelino,T., Kotnik,P. and Dovc,K.
  TITLE     Heterozygous NPR2 Variants in Idiopathic Short Stature
  JOURNAL   Genes (Basel) 13 (6), 1065 (2022)
   PUBMED   35741827
  REMARK    GeneRIF: Heterozygous NPR2 Variants in Idiopathic Short Stature.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4257)
  AUTHORS   Li,Q., Fan,X., Lu,W., Sun,C., Pei,Z., Zhang,M., Ni,J., Wu,J.,
            Yu,F.X. and Luo,F.
  TITLE     Novel NPR2 Gene Mutations Affect Chondrocytes Function via ER
            Stress in Short Stature
  JOURNAL   Cells 11 (8), 1265 (2022)
   PUBMED   35455946
  REMARK    GeneRIF: Novel NPR2 Gene Mutations Affect Chondrocytes Function via
            ER Stress in Short Stature.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4257)
  AUTHORS   Yuan,K., Chen,J., Chen,Q., Chen,H., Zhu,J., Fang,Y. and Wang,C.
  TITLE     NPR2 gene variants in familial short stature: a single-center study
  JOURNAL   J Pediatr Endocrinol Metab 35 (2), 185-190 (2021)
   PUBMED   34565054
  REMARK    GeneRIF: NPR2 gene variants in familial short stature: a
            single-center study.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4257)
  AUTHORS   Koller,K.J. and Goeddel,D.V.
  TITLE     Molecular biology of the natriuretic peptides and their receptors
  JOURNAL   Circulation 86 (4), 1081-1088 (1992)
   PUBMED   1327579
  REMARK    Review article
REFERENCE   7  (bases 1 to 4257)
  AUTHORS   Bennett,B.D., Bennett,G.L., Vitangcol,R.V., Jewett,J.R.,
            Burnier,J., Henzel,W. and Lowe,D.G.
  TITLE     Extracellular domain-IgG fusion proteins for three human
            natriuretic peptide receptors. Hormone pharmacology and application
            to solid phase screening of synthetic peptide antisera
  JOURNAL   J Biol Chem 266 (34), 23060-23067 (1991)
   PUBMED   1660465
REFERENCE   8  (bases 1 to 4257)
  AUTHORS   Koller,K.J., Lowe,D.G., Bennett,G.L., Minamino,N., Kangawa,K.,
            Matsuo,H. and Goeddel,D.V.
  TITLE     Selective activation of the B natriuretic peptide receptor by
            C-type natriuretic peptide (CNP)
  JOURNAL   Science 252 (5002), 120-123 (1991)
   PUBMED   1672777
REFERENCE   9  (bases 1 to 4257)
  AUTHORS   Lowe,D.G., Klisak,I., Sparkes,R.S., Mohandas,T. and Goeddel,D.V.
  TITLE     Chromosomal distribution of three members of the human natriuretic
            peptide receptor/guanylyl cyclase gene family
  JOURNAL   Genomics 8 (2), 304-312 (1990)
   PUBMED   1979052
REFERENCE   10 (bases 1 to 4257)
  AUTHORS   Chang,M.S., Lowe,D.G., Lewis,M., Hellmiss,R., Chen,E. and
            Goeddel,D.V.
  TITLE     Differential activation by atrial and brain natriuretic peptides of
            two different receptor guanylate cyclases
  JOURNAL   Nature 341 (6237), 68-72 (1989)
   PUBMED   2570358
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133410.32.
            
            On Mar 13, 2020 this sequence version replaced XM_005251478.3.
            
            Summary: This gene encodes natriuretic peptide receptor B, one of
            two integral membrane receptors for natriuretic peptides. Both NPR1
            and NPR2 contain five functional domains: an extracellular
            ligand-binding domain, a single membrane-spanning region, and
            intracellularly a protein kinase homology domain, a helical hinge
            region involved in oligomerization, and a carboxyl-terminal
            guanylyl cyclase catalytic domain. The protein is the primary
            receptor for C-type natriuretic peptide (CNP), which upon ligand
            binding exhibits greatly increased guanylyl cyclase activity.
            Mutations in this gene are the cause of acromesomelic dysplasia
            Maroteaux type. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.1775953.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1485              AL133410.32        111472-112956
            1486-1691           AL133410.32        113779-113984
            1692-1805           AL133410.32        119499-119612
            1806-1941           AL133410.32        119903-120038
            1942-2036           AL133410.32        120270-120364
            2037-2169           AL133410.32        120590-120722
            2170-2254           AL133410.32        120951-121035
            2255-2384           AL133410.32        121515-121644
            2385-2459           AL133410.32        121807-121881
            2460-2537           AL133410.32        122087-122164
            2538-2642           AL133410.32        122384-122488
            2643-2714           AL133410.32        122613-122684
            2715-2874           AL133410.32        125392-125551
            2875-3030           AL133410.32        125711-125866
            3031-3199           AL133410.32        125946-126114
            3200-3346           AL133410.32        126273-126419
            3347-3470           AL133410.32        126904-127027
            3471-3539           AL133410.32        127211-127279
            3540-3714           AL133410.32        128390-128564
            3715-3813           AL133410.32        128636-128734
            3814-3905           AL133410.32        129037-129128
            3906-4257           AL133410.32        129261-129612
FEATURES             Location/Qualifiers
     source          1..4257
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..4257
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /note="natriuretic peptide receptor 2"
                     /db_xref="GeneID:4882"
                     /db_xref="HGNC:HGNC:7944"
                     /db_xref="MIM:108961"
     exon            1..1485
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     CDS             819..3971
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /EC_number="4.6.1.2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; atrial natriuretic peptide receptor 2;
                     natriuretic peptide receptor B/guanylate cyclase B
                     (atrionatriuretic peptide receptor B); atrial natriuretic
                     peptide B-type receptor; atrial natriuretic peptide
                     receptor type B; guanylate cyclase 2B; guanylyl cyclase B"
                     /codon_start=1
                     /product="atrial natriuretic peptide receptor 2 isoform 2
                     precursor"
                     /protein_id="NP_001365852.1"
                     /db_xref="GeneID:4882"
                     /db_xref="HGNC:HGNC:7944"
                     /db_xref="MIM:108961"
                     /translation="MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPR
                     VGPAVALAVEALGRALPVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCV
                     YPAASVARFASHWRLPLLTAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHF
                     NWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIR
                     ANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQD
                     NRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIA
                     GCFYDGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDF
                     VLWAMGDLDSGDFQPAAHYSGAEKQIWWTGRPIPWVKGAPPSDNPPCAFDLDDPSCDK
                     TPLSTLAIVALGTGITFIMFGVSSFLIFRPYRKLMLEKELASMLWRIRWEELQFGNSE
                     RYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQ
                     VLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRY
                     SLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHA
                     LYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIV
                     QKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGT
                     SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQ
                     AEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDA
                     YMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGV
                     VGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKG
                     KGKMRTYWLLGERKGPPGLL"
     exon            1486..1691
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1805
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1941
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2036
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2169
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2254
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2384
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2459
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2537
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2642
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2714
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..2874
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..3030
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3199
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3346
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            3347..3470
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            3471..3539
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..3714
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            3715..3813
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            3814..3905
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     exon            3906..4257
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4225..4230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /note="hexamer: TATAAA"
     regulatory      4236..4241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /note="hexamer: AATAAA"
     polyA_site      4245
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
                     /note="major polyA site"
     polyA_site      4257
                     /gene="NPR2"
                     /gene_synonym="AMD1; AMDM; ANPb; ANPRB; ECDM; GC-B; GCB;
                     GUC2B; GUCY2B; NPRB; NPRBi; SNSK"
ORIGIN      
        1 gggagtcgca ctcggccgcc ggcgcagcga gcggagacgg gccgggccga ggcgacctga
       61 cccggacgag cggcgcgcgc ggggcccagg cggggggcgg gaggaagcgc cgggcagcgc
      121 cggccgccag ggcccaggag aagcggagca gagaggagcg gggacacggg cggggccgcc
      181 gtagctccgg atgggaccag cgcccgggcc cgttagtcca agcaggagct ccgggagaat
      241 ccttcacagg gagatttacc cctgccttcc cctgccctcc ggcccaggcc tcgcttcgct
      301 ccccgcctgc ccatgatccc agtccttccg cggcgcgggc accctcccac cttaccccct
      361 tggtcctatg tggcgcagcg ccctcctgcc ctcccggccc tttcagctgt gaggttcccc
      421 caggccgttt ctttgtacca cccgcccccc acccccaccc catcccagtc ccagatcccc
      481 ttttccttct cagctttaga tttatcaggc ttcttcacct cgcactgtcc ccatcctggc
      541 cgcaggcccc ctcggtccct ccctccccct gccaccccgt tctcagtcct cagtccttgc
      601 cctaggctgg tagcccactc cttgcccgcc ccccgccttc ctcccatctc cccctcctct
      661 ccccggcccc cagcaccttc tgcatcccag cctacctagc ctactcctcc tcttcctggc
      721 cctcttcccc aggctccagg ctggggggtg ctcgcgtctc ccctgtaggc cagagcagcc
      781 ccaagttctg ggggcggtgg ggctgctgct ttatccccat ggcgctgcca tcacttctgc
      841 tgttggtggc agccctggca ggtggggtgc gtcctcccgg ggcgcggaac ctgacgctgg
      901 cggtggtgct gccagaacac aacctgagct atgcctgggc ctggccacgg gtgggacccg
      961 ctgtggcact agctgtggag gctctgggcc gggcactgcc cgtggacctg cggtttgtca
     1021 gctccgaact ggaaggcgcc tgctctgagt acctggcacc gctgagcgct gtggacctca
     1081 agctgtacca tgaccccgac ctgctgttag gtcccggttg cgtgtaccct gctgcctctg
     1141 tggcccgctt tgcctcccac tggcgccttc ccctgctgac tgcgggtgct gtggcctctg
     1201 gtttttcggc taagaatgac cattatcgta ccctggttcg cactggcccc tctgctccca
     1261 agctgggtga gtttgtggtg acactacacg ggcacttcaa ttggactgcc cgtgctgcct
     1321 tgctgtacct ggatgctcgc acagatgacc ggcctcacta cttcaccatc gagggcgtct
     1381 ttgaggccct gcagggcagc aacctcagtg tgcagcacca ggtgtatgcc cgagagccag
     1441 ggggccccga gcaggccacc cacttcatcc gggccaacgg gcgcattgtg tatatctgcg
     1501 gccctctgga gatgctgcat gagatcctgc ttcaggccca gagggagaat ctgaccaatg
     1561 gggattatgt cttcttttac ctggatgtct ttggggagag tctccgtgca ggccccacac
     1621 gtgctacagg ccggccctgg caggacaatc gcacccggga acaggcccag gccctcagag
     1681 aggcctttca gactgtattg gtgatcacgt accgagaacc cccaaatcct gagtatcagg
     1741 aattccagaa tcgtctgctg ataagagccc gggaagactt tggtgtggag ctgggccctt
     1801 ccctgatgaa cctcatcgct ggctgcttct atgatgggat cctgctatat gctgaagtcc
     1861 tgaatgagac aatacaggaa ggaggcaccc gggaggatgg acttcgaatt gtggaaaaga
     1921 tgcagggacg aagatatcac ggtgtaactg ggctggttgt catggacaag aacaatgacc
     1981 gagagactga ctttgtcctc tgggccatgg gagacctgga ttctggggac tttcagcctg
     2041 cagcccacta ctcgggagct gagaagcaga tttggtggac gggacggcct attccctggg
     2101 tgaagggggc tcctccctcg gacaatcccc cctgtgcctt tgacttggac gacccatcct
     2161 gtgataaaac tccactttca accctggcaa ttgtggctct gggcacagga atcaccttca
     2221 tcatgtttgg tgtttccagc ttcctaattt tccgtcctta cagaaagctg atgctggaga
     2281 aggagctggc tagcatgttg tggcgtattc gctgggaaga actgcagttt ggcaactcag
     2341 agcgttatca caaaggtgca ggcagtcgcc tcacactgtc gctgcgggga tccagttacg
     2401 gctcgctcat gacagcccat gggaaatacc agatctttgc caacaccggt cacttcaagg
     2461 gaaatgttgt cgccatcaaa catgtgaata agaagcgcat tgagctgacc cggcaggttc
     2521 tgtttgaact caaacatatg agagatgttc agttcaacca tctcactcgc ttcattggcg
     2581 cctgcataga ccctcccaac atttgcattg tcactgaata ctgtcctcgt gggagtttac
     2641 aggatattct agaaaatgac agcatcaact tggactggat gtttcgttat tcactcatta
     2701 atgaccttgt taagggcatg gcctttctcc acaacagcat tatttcatcg catgggagtc
     2761 tcaagtcctc caactgtgtg gtggatagtc gttttgtgct caaaatcaca gactatggcc
     2821 tggccagctt ccgatcaact gctgaacctg atgacagcca tgccctctat gccaagaagc
     2881 tgtggactgc cccagaactg ctcagtggga accccttgcc aaccacaggc atgcagaagg
     2941 ctgacgtcta tagctttggg atcatcctgc aggagatagc acttcgcagt ggtcctttct
     3001 acttggaggg cctggacctc agccccaaag agattgtcca gaaggtacga aatggtcagc
     3061 ggccatattt ccggccaagc attgaccgga cccaactgaa tgaagagcta gttttgctga
     3121 tggagcgatg ttgggctcag gacccagctg agcggccaga ctttggacag attaagggct
     3181 tcattcggcg ctttaacaag gagggtggca ccagcatatt ggacaacctc ctgctgcgca
     3241 tggaacagta tgccaataac ttggagaagc tggtggagga acgcacacag gcctatctgg
     3301 aggaaaaacg caaggctgaa gctctgctct accaaatcct accccattca gtggcagagc
     3361 agttaaaacg gggagagact gtacaggctg aggcctttga cagtgttacc atctacttca
     3421 gtgacattgt tggcttcaca gcattgtcag cagagagcac ccccatgcag gtagtgacac
     3481 ttcttaatga cctgtatacc tgctttgatg ccataattga caactttgat gtctacaagg
     3541 tggagacgat tggggatgct tacatggtgg tatctggcct cccaggccga aatggtcaac
     3601 gccatgcacc agaaattgct cgtatggccc tagcattact agatgcagtt tcttcctttc
     3661 gcatccgcca ccgaccccat gaccagctga ggctacgcat aggggtccat actgggccag
     3721 tctgtgctgg ggttgttggc ctgaagatgc cccgttattg tctttttgga gacacagtga
     3781 acactgcttc tcgaatggag tctaatggtc aagcgctgaa gatccatgtc tcctctacca
     3841 ccaaggatgc cctagatgag ctaggatgct tccagctaga gcttcggggg gatgtggaaa
     3901 tgaagggaaa aggaaagatg cgaacatact ggctcttagg agagcggaaa ggacctcctg
     3961 gactcctgta aacccccatt ctttccaagt cagatagtct tctgctgctg gtacctgggt
     4021 gggcaatggc caccatgtct gcacacacca gaaatggaca ttttcatatg caatggaaaa
     4081 cagccacaaa aaaacctacc ttatatggaa gttgtagccc tctgcagctc agccctgtac
     4141 atatacctgt ccctctctgg cttggtcccc ttcctcccta ctttctgtaa atatctgtat
     4201 ctaaaccaga atattttggt caaatataaa acaataataa aaaaagttct gatgtca
//
