LOCUS       XM_005245218            4107 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens natriuretic peptide receptor 1 (NPR1),
            transcript variant X1, mRNA.
ACCESSION   XM_005245218
VERSION     XM_005245218.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_005245218.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4107
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..4107
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /note="natriuretic peptide receptor 1; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 39 ESTs, 132 long SRA reads, 2 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 58 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:4881"
                     /db_xref="HGNC:HGNC:7943"
                     /db_xref="MIM:108960"
     CDS             422..3529
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /codon_start=1
                     /product="atrial natriuretic peptide receptor 1 isoform
                     X1"
                     /protein_id="XP_005245275.1"
                     /db_xref="GeneID:4881"
                     /db_xref="HGNC:HGNC:7943"
                     /db_xref="MIM:108960"
                     /translation="MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLA
                     NTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAV
                     DLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGP
                     SYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHL
                     EFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIF
                     GQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAY
                     EQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGV
                     TGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPP
                     DIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELW
                     RVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKMRDVQN
                     EHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFL
                     HNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLR
                     MASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPS
                     LALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYA
                     NNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDI
                     VGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRL
                     HACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDT
                     VNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERG
                     SSTRG"
ORIGIN      
        1 acactccctg gggcaggcgc tcacgcacgc tacaaacaca cactcctctt tcctccctcg
       61 cgcgccctct ctcatccttc ttcacgaagc gctcactcgc accctttctc tctctctctc
      121 tctctctcta acacgcacgc acactcccag ttgttcacac tcgggtcctc tccagcccga
      181 cgttctcctg gcacccacct gctccgcggc gccctgcgcg cccccctcgg tcgcgcccct
      241 tgcgctctcg gcccagaccg tcgcagctac agggggcctc gagccccggg gtgagcgtcc
      301 ccgtcccgct cctgctcctt cccataggga cgcgcctgat gcctgggacc ggccgctgag
      361 cccaagggga ccgaggaggc catggtagga gcgctcgcct gctgcggtgc ccgctgaggc
      421 catgccgggg ccccggcgcc ccgctggctc ccgcctgcgc ctgctcctgc tcctgctgct
      481 gccgccgctg ctgctgctgc tccggggcag ccacgcgggc aacctgacgg tagccgtggt
      541 actgccgctg gccaatacct cgtacccctg gtcgtgggcg cgcgtgggac ccgccgtgga
      601 gctggccctg gcccaggtga aggcgcgccc cgacttgctg ccgggctgga cggtccgcac
      661 ggtgctgggc agcagcgaaa acgcgctggg cgtctgctcc gacaccgcag cgcccctggc
      721 cgcggtggac ctcaagtggg agcacaaccc cgctgtgttc ctgggccccg gctgcgtgta
      781 cgccgccgcc ccagtggggc gcttcaccgc gcactggcgg gtcccgctgc tgaccgccgg
      841 cgccccggcg ctgggcttcg gtgtcaagga cgagtatgcg ctgaccaccc gcgcggggcc
      901 cagctacgcc aagctggggg acttcgtggc ggcgctgcac cgacggctgg gctgggagcg
      961 ccaagcgctc atgctctacg cctaccggcc gggtgacgaa gagcactgct tcttcctcgt
     1021 ggaggggctg ttcatgcggg tccgcgaccg cctcaatatt acggtggacc acctggagtt
     1081 cgccgaggac gacctcagcc actacaccag gctgctgcgg accatgccgc gcaaaggccg
     1141 agttatctac atctgcagct cccctgatgc cttcagaacc ctcatgctcc tggccctgga
     1201 agctggcttg tgtggggagg actacgtttt cttccacctg gatatctttg ggcaaagcct
     1261 gcaaggtgga cagggccctg ctccccgcag gccctgggag agaggggatg ggcaggatgt
     1321 cagtgcccgc caggcctttc aggctgccaa aatcattaca tataaagacc cagataatcc
     1381 cgagtacttg gaattcctga agcagttaaa acacctggcc tatgagcagt tcaacttcac
     1441 catggaggat ggcctggtga acaccatccc agcatccttc cacgacgggc tcctgctcta
     1501 tatccaggca gtgacggaga ctctggcaca tgggggaact gttactgatg gggagaacat
     1561 cactcagcgg atgtggaacc gaagctttca aggtgtgaca ggatacctga aaattgatag
     1621 cagtggcgat cgggaaacag acttctccct ctgggatatg gatcccgaga atggtgcctt
     1681 cagggttgta ctgaactaca atgggacttc ccaagagctg gtggctgtgt cggggcgcaa
     1741 actgaactgg cccctggggt accctcctcc tgacatcccc aaatgtggct ttgacaacga
     1801 agacccagca tgcaaccaag atcacctttc caccctggag gtgctggctt tggtgggcag
     1861 cctctccttg ctcggcattc tgattgtctc cttcttcata tacaggaaga tgcagctgga
     1921 gaaggaactg gcctcggagc tgtggcgggt gcgctgggag gacgttgagc ccagtagcct
     1981 tgagaggcac ctgcggagtg caggcagccg gctgaccctg agcgggagag gctccaatta
     2041 cggctccctg ctaaccacag agggccagtt ccaagtcttt gccaagacag catattataa
     2101 gatgcgggat gtgcagaatg aacacctgac caggtttgtg ggagcctgca ccgacccccc
     2161 caatatctgc atcctcacag agtactgtcc ccgtgggagc ctgcaggaca ttctggagaa
     2221 tgagagcatc accctggact ggatgttccg gtactcactc accaatgaca tcgtcaaggg
     2281 catgctgttt ctacacaatg gggctatctg ttcccatggg aacctcaagt catccaactg
     2341 cgtggtagat gggcgctttg tgctcaagat caccgactat gggctggaga gcttcaggga
     2401 cctggaccca gagcaaggac acaccgttta tgccaaaaag ctgtggacgg cccctgagct
     2461 cctgcgaatg gcttcacccc ctgtgcgggg ctcccaggct ggtgacgtat acagctttgg
     2521 gatcatcctt caggagattg ccctgaggag tggggtcttc cacgtggaag gtttggacct
     2581 gagccccaaa gagatcatcg agcgggtgac tcggggtgag cagcccccct tccggccctc
     2641 cctggccctg cagagtcacc tggaggagtt ggggctgctc atgcagcggt gctgggctga
     2701 ggacccacag gagaggccac cattccagca gatccgcctg acgttgcgca aatttaacag
     2761 ggagaacagc agcaacatcc tggacaacct gctgtcccgc atggagcagt acgcgaacaa
     2821 tctggaggaa ctggtggagg agcggaccca ggcatacctg gaggagaagc gcaaggctga
     2881 ggccctgctc taccagatcc tgcctcactc agtggctgag cagctgaagc gtggggagac
     2941 ggtgcaggcc gaagcctttg acagtgttac catctacttc agtgacattg tgggtttcac
     3001 agcgctgtcg gcggagagca cacccatgca ggtggtgacc ctgctcaatg acctgtacac
     3061 ttgctttgat gctgtcatag acaactttga tgtgtacaag gtggagacaa ttggcgatgc
     3121 ctacatggtg gtgtcagggc tccctgtgcg gaacgggcgg ctacacgcct gcgaggtagc
     3181 ccgcatggcc ctggcactgc tggatgctgt gcgctccttc cgaatccgcc accggcccca
     3241 ggagcagctg cgcttgcgca ttggcatcca cacaggacct gtgtgtgctg gagtggtggg
     3301 actgaagatg ccccgttact gtctctttgg ggatacagtc aacacagcct caagaatgga
     3361 gtctaatggg gaagccctga agatccactt gtcttctgag accaaggctg tcctggagga
     3421 gtttggtggt ttcgagctgg agcttcgagg ggatgtagaa atgaagggca aaggcaaggt
     3481 tcggacctac tggctccttg gggagagggg gagtagcacc cgaggctgac ctgcctcctc
     3541 tcctatccct ccacacctcc ctaccctgtg ccagaagcaa cagaggtgcc aggcctcagc
     3601 ctcacccaca gcagccccat cgccaaagga tggaagtaat ttgaatagct caggtgtgct
     3661 gaccccagtg aagacaccag ataggacctc tgagagggga ctggcatggg gggatctcag
     3721 agcttacagg ctgagccaag cccacggcca tgcacaggga cactcacaca ggcacacgca
     3781 cctgctctcc acctggactc aggccgggct gggctgtgga ttcctgatcc cctcccctcc
     3841 ccatgctctc ctccctcagc cttgctaccc tgtgacttac tgggaggaga aagagtcacc
     3901 tgaaggggaa catgaaaaga gactaggtga agagagggca ggggagccca catctggggc
     3961 tggcccacaa tacctgctcc cccgaccccc tccacccagc agtagacaca gtgcacaggg
     4021 gagaagaggg gtggcgcaga agggttgggg gcctgtatgc cttgcttcta ccatgagcag
     4081 agacaattaa aatctttatt ccagtga
//
