LOCUS       NM_006993                910 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens nucleophosmin/nucleoplasmin 3 (NPM3), mRNA.
ACCESSION   NM_006993
VERSION     NM_006993.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 910)
  AUTHORS   Martisova,A., Faktor,J., Sosolikova,T., Klemesova,I., Kolarova,T.,
            Holcakova,J. and Hrstka,R.
  TITLE     Characterization of the AGR2-NPM3 axis uncovers the AGR2
            involvement in PD-L1 regulation in colorectal cancer
  JOURNAL   Sci Rep 14 (1), 21926 (2024)
   PUBMED   39300184
  REMARK    GeneRIF: Characterization of the AGR2-NPM3 axis uncovers the AGR2
            involvement in PD-L1 regulation in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 910)
  AUTHORS   Wang,H., Zhou,Z., Zhang,J., Hao,T., Wang,P., Wu,P., Su,R., Yang,H.,
            Deng,G., Chen,S., Gu,L., He,Y., Zeng,L., Zhang,C. and Yin,S.
  TITLE     Pumilio1 regulates NPM3/NPM1 axis to promote PD-L1-mediated immune
            escape in gastric cancer
  JOURNAL   Cancer Lett 581, 216498 (2024)
   PUBMED   38029539
  REMARK    GeneRIF: Pumilio1 regulates NPM3/NPM1 axis to promote
            PD-L1-mediated immune escape in gastric cancer.
REFERENCE   3  (bases 1 to 910)
  AUTHORS   Wei,S., Xing,J., Lu,K., Wang,K. and Yu,W.
  TITLE     NPM3 as a novel oncogenic factor and poor prognostic marker
            contributes to cell proliferation and migration in lung
            adenocarcinoma
  JOURNAL   Hereditas 160 (1), 27 (2023)
   PUBMED   37254219
  REMARK    GeneRIF: NPM3 as a novel oncogenic factor and poor prognostic
            marker contributes to cell proliferation and migration in lung
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 910)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 910)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 910)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   7  (bases 1 to 910)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   8  (bases 1 to 910)
  AUTHORS   Shackleford,G.M., Ganguly,A. and MacArthur,C.A.
  TITLE     Cloning, expression and nuclear localization of human NPM3, a
            member of the nucleophosmin/nucleoplasmin family of nuclear
            chaperones
  JOURNAL   BMC Genomics 2, 8 (2001)
   PUBMED   11722795
REFERENCE   9  (bases 1 to 910)
  AUTHORS   Philpott,A., Krude,T. and Laskey,R.A.
  TITLE     Nuclear chaperones
  JOURNAL   Semin Cell Dev Biol 11 (1), 7-14 (2000)
   PUBMED   10736259
  REMARK    Review article
REFERENCE   10 (bases 1 to 910)
  AUTHORS   MacArthur,C.A. and Shackleford,G.M.
  TITLE     Npm3: a novel, widely expressed gene encoding a protein related to
            the molecular chaperones nucleoplasmin and nucleophosmin
  JOURNAL   Genomics 42 (1), 137-140 (1997)
   PUBMED   9177783
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010789.9.
            
            On Jun 16, 2021 this sequence version replaced NM_006993.2.
            
            Summary: The protein encoded by this gene is related to the nuclear
            chaperone phosphoproteins, nucleoplasmin and nucleophosmin. This
            protein is strongly expressed in diverse cell types where it
            localizes primarily to the nucleus. Based on its similarity to
            nucleoplasmin and nucleophosmin, this protein likely functions as a
            molecular chaperone in the cell nucleus. [provided by RefSeq, Oct
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041067.1, AY049737.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370110.6/ ENSP00000359128.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AC010789.9         111970-112143       c
            175-260             AC010789.9         111536-111621       c
            261-380             AC010789.9         111175-111294       c
            381-474             AC010789.9         110955-111048       c
            475-602             AC010789.9         110424-110551       c
            603-910             AC010789.9         110022-110329       c
FEATURES             Location/Qualifiers
     source          1..910
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..910
                     /gene="NPM3"
                     /gene_synonym="PORMIN; TMEM123"
                     /note="nucleophosmin/nucleoplasmin 3"
                     /db_xref="GeneID:10360"
                     /db_xref="HGNC:HGNC:7931"
                     /db_xref="MIM:606456"
     exon            1..174
                     /gene="NPM3"
                     /gene_synonym="PORMIN; TMEM123"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..593
                     /gene="NPM3"
                     /gene_synonym="PORMIN; TMEM123"
                     /note="nucleophosmin/nucleoplasmin family, member 3"
                     /codon_start=1
                     /product="nucleoplasmin-3"
                     /protein_id="NP_008924.1"
                     /db_xref="CCDS:CCDS7519.1"
                     /db_xref="GeneID:10360"
                     /db_xref="HGNC:HGNC:7931"
                     /db_xref="MIM:606456"
                     /translation="MAAGTAAALAFLSQESRTRAGGVGGLRVPAPVTMDSFFFGCELS
                     GHTRSFTFKVEEEDDAEHVLALTMLCLTEGAKDECNVVEVVARNHDHQEIAVPVANLK
                     LSCQPMLSLDDFQLQPPVTFRLKSGSGPVRITGRHQIVTMSNDVSEEESEEEEEDSDE
                     EEVELCPILPAKKQGGRP"
     exon            175..260
                     /gene="NPM3"
                     /gene_synonym="PORMIN; TMEM123"
                     /inference="alignment:Splign:2.1.0"
     exon            261..380
                     /gene="NPM3"
                     /gene_synonym="PORMIN; TMEM123"
                     /inference="alignment:Splign:2.1.0"
     exon            381..474
                     /gene="NPM3"
                     /gene_synonym="PORMIN; TMEM123"
                     /inference="alignment:Splign:2.1.0"
     exon            475..602
                     /gene="NPM3"
                     /gene_synonym="PORMIN; TMEM123"
                     /inference="alignment:Splign:2.1.0"
     exon            603..910
                     /gene="NPM3"
                     /gene_synonym="PORMIN; TMEM123"
                     /inference="alignment:Splign:2.1.0"
     regulatory      886..891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPM3"
                     /gene_synonym="PORMIN; TMEM123"
                     /note="hexamer: AATAAA"
     polyA_site      910
                     /gene="NPM3"
                     /gene_synonym="PORMIN; TMEM123"
                     /note="major polyA site"
ORIGIN      
        1 gagggtcccc ggctttgtgc gtgtcggggg cggagtttga agaaggctct tacagcatgg
       61 ccgccggtac tgcagctgcc ttagcgtttt tgagtcagga gagccgaacg cgggccgggg
      121 gtgtcggggg cctacgggtc ccggccccgg tcactatgga cagttttttc ttcggctgtg
      181 agctctccgg ccacacccgc tccttcacct ttaaggtaga ggaagaggat gatgcggagc
      241 acgtgctggc actaaccatg ctctgcctca ccgagggagc caaagacgag tgtaatgtgg
      301 tagaagttgt ggcccggaac catgaccatc aggagatcgc agtccctgtg gccaacctca
      361 agctgtcctg ccaacccatg ctcagtctgg atgacttcca gctccaacca cctgtaacct
      421 tccgcctgaa gtcgggctct ggccctgtgc ggatcactgg gcggcaccag attgttacga
      481 tgagcaatga tgtttctgag gaggagagcg aggaagagga agaggacagt gatgaggaag
      541 aagttgagct gtgccccatc cttcctgcca aaaagcaggg gggcaggccc tagccctcct
      601 aggtcagctc catgtgccat gcaccgccat gcaccctgtt ccctgacaag tttcaacaat
      661 tgtaaatatt tcttccttga agaggagagc ttgggtgggg gttgggtggg agggacttgg
      721 gtctttggtg ctaggagagg gcctgtgctc cacacagccg tggttttctg attttcacca
      781 tgcccggggc ctcccttccc acctgcctgt gagaattgga ggttagtgcc tgaagctcag
      841 agctacacat ttttaatagt ttttacattt ttggataaag gttgaaataa agtggtgtgg
      901 agtttttgca
//
