LOCUS       NM_003717                440 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens neuropeptide FF-amide peptide precursor (NPFF),
            transcript variant 1, mRNA.
ACCESSION   NM_003717
VERSION     NM_003717.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Lee,H., Amatya,B., Villar,V.A.M., Asico,L.D., Jeong,J.K.,
            Feranil,J., Moore,S.C., Zheng,X., Bishop,M., Gomes,J.P., Polzin,J.,
            Smeriglio,N., de Castro,P.A.S.V., Armando,I., Felder,R.A., Hao,L.
            and Jose,P.A.
  TITLE     Renal autocrine neuropeptide FF (NPFF) signaling regulates blood
            pressure
  JOURNAL   Sci Rep 14 (1), 15407 (2024)
   PUBMED   38965251
  REMARK    GeneRIF: Renal autocrine neuropeptide FF (NPFF) signaling regulates
            blood pressure.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Koller,J., Herzog,H. and Zhang,L.
  TITLE     The distribution of Neuropeptide FF and Neuropeptide VF in central
            and peripheral tissues and their role in energy homeostasis control
  JOURNAL   Neuropeptides 90, 102198 (2021)
   PUBMED   34534716
  REMARK    GeneRIF: The distribution of Neuropeptide FF and Neuropeptide VF in
            central and peripheral tissues and their role in energy homeostasis
            control.
            Review article
REFERENCE   3  (bases 1 to 440)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 440)
  AUTHORS   Zhao,H., Eising,E., de Vries,B., Vijfhuizen,L.S., Anttila,V.,
            Winsvold,B.S., Kurth,T., Stefansson,H., Kallela,M., Malik,R.,
            Stam,A.H., Ikram,M.A., Ligthart,L., Freilinger,T., Alexander,M.,
            Muller-Myhsok,B., Schreiber,S., Meitinger,T., Aromas,A.,
            Eriksson,J.G., Boomsma,D.I., van Duijn,C.M., Zwart,J.A., Quaye,L.,
            Kubisch,C., Dichgans,M., Wessman,M., Stefansson,K., Chasman,D.I.,
            Palotie,A., Martin,N.G., Montgomery,G.W., Ferrari,M.D.,
            Terwindt,G.M., van den Maagdenberg,A.M. and Nyholt,D.R.
  CONSRTM   International Headache Genetics Consortium
  TITLE     Gene-based pleiotropy across migraine with aura and migraine
            without aura patient groups
  JOURNAL   Cephalalgia 36 (7), 648-657 (2016)
   PUBMED   26660531
  REMARK    GeneRIF: Our results...highlight the neuropeptide FF-amide peptide
            encoding gene (NPFF) as a novel candidate risk gene for both
            migraine with aura and migraine without aura
REFERENCE   5  (bases 1 to 440)
  AUTHORS   Sandvik,G.K., Hodne,K., Haug,T.M., Okubo,K. and Weltzien,F.A.
  TITLE     RFamide Peptides in Early Vertebrate Development
  JOURNAL   Front Endocrinol (Lausanne) 5, 203 (2014)
   PUBMED   25538682
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 440)
  AUTHORS   Elshourbagy,N.A., Ames,R.S., Fitzgerald,L.R., Foley,J.J.,
            Chambers,J.K., Szekeres,P.G., Evans,N.A., Schmidt,D.B.,
            Buckley,P.T., Dytko,G.M., Murdock,P.R., Milligan,G., Groarke,D.A.,
            Tan,K.B., Shabon,U., Nuthulaganti,P., Wang,D.Y., Wilson,S.,
            Bergsma,D.J. and Sarau,H.M.
  TITLE     Receptor for the pain modulatory neuropeptides FF and AF is an
            orphan G protein-coupled receptor
  JOURNAL   J Biol Chem 275 (34), 25965-25971 (2000)
   PUBMED   10851242
REFERENCE   7  (bases 1 to 440)
  AUTHORS   Sundblom,D.M., Hyrkko,A. and Fyhrquist,F.
  TITLE     Pulsatile secretion of neuropeptide FF into human blood
  JOURNAL   Peptides 19 (7), 1165-1170 (1998)
   PUBMED   9786165
REFERENCE   8  (bases 1 to 440)
  AUTHORS   Perry,S.J., Yi-Kung Huang,E., Cronk,D., Bagust,J., Sharma,R.,
            Walker,R.J., Wilson,S. and Burke,J.F.
  TITLE     A human gene encoding morphine modulating peptides related to NPFF
            and FMRFamide
  JOURNAL   FEBS Lett 409 (3), 426-430 (1997)
   PUBMED   9224703
REFERENCE   9  (bases 1 to 440)
  AUTHORS   Panula,P., Aarnisalo,A.A. and Wasowicz,K.
  TITLE     Neuropeptide FF, a mammalian neuropeptide with multiple functions
  JOURNAL   Prog Neurobiol 48 (4-5), 461-487 (1996)
   PUBMED   8804117
  REMARK    Review article
            Erratum:[Prog Neurobiol 1996 Jun;49(3):285]
REFERENCE   10 (bases 1 to 440)
  AUTHORS   Sundblom,D.M., Panula,P. and Fyhrquist,F.
  TITLE     Neuropeptide FF-like immunoreactivity in human plasma
  JOURNAL   Peptides 16 (2), 347-350 (1995)
   PUBMED   7784266
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF005271.1 and BC035758.1.
            
            On Jun 2, 2019 this sequence version replaced NM_003717.3.
            
            Summary: This gene encodes a member of the FMRFamide related
            peptide (FARP) family of neuropeptides. The encoded preproprotein
            is proteolytically processed to generate multiple amidated
            peptides. These peptides may play a role in the regulation of heart
            rate and blood pressure and the modulation of morphine-induced
            antinociception. Patients with hypertension exhibit decreased
            expression of the encoded protein. Alternative splicing results in
            multiple transcript variants, at least one of which encodes an
            isoform that is proteolytically processed. [provided by RefSeq, Feb
            2016].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF005271.1, AA336101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267017.4/ ENSP00000267017.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-438               AF005271.1         154-591
            439-440             BC035758.1         1405-1406
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..440
                     /gene="NPFF"
                     /gene_synonym="FMRFAL"
                     /note="neuropeptide FF-amide peptide precursor"
                     /db_xref="GeneID:8620"
                     /db_xref="HGNC:HGNC:7901"
                     /db_xref="MIM:604643"
     exon            1..112
                     /gene="NPFF"
                     /gene_synonym="FMRFAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..352
                     /gene="NPFF"
                     /gene_synonym="FMRFAL"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; pro-FMRFamide-related neuropeptide FF"
                     /codon_start=1
                     /product="pro-FMRFamide-related neuropeptide FF isoform 1
                     preproprotein"
                     /protein_id="NP_003708.1"
                     /db_xref="CCDS:CCDS8862.1"
                     /db_xref="GeneID:8620"
                     /db_xref="HGNC:HGNC:7901"
                     /db_xref="MIM:604643"
                     /translation="MDSRQAAALLVLLLLIDGGCAEGPGGQQEDQLSAEEDSEPLPPQ
                     DAQTSGSLLHYLLQAMERPGRSQAFLFQPQRFGRNTQGSWRNEWLSPRAGEGLNSQFW
                     SLAAPQRFGKK"
     exon            113..234
                     /gene="NPFF"
                     /gene_synonym="FMRFAL"
                     /inference="alignment:Splign:2.1.0"
     exon            235..440
                     /gene="NPFF"
                     /gene_synonym="FMRFAL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      418..423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPFF"
                     /gene_synonym="FMRFAL"
                     /note="hexamer: AATAAA"
     polyA_site      440
                     /gene="NPFF"
                     /gene_synonym="FMRFAL"
                     /note="major polyA site"
ORIGIN      
        1 aggtggcagc atggattcta ggcaggctgc tgcactgctg gtgctgctgc tgttaataga
       61 cgggggctgt gctgaagggc caggaggcca gcaggaagac cagctctccg cggaggaaga
      121 cagcgaaccc ctcccaccac aggatgccca gacctctggg tcactgttgc actacctgct
      181 ccaggcaatg gagagacctg gccggagcca agccttcctg tttcagcccc agaggtttgg
      241 cagaaatacc cagggatcct ggaggaatga atggctgagt ccccgggctg gagaggggct
      301 gaattcccag ttctggagcc tggctgcccc tcaacgcttt gggaagaagt gacatgtcat
      361 cccttgatat gtctgcatgc aaggtccaca cccaaaagtg tcaatgtttg ccccccaaat
      421 aaaattgtct ggcttctgaa
//
