LOCUS       NM_130464               3691 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nuclear pore complex interacting protein family member
            B3 (NPIPB3), mRNA.
ACCESSION   NM_130464 XM_933834 XM_933869
VERSION     NM_130464.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3691)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3691)
  AUTHORS   Huang,S.H., Lee,T.Y., Lin,Y.J., Wan,L., Lai,C.H. and Lin,C.W.
  TITLE     Phage display technique identifies the interaction of severe acute
            respiratory syndrome coronavirus open reading frame 6 protein with
            nuclear pore complex interacting protein NPIPB3 in modulating Type
            I interferon antagonism
  JOURNAL   J Microbiol Immunol Infect 50 (3), 277-285 (2017)
   PUBMED   26320399
  REMARK    GeneRIF: The overexpression of NPIPB3 restored the interferon-beta
            responses in severe acute respiratory syndrome coronavirus open
            reading frame 6 (SARS-CoV ORF6) expressing cells, indicating that
            the interaction of SARS CoV ORF6 and NPIPB3 reduced Type I
            interferon antagonism by SARS-CoV ORF6.
REFERENCE   3  (bases 1 to 3691)
  AUTHORS   Martin,J., Han,C., Gordon,L.A., Terry,A., Prabhakar,S., She,X.,
            Xie,G., Hellsten,U., Chan,Y.M., Altherr,M., Couronne,O., Aerts,A.,
            Bajorek,E., Black,S., Blumer,H., Branscomb,E., Brown,N.C.,
            Bruno,W.J., Buckingham,J.M., Callen,D.F., Campbell,C.S.,
            Campbell,M.L., Campbell,E.W., Caoile,C., Challacombe,J.F.,
            Chasteen,L.A., Chertkov,O., Chi,H.C., Christensen,M., Clark,L.M.,
            Cohn,J.D., Denys,M., Detter,J.C., Dickson,M.,
            Dimitrijevic-Bussod,M., Escobar,J., Fawcett,J.J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Goodwin,L.A., Grady,D.L., Grigoriev,I., Groza,M., Hammon,N.,
            Hawkins,T., Haydu,L., Hildebrand,C.E., Huang,W., Israni,S.,
            Jett,J., Jewett,P.B., Kadner,K., Kimball,H., Kobayashi,A.,
            Krawczyk,M.C., Leyba,T., Longmire,J.L., Lopez,F., Lou,Y., Lowry,S.,
            Ludeman,T., Manohar,C.F., Mark,G.A., McMurray,K.L., Meincke,L.J.,
            Morgan,J., Moyzis,R.K., Mundt,M.O., Munk,A.C., Nandkeshwar,R.D.,
            Pitluck,S., Pollard,M., Predki,P., Parson-Quintana,B., Ramirez,L.,
            Rash,S., Retterer,J., Ricke,D.O., Robinson,D.L., Rodriguez,A.,
            Salamov,A., Saunders,E.H., Scott,D., Shough,T., Stallings,R.L.,
            Stalvey,M., Sutherland,R.D., Tapia,R., Tesmer,J.G., Thayer,N.,
            Thompson,L.S., Tice,H., Torney,D.C., Tran-Gyamfi,M., Tsai,M.,
            Ulanovsky,L.E., Ustaszewska,A., Vo,N., White,P.S., Williams,A.L.,
            Wills,P.L., Wu,J.R., Wu,K., Yang,J., Dejong,P., Bruce,D.,
            Doggett,N.A., Deaven,L., Schmutz,J., Grimwood,J., Richardson,P.,
            Rokhsar,D.S., Eichler,E.E., Gilna,P., Lucas,S.M., Myers,R.M.,
            Rubin,E.M. and Pennacchio,L.A.
  TITLE     The sequence and analysis of duplication-rich human chromosome 16
  JOURNAL   Nature 432 (7020), 988-994 (2004)
   PUBMED   15616553
REFERENCE   4  (bases 1 to 3691)
  AUTHORS   Eichler,E.E., Johnson,M.E., Alkan,C., Tuzun,E., Sahinalp,C.,
            Misceo,D., Archidiacono,N. and Rocchi,M.
  TITLE     Divergent origins and concerted expansion of two segmental
            duplications on chromosome 16
  JOURNAL   J Hered 92 (6), 462-468 (2001)
   PUBMED   11948212
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC309942.1, BC036263.1, AK294452.1 and BQ950195.1.
            
            On Jul 22, 2017 this sequence version replaced NM_130464.2.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-443               DC309942.1         115-557
            444-478             BC036263.1         403-437
            479-3641            AK294452.1         1-3163
            3642-3691           BQ950195.1         572-621
FEATURES             Location/Qualifiers
     source          1..3691
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.2"
     gene            1..3691
                     /gene="NPIPB3"
                     /gene_synonym="KIAA0220L; NPIP; NPIPB; NPIPB5; NPIPL3"
                     /note="nuclear pore complex interacting protein family
                     member B3"
                     /db_xref="GeneID:23117"
                     /db_xref="HGNC:HGNC:28989"
                     /db_xref="MIM:619984"
     exon            1..79
                     /gene="NPIPB3"
                     /gene_synonym="KIAA0220L; NPIP; NPIPB; NPIPB5; NPIPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            80..237
                     /gene="NPIPB3"
                     /gene_synonym="KIAA0220L; NPIP; NPIPB; NPIPB5; NPIPL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..3519
                     /gene="NPIPB3"
                     /gene_synonym="KIAA0220L; NPIP; NPIPB; NPIPB5; NPIPL3"
                     /note="nuclear pore complex-interacting protein-like 3;
                     KIAA0220-like protein; protein pps22-1; nuclear pore
                     complex-interacting protein B type"
                     /codon_start=1
                     /product="nuclear pore complex-interacting protein family
                     member B3"
                     /protein_id="NP_569731.2"
                     /db_xref="GeneID:23117"
                     /db_xref="HGNC:HGNC:28989"
                     /db_xref="MIM:619984"
                     /translation="MVKLSIVLTPQFLSHDQGQLTKELQQHVKSVTCPCEYLRKVINT
                     LADHHHRGTDFGGSPWLHVIIAFPTSYKVVITLWIVYLWVSLLKTIFWSRNGHDGSTD
                     VQQRAWRSNRRRQEGLRSICMHTKKRVSSFRGNKIGLKDVITLRRHVETKVRAKIRKR
                     KVTTKINHHDKINGKRKTARKQKMFQRAQELRRRAEDYHKCKIPPSARKALCNWVRMA
                     AAEHRHSSGLPYWPYLTAETLKNRMGHQPPPPTQQHSITDNSLSLKTPPECLLTPLPP
                     SADDNLKTPPECVLTPLPPSADDNLKTPPECVLTPLPPSADDNLKTPPECLLTPLPPS
                     ADDNLKTPPECLLTPLPPSALPSAPPSADDNLKTRAECLLHPLPPSADDNLKTPSERQ
                     LTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNI
                     KTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSAD
                     DNLKTPSERQLTALPPSADDNINTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPP
                     SADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAFHPQRM
                     ISRHLPSVSSLPFHPQLHPQQMIISRYLLSVCGFRFHHQPMIISRHLPSVSSLPFHPQ
                     LHPQQMIISRHLPSVCGGRFHPERMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVC
                     GGRFHPQRMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQQMIISRHLP
                     SVSSLPFHPQLHPQQMIISRHLPSVCGGRFHPQRMIISRHLPSVSSLPFHPQLHPQQM
                     IISRHLPSVCGERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRG
                     PLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSER
                     QLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPPLATQEAEAEKPRKPKRQR
                     AAEMEPPPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPKRRRVGDVEPSRKPKRRRA
                     ADVEPSSPEPKRRRVGDVEPSRKPKRRRAADVEPSLPEPKRRRLS"
     exon            238..366
                     /gene="NPIPB3"
                     /gene_synonym="KIAA0220L; NPIP; NPIPB; NPIPB5; NPIPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            367..466
                     /gene="NPIPB3"
                     /gene_synonym="KIAA0220L; NPIP; NPIPB; NPIPB5; NPIPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            467..662
                     /gene="NPIPB3"
                     /gene_synonym="KIAA0220L; NPIP; NPIPB; NPIPB5; NPIPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            663..723
                     /gene="NPIPB3"
                     /gene_synonym="KIAA0220L; NPIP; NPIPB; NPIPB5; NPIPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            724..759
                     /gene="NPIPB3"
                     /gene_synonym="KIAA0220L; NPIP; NPIPB; NPIPB5; NPIPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            760..3674
                     /gene="NPIPB3"
                     /gene_synonym="KIAA0220L; NPIP; NPIPB; NPIPB5; NPIPL3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtatgatctc gtgaaatctt gagagaaact gaatgacgaa tgaaactatt gttcctgttt
       61 cacacagaag aaaactgagg ttggcactca tcatgagccc ctgttctcat tctgcaaatg
      121 gtgaagctct ctattgtcct gaccccacag ttcctgtccc atgaccaggg ccagctcacc
      181 aaggagctgc agcagcatgt aaagtcagtg acatgcccat gcgagtacct gaggaaggtt
      241 atcaatactc tggctgacca tcatcatcgt gggactgact ttggtggaag tccttggtta
      301 catgtcatta ttgcgtttcc gacaagttat aaagttgtca ttaccctctg gatagtttac
      361 ctttgggtgt ctctcctgaa gactatcttc tggtctcgaa atggacatga tggatccacg
      421 gatgtacagc agagagcctg gaggtccaac cgccgtagac aggaagggct gaggtccatt
      481 tgtatgcaca caaagaaaag agtttcttcc tttcgaggaa ataaaattgg cctgaaagac
      541 gtcattactc tacggagaca tgtggaaaca aaagttagag ctaaaatccg taagaggaag
      601 gtgacaacga aaatcaacca tcatgacaaa atcaatggaa agaggaagac cgccagaaaa
      661 cagaaaatgt ttcaacgtgc gcaagagttg cggcggcgag cagaggacta ccacaaatgc
      721 aaaatccccc cttctgcaag aaaggctctt tgcaactggg tcagaatggc ggcagcggag
      781 catcgtcatt cttcaggatt gccctactgg ccctacctca cagctgaaac tttaaaaaac
      841 aggatgggcc accagccacc tcctccaact caacaacatt ctataactga taactccctg
      901 agcctcaaga cacctcccga gtgtctgctc actccccttc caccctcagc ggatgataat
      961 ctcaagacac ctcccgagtg tgtgctcact ccccttccac cctcagcgga tgataatctc
     1021 aagacacctc ccgagtgtgt gctcactccc cttccaccct cagcggatga taatctcaag
     1081 acacctcctg agtgtctgct cactcccctt ccaccctcag cggatgataa tctcaagaca
     1141 cctcccgagt gtctactcac tccccttcca ccctcagctc taccctcagc tccaccctca
     1201 gcggatgata atctcaagac acgtgccgag tgtctgctcc atccccttcc accctcagcg
     1261 gatgataatc tcaagacacc ttccgagcgt cagctcactc cccttccacc ctcagctcca
     1321 ccctcagcag atgataatat caagacacct gccgagcgtc tgcgggggcc gcttccaccc
     1381 tcagcggatg ataatctcaa gacaccttcc gagcgtcagc tcactcccct tccaccctca
     1441 gctccaccct cagcagatga taatatcaag acacctgccg agcgtctgcg ggggccgctt
     1501 ccaccctcag cggatgataa tctcaagaca ccttccgagc gtcagctcac tccccttcca
     1561 ccctcagctc caccctcagc agatgataat atcaagacac ctgccgagcg tctgcggggg
     1621 ccgcttccac cctcagcgga tgataatctc aagacacctt ccgagcgtca gctcactgcc
     1681 cttccaccct cagcagatga taatatcaat acacctgccg agcgtctgcg ggggccgctt
     1741 ccaccctcag cggatgataa tctcaagaca ccttccgagc gtcagctcac tccccttcca
     1801 ccctcagctc caccctcagc agatgataat atcaagacac ctgccgagcg tctgcggggg
     1861 ccgcttccac cctcagcgga tgataatctc aagacacctt ccgagcgtca gctcactccc
     1921 cttccaccct cagctccacc ctcagcagat gataatatca agacacctgc cttccaccct
     1981 cagcggatga tctcaagaca ccttccgagc gtcagctcac tccccttcca ccctcagctc
     2041 caccctcagc agatgataat atcaagatac ctgctgagcg tctgcggatt ccgcttccac
     2101 catcagccga tgataatctc aagacacctt ccgagcgtca gctcactccc cttccaccct
     2161 cagctccacc ctcagcagat gataatatca agacacctgc cgagcgtctg cgggggccgc
     2221 ttccaccctg agcggatgat aatctcaaga caccttccga gcgtcagctc actccccttc
     2281 caccctcagc tccaccctca gcagatgata atatcaagac acctgccgag cgtctgcggg
     2341 ggccgcttcc accctcagcg gatgataatc tcaagacacc ttccgagcgt cagctcactc
     2401 cccttccacc ctcagctcca ccctcagcag atgataatat caagacacct gccgagcgtc
     2461 tgcgggggcc gcttccaccc tcagcagatg ataatctcaa gacaccttcc gagcgtcagc
     2521 tcactcccct tccaccctca gctccaccct cagcagatga taatatcaag acacctgccg
     2581 agcgtctgcg ggggccgctt ccaccctcag cggatgataa tctcaagaca ccttccgagc
     2641 gtcagctcac tccctttcca ccctcagctc caccctcagc agatgataat atcaagacac
     2701 ctgccgagcg tctgcgggga gcgtctgcgg gggccgcttc caccctcagc ggatgataat
     2761 ctcaagacac cttccgagcg tcagctcact ccccttccac cctcagctcc accctcagca
     2821 gatgataata tcaagacacc tgccgagcgt ctgcgggggc cgcttccacc ctcagcggat
     2881 gataatctca agacaccttc cgagcgtcag ctcactcccc ttccaccctc agctccaccc
     2941 tcagcagatg ataatatcaa gacacctgct gagcgtctgc gggggccgct tccaccctca
     3001 gcggatgata atctcaagac accttccgag cgtcagctca ctccccttcc accctcagct
     3061 ccaccctcag cagatgataa tatcaagaca cctgccgagc gtctgcgggg gccgcttcca
     3121 ccctcagccg atgataatct caagacacct cccttagcta ctcaggaggc tgaggcagaa
     3181 aaaccacgca aacccaagag gcagagggcg gctgagatgg aaccacctcc cgaacccaag
     3241 aggcggaggg tcggtgacgt ggaaccgtca cgcaaaccca agaggcggag ggccgctgac
     3301 gtggaaccat catcacccga acccaagagg cggagggtcg gtgatgtgga accgtcacgc
     3361 aaacccaaga ggcggagggc cgctgacgtg gaaccatcat cacccgaacc caagaggcgg
     3421 agggtcggtg acgtggaacc gtcacgcaaa cccaagaggc ggagggccgc tgacgtggaa
     3481 ccatcattac ccgaacccaa gaggcggagg ttgagctgag aagaggccag tgcactcaag
     3541 cctgagcaat aagaataaaa ccgagtagaa caaaataaaa aattcaaaaa acaaaacaaa
     3601 acccacactc caaaaactaa caaagaataa ataaataata taaaaataaa ataaatactg
     3661 cagtccttat gttaaaaaaa aaaaaaaaaa a
//
