LOCUS       NM_002521                708 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens natriuretic peptide B (NPPB), mRNA.
ACCESSION   NM_002521
VERSION     NM_002521.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 708)
  AUTHORS   Nattkemper,L.A., Kim,B.S., Yap,Q.V., Hoon,M.A., Mishra,S.K. and
            Yosipovitch,G.
  TITLE     Increased Systemic Levels of Centrally Acting B-Type Natriuretic
            Peptide Are Associated with Chronic Itch of Different Types
  JOURNAL   J Invest Dermatol 144 (10), 2267-2272 (2024)
   PUBMED   38522572
  REMARK    GeneRIF: Increased Systemic Levels of Centrally Acting B-Type
            Natriuretic Peptide Are Associated with Chronic Itch of Different
            Types.
REFERENCE   2  (bases 1 to 708)
  AUTHORS   Bie,P.
  TITLE     Plasma concentrations of peptide hormones: Unrealistic levels of
            vasopressin (AVP), oxytocin (OXT), and brain natriuretic peptide
            (BNP)
  JOURNAL   Acta Physiol (Oxf) 240 (9), e14200 (2024)
   PUBMED   39034759
  REMARK    GeneRIF: Plasma concentrations of peptide hormones: Unrealistic
            levels of vasopressin (AVP), oxytocin (OXT), and brain natriuretic
            peptide (BNP).
            Review article
REFERENCE   3  (bases 1 to 708)
  AUTHORS   Wang,X., Shi,J., Jiang,X. and Wang,X.
  TITLE     Association of depressive symptoms with cardiovascular events and
            plasma BNP: A prospective cohort study of the elderly Chinese
            population
  JOURNAL   Arch Gerontol Geriatr 123, 105413 (2024)
   PUBMED   38555650
  REMARK    GeneRIF: Association of depressive symptoms with cardiovascular
            events and plasma BNP: A prospective cohort study of the elderly
            Chinese population.
REFERENCE   4  (bases 1 to 708)
  AUTHORS   Yumita,Y., Xu,Z., Diller,G.P., Kempny,A., Rafiq,I., Montanaro,C.,
            Li,W., Gu,H., Dimopoulos,K., Niwa,K., Gatzoulis,M.A. and Brida,M.
  TITLE     B-type natriuretic peptide levels predict long-term mortality in a
            large cohort of adults with congenital heart disease
  JOURNAL   Eur Heart J 45 (23), 2066-2075 (2024)
   PUBMED   38743452
  REMARK    GeneRIF: B-type natriuretic peptide levels predict long-term
            mortality in a large cohort of adults with congenital heart
            disease.
REFERENCE   5  (bases 1 to 708)
  AUTHORS   Krause,A., Liepke,C., Meyer,M., Adermann,K., Forssmann,W.G. and
            Maronde,E.
  TITLE     Human natriuretic peptides exhibit antimicrobial activity
  JOURNAL   Eur J Med Res 6 (5), 215-218 (2001)
   PUBMED   11410403
  REMARK    GeneRIF: Brain-type natriuretic peptide (hBNP-32) is an
            antimicrobial peptide active against Gram-positive and
            Gram-negative bacteria and yeast.
REFERENCE   6  (bases 1 to 708)
  AUTHORS   Arden,K.C., Viars,C.S., Weiss,S., Argentin,S. and Nemer,M.
  TITLE     Localization of the human B-type natriuretic peptide precursor
            (NPPB) gene to chromosome 1p36
  JOURNAL   Genomics 26 (2), 385-389 (1995)
   PUBMED   7601467
REFERENCE   7  (bases 1 to 708)
  AUTHORS   Suga,S., Nakao,K., Hosoda,K., Mukoyama,M., Ogawa,Y., Shirakami,G.,
            Arai,H., Saito,Y., Kambayashi,Y., Inouye,K. et al.
  TITLE     Receptor selectivity of natriuretic peptide family, atrial
            natriuretic peptide, brain natriuretic peptide, and C-type
            natriuretic peptide
  JOURNAL   Endocrinology 130 (1), 229-239 (1992)
   PUBMED   1309330
REFERENCE   8  (bases 1 to 708)
  AUTHORS   Bennett,B.D., Bennett,G.L., Vitangcol,R.V., Jewett,J.R.,
            Burnier,J., Henzel,W. and Lowe,D.G.
  TITLE     Extracellular domain-IgG fusion proteins for three human
            natriuretic peptide receptors. Hormone pharmacology and application
            to solid phase screening of synthetic peptide antisera
  JOURNAL   J Biol Chem 266 (34), 23060-23067 (1991)
   PUBMED   1660465
REFERENCE   9  (bases 1 to 708)
  AUTHORS   Koller,K.J., Lowe,D.G., Bennett,G.L., Minamino,N., Kangawa,K.,
            Matsuo,H. and Goeddel,D.V.
  TITLE     Selective activation of the B natriuretic peptide receptor by
            C-type natriuretic peptide (CNP)
  JOURNAL   Science 252 (5002), 120-123 (1991)
   PUBMED   1672777
REFERENCE   10 (bases 1 to 708)
  AUTHORS   Sudoh,T., Maekawa,K., Kojima,M., Minamino,N., Kangawa,K. and
            Matsuo,H.
  TITLE     Cloning and sequence analysis of cDNA encoding a precursor for
            human brain natriuretic peptide
  JOURNAL   Biochem Biophys Res Commun 159 (3), 1427-1434 (1989)
   PUBMED   2522777
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL021155.1, AJ708502.1,
            M25296.1 and BC025785.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002521.2.
            
            Summary: This gene is a member of the natriuretic peptide family
            and encodes a secreted protein which functions as a cardiac
            hormone. The protein undergoes two cleavage events, one within the
            cell and a second after secretion into the blood. The protein's
            biological actions include natriuresis, diuresis, vasorelaxation,
            inhibition of renin and aldosterone secretion, and a key role in
            cardiovascular homeostasis. A high concentration of this protein in
            the bloodstream is indicative of heart failure. The presence of
            myocardial injury is a significant predictor of mortality in
            hospitalized coronavirus disease 2019 (COVID-19) patients, and
            there is evidence of increased levels of natriuretic peptide B in
            hospitalized non-survivor COVID-19 patients. The protein also acts
            as an antimicrobial peptide with antibacterial and antifungal
            activity. Mutations in this gene have been associated with
            postmenopausal osteoporosis. [provided by RefSeq, Aug 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025785.1, SRR5189655.214911.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2151741
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related                :: relevant for COVID-19
                                                  prognosis
            MANE Ensembl match                 :: ENST00000376468.4/
                                                  ENSP00000365651.3
            Protein has antimicrobial activity :: PMID: 11410403
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AL021155.1         44450-44459         c
            11-14               AJ708502.1         19-22
            15-705              M25296.1           2-692
            706-708             BC025785.1         683-685
FEATURES             Location/Qualifiers
     source          1..708
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..708
                     /gene="NPPB"
                     /gene_synonym="BNP; Iso-ANP"
                     /note="natriuretic peptide B"
                     /db_xref="GeneID:4879"
                     /db_xref="HGNC:HGNC:7940"
                     /db_xref="MIM:600295"
     exon            1..244
                     /gene="NPPB"
                     /gene_synonym="BNP; Iso-ANP"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..517
                     /gene="NPPB"
                     /gene_synonym="BNP; Iso-ANP"
                     /note="natriuretic peptide precursor B; brain type
                     natriuretic peptide; natriuretic peptides B; natriuretic
                     protein; gamma-brain natriuretic peptide; proBNP;
                     preproBNP; brain natriuretic factor prohormone"
                     /codon_start=1
                     /product="natriuretic peptides B preproprotein"
                     /protein_id="NP_002512.1"
                     /db_xref="CCDS:CCDS140.1"
                     /db_xref="GeneID:4879"
                     /db_xref="HGNC:HGNC:7940"
                     /db_xref="MIM:600295"
                     /translation="MDPQTAPSRALLLLLFLHLAFLGGRSHPLGSPGSASDLETSGLQ
                     EQRNHLQGKLSELQVEQTSLEPLQESPRPTGVWKSREVATEGIRGHRKMVLYTLRAPR
                     SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH"
     exon            245..500
                     /gene="NPPB"
                     /gene_synonym="BNP; Iso-ANP"
                     /inference="alignment:Splign:2.1.0"
     exon            501..708
                     /gene="NPPB"
                     /gene_synonym="BNP; Iso-ANP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      684..689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPPB"
                     /gene_synonym="BNP; Iso-ANP"
                     /note="hexamer: AATAAA"
     polyA_site      708
                     /gene="NPPB"
                     /gene_synonym="BNP; Iso-ANP"
                     /note="major polyA site"
ORIGIN      
        1 aggaggagca ccccgcaggc tgagggcagg tgggaagcaa acccggacgc atcgcagcag
       61 cagcagcagc agcagaagca gcagcagcag cctccgcagt ccctccagag acatggatcc
      121 ccagacagca ccttcccggg cgctcctgct cctgctcttc ttgcatctgg ctttcctggg
      181 aggtcgttcc cacccgctgg gcagccccgg ttcagcctcg gacttggaaa cgtccgggtt
      241 acaggagcag cgcaaccatt tgcagggcaa actgtcggag ctgcaggtgg agcagacatc
      301 cctggagccc ctccaggaga gcccccgtcc cacaggtgtc tggaagtccc gggaggtagc
      361 caccgagggc atccgtgggc accgcaaaat ggtcctctac accctgcggg caccacgaag
      421 ccccaagatg gtgcaagggt ctggctgctt tgggaggaag atggaccgga tcagctcctc
      481 cagtggcctg ggctgcaaag tgctgaggcg gcattaagag gaagtcctgg ctgcagacac
      541 ctgcttctga ttccacaagg ggctttttcc tcaaccctgt ggccgccttt gaagtgactc
      601 atttttttaa tgtatttatg tatttatttg attgttttat ataagatggt ttcttacctt
      661 tgagcacaaa atttccacgg tgaaataaag tcaacattat aagcttta
//
