LOCUS       NM_024409               1055 bp    mRNA    linear   PRI 24-APR-2024
DEFINITION  Homo sapiens natriuretic peptide C (NPPC), mRNA.
ACCESSION   NM_024409
VERSION     NM_024409.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1055)
  AUTHORS   Bachmann,J.C., Kirchhoff,J.E., Napolitano,J.E., Sorota,S.,
            Gordon,W.M., Feric,N., Aschar-Sobbi,R., Lv,J., Cao,Z.,
            Coppieters,K., Borghetti,G. and Nyberg,M.
  TITLE     C-type natriuretic peptide induces inotropic and lusitropic effects
            in human 3D-engineered cardiac tissue: Implications for the
            regulation of cardiac function in humans
  JOURNAL   Exp Physiol 108 (9), 1172-1188 (2023)
   PUBMED   37493451
  REMARK    GeneRIF: C-type natriuretic peptide induces inotropic and
            lusitropic effects in human 3D-engineered cardiac tissue:
            Implications for the regulation of cardiac function in humans.
REFERENCE   2  (bases 1 to 1055)
  AUTHORS   Park,J.Y., Go,M., Lyu,S.W., Yoon,T.K., Kang,K.M., Kim,J.W. and
            Shim,S.H.
  TITLE     A novel variant of NPPC causes abnormal post-translational
            cleavage: A candidate gene for premature ovarian insufficiency
  JOURNAL   Maturitas 157, 40-48 (2022)
   PUBMED   35120671
  REMARK    GeneRIF: A novel variant of NPPC causes abnormal post-translational
            cleavage: A candidate gene for premature ovarian insufficiency.
REFERENCE   3  (bases 1 to 1055)
  AUTHORS   Taura,D., Nakao,K., Nakagawa,Y., Kinoshita,H., Sone,M. and Nakao,K.
  TITLE     C-type natriuretic peptide (CNP)/guanylate cyclase B (GC-B) system
            and endothelin-1(ET-1)/ET receptor A and B system in human
            vasculature
  JOURNAL   Can J Physiol Pharmacol 98 (9), 611-617 (2020)
   PUBMED   32268070
  REMARK    GeneRIF: C-type natriuretic peptide (CNP)/guanylate cyclase B
            (GC-B) system and endothelin-1(ET-1)/ET receptor A and B system in
            human vasculature.
REFERENCE   4  (bases 1 to 1055)
  AUTHORS   Chen,W., Werner,F., Illerhaus,A., Knopp,T., Volker,K.,
            Potapenko,T., Hofmann,U., Frantz,S., Baba,H.A., Rosch,M.,
            Zernecke,A., Karbach,S., Wenzel,P. and Kuhn,M.
  TITLE     Stabilization of Perivascular Mast Cells by Endothelial CNP (C-Type
            Natriuretic Peptide)
  JOURNAL   Arterioscler Thromb Vasc Biol 40 (3), 682-696 (2020)
   PUBMED   31893950
  REMARK    GeneRIF: CNP, via guanylyl cyclase-B/cyclic GMP signaling,
            stabilizes resident perivascular mast cells at baseline and
            prevents their excessive activation under pathological conditions.
REFERENCE   5  (bases 1 to 1055)
  AUTHORS   Nishikimi,T., Kuwahara,K. and Nakao,K.
  TITLE     Current biochemistry, molecular biology, and clinical relevance of
            natriuretic peptides
  JOURNAL   J Cardiol 57 (2), 131-140 (2011)
   PUBMED   21296556
  REMARK    Review article
            Erratum:[J Cardiol. 2012 Jan;59(1):98-9]
REFERENCE   6  (bases 1 to 1055)
  AUTHORS   Ishizaka,Y., Kangawa,K., Minamino,N., Ishii,K., Takano,S., Eto,T.
            and Matsuo,H.
  TITLE     Isolation and identification of C-type natriuretic peptide in human
            monocytic cell line, THP-1
  JOURNAL   Biochem Biophys Res Commun 189 (2), 697-704 (1992)
   PUBMED   1472040
REFERENCE   7  (bases 1 to 1055)
  AUTHORS   Ogawa,Y., Nakao,K., Nakagawa,O., Komatsu,Y., Hosoda,K., Suga,S.,
            Arai,H., Nagata,K., Yoshida,N. and Imura,H.
  TITLE     Human C-type natriuretic peptide. Characterization of the gene and
            peptide
  JOURNAL   Hypertension 19 (6 Pt 2), 809-813 (1992)
   PUBMED   1339402
REFERENCE   8  (bases 1 to 1055)
  AUTHORS   Suga,S., Nakao,K., Hosoda,K., Mukoyama,M., Ogawa,Y., Shirakami,G.,
            Arai,H., Saito,Y., Kambayashi,Y., Inouye,K. et al.
  TITLE     Receptor selectivity of natriuretic peptide family, atrial
            natriuretic peptide, brain natriuretic peptide, and C-type
            natriuretic peptide
  JOURNAL   Endocrinology 130 (1), 229-239 (1992)
   PUBMED   1309330
REFERENCE   9  (bases 1 to 1055)
  AUTHORS   Bennett,B.D., Bennett,G.L., Vitangcol,R.V., Jewett,J.R.,
            Burnier,J., Henzel,W. and Lowe,D.G.
  TITLE     Extracellular domain-IgG fusion proteins for three human
            natriuretic peptide receptors. Hormone pharmacology and application
            to solid phase screening of synthetic peptide antisera
  JOURNAL   J Biol Chem 266 (34), 23060-23067 (1991)
   PUBMED   1660465
REFERENCE   10 (bases 1 to 1055)
  AUTHORS   Tawaragi,Y., Fuchimura,K., Tanaka,S., Minamino,N., Kangawa,K. and
            Matsuo,H.
  TITLE     Gene and precursor structures of human C-type natriuretic peptide
  JOURNAL   Biochem Biophys Res Commun 175 (2), 645-651 (1991)
   PUBMED   2018508
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR003533.1, JF420840.1,
            D20847.1 and AC013435.7.
            
            On Nov 22, 2018 this sequence version replaced NM_024409.3.
            
            Summary: This gene encodes a preproprotein that is proteolytically
            processed to generate multiple protein products. These products
            include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22,
            which belong to the natriuretic family of peptides. The encoded
            peptides exhibit vasorelaxation activity in laboratory animals and
            elevated levels of CNP-22 have been observed in the plasma of
            chronic heart failure patients. [provided by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.327341.1, DR003533.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409852.2/ ENSP00000387159.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-618               DR003533.1         16-633
            619-769             JF420840.1         277-427
            770-770             D20847.1           222-222
            771-1055            AC013435.7         69136-69420         c
FEATURES             Location/Qualifiers
     source          1..1055
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..1055
                     /gene="NPPC"
                     /gene_synonym="CNP; CNP2"
                     /note="natriuretic peptide C"
                     /db_xref="GeneID:4880"
                     /db_xref="HGNC:HGNC:7941"
                     /db_xref="MIM:600296"
     exon            1..237
                     /gene="NPPC"
                     /gene_synonym="CNP; CNP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..528
                     /gene="NPPC"
                     /gene_synonym="CNP; CNP2"
                     /note="C-type natriuretic peptide; natriuretic peptide
                     precursor type C"
                     /codon_start=1
                     /product="C-type natriuretic peptide preproprotein"
                     /protein_id="NP_077720.1"
                     /db_xref="CCDS:CCDS2489.1"
                     /db_xref="GeneID:4880"
                     /db_xref="HGNC:HGNC:7941"
                     /db_xref="MIM:600296"
                     /translation="MHLSQLLACALLLTLLSLRPSEAKPGAPPKVPRTPPAEELAEPQ
                     AAGGGQKKGDKAPGGGGANLKGDRSRLLRDLRVDTKSRAAWARLLQEHPNARKYKGAN
                     KKGLSKGCFGLKLDRIGSMSGLGC"
     exon            238..548
                     /gene="NPPC"
                     /gene_synonym="CNP; CNP2"
                     /inference="alignment:Splign:2.1.0"
     exon            549..1055
                     /gene="NPPC"
                     /gene_synonym="CNP; CNP2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1055
                     /gene="NPPC"
                     /gene_synonym="CNP; CNP2"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcacc cagccggcgc cgcgcagcac tgggaccctg ctcgccctgc agcccagcca
       61 gcctgctccg catccccctg ctggtctgcc cgccgacctg cgcgccctcg ctgccgcccg
      121 tgtgcgcccc tcgaccccag cggcaccatg catctctccc agctgctggc ctgcgccctg
      181 ctgctcacgc tgctctccct ccggccctcc gaagccaagc ccggggcgcc gccgaaggtc
      241 ccgcgaaccc cgccggcaga ggagctggcc gagccgcagg ctgcgggcgg cggtcagaag
      301 aagggcgaca aggctcccgg gggcgggggc gccaatctca agggcgaccg gtcgcgactg
      361 ctccgggacc tgcgcgtgga caccaagtcg cgggcagcgt gggctcgcct tctgcaagag
      421 caccccaacg cgcgcaaata caaaggagcc aacaagaagg gcttgtccaa gggctgcttc
      481 ggcctcaagc tggaccgaat cggctccatg agcggcctgg gatgttagtg cggcgccccc
      541 tggcggcgga tcgggaactg gctccgttgt gctgaggtca tctttggtca tcagcctcca
      601 gcatctggaa acacctccaa cgcaatgtgg cttttacatt tctttctttc tttctttttt
      661 tttcctggta ctgggaatac acaacaccag ctgttttatt attatttggg gagggggttg
      721 tgattttatt atttgttttt ttaaaatgaa aaataaaaag ttatatatta tatatatatt
      781 atatacatga aacacacaca cctacaccga cttgatgaca agggacagtt tttaagagac
      841 tgacagaacc agctgtaaaa cattgctgtt tgtaaattca tgtcatgcat aaatgtattt
      901 atgttgtaaa gctatttata ttgtttataa agagatattt ataaaaattt tatttatgta
      961 actaaatgaa agaagtcaat cattgtaatg tttttgtcct aactagttaa aaaaaatgta
     1021 aaaaaaaaaa agtcattcca tgaatatctt gaaaa
//
