LOCUS       NM_153240               5348 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens nephrocystin 3 (NPHP3), mRNA.
ACCESSION   NM_153240 NM_152530
VERSION     NM_153240.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5348)
  AUTHORS   Thuy,P.X., Jang,T.K. and Moon,E.Y.
  TITLE     Vinblastine Resistance Is Associated with Nephronophthisis
            3-Mediated Primary Cilia via Intraflagellar Transport Protein 88
            and Apoptosis-Antagonizing Transcription Factor
  JOURNAL   Int J Mol Sci 25 (19), 10369 (2024)
   PUBMED   39408701
  REMARK    GeneRIF: Vinblastine Resistance Is Associated with Nephronophthisis
            3-Mediated Primary Cilia via Intraflagellar Transport Protein 88
            and Apoptosis-Antagonizing Transcription Factor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5348)
  AUTHORS   Lee,J.W., Cho,J.Y., Thuy,P.X. and Moon,E.Y.
  TITLE     HeLa Cervical Cancer Cells Are Maintained by Nephronophthisis
            3-Associated Primary Cilium Formation via ROS-Induced ERK and
            HIF-1alpha Activation under Serum-Deprived Normoxic Condition
  JOURNAL   Int J Mol Sci 23 (23), 14500 (2022)
   PUBMED   36498831
  REMARK    GeneRIF: HeLa Cervical Cancer Cells Are Maintained by
            Nephronophthisis 3-Associated Primary Cilium Formation via
            ROS-Induced ERK and HIF-1alpha Activation under Serum-Deprived
            Normoxic Condition.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5348)
  AUTHORS   Olinger,E., Alawi,I.A., Al Riyami,M.S., Salmi,I.A., Molinari,E.,
            Faqeih,E.A., Al-Hamed,M.H., Barroso-Gil,M., Powell,L.,
            Al-Hussaini,A.A., Rahim,K.A., Almontashiri,N.A.M., Miles,C.,
            Shril,S., Hildebrandt,F., Consortium,G.E.R., Wilson,I.J. and
            Sayer,J.A.
  TITLE     A discarded synonymous variant in NPHP3 explains nephronophthisis
            and congenital hepatic fibrosis in several families
  JOURNAL   Hum Mutat 42 (10), 1221-1228 (2021)
   PUBMED   34212438
  REMARK    GeneRIF: A discarded synonymous variant in NPHP3 explains
            nephronophthisis and congenital hepatic fibrosis in several
            families.
REFERENCE   4  (bases 1 to 5348)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5348)
  AUTHORS   Olbrich,H., Fliegauf,M., Hoefele,J., Kispert,A., Otto,E., Volz,A.,
            Wolf,M.T., Sasmaz,G., Trauer,U., Reinhardt,R., Sudbrak,R.,
            Antignac,C., Gretz,N., Walz,G., Schermer,B., Benzing,T.,
            Hildebrandt,F. and Omran,H.
  TITLE     Mutations in a novel gene, NPHP3, cause adolescent
            nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis
  JOURNAL   Nat Genet 34 (4), 455-459 (2003)
   PUBMED   12872122
  REMARK    GeneRIF: Mutations in a novel gene, NPHP3, cause adolescent
            nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis.
REFERENCE   6  (bases 1 to 5348)
  AUTHORS   Omran,H., Sasmaz,G., Haffner,K., Volz,A., Olbrich,H., Melkaoui,R.,
            Otto,E., Wienker,T.F., Korinthenberg,R., Brandis,M., Antignac,C.
            and Hildebrandt,F.
  TITLE     Identification of a gene locus for Senior-Loken syndrome in the
            region of the nephronophthisis type 3 gene
  JOURNAL   J Am Soc Nephrol 13 (1), 75-79 (2002)
   PUBMED   11752023
REFERENCE   7  (bases 1 to 5348)
  AUTHORS   Omran,H., Haffner,K., Burth,S., Fernandez,C., Fargier,B.,
            Villaquiran,A., Nothwang,H.G., Schnittger,S., Lehrach,H., Woo,D.,
            Brandis,M., Sudbrak,R. and Hildebrandt,F.
  TITLE     Human adolescent nephronophthisis: gene locus synteny with
            polycystic kidney disease in pcy mice
  JOURNAL   J Am Soc Nephrol 12 (1), 107-113 (2001)
   PUBMED   11134256
REFERENCE   8  (bases 1 to 5348)
  AUTHORS   Omran,H., Fernandez,C., Jung,M., Haffner,K., Fargier,B.,
            Villaquiran,A., Waldherr,R., Gretz,N., Brandis,M., Ruschendorf,F.,
            Reis,A. and Hildebrandt,F.
  TITLE     Identification of a new gene locus for adolescent nephronophthisis,
            on chromosome 3q22 in a large Venezuelan pedigree
  JOURNAL   Am J Hum Genet 66 (1), 118-127 (2000)
   PUBMED   10631142
REFERENCE   9  (bases 1 to 5348)
  AUTHORS   Stokman,M., Lilien,M. and Knoers,N.
  TITLE     Nephronophthisis-Related Ciliopathies
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   27336129
REFERENCE   10 (bases 1 to 5348)
  AUTHORS   Gunay-Aygun,M., Gahl,W.A. and Heller,T.
  TITLE     Congenital Hepatic Fibrosis Overview horizontal line RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301743
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB114822.1, AY257864.1,
            AC055732.16 and EB387619.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_153240.4.
            
            Summary: This gene encodes a protein containing a coiled-coil (CC)
            domain, a tubulin-tyrosine ligase (TTL) domain, and a tetratrico
            peptide repeat (TPR) domain. The encoded protein interacts with
            nephrocystin, it is required for normal ciliary development, and it
            functions in renal tubular development. Mutations in this gene are
            associated with nephronophthisis type 3, and also with
            renal-hepatic-pancreatic dysplasia, and Meckel syndrome type 7.
            Naturally occurring read-through transcripts exist between this
            gene and the downstream ACAD11 (acyl-CoA dehydrogenase family,
            member 11) gene. [provided by RefSeq, Feb 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY257864.1, SRR14038196.2431912.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337331.10/ ENSP00000338766.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DB114822.1         34-54
            22-4329             AY257864.1         1-4308
            4330-4948           AC055732.16        171865-172483
            4949-5348           EB387619.1         1-400
FEATURES             Location/Qualifiers
     source          1..5348
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1"
     gene            1..5348
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /note="nephrocystin 3"
                     /db_xref="GeneID:27031"
                     /db_xref="HGNC:HGNC:7907"
                     /db_xref="MIM:608002"
     exon            1..447
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..4047
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /note="Meckel syndrome, type 7; cilia and flagella
                     associated protein 31; nephronophthisis 3 (adolescent)"
                     /codon_start=1
                     /product="nephrocystin-3"
                     /protein_id="NP_694972.3"
                     /db_xref="CCDS:CCDS3078.1"
                     /db_xref="GeneID:27031"
                     /db_xref="HGNC:HGNC:7907"
                     /db_xref="MIM:608002"
                     /translation="MGTASSLVSPAGGEVIEDTYGAGGGEACEIPVEVKPKARLLRNS
                     FRRGAGAAAGAGPGSLPRGVGAGGLLGASFKSTGSSVPELEYAAAEYERLRKEYEIFR
                     VSKNQELLSMGRREAKLDTENKRLRAELQALQKTYQKILREKESALEAKYQAMERAAT
                     FEHDRDKVKRQFKIFRETKENEIQDLLRAKRELESKLQRLQAQGIQVFDPGESDSDDN
                     CTDVTAAGTQCEYWTGGALGSEPSIGSMIQLQQSFRGPEFAHSSIDVEGPFANVNRDD
                     WDIAVASLLQVTPLFSHSLWSNTVRCYLIYTDETQPEMDLFLKDYSPKLKRMCETMGY
                     FFHAVYFPIDVENQYLTVRKWEIEKSSLVILFIHLTLPSLLLEDCEEAFLKNPEGKPR
                     LIFHRLEDGKVSSDSVQQLIDQVSNLNKTSKAKIIDHSGDPAEGVYKTYICVEKIIKQ
                     DILGFENTDLETKDLGSEDSIPEEDDFGDVLWDIHDEQEQMETFQQASNSAHELGFEK
                     YYQRLNDLVAAPAPIPPLLVSGGPGSGKSLLLSKWIQLQQKNSPNTLILSHFVGRPMS
                     TSSESSLIIKRLTLKLMQHSWSVSALTLDPAKLLEEFPRWLEKLSARHQGSIIIVIDS
                     IDQVQQVEKHMKWLIDPLPVNVRVIVSVNVETCPPAWRLWPTLHLDPLSPKDAKSIII
                     AECHSVDIKLSKEQEKKLERHCRSATTCNALYVTLFGKMIARAGRAGNLDKILHQCFQ
                     CQDTLSLYRLVLHSIRESMANDVDKELMKQILCLVNVSHNGVSESELMELYPEMSWTF
                     LTSLIHSLYKMCLLTYGCGLLRFQHLQAWETVRLEYLEGPTVTSSYRQKLINYFTLQL
                     SQDRVTWRSADELPWLFQQQGSKQKLHDCLLNLFVSQNLYKRGHFAELLSYWQFVGKD
                     KSAMATEYFDSLKQYEKNCEGEDNMSCLADLYETLGRFLKDLGLLSQAIVPLQRSLEI
                     RETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTAREL
                     EALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKD
                     TPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCN
                     EKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAV
                     EIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGE
                     TLKNLAVLSYEGGDFEKAAELYKRAMEIKEAETSLLGGKAPSRHSSSGDTFSLKTAHS
                     PNVFLQQGQR"
     exon            448..573
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            574..724
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            725..877
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1011
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1172
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1329
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1404
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1578
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1682
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1797
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1941
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2039
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2142
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2225
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2364
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2529
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2624
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2747
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2937
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2938..3179
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..3255
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..3383
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3384..3624
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3625..3750
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3751..3866
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     exon            3867..5348
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5326..5331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /note="hexamer: AATAAA"
     polyA_site      5348
                     /gene="NPHP3"
                     /gene_synonym="CFAP31; MKS7; NPH3; RHPD; RHPD1; SLSN3"
                     /note="major polyA site"
ORIGIN      
        1 gttccgctgc ccagtcctgc tggtactcac taggtagtag cggcaacgga cgccatgggg
       61 accgcctcgt cgctcgtgag ccccgcgggc ggggaagtga tcgaggacac gtacggggcg
      121 ggcggcggcg aggcctgcga gatcccggtg gaggtgaagc ccaaggcccg cctgctgcgc
      181 aactcgttcc gccgaggcgc gggggcggca gcaggggccg ggcccgggtc gctgccccgc
      241 ggggtgggcg cgggcgggct gctgggggcc agcttcaagt ccactggctc gtcggtgcca
      301 gagctggagt acgcggcggc cgagtacgag cggctcagga aggagtacga gatctttcgc
      361 gtcagcaaga accaggagtt gttgtccatg ggccgccgcg aggccaagct ggacacggag
      421 aacaagcggc tgcgggccga actgcaggca cttcaaaaaa cgtatcagaa gatacttcga
      481 gaaaaagaaa gtgctttaga agcgaaatac caagcaatgg agagagcagc aacatttgaa
      541 catgacagag ataaagttaa aaggcaattc aagattttta gggagaccaa agaaaatgaa
      601 attcaggact tactgagggc caagagggag ttggagagca aacttcagag gctacaggct
      661 cagggtatcc aagtatttga tcctggggag tctgattcag atgacaactg tacagatgtc
      721 actgctgctg gaacccaatg tgaatattgg actggcggag ccttgggaag tgaaccttcc
      781 ataggaagca tgatccagct tcagcagtcc ttcagaggcc ctgagtttgc ccatagttct
      841 atagatgtgg aaggaccctt tgcaaatgtt aatagagatg actgggatat tgctgtagct
      901 agtttattac aagttactcc tctgttttca cattctctgt ggagtaacac tgtcagatgt
      961 tacctcattt atacagatga aacccagcct gagatggatc ttttccttaa ggactattca
     1021 cctaaactta agagaatgtg cgagacaatg ggatattttt tccatgctgt ttattttcca
     1081 atagatgttg aaaatcaata cctcactgta agaaaatggg aaattgagaa aagttcttta
     1141 gttattttat ttattcactt aacattacca agccttttat tggaagactg tgaagaagct
     1201 tttctgaaaa accctgaagg aaaacctcga ttaatctttc atcgtttgga agatggaaaa
     1261 gtcagttctg actctgtcca gcaattgatt gatcaagttt ctaatctaaa caagaccagc
     1321 aaagccaaga tcattgatca ctcaggagat cctgcagaag gagtatataa aacttatatt
     1381 tgtgtagaaa agattattaa acaggacata ctgggttttg agaacacaga cttggagact
     1441 aaggatttgg gcagtgagga ttccattcca gaagaagatg attttggtga tgttctgtgg
     1501 gacatacatg atgaacaaga gcaaatggaa acttttcagc aggcttctaa ttcagcccat
     1561 gagttgggat ttgagaaata ttaccaacgc cttaatgatc tagtggcagc accagccccg
     1621 attccacctc ttctcgtgtc tggaggacca ggttctggga agtctcttct tttatcaaag
     1681 tggattcaat tacaacagaa gaattccccc aacacactga ttctttccca ttttgtggga
     1741 aggcccatgt caaccagctc agagtcctcc ttgattatta aacgactaac tctaaagttg
     1801 atgcagcact cttggtcagt ctctgctctg acactggatc ctgctaagct tctggaagaa
     1861 tttccacgtt ggctggaaaa actctctgct cgtcatcaag gcagcatcat catcgttatt
     1921 gattctatag atcaagttca gcaagttgaa aaacacatga aatggctgat agatccactg
     1981 ccagtgaatg taagagtaat tgtttctgtg aatgtagaaa catgccctcc agcatggagg
     2041 ttgtggccta cacttcatct tgatccctta agtccaaaag atgcaaaatc tattataatt
     2101 gcagaatgcc actctgtaga cattaaattg agtaaagagc aggagaagaa gctagaacga
     2161 cactgtcgtt ctgctacaac ctgcaatgcc ctttatgtca cccttttcgg caaaatgatc
     2221 gcgcgtgctg ggagagcagg caatttagat aaaatccttc atcagtgttt ccagtgtcaa
     2281 gatactcttt cattatatag acttgttctg cactctatcc gggagtccat ggcaaatgat
     2341 gtggataaag agctaatgaa gcagatcctc tgccttgtca atgttagtca caatggtgtg
     2401 agtgaatcag aactgatgga actctatcct gagatgtcct ggactttctt gacctccctt
     2461 attcacagtt tatacaaaat gtgtttgttg acttatggat gtggcttgct taggtttcaa
     2521 catctgcagg cttgggaaac agtgagattg gagtacctgg aaggccccac tgttacttct
     2581 tcatacaggc aaaagctaat caactatttc accttgcagc taagtcagga cagagtgact
     2641 tggagaagtg cagatgaact cccgtggctt tttcagcagc agggaagtaa acagaagctg
     2701 catgattgcc ttcttaatct ctttgtgtct caaaaccttt ataaaagggg acactttgct
     2761 gagttgctga gttattggca gtttgttggc aaagacaaaa gtgcaatggc aacagaatac
     2821 ttcgattcat tgaagcagta tgagaaaaac tgcgaaggcg aggacaacat gagttgctta
     2881 gctgatcttt atgaaacctt ggggcgattt ctcaaggatc taggccttct cagtcaggcc
     2941 atagtacctt tgcagaggtc tttagagatt cgagaaacag ctttagatcc cgatcaccca
     3001 agagtagccc agtccctcca ccaactagca agtgtatacg tgcagtggaa gaagtttggc
     3061 aatgcagaac aactgtataa acaggcgttg gaaatctcag aaaatgctta tggtgcggac
     3121 catccatata ctgctcgtga acttgaagca cttgcaactt tgtaccagaa acaaaataaa
     3181 tatgaacaag ctgaacattt taggaaaaaa tcctttaaaa ttcatcagaa agctataaag
     3241 aaaaaaggca acttgtacgg atttgccctt ttacgtagac gggctttaca gttagaagag
     3301 cttacattag gtaaggacac acctgataat gctcggaccc tcaatgaact gggtgttctc
     3361 tactatcttc aaaataacct ggaaacagct gaccagtttc tgaagcgttc cttagaaatg
     3421 agggagcgag ttctaggacc agatcaccct gactgtgctc agtctttgaa taatctggca
     3481 gctctatgca atgaaaagaa acagtatgat aaagcagaag aactttatga aagagcttta
     3541 gatattcgga gacgtgcatt agctcctgat cacccttctt tggcatatac ggtgaagcat
     3601 cttgccatct tgtataagaa aatggggaaa cttgacaaag ctgtaccttt gtatgaattg
     3661 gctgttgaaa ttcgacagaa atcttttggc ccaaagcacc ctagtgtagc tactgccttg
     3721 gtgaacttag ctgttcttta tagccaaatg aaaaaacacg ttgaagcttt gccattatat
     3781 gaaagagcat taaagattta tgaagatagc ctgggtcgga tgcatcctcg agttggagaa
     3841 acactgaaaa atttagctgt gcttagctat gaaggaggag attttgaaaa agctgctgaa
     3901 ttatacaaaa gggcaatgga aataaaagaa gcagaaacat cactcttggg tggaaaagct
     3961 ccttcacgcc attcatcaag tggagacacg tttagcttaa aaacagctca ttctcctaat
     4021 gttttccttc agcaaggaca aaggtaatag cagcagttag aattctttgc aaatgtacct
     4081 taagacaaaa taattaaaca tttggaacat ttgaatttga aactttaaaa aaatgttgta
     4141 cgaaatttta ctacgtgtga tttaactgct atttgtatga agttgtattg gattacatta
     4201 agttggaatt gtgattatgt ctgttttagt tgtttaaaag aattttccta ttatatggta
     4261 tccaaggatg tagacacatt agaattataa gaagacatga ggagcaaatc atgaagagcg
     4321 gattggtctt tgttcaacaa gagctggcag agtagttaag acaaggagtt caaaaattcc
     4381 atgaatcttg gccaggcatg gtggctcatg cctgtaatcc caccactttg ggagggtgat
     4441 gcaggaggat cacttgaggc caggagttgg agaccagcct ggccaacatg gtgaaaccct
     4501 gtctctacta aaaatacaaa aaaaaattag ctggacctgg tggcgcatgc ctgtaatcct
     4561 agctactcag gaggctgagg catgagaatc gcttgaactc agcaagtgga ggttgctatg
     4621 agctgagatt gtgccagttc attccaccct gggcaacagg gtgagactct gtctcaaaaa
     4681 aaaaaaaaaa aaaaaaaaga attccatgat tcttttgagc tctcaagagc tactttagcc
     4741 ttgccattcc tcttgctttt cagcagtagt ctggcccaat tctctacctc aaaggaaagt
     4801 ttcaaggatt aaagggttaa tgtttatgaa cgattcaaat tgtcttcagt gaaacacatt
     4861 agtcacaaga atccctgatt gctgcacttt aaaaaattct ttaccttttc cttgagcaga
     4921 ttggtccagt ccctctgctt tctgttctgt ctacattgtg tattatttat tactatatag
     4981 tatatgtatc tgcataatgt ctgaagtcat taatgcagta acaggtcaag ctctttagca
     5041 ttctttgact tttcccaaaa tatagatatg acattctcct ttatcttcct tcttagatgg
     5101 cctaaatctg tctcttcatt tacctcaaac tcaaattagt atgccatttt catactgaaa
     5161 attaaatatt tttatggatt ttataaatat tgcaacattt tagatattgt tttggaccat
     5221 ttgtgtattt atatataata aaatcatcaa tttaatactt gtaagatcct aacatgtatt
     5281 gattgtaaaa gtgaaatatg taatagccac acttcactgt tttaaaataa aagtgcaatt
     5341 tcaagttc
//
