LOCUS       NM_001395849            6463 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens nuclear pore complex interacting protein family member
            B5 (NPIPB5), transcript variant 1, mRNA.
ACCESSION   NM_001395849
VERSION     NM_001395849.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6463)
  AUTHORS   Eichler,E.E., Johnson,M.E., Alkan,C., Tuzun,E., Sahinalp,C.,
            Misceo,D., Archidiacono,N. and Rocchi,M.
  TITLE     Divergent origins and concerted expansion of two segmental
            duplications on chromosome 16
  JOURNAL   J Hered 92 (6), 462-468 (2001)
   PUBMED   11948212
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC106788.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK296338.1, SRR18074968.517312.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000424340.7/ ENSP00000440703.1
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3031              AC106788.3         75946-78976         c
            3032-3160           AC106788.3         65919-66047         c
            3161-3260           AC106788.3         62202-62301         c
            3261-3456           AC106788.3         61894-62089         c
            3457-3517           AC106788.3         57747-57807         c
            3518-3553           AC106788.3         57602-57637         c
            3554-6463           AC106788.3         53332-56241         c
FEATURES             Location/Qualifiers
     source          1..6463
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.2"
     gene            1..6463
                     /gene="NPIPB5"
                     /note="nuclear pore complex interacting protein family
                     member B5"
                     /db_xref="GeneID:100132247"
                     /db_xref="HGNC:HGNC:37233"
     exon            1..3031
                     /gene="NPIPB5"
                     /inference="alignment:Splign:2.1.0"
     CDS             2912..6313
                     /gene="NPIPB5"
                     /note="nuclear pore complex interacting protein related"
                     /codon_start=1
                     /product="nuclear pore complex-interacting protein family
                     member B5"
                     /protein_id="NP_001382778.1"
                     /db_xref="CCDS:CCDS45443.1"
                     /db_xref="GeneID:100132247"
                     /db_xref="HGNC:HGNC:37233"
                     /translation="MVKLSIVLTPQFLSHDQGQLTKELQQHVKSVTCPCEYLRKVINT
                     LADHHHRGTDFGGSPWLHVIIAFPTSYKVVITLWIVYLWVSLLKTIFWSRNGHDGSTD
                     VQQRAWRSNRRRQEGLRSICMHTKKRVSSFRGNKIGLKDVITLRRHVETKVRAKIRKR
                     KVTTKINHHDKINGKRKTARKQKMFQRAQELRRRAEDYHKCKIPPSARKALCNWVRMA
                     AAEHRHSSGLPYWPYLTAETLKNRMGHQPPPPTQQHSITDNSLSLKTPPECLLTPLPP
                     SADDNLKTPPECVLTPLPPSADDNLKTPPECVLTPLPPSADDNLKTPPECLLTPLPPS
                     ADDNLKTPPECLLTPLPPSALPSAPPSADDNLKTRAECLLHPLPPSADDNLKTPSERQ
                     LTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNI
                     KTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSAD
                     DNLKTPSERQLTALPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPP
                     SADDNIKTPAFHPQRMISRHLPSVSSLPFHPQLHPQQMIISRYLLSVCGFRFHHQPMI
                     ISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPERMIISRHLPSVSSLPFHPQ
                     LHPQQMIISRHLPSVCGGRFHPQQMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVC
                     GGRFHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQQMIISRHLP
                     SVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQRMIISRHLPSVSSLPFHPQLHPQQM
                     IISRHLPSVCGERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRG
                     PLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSER
                     QLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPPLATQEAEAEKPRKPKRQR
                     AAEMEPPPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPKRRRVGDVEPSRKPKRRRA
                     ADVEPSSPEPKRRRVGDVEPSRKPKRRRAADVEPSLPEPKRRRLS"
     exon            3032..3160
                     /gene="NPIPB5"
                     /inference="alignment:Splign:2.1.0"
     exon            3161..3260
                     /gene="NPIPB5"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..3456
                     /gene="NPIPB5"
                     /inference="alignment:Splign:2.1.0"
     exon            3457..3517
                     /gene="NPIPB5"
                     /inference="alignment:Splign:2.1.0"
     exon            3518..3553
                     /gene="NPIPB5"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..6463
                     /gene="NPIPB5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6428..6433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPIPB5"
                     /note="hexamer: AATAAT"
     regulatory      6433..6438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPIPB5"
                     /note="hexamer: TATAAA"
     regulatory      6444..6449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPIPB5"
                     /note="hexamer: AATAAA"
     polyA_site      6445
                     /gene="NPIPB5"
                     /note="major polyA site"
     polyA_site      6449
                     /gene="NPIPB5"
                     /note="major polyA site"
     polyA_site      6463
                     /gene="NPIPB5"
                     /note="major polyA site"
ORIGIN      
        1 gatagattct acctttgtca cccaggcggg agtgcagtgg catgatctcg gctcactaca
       61 acctccgcat cctgggttca agcagttctc ctgtctcagc ctcccgagta gctgagatta
      121 caggcatgtg ccaccaggca tggctaattt ttgtattttt agtggagaca gggtttcact
      181 ctattaggct ggtctggaac tcccgacctc aggtgatcca cgtgcctttg tctcccaaag
      241 tgctgggatt acaggcatga gtgacggtgc ccagccattc gtgacatgtt tatacaaata
      301 taactttagc aaatatttag cataactatc aaaattacaa atcatattaa atttgtataa
      361 atgtatgcaa tttttggaac acgcatatca acaacatacc cataaatata actgagatga
      421 gatctaatgt cacctcactt gacagtgccc tcccatgcag tatcgccaca tttgacaatg
      481 cctgcccatt taatctacca aataaatcga atcacttaat acctctacaa gatgagagat
      541 acattcttta gactccccaa gggatgcagc tgaaaaaaat cccaaagtta gttttaagcc
      601 aaaaagactt gatttaggat tttgacactg gagaaaccca tcaaagatgt caagtttgaa
      661 aacacttgat caaaacagaa tcacaggtca ctattaaaag agtattaatt taaccagaga
      721 cttccaaagc aatacagaaa cttacatgga tataaaaacc ctaacccttt taaaggtcag
      781 atttgctaag tgatcaaaag gggtacttga attgaatcga cacaggaaga gtgtgtacag
      841 ggttatgagt gtaggcaggt ggttactttg gtcatatctc catttgccac ctgattacac
      901 atgagaatgg catctttact caccagaaag ccagtattat aggaggtgta ggaggcattc
      961 ttggacttga gacaagaaca ttgttgtgta gaaatttcat tgactgtgtt aaaattattc
     1021 tccatgggct ggagaacaca taacatggcc tttagaatga gacgggcatt gattggatgc
     1081 aaggtctcca cacttactag ctgtgtgaca ttggacagag tgcttcatca ttccgagact
     1141 cagtttttaa aggaaaaaca actaactacc ttgcaagctt gctagcaggt ttaagtgtaa
     1201 taatgtgtgg gaatgactgc accgtgacta acatgcagtg acagcttaat taatgttaac
     1261 ccttatcatt atcatataag aatgtgagtt acataagaga ggagtcctgt cagttcgttc
     1321 tctgctgtgt ccccaagacc atgaatcatg gctggcatgt agtaggcatt taataatata
     1381 tgttcaacaa gtatttggca gtcttggagg gcagaaaagg aggtggggaa gatttttaaa
     1441 taacattttt taaaaagtca cattgtccta caataccgat ttttcttgca tatttaggaa
     1501 attgagggtt tttttctaaa acatgcggac atatgggaaa taggatgcaa catttgcact
     1561 aatgtttcag acacagttag aggtttccaa gagattttgc gctggggagg ctgcttgcta
     1621 caagctccca aagctctggg aggacatagt attcattcct ccctcagcag aagcggtgag
     1681 gcaagaagct ctggggagca cccagcgttg gacttttagc atagtgtgtc aggtcttcat
     1741 agtttgggcc cagggcacag agaagtcaca gctctccggc atcctgtgac ctttaccctc
     1801 tttgccaagg gaaaatgtgg cccaccaaag caagaaactt gagggcatgg gtcaccccag
     1861 ccctggcatc tgcccagagc ccgagaagga aggaacaatg atcctccagc tacctcacgg
     1921 ggctggcaca ggtgaccact gccctggcat cacccagctg tgtccggcag cctgaacccc
     1981 atctgtgggg atgcgaggag gaaaatacaa aagtccttag gtgaacactg agaaggcaga
     2041 tgcagcagaa acctccaggc cagaactacc cagtcttgga cctatggtgg agatagagca
     2101 tagctggcga tcatgtgtac ttacactcta aggtcacctg gttgcactat ggcctcatct
     2161 gtggctctga aaatgaagat ttggaaggag atcatcacag ctaatgttta acaagcccct
     2221 cctgtgtgcc aaatcattca cccctcacca caaccgaatg agctaaggat tctcattata
     2281 tatagtttat ggagagggaa gtgcagacat aaagaggtga attatcttac ccagatcaca
     2341 cagctgataa gtggtggagg cagaatagaa tctaaacagt gtggctccgg agcccacatg
     2401 cattgattcg acaagtgttt attgagcacc tgccgcggac aaggccttgt gtgattaaat
     2461 agggttataa ttagtaatat aaaaatgaga aatcactaat gctttttaga cttaacattt
     2521 tgtttttttg taggtttcag gcacagaact gtatatccaa taatagtgaa atggatccca
     2581 ctaattatga cagaaatgat gatacattta aatgacttgg atgttttata ggtatgatct
     2641 cgtgaaatct tgagagaaac tgaatgacga atgaaactat tgttcctgtt tcacacagaa
     2701 gaaaactgag gttaaaaggg gtaaagtaat tttgcatggc atgaagtaga aattcaaagt
     2761 acaggaattt gaacttggtt ctgtcctttt ctgaagccct tgaccactat agactcaaac
     2821 atcaccttgt ttttccactc attcaacact ttttttttta aattatctaa taggttggca
     2881 ctcatcatga gcccctgttc tcattctgca aatggtgaag ctctctattg tcctgacccc
     2941 acagttcctg tcccatgacc agggccagct caccaaggag ctgcagcagc atgtaaagtc
     3001 agtgacatgc ccatgcgagt acctgaggaa ggttatcaat actctggctg accatcatca
     3061 tcgtgggact gactttggtg gaagtccttg gttacatgtc attattgcgt ttccgacaag
     3121 ttataaagtt gtcattaccc tctggatagt ttacctttgg gtgtctctcc tgaagactat
     3181 cttctggtct cgaaatggac atgatggatc cacggatgta cagcagagag cctggaggtc
     3241 caaccgccgt agacaggaag ggctgaggtc catttgtatg cacacaaaga aaagagtttc
     3301 ttcctttcga ggaaataaaa ttggcctgaa agacgtcatt actctacgga gacatgtgga
     3361 aacaaaagtt agagctaaaa tccgtaagag gaaggtgaca acgaaaatca accatcatga
     3421 caaaatcaat ggaaagagga agaccgccag aaaacagaaa atgtttcaac gtgcgcaaga
     3481 gttgcggcgg cgagcagagg actaccacaa atgcaaaatc cccccttctg caagaaaggc
     3541 tctttgcaac tgggtcagaa tggcggcagc ggagcatcgt cattcttcag gattgcccta
     3601 ctggccctac ctcacagctg aaactttaaa aaacaggatg ggccaccagc cacctcctcc
     3661 aactcaacaa cattctataa ctgataactc cctgagcctc aagacacctc ccgagtgtct
     3721 gctcactccc cttccaccct cagcggatga taatctcaag acacctcccg agtgtgtgct
     3781 cactcccctt ccaccctcag cggatgataa tctcaagaca cctcccgagt gtgtgctcac
     3841 tccccttcca ccctcagcgg atgataatct caagacacct cctgagtgtc tgctcactcc
     3901 ccttccaccc tcagcggatg ataatctcaa gacacctccc gagtgtctgc tcactcccct
     3961 tccaccctca gctctaccct cagctccacc ctcagcggat gataatctca agacacgtgc
     4021 cgagtgtctg ctccatcccc ttccaccctc agcggatgat aatctcaaga caccttccga
     4081 gcgtcagctc actccccttc caccctcagc tccaccctca gcagatgata atatcaagac
     4141 acctgccgag cgtctgcggg ggccgcttcc accctcagcg gatgataatc tcaagacacc
     4201 ttccgagcgt cagctcactc cccttccacc ctcagctcca ccctcagcag atgataatat
     4261 caagacacct gctgagcgtc tgcgggggcc gcttccaccc tcagcggatg ataatctcaa
     4321 gacaccttcc gagcgtcagc tcactcccct tccaccctca gctccaccct cagcagatga
     4381 taatatcaag acacctgccg agcgtctgcg ggggccgctt ccaccctcag cggatgataa
     4441 tctcaagaca ccttccgagc gtcagctcac tgcccttcca ccctcagcag atgataatat
     4501 caagacacct gccgagcgtc tgcgggggcc gcttccaccc tcagcggatg ataatctcaa
     4561 gacaccttcc gagcgtcagc tcactcccct tccaccctca gctccaccct cagcagatga
     4621 taatatcaag acacctgcct tccaccctca gcggatgatc tcaagacacc ttccgagcgt
     4681 cagctcactc cccttccacc ctcagctcca ccctcagcag atgataatat caagatacct
     4741 gctgagcgtc tgcggattcc gcttccacca tcagccgatg ataatctcaa gacaccttcc
     4801 gagcgtcagc tcactcccct tccaccctca gctccaccct cagcagatga taatatcaag
     4861 acacctgccg agcgtctgcg ggggccgctt ccaccctgag cggatgataa tctcaagaca
     4921 ccttccgagc gtcagctcac tccccttcca ccctcagctc caccctcagc agatgataat
     4981 atcaagacac ctgccgagcg tctgcggggg ccgcttccac cctcagcaga tgataatctc
     5041 aagacacctt ccgagcgtca gctcactccc cttccaccct cagctccacc ctcagcagat
     5101 gataatatca agacacctgc cgagcgtctg cgggggccgc ttccaccctc agcggatgat
     5161 aatctcaaga caccttccga gcgtcagctc actccccttc caccctcagc tccaccctca
     5221 gcagatgata atatcaagac acctgccgag cgtctgcggg ggccgcttcc accctcagca
     5281 gatgataatc tcaagacacc ttccgagcgt cagctcactc cccttccacc ctcagctcca
     5341 ccctcagcag atgataatat caagacacct gccgagcgtc tgcgggggcc gcttccaccc
     5401 tcagcggatg ataatctcaa gacaccttcc gagcgtcagc tcactccctt tccaccctca
     5461 gctccaccct cagcagatga taatatcaag acacctgccg agcgtctgcg gggagcgtct
     5521 gcgggggccg cttccaccct cagcggatga taatctcaag acaccttccg agcgtcagct
     5581 cactcccctt ccaccctcag ctccaccctc agcagatgat aatatcaaga cacctgccga
     5641 gcgtctgcgg gggccgcttc caccctcagc ggatgataat ctcaagacac cttccgagcg
     5701 tcagctcact ccccttccac cctcagctcc accctcagca gatgataata tcaagacacc
     5761 tgccgagcgt ctgcgggggc cgcttccacc ctcagcggat gataatctca agacaccttc
     5821 cgagcgtcag ctcactcccc ttccaccctc agctccaccc tcagcagatg ataatatcaa
     5881 gacacctgcc gagcgtctgc gggggccgct tccaccctca gccgatgata atctcaagac
     5941 acctccctta gctactcagg aggctgaggc agaaaaacca cgcaaaccca agaggcagag
     6001 ggcggctgag atggaaccac ctcccgaacc caagaggcgg agggtcggtg acgtggaacc
     6061 gtcacgcaaa cccaagaggc ggagggccgc tgacgtggaa ccatcatcac ccgaacccaa
     6121 gaggcggagg gtcggtgatg tggaaccgtc acgcaaaccc aagaggcgga gggccgctga
     6181 cgtggaacca tcatcacccg aacccaagag gcggagggtc ggtgacgtgg aaccgtcacg
     6241 caaacccaag aggcggaggg ccgctgacgt ggaaccatca ttacccgaac ccaagaggcg
     6301 gaggttgagc tgagaagagg ccagtgcact caagcctgag caataagaat aaaaccgagt
     6361 agaacaaaat aaaaaattca aaaaacaaaa caaaacccac actccaaaaa ctaacaaaga
     6421 ataaataaat aatataaaaa taaaataaat actgcagtcc tta
//
