LOCUS       NM_024663               2191 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens aminopeptidase like 1 (NPEPL1), transcript variant 1,
            mRNA.
ACCESSION   NM_024663 NM_207402
VERSION     NM_024663.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2191)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2191)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2191)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 2191)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139349.37, BM544905.1 and BC020507.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024663.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020507.1, SRR3476690.738314.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356091.11/ ENSP00000348395.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AL139349.37        28075-28080
            7-53                BM544905.1         41-87
            54-251              AL139349.37        28128-28325
            252-437             AL139349.37        29012-29197
            438-608             AL139349.37        29697-29867
            609-698             AL139349.37        33959-34048
            699-780             AL139349.37        34472-34553
            781-923             AL139349.37        36291-36433
            924-1001            AL139349.37        42398-42475
            1002-1102           AL139349.37        47754-47854
            1103-1226           AL139349.37        48695-48818
            1227-1403           AL139349.37        49192-49368
            1404-1514           AL139349.37        49835-49945
            1515-1726           AL139349.37        50443-50654
            1727-2191           BC020507.1         1687-2151
FEATURES             Location/Qualifiers
     source          1..2191
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.32"
     gene            1..2191
                     /gene="NPEPL1"
                     /gene_synonym="bA261P9.2"
                     /note="aminopeptidase like 1"
                     /db_xref="GeneID:79716"
                     /db_xref="HGNC:HGNC:16244"
     exon            1..251
                     /gene="NPEPL1"
                     /gene_synonym="bA261P9.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1673
                     /gene="NPEPL1"
                     /gene_synonym="bA261P9.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable aminopeptidase NPEPL1"
                     /codon_start=1
                     /product="probable aminopeptidase NPEPL1 isoform 1"
                     /protein_id="NP_078939.3"
                     /db_xref="CCDS:CCDS46621.1"
                     /db_xref="GeneID:79716"
                     /db_xref="HGNC:HGNC:16244"
                     /translation="MANVGLQFQASAGDSDPQSRPLLLLGQLHHLHRVPWSHVRGKLQ
                     PRVTEELWQAALSTLNPNPTDSCPLYLNYATVAALPCRVSRHNSPSAAHFITRLVRTC
                     LPPGAHRCIVMVCEQPEVFASACALARAFPLFTHRSGASRRLEKKTVTVEFFLVGQDN
                     GPVEVSTLQCLANATDGVRLAARIVDTPCNEMNTDTFLEEINKVGKELGIIPTIIRDE
                     ELKTRGFGGIYGVGKAALHPPALAVLSHTPDGATQTIAWVGKGIVYDTGGLSIKGKTT
                     MPGMKRDCGGAAAVLGAFRAAIKQGFKDNLHAVFCLAENSVGPNATRPDDIHLLYSGK
                     TVEINNTDAEGRLVLADGVSYACKDLGADIILDMATLTGAQGIATGKYHAAVLTNSAE
                     WEAACVKAGRKCGDLVHPLVYCPELHFSEFTSAVADMKNSVADRDNSPSSCAGLFIAS
                     HIGFDWPGVWVHLDIAAPVHAGERATGFGVALLLALFGRASEDPLLNLVSPLGCEVDV
                     EEGDLGRDSKRRRLV"
     exon            252..437
                     /gene="NPEPL1"
                     /gene_synonym="bA261P9.2"
                     /inference="alignment:Splign:2.1.0"
     exon            438..608
                     /gene="NPEPL1"
                     /gene_synonym="bA261P9.2"
                     /inference="alignment:Splign:2.1.0"
     exon            609..698
                     /gene="NPEPL1"
                     /gene_synonym="bA261P9.2"
                     /inference="alignment:Splign:2.1.0"
     exon            699..780
                     /gene="NPEPL1"
                     /gene_synonym="bA261P9.2"
                     /inference="alignment:Splign:2.1.0"
     exon            781..923
                     /gene="NPEPL1"
                     /gene_synonym="bA261P9.2"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1001
                     /gene="NPEPL1"
                     /gene_synonym="bA261P9.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1102
                     /gene="NPEPL1"
                     /gene_synonym="bA261P9.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1226
                     /gene="NPEPL1"
                     /gene_synonym="bA261P9.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1403
                     /gene="NPEPL1"
                     /gene_synonym="bA261P9.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1514
                     /gene="NPEPL1"
                     /gene_synonym="bA261P9.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..2191
                     /gene="NPEPL1"
                     /gene_synonym="bA261P9.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2165..2170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPEPL1"
                     /gene_synonym="bA261P9.2"
                     /note="hexamer: ATTAAA"
     polyA_site      2191
                     /gene="NPEPL1"
                     /gene_synonym="bA261P9.2"
                     /note="major polyA site"
ORIGIN      
        1 agggccgggg cggtgccgag gccgggccgg agcggggcga agggggccga gcggcgggcc
       61 gggccgggcc gggcagggcc ggggcgtggg ccggcaggaa gatggcgaac gtggggctgc
      121 agttccaggc gagcgcgggg gactcggacc cacagagccg gcccctgctg ctgctcgggc
      181 agctgcacca cctgcaccgc gtgccctgga gccacgtccg cgggaagctg cagccccggg
      241 tcaccgagga gctctggcag gctgccctga gcacgctcaa ccccaacccc acggacagct
      301 gtcccctcta cctgaactac gccaccgtgg ctgccctgcc ctgcagggtg agccggcaca
      361 acagcccctc ggccgcccac ttcatcacgc ggctggtgcg gacctgcctg ccgcccggag
      421 cgcatcgctg cattgtgatg gtctgcgagc agccggaggt ctttgcttcc gcctgtgccc
      481 tggcccgggc cttcccgctg ttcacccacc gctcaggtgc ctctcggcgc ttggagaaga
      541 agacggtcac cgtggagttt ttcctggtgg gacaagacaa cgggccggtg gaggtgtcca
      601 cattgcagtg cttagcgaat gccacagacg gcgtgcggct agcagcccgc atcgtggaca
      661 caccctgcaa tgagatgaac accgacacct tcctcgagga gattaacaaa gttggaaagg
      721 agctggggat catcccaacc atcatccggg atgaggaact gaagacgaga ggatttggag
      781 gaatctatgg ggttggcaaa gccgccctgc atcccccagc cctggccgtc ctcagccaca
      841 ccccagatgg agccacgcag accatcgcct gggtgggcaa aggcatcgtc tatgacactg
      901 gaggcctcag catcaaaggg aagactacca tgccggggat gaagcgagac tgcgggggtg
      961 ctgcggccgt cctgggggcc ttcagagccg caatcaagca gggtttcaaa gacaacctcc
     1021 acgctgtgtt ctgcttggct gagaactcgg tggggcccaa tgcgacaagg ccagatgaca
     1081 tccacctgct gtactcaggg aagacggtgg aaatcaacaa cacggatgcc gagggcaggc
     1141 tggtgctggc agatggcgtg tcctatgctt gcaaggacct gggggccgac atcatcctgg
     1201 acatggccac cctgaccggg gctcagggca ttgccacagg gaagtaccac gccgcggtgc
     1261 tcaccaacag cgctgagtgg gaggccgcct gtgtgaaggc gggcaggaag tgtggggacc
     1321 tggtgcaccc gctggtctac tgccccgagc tgcacttcag cgagttcacc tcagctgtgg
     1381 cggacatgaa gaactcagtg gcggaccgag acaacagccc cagctcctgt gctggcctct
     1441 tcatcgcctc acacatcggc ttcgactggc ccggagtctg ggtccacctg gacattgctg
     1501 caccggtgca tgctggtgag cgagccacag gcttcggtgt ggccctcctg ctggcgctct
     1561 tcggccgtgc ctctgaggac cctctgctga acctggtgtc cccactgggc tgtgaggtgg
     1621 atgtcgagga gggggacctg gggagggact ccaagagacg caggcttgtg tgagcctcct
     1681 gcctcggccc tgacaaacgg ggatctttta cctcactttg cactgattaa ttttaagcaa
     1741 ttgaaagatt gcccttcata tgggttttgg tttgtctttc tggtcgtcag cgtggtggtg
     1801 gaaacagctg aagttttagg agacagctta gggtttggtg cgggccacgg ggaggggacc
     1861 gggaagcgct ggggcttgtt tctgtttgtt acttacagga ctgagacatc ttctgtaaac
     1921 tgctacccct ggggccttct gcaccccggg gtgaggcctc ctgcctgcct ggtgccctgt
     1981 cccagcccca ggtcctgtgc agggcacctg cgtggctgac agccaggctc ttactccagc
     2041 cggggctgcc agcgcatcca gccagcccag ccctgtgaaa gatggagctg acttgctgca
     2101 ggggacctga tttatagggc aagagaagtc acactccggc ctctcagaat tcacttgagg
     2161 ttcaattaaa tacagtcaca ccgccccctc a
//
