LOCUS       NM_000906               4185 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens natriuretic peptide receptor 1 (NPR1), mRNA.
ACCESSION   NM_000906
VERSION     NM_000906.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4185)
  AUTHORS   Capri,Y., Kwon,T., Boyer,O., Bourmance,L., Testa,N., Baudouin,V.,
            Bonnefoy,R., Couderc,A., Meziane,C., Tournier-Lasserve,E.,
            Heidet,L. and Melki,J.
  TITLE     Biallelic NPR1 loss of function variants are responsible for
            neonatal systemic hypertension
  JOURNAL   J Med Genet 60 (10), 993-998 (2023)
   PUBMED   37080586
  REMARK    GeneRIF: Biallelic NPR1 loss of function variants are responsible
            for neonatal systemic hypertension.
REFERENCE   2  (bases 1 to 4185)
  AUTHORS   Sugioka,S., Yamada,H., Ishii,A., Kato,Y., Yamada,R., Mori,K.P.,
            Ohno,S., Handa,T., Ikushima,A., Ishimura,T., Osaki,K., Tokudome,T.,
            Matsusaka,T., Nebreda,A.R., Yanagita,M. and Yokoi,H.
  TITLE     Dual deletion of guanylyl cyclase-A and p38 mitogen-activated
            protein kinase in podocytes with aldosterone administration causes
            glomerular intra-capillary thrombi
  JOURNAL   Kidney Int 104 (3), 508-525 (2023)
   PUBMED   37356621
  REMARK    GeneRIF: Dual deletion of guanylyl cyclase-A and p38
            mitogen-activated protein kinase in podocytes with aldosterone
            administration causes glomerular intra-capillary thrombi.
REFERENCE   3  (bases 1 to 4185)
  AUTHORS   Sangaralingham,S.J., Whig,K., Peddibhotla,S., Kirby,R.J.,
            Sessions,H.E., Maloney,P.R., Hershberger,P.M., Mose-Yates,H.,
            Hood,B.L., Vasile,S., Pan,S., Zheng,Y., Malany,S. and Burnett,J.C.
            Jr.
  TITLE     Discovery of small molecule guanylyl cyclase A receptor positive
            allosteric modulators
  JOURNAL   Proc Natl Acad Sci U S A 118 (52) (2021)
   PUBMED   34930837
  REMARK    GeneRIF: Discovery of small molecule guanylyl cyclase A receptor
            positive allosteric modulators.
REFERENCE   4  (bases 1 to 4185)
  AUTHORS   Li,Z., Fan,H., Cao,J., Sun,G., Sen,Wang., Lv,J., Xuan,Z., Xia,Y.,
            Wang,L., Zhang,D., Xu,H. and Xu,Z.
  TITLE     Natriuretic peptide receptor a promotes gastric malignancy through
            angiogenesis process
  JOURNAL   Cell Death Dis 12 (11), 968 (2021)
   PUBMED   34671022
  REMARK    GeneRIF: Natriuretic peptide receptor a promotes gastric malignancy
            through angiogenesis process.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4185)
  AUTHORS   Mezzasoma,L., Talesa,V.N., Romani,R. and Bellezza,I.
  TITLE     ANP and BNP Exert Anti-Inflammatory Action via NPR-1/cGMP Axis by
            Interfering with Canonical, Non-Canonical, and Alternative Routes
            of Inflammasome Activation in Human THP1 Cells
  JOURNAL   Int J Mol Sci 22 (1), 24 (2020)
   PUBMED   33375031
  REMARK    GeneRIF: ANP and BNP Exert Anti-Inflammatory Action via NPR-1/cGMP
            Axis by Interfering with Canonical, Non-Canonical, and Alternative
            Routes of Inflammasome Activation in Human THP1 Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4185)
  AUTHORS   Suga,S., Nakao,K., Hosoda,K., Mukoyama,M., Ogawa,Y., Shirakami,G.,
            Arai,H., Saito,Y., Kambayashi,Y., Inouye,K. et al.
  TITLE     Receptor selectivity of natriuretic peptide family, atrial
            natriuretic peptide, brain natriuretic peptide, and C-type
            natriuretic peptide
  JOURNAL   Endocrinology 130 (1), 229-239 (1992)
   PUBMED   1309330
REFERENCE   7  (bases 1 to 4185)
  AUTHORS   Bennett,B.D., Bennett,G.L., Vitangcol,R.V., Jewett,J.R.,
            Burnier,J., Henzel,W. and Lowe,D.G.
  TITLE     Extracellular domain-IgG fusion proteins for three human
            natriuretic peptide receptors. Hormone pharmacology and application
            to solid phase screening of synthetic peptide antisera
  JOURNAL   J Biol Chem 266 (34), 23060-23067 (1991)
   PUBMED   1660465
REFERENCE   8  (bases 1 to 4185)
  AUTHORS   Koller,K.J., Lowe,D.G., Bennett,G.L., Minamino,N., Kangawa,K.,
            Matsuo,H. and Goeddel,D.V.
  TITLE     Selective activation of the B natriuretic peptide receptor by
            C-type natriuretic peptide (CNP)
  JOURNAL   Science 252 (5002), 120-123 (1991)
   PUBMED   1672777
REFERENCE   9  (bases 1 to 4185)
  AUTHORS   Lowe,D.G., Klisak,I., Sparkes,R.S., Mohandas,T. and Goeddel,D.V.
  TITLE     Chromosomal distribution of three members of the human natriuretic
            peptide receptor/guanylyl cyclase gene family
  JOURNAL   Genomics 8 (2), 304-312 (1990)
   PUBMED   1979052
REFERENCE   10 (bases 1 to 4185)
  AUTHORS   Lowe,D.G., Chang,M.S., Hellmiss,R., Chen,E., Singh,S., Garbers,D.L.
            and Goeddel,D.V.
  TITLE     Human atrial natriuretic peptide receptor defines a new paradigm
            for second messenger signal transduction
  JOURNAL   EMBO J 8 (5), 1377-1384 (1989)
   PUBMED   2569967
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK025024.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000906.3.
            
            Summary: Guanylyl cyclases, catalyzing the production of cGMP from
            GTP, are classified as soluble and membrane forms (Garbers and
            Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often
            termed guanylyl cyclases A through F, form a family of cell-surface
            receptors with a similar topographic structure: an extracellular
            ligand-binding domain, a single membrane-spanning domain, and an
            intracellular region that contains a protein kinase-like domain and
            a cyclase catalytic domain. GC-A and GC-B function as receptors for
            natriuretic peptides; they are also referred to as atrial
            natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM
            108961). Also see NPR3 (MIM 108962), which encodes a protein with
            only the ligand-binding transmembrane and 37-amino acid cytoplasmic
            domains. NPR1 is a membrane-bound guanylate cyclase that serves as
            the receptor for both atrial and brain natriuretic peptides (ANP
            (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM,
            May 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK025024.1, HM005333.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368680.4/ ENSP00000357669.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4185              AK025024.1         1-4185
FEATURES             Location/Qualifiers
     source          1..4185
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..4185
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /note="natriuretic peptide receptor 1"
                     /db_xref="GeneID:4881"
                     /db_xref="HGNC:HGNC:7943"
                     /db_xref="MIM:108960"
     exon            1..1142
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     CDS             422..3607
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /EC_number="4.6.1.2"
                     /note="atrial natriuretic peptide receptor 1; natriuretic
                     peptide receptor A; guanylate cyclase A; natriuretic
                     peptide receptor A/guanylate cyclase A (atrionatriuretic
                     peptide receptor A); testicular tissue protein Li 20;
                     natriuretic peptide A type receptor; GC-A; ANP-A; NPR-A;
                     ANPR-A; atrial natriuretic peptide receptor type A"
                     /codon_start=1
                     /product="atrial natriuretic peptide receptor 1 precursor"
                     /protein_id="NP_000897.3"
                     /db_xref="CCDS:CCDS1051.1"
                     /db_xref="GeneID:4881"
                     /db_xref="HGNC:HGNC:7943"
                     /db_xref="MIM:108960"
                     /translation="MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLA
                     NTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAV
                     DLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGP
                     SYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHL
                     EFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIF
                     GQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAY
                     EQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGV
                     TGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPP
                     DIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELW
                     RVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAV
                     KRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDIL
                     ENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLE
                     SFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFH
                     VEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIR
                     LTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHS
                     VAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDN
                     FDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLR
                     IGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGF
                     ELELRGDVEMKGKGKVRTYWLLGERGSSTRG"
     exon            1143..1342
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1456
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1592
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1684
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1820
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1905
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2026
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2101
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2179
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2284
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2356
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2513
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2669
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2838
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..2985
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3109
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     exon            3110..3178
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     exon            3179..3353
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     exon            3354..3452
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     exon            3453..3544
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     exon            3545..4185
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4164..4169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /note="hexamer: ATTAAA"
     polyA_site      4185
                     /gene="NPR1"
                     /gene_synonym="ANPa; ANPRA; GUC2A; GUCY2A; NPRA"
                     /note="major polyA site"
ORIGIN      
        1 acactccctg gggcaggcgc tcacgcacgc tacaaacaca cactcctctt tcctccctcg
       61 cgcgccctct ctcatccttc ttcacgaagc gctcactcgc accctttctc tctctctctc
      121 tctctctcta acacgcacgc acactcccag ttgttcacac tcgggtcctc tccagcccga
      181 cgttctcctg gcacccacct gctccgcggc gccctgcgcg cccccctcgg tcgcgcccct
      241 tgcgctctcg gcccagaccg tcgcagctac agggggcctc gagccccggg gtgagcgtcc
      301 ccgtcccgct cctgctcctt cccataggga cgcgcctgat gcctgggacc ggccgctgag
      361 cccaagggga ccgaggaggc catggtagga gcgctcgcct gctgcggtgc ccgctgaggc
      421 catgccgggg ccccggcgcc ccgctggctc ccgcctgcgc ctgctcctgc tcctgctgct
      481 gccgccgctg ctgctgctgc tccggggcag ccacgcgggc aacctgacgg tagccgtggt
      541 actgccgctg gccaatacct cgtacccctg gtcgtgggcg cgcgtgggac ccgccgtgga
      601 gctggccctg gcccaggtga aggcgcgccc cgacttgctg ccgggctgga cggtccgcac
      661 ggtgctgggc agcagcgaaa acgcgctggg cgtctgctcc gacaccgcag cgcccctggc
      721 cgcggtggac ctcaagtggg agcacaaccc cgctgtgttc ctgggccccg gctgcgtgta
      781 cgccgccgcc ccagtggggc gcttcaccgc gcactggcgg gtcccgctgc tgaccgccgg
      841 cgccccggcg ctgggcttcg gtgtcaagga cgagtatgcg ctgaccaccc gcgcggggcc
      901 cagctacgcc aagctggggg acttcgtggc ggcgctgcac cgacggctgg gctgggagcg
      961 ccaagcgctc atgctctacg cctaccggcc gggtgacgaa gagcactgct tcttcctcgt
     1021 ggaggggctg ttcatgcggg tccgcgaccg cctcaatatt acggtggacc acctggagtt
     1081 cgccgaggac gacctcagcc actacaccag gctgctgcgg accatgccgc gcaaaggccg
     1141 agttatctac atctgcagct cccctgatgc cttcagaacc ctcatgctcc tggccctgga
     1201 agctggcttg tgtggggagg actacgtttt cttccacctg gatatctttg ggcaaagcct
     1261 gcaaggtgga cagggccctg ctccccgcag gccctgggag agaggggatg ggcaggatgt
     1321 cagtgcccgc caggcctttc aggctgccaa aatcattaca tataaagacc cagataatcc
     1381 cgagtacttg gaattcctga agcagttaaa acacctggcc tatgagcagt tcaacttcac
     1441 catggaggat ggcctggtga acaccatccc agcatccttc cacgacgggc tcctgctcta
     1501 tatccaggca gtgacggaga ctctggcaca tgggggaact gttactgatg gggagaacat
     1561 cactcagcgg atgtggaacc gaagctttca aggtgtgaca ggatacctga aaattgatag
     1621 cagtggcgat cgggaaacag acttctccct ctgggatatg gatcccgaga atggtgcctt
     1681 cagggttgta ctgaactaca atgggacttc ccaagagctg gtggctgtgt cggggcgcaa
     1741 actgaactgg cccctggggt accctcctcc tgacatcccc aaatgtggct ttgacaacga
     1801 agacccagca tgcaaccaag atcacctttc caccctggag gtgctggctt tggtgggcag
     1861 cctctccttg ctcggcattc tgattgtctc cttcttcata tacaggaaga tgcagctgga
     1921 gaaggaactg gcctcggagc tgtggcgggt gcgctgggag gacgttgagc ccagtagcct
     1981 tgagaggcac ctgcggagtg caggcagccg gctgaccctg agcgggagag gctccaatta
     2041 cggctccctg ctaaccacag agggccagtt ccaagtcttt gccaagacag catattataa
     2101 gggcaacctc gtggctgtga aacgtgtgaa ccgtaaacgc attgagctga cacgaaaagt
     2161 cctgtttgaa ctgaagcata tgcgggatgt gcagaatgaa cacctgacca ggtttgtggg
     2221 agcctgcacc gaccccccca atatctgcat cctcacagag tactgtcccc gtgggagcct
     2281 gcaggacatt ctggagaatg agagcatcac cctggactgg atgttccggt actcactcac
     2341 caatgacatc gtcaagggca tgctgtttct acacaatggg gctatctgtt cccatgggaa
     2401 cctcaagtca tccaactgcg tggtagatgg gcgctttgtg ctcaagatca ccgactatgg
     2461 gctggagagc ttcagggacc tggacccaga gcaaggacac accgtttatg ccaaaaagct
     2521 gtggacggcc cctgagctcc tgcgaatggc ttcaccccct gtgcggggct cccaggctgg
     2581 tgacgtatac agctttggga tcatccttca ggagattgcc ctgaggagtg gggtcttcca
     2641 cgtggaaggt ttggacctga gccccaaaga gatcatcgag cgggtgactc ggggtgagca
     2701 gccccccttc cggccctccc tggccctgca gagtcacctg gaggagttgg ggctgctcat
     2761 gcagcggtgc tgggctgagg acccacagga gaggccacca ttccagcaga tccgcctgac
     2821 gttgcgcaaa tttaacaggg agaacagcag caacatcctg gacaacctgc tgtcccgcat
     2881 ggagcagtac gcgaacaatc tggaggaact ggtggaggag cggacccagg catacctgga
     2941 ggagaagcgc aaggctgagg ccctgctcta ccagatcctg cctcactcag tggctgagca
     3001 gctgaagcgt ggggagacgg tgcaggccga agcctttgac agtgttacca tctacttcag
     3061 tgacattgtg ggtttcacag cgctgtcggc ggagagcaca cccatgcagg tggtgaccct
     3121 gctcaatgac ctgtacactt gctttgatgc tgtcatagac aactttgatg tgtacaaggt
     3181 ggagacaatt ggcgatgcct acatggtggt gtcagggctc cctgtgcgga acgggcggct
     3241 acacgcctgc gaggtagccc gcatggccct ggcactgctg gatgctgtgc gctccttccg
     3301 aatccgccac cggccccagg agcagctgcg cttgcgcatt ggcatccaca caggacctgt
     3361 gtgtgctgga gtggtgggac tgaagatgcc ccgttactgt ctctttgggg atacagtcaa
     3421 cacagcctca agaatggagt ctaatgggga agccctgaag atccacttgt cttctgagac
     3481 caaggctgtc ctggaggagt ttggtggttt cgagctggag cttcgagggg atgtagaaat
     3541 gaagggcaaa ggcaaggttc ggacctactg gctccttggg gagaggggga gtagcacccg
     3601 aggctgacct gcctcctctc ctatccctcc acacctccct accctgtgcc agaagcaaca
     3661 gaggtgccag gcctcagcct cacccacagc agccccatcg ccaaaggatg gaagtaattt
     3721 gaatagctca ggtgtgctga ccccagtgaa gacaccagat aggacctctg agaggggact
     3781 ggcatggggg gatctcagag cttacaggct gagccaagcc cacggccatg cacagggaca
     3841 ctcacacagg cacacgcacc tgctctccac ctggactcag gccgggctgg gctgtggatt
     3901 cctgatcccc tcccctcccc atgctctcct ccctcagcct tgctaccctg tgacttactg
     3961 ggaggagaaa gagtcacctg aaggggaaca tgaaaagaga ctaggtgaag agagggcagg
     4021 ggagcccaca tctggggctg gcccacaata cctgctcccc cgaccccctc cacccagcag
     4081 tagacacagt gcacagggga gaagaggggt ggcgcagaag ggttgggggc ctgtatgcct
     4141 tgcttctacc atgagcagag acaattaaaa tctttattcc agtga
//
