LOCUS       NM_006172                855 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens natriuretic peptide A (NPPA), mRNA.
ACCESSION   NM_006172
VERSION     NM_006172.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 855)
  AUTHORS   Baris Feldman,H., Chai Gadot,C., Zahler,D., Mory,A., Aviram,G.,
            Elhanan,E., Shefer,G., Goldiner,I., Amir,Y., Kurolap,A. and
            Ablin,J.N.
  TITLE     Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and
            Fibrosis
  JOURNAL   N Engl J Med 389 (18), 1685-1692 (2023)
   PUBMED   37913506
  REMARK    GeneRIF: Corin and Left Atrial Cardiomyopathy, Hypertension,
            Arrhythmia, and Fibrosis.
REFERENCE   2  (bases 1 to 855)
  AUTHORS   Ichiki,T., Cannone,V., Scott,C.G., Iyer,S.R., Sangaralingham,S.J.,
            Bailey,K.R., Goetze,J.P., Tsuji,Y., Rodeheffer,R.J. and
            Burnett,J.C. Jr.
  TITLE     Sex-based differences in metabolic protection by the ANP genetic
            variant rs5068 in the general population
  JOURNAL   Am J Physiol Heart Circ Physiol 325 (3), H545-H552 (2023)
   PUBMED   37417873
  REMARK    GeneRIF: Sex-based differences in metabolic protection by the ANP
            genetic variant rs5068 in the general population.
REFERENCE   3  (bases 1 to 855)
  AUTHORS   Raffa,S., Forte,M., Gallo,G., Ranieri,D., Marchitti,S., Magri,D.,
            Testa,M., Stanzione,R., Bianchi,F., Cotugno,M., Fiori,E., Visco,V.,
            Sciarretta,S., Volpe,M. and Rubattu,S.
  TITLE     Atrial natriuretic peptide stimulates autophagy/mitophagy and
            improves mitochondrial function in chronic heart failure
  JOURNAL   Cell Mol Life Sci 80 (5), 134 (2023)
   PUBMED   37099206
  REMARK    GeneRIF: Atrial natriuretic peptide stimulates autophagy/mitophagy
            and improves mitochondrial function in chronic heart failure.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 855)
  AUTHORS   Lu,G., Hu,R., Tao,T., Hu,M., Dong,Z. and Wang,C.
  TITLE     Regulatory role of atrial natriuretic peptide in brown adipose
            tissue: A narrative review
  JOURNAL   Obes Rev 24 (1), e13522 (2023)
   PUBMED   36336901
  REMARK    GeneRIF: Regulatory role of atrial natriuretic peptide in brown
            adipose tissue: A narrative review.
            Review article
REFERENCE   5  (bases 1 to 855)
  AUTHORS   Suga,S., Nakao,K., Hosoda,K., Mukoyama,M., Ogawa,Y., Shirakami,G.,
            Arai,H., Saito,Y., Kambayashi,Y., Inouye,K. et al.
  TITLE     Receptor selectivity of natriuretic peptide family, atrial
            natriuretic peptide, brain natriuretic peptide, and C-type
            natriuretic peptide
  JOURNAL   Endocrinology 130 (1), 229-239 (1992)
   PUBMED   1309330
REFERENCE   6  (bases 1 to 855)
  AUTHORS   Bennett,B.D., Bennett,G.L., Vitangcol,R.V., Jewett,J.R.,
            Burnier,J., Henzel,W. and Lowe,D.G.
  TITLE     Extracellular domain-IgG fusion proteins for three human
            natriuretic peptide receptors. Hormone pharmacology and application
            to solid phase screening of synthetic peptide antisera
  JOURNAL   J Biol Chem 266 (34), 23060-23067 (1991)
   PUBMED   1660465
REFERENCE   7  (bases 1 to 855)
  AUTHORS   Koller,K.J., Lowe,D.G., Bennett,G.L., Minamino,N., Kangawa,K.,
            Matsuo,H. and Goeddel,D.V.
  TITLE     Selective activation of the B natriuretic peptide receptor by
            C-type natriuretic peptide (CNP)
  JOURNAL   Science 252 (5002), 120-123 (1991)
   PUBMED   1672777
REFERENCE   8  (bases 1 to 855)
  AUTHORS   Yang-Feng,T.L., Floyd-Smith,G., Nemer,M., Drouin,J. and Francke,U.
  TITLE     The pronatriodilatin gene is located on the distal short arm of
            human chromosome 1 and on mouse chromosome 4
  JOURNAL   Am J Hum Genet 37 (6), 1117-1128 (1985)
   PUBMED   2934979
REFERENCE   9  (bases 1 to 855)
  AUTHORS   Zivin,R.A., Condra,J.H., Dixon,R.A., Seidah,N.G., Chretien,M.,
            Nemer,M., Chamberland,M. and Drouin,J.
  TITLE     Molecular cloning and characterization of DNA sequences encoding
            rat and human atrial natriuretic factors
  JOURNAL   Proc Natl Acad Sci U S A 81 (20), 6325-6329 (1984)
   PUBMED   6238331
REFERENCE   10 (bases 1 to 855)
  AUTHORS   Oikawa,S., Imai,M., Ueno,A., Tanaka,S., Noguchi,T., Nakazato,H.,
            Kangawa,K., Fukuda,A. and Matsuo,H.
  TITLE     Cloning and sequence analysis of cDNA encoding a precursor for
            human atrial natriuretic polypeptide
  JOURNAL   Nature 309 (5970), 724-726 (1984)
   PUBMED   6203042
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC005893.1 and AA779538.1.
            
            On May 17, 2019 this sequence version replaced NM_006172.3.
            
            Summary: The protein encoded by this gene belongs to the
            natriuretic peptide family. Natriuretic peptides are implicated in
            the control of extracellular fluid volume and electrolyte
            homeostasis. This protein is synthesized as a large precursor
            (containing a signal peptide), which is processed to release a
            peptide from the N-terminus with similarity to vasoactive peptide,
            cardiodilatin, and another peptide from the C-terminus with
            natriuretic-diuretic activity. Mutations in this gene have been
            associated with atrial fibrillation familial type 6. This gene is
            located adjacent to another member of the natriuretic family of
            peptides on chromosome 1. [provided by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.46023.1,
                                           SRR5189655.166306.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154361, SAMEA2155550
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376480.7/ ENSP00000365663.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-552               BC005893.1         1-552
            553-855             AA779538.1         4-306               c
FEATURES             Location/Qualifiers
     source          1..855
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..855
                     /gene="NPPA"
                     /gene_synonym="ANF; ANP; ATFB6; ATRST2; CDD; CDD-ANF; CDP;
                     PND"
                     /note="natriuretic peptide A"
                     /db_xref="GeneID:4878"
                     /db_xref="HGNC:HGNC:7939"
                     /db_xref="MIM:108780"
     exon            1..222
                     /gene="NPPA"
                     /gene_synonym="ANF; ANP; ATFB6; ATRST2; CDD; CDD-ANF; CDP;
                     PND"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..555
                     /gene="NPPA"
                     /gene_synonym="ANF; ANP; ATFB6; ATRST2; CDD; CDD-ANF; CDP;
                     PND"
                     /note="cardiodilatin-related peptide; cardionatrin;
                     atriopeptin; prepronatriodilatin; proANF; proANP;
                     preproANP; atriopeptigen; preproCDD-ANF; atrial
                     natriuretic factor prohormone; atrial natriuretic peptide
                     prohormone; natriuretic peptide precursor A"
                     /codon_start=1
                     /product="natriuretic peptides A preproprotein"
                     /protein_id="NP_006163.1"
                     /db_xref="CCDS:CCDS139.1"
                     /db_xref="GeneID:4878"
                     /db_xref="HGNC:HGNC:7939"
                     /db_xref="MIM:108780"
                     /translation="MSSFSTTTVSFLLLLAFQLLGQTRANPMYNAVSNADLMDFKNLL
                     DHLEEKMPLEDEVVPPQVLSEPNEEAGAALSPLPEVPPWTGEVSPAQRDGGALGRGPW
                     DSSDRSALLKSKLRALLTAPRSLRRSSCFGGRMDRIGAQSGLGCNSFRY"
     exon            223..549
                     /gene="NPPA"
                     /gene_synonym="ANF; ANP; ATFB6; ATRST2; CDD; CDD-ANF; CDP;
                     PND"
                     /inference="alignment:Splign:2.1.0"
     exon            550..855
                     /gene="NPPA"
                     /gene_synonym="ANF; ANP; ATFB6; ATRST2; CDD; CDD-ANF; CDP;
                     PND"
                     /inference="alignment:Splign:2.1.0"
     regulatory      824..829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPPA"
                     /gene_synonym="ANF; ANP; ATFB6; ATRST2; CDD; CDD-ANF; CDP;
                     PND"
                     /note="hexamer: AATAAA"
     polyA_site      855
                     /gene="NPPA"
                     /gene_synonym="ANF; ANP; ATFB6; ATRST2; CDD; CDD-ANF; CDP;
                     PND"
                     /note="major polyA site"
ORIGIN      
        1 gagacaggga cagacgtagg ccaagagagg ggaaccagag aggaaccaga ggggagagac
       61 agagcagcaa gcagtggatt gctccttgac gacgccagca tgagctcctt ctccaccacc
      121 accgtgagct tcctcctttt actggcattc cagctcctag gtcagaccag agctaatccc
      181 atgtacaatg ccgtgtccaa cgcagacctg atggatttca agaatttgct ggaccatttg
      241 gaagaaaaga tgcctttaga agatgaggtc gtgcccccac aagtgctcag tgagccgaat
      301 gaagaagcgg gggctgctct cagccccctc cctgaggtgc ctccctggac cggggaagtc
      361 agcccagccc agagagatgg aggtgccctc gggcggggcc cctgggactc ctctgatcga
      421 tctgccctcc taaaaagcaa gctgagggcg ctgctcactg cccctcggag cctgcggaga
      481 tccagctgct tcgggggcag gatggacagg attggagccc agagcggact gggctgtaac
      541 agcttccggt actgaagata acagccaggg aggacaagca gggctgggcc tagggacaga
      601 ctgcaagagg ctcctgtccc ctggggtctc tgctgcattt gtgtcatctt gttgccatgg
      661 agttgtgatc atcccatcta agctgcagct tcctgtcaac acttctcaca tcttatgcta
      721 actgtagata aagtggtttg atggtgactt cctcgcctct cccaccccat gcattaaatt
      781 ttaaggtaga acctcacctg ttactgaaag tggtttgaaa gtgaataaac ttcagcacca
      841 tggacagaag acaaa
//
