LOCUS       NM_001286680            1490 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nucleophosmin/nucleoplasmin 2 (NPM2), transcript
            variant 2, mRNA.
ACCESSION   NM_001286680 XM_005273372
VERSION     NM_001286680.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1490)
  AUTHORS   Zhao,M.L., Wang,J.X., Bian,X.K., Zhang,J., Han,Y.W., Xu,S.X.,
            Lee,S.C. and Zhao,J.Z.
  TITLE     Hexavalent chromium causes centrosome amplification by inhibiting
            the binding between TMOD2 and NPM2
  JOURNAL   Toxicol Lett 380, 12-22 (2023)
   PUBMED   36963620
  REMARK    GeneRIF: Hexavalent chromium causes centrosome amplification by
            inhibiting the binding between TMOD2 and NPM2.
REFERENCE   2  (bases 1 to 1490)
  AUTHORS   Wu,H.L., Yang,Z.R., Su,Y.D., Ma,R., Du,X.M., Gao,Y. and Li,Y.
  TITLE     Loss of NPM2 expression is a potential immunohistochemical marker
            for malignant peritoneal mesothelioma: a single-center study of 92
            cases
  JOURNAL   World J Surg Oncol 20 (1), 350 (2022)
   PUBMED   36280841
  REMARK    GeneRIF: Loss of NPM2 expression is a potential immunohistochemical
            marker for malignant peritoneal mesothelioma: a single-center study
            of 92 cases.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1490)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1490)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1490)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1490)
  AUTHORS   Olson,J.E., Wang,X., Pankratz,V.S., Fredericksen,Z.S., Vachon,C.M.,
            Vierkant,R.A., Cerhan,J.R. and Couch,F.J.
  TITLE     Centrosome-related genes, genetic variation, and risk of breast
            cancer
  JOURNAL   Breast Cancer Res Treat 125 (1), 221-228 (2011)
   PUBMED   20508983
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1490)
  AUTHORS   Koga,Y., Pelizzola,M., Cheng,E., Krauthammer,M., Sznol,M.,
            Ariyan,S., Narayan,D., Molinaro,A.M., Halaban,R. and Weissman,S.M.
  TITLE     Genome-wide screen of promoter methylation identifies novel markers
            in melanoma
  JOURNAL   Genome Res 19 (8), 1462-1470 (2009)
   PUBMED   19491193
  REMARK    GeneRIF: Promoter methylation and differential gene expression of
            five markers: COL1A2, NPM2, HSPB6, DDIT4L and MT1G were validated
            by sequencing of bisulfite-modified DNA and real-time reverse
            transcriptase PCR, respectively.
REFERENCE   8  (bases 1 to 1490)
  AUTHORS   Burns,K.H., Viveiros,M.M., Ren,Y., Wang,P., DeMayo,F.J.,
            Frail,D.E., Eppig,J.J. and Matzuk,M.M.
  TITLE     Roles of NPM2 in chromatin and nucleolar organization in oocytes
            and embryos
  JOURNAL   Science 300 (5619), 633-636 (2003)
   PUBMED   12714744
REFERENCE   9  (bases 1 to 1490)
  AUTHORS   Akey,C.W. and Luger,K.
  TITLE     Histone chaperones and nucleosome assembly
  JOURNAL   Curr Opin Struct Biol 13 (1), 6-14 (2003)
   PUBMED   12581654
  REMARK    Review article
REFERENCE   10 (bases 1 to 1490)
  AUTHORS   Dalenc,F., Drouet,J., Ader,I., Delmas,C., Rochaix,P., Favre,G.,
            Cohen-Jonathan,E. and Toulas,C.
  TITLE     Increased expression of a COOH-truncated nucleophosmin resulting
            from alternative splicing is associated with cellular resistance to
            ionizing radiation in HeLa cells
  JOURNAL   Int J Cancer 100 (6), 662-668 (2002)
   PUBMED   12209603
  REMARK    GeneRIF: Expression of NPM2 in HeLa cells
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB262972.1 and AY262113.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001286680.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY262113.1, SRR14038192.2013704.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000518119.6/ ENSP00000427741.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               DB262972.1         25-324
            301-1490            AY262113.1         1-1190
FEATURES             Location/Qualifiers
     source          1..1490
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..1490
                     /gene="NPM2"
                     /note="nucleophosmin/nucleoplasmin 2"
                     /db_xref="GeneID:10361"
                     /db_xref="HGNC:HGNC:7930"
                     /db_xref="MIM:608073"
     exon            1..490
                     /gene="NPM2"
                     /inference="alignment:Splign:2.1.0"
     exon            491..597
                     /gene="NPM2"
                     /inference="alignment:Splign:2.1.0"
     exon            598..688
                     /gene="NPM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             631..1275
                     /gene="NPM2"
                     /note="isoform 1 is encoded by transcript variant 2;
                     nucleoplasmin-2"
                     /codon_start=1
                     /product="nucleoplasmin-2 isoform 1"
                     /protein_id="NP_001273609.1"
                     /db_xref="CCDS:CCDS6018.1"
                     /db_xref="GeneID:10361"
                     /db_xref="HGNC:HGNC:7930"
                     /db_xref="MIM:608073"
                     /translation="MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRL
                     LLHTICLGEKAKEEMHRVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPV
                     TFQLRAGSGPVFLSGQERYEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSP
                     VKQVKRLVPQKQASVAKKKKLEKEEEEIRASVRDKSPVKKAKATARAKKPGFKK"
     exon            689..774
                     /gene="NPM2"
                     /inference="alignment:Splign:2.1.0"
     exon            775..900
                     /gene="NPM2"
                     /inference="alignment:Splign:2.1.0"
     exon            901..994
                     /gene="NPM2"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1161
                     /gene="NPM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1196
                     /gene="NPM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1230
                     /gene="NPM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1490
                     /gene="NPM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1470..1475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPM2"
                     /note="hexamer: AATAAA"
     polyA_site      1490
                     /gene="NPM2"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgctcc ccgccccctg ccgcggcgcc tcgcctcccg gctcacctcc ccaccccacc
       61 tgcccgctgc ggctctccgc gggagatctc accgttctgg agacagggct cgctcgctct
      121 cacggtaggc tggaagaacg ggctgtctgg gccttaggaa aggcccatgc tgtataaggc
      181 atggggaaag gaaaggaaga aaggcaacga acaagaagga gggcttccaa ctgcagcttc
      241 ctgccggctg caggcctccc ttcctaagct gagctgaggc ttcctctcca tgggctgggg
      301 agggggcgcc aggaggcctc ggcgggtccg caattggccg ggacagcttc tcacgaaagg
      361 tcctgggccg gcatcatcag cctcacctgg gaactggtta gaactacaaa ttccctcggc
      421 cccacccaga ccgacgccaa gggcagctgt ggagtggggc gcggcaatgc gccccttaac
      481 agccctccag gcttcttagc ccgggcttgg acagccgcct tccggccaga ggggatgagg
      541 ttgcgctgcg ctccgggagc gccgatggcg tgactggccc cgcgcggagc agcgacactg
      601 cccggccagc ccgcttctct gcccggagcc atgaatctca gtagcgccag tagcacggag
      661 gaaaaggcag tgacgaccgt gctctggggc tgcgagctca gtcaggagag gcggacttgg
      721 accttcagac cccagctgga ggggaagcag agctgcaggc tgttgcttca tacgatttgc
      781 ttgggggaga aagccaaaga ggagatgcat cgcgtggaga tcctgccccc agcaaaccag
      841 gaggacaaga agatgcagcc ggtcaccatt gcctcactcc aggcctcagt cctccccatg
      901 gtctccatgg taggagtgca gctttctccc ccagttactt tccagctccg ggctggctca
      961 ggacccgtgt tcctcagtgg ccaggaacgt tatgaagcat cagacctaac ctgggaggag
     1021 gaggaggaag aagaagggga ggaggaggaa gaggaagagg aagatgatga ggatgaggat
     1081 gcagatatat ctctggagga gcaaagccct gtcaaacaag tcaaaaggct ggtgccccag
     1141 aagcaggcga gcgtggctaa gaaaaaaaag ctggaaaaag aagaagagga aataagagcc
     1201 agcgttagag acaagagccc tgtgaaaaag gccaaagcca cagccagagc caagaagcca
     1261 ggattcaaga aatgaggagc cacgccttgg ggggcacggt gcaaagtggg ccttccctgg
     1321 gctgtgctgc aggcacaggg tgcccctgtc cagcccctcc acctgtgtct gaatgcaaca
     1381 ggggtgttgc gggggcaaca tgagagcccc tcacccccaa ctctccactt tcaggaggcc
     1441 cccagtgaag agccccacct cggggtcaca ataaagttgc ctggtcagga
//
