LOCUS       NM_015392               1475 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens neural proliferation, differentiation and control 1
            (NPDC1), mRNA.
ACCESSION   NM_015392
VERSION     NM_015392.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1475)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1475)
  AUTHORS   Rathore,N., Ramani,S.R., Pantua,H., Payandeh,J., Bhangale,T.,
            Wuster,A., Kapoor,M., Sun,Y., Kapadia,S.B., Gonzalez,L.,
            Zarrin,A.A., Goate,A., Hansen,D.V., Behrens,T.W. and Graham,R.R.
  TITLE     Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant
            alters ligand binding and confers protection to Alzheimer's disease
  JOURNAL   PLoS Genet 14 (11), e1007427 (2018)
   PUBMED   30388101
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1475)
  AUTHORS   Sun,Y., Senger,K., Baginski,T.K., Mazloom,A., Chinn,Y., Pantua,H.,
            Hamidzadeh,K., Ramani,S.R., Luis,E., Tom,I., Sebrell,A.,
            Quinones,G., Ma,Y., Mukhyala,K., Sai,T., Ding,J., Haley,B.,
            Shadnia,H., Kapadia,S.B., Gonzalez,L.C., Hass,P.E. and Zarrin,A.A.
  TITLE     Evolutionarily conserved paired immunoglobulin-like receptor alpha
            (PILRalpha) domain mediates its interaction with diverse sialylated
            ligands
  JOURNAL   J Biol Chem 287 (19), 15837-15850 (2012)
   PUBMED   22396535
REFERENCE   4  (bases 1 to 1475)
  AUTHORS   Evrard,C., Caron,S. and Rouget,P.
  TITLE     Functional analysis of the NPDC-1 gene
  JOURNAL   Gene 343 (1), 153-163 (2004)
   PUBMED   15563841
  REMARK    GeneRIF: Human gene mapped to chromosome 9q34.3.
REFERENCE   5  (bases 1 to 1475)
  AUTHORS   Spencer,M.L., Theodosiou,M. and Noonan,D.J.
  TITLE     NPDC-1, a novel regulator of neuronal proliferation, is degraded by
            the ubiquitin/proteasome system through a PEST degradation motif
  JOURNAL   J Biol Chem 279 (35), 37069-37078 (2004)
   PUBMED   15229225
  REMARK    GeneRIF: NPDC-1 has a role in regulating neuronal proliferation and
            is degraded by the ubiquitin/proteasome system through a PEST
            degradation motif
REFERENCE   6  (bases 1 to 1475)
  AUTHORS   Qu,X., Zhang,C., Zhai,Y., Xing,G., Wei,H., Yu,Y., Wu,S. and He,F.
  TITLE     Characterization and tissue expression of a novel human gene npdc1
  JOURNAL   Gene 264 (1), 37-44 (2001)
   PUBMED   11245976
REFERENCE   7  (bases 1 to 1475)
  AUTHORS   Sansal,I., Dupont,E., Toru,D., Evrard,C. and Rouget,P.
  TITLE     NPDC-1, a regulator of neural cell proliferation and
            differentiation, interacts with E2F-1, reduces its binding to DNA
            and modulates its transcriptional activity
  JOURNAL   Oncogene 19 (43), 5000-5009 (2000)
   PUBMED   11042687
REFERENCE   8  (bases 1 to 1475)
  AUTHORS   Iwasaki,K. and Toyonaga,R.
  TITLE     The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function
            in synaptic transmission
  JOURNAL   EMBO J 19 (17), 4806-4816 (2000)
   PUBMED   10970871
REFERENCE   9  (bases 1 to 1475)
  AUTHORS   Dupont,E., Sansal,I., Toru,D., Evrard,C. and Rouget,P.
  TITLE     [Identification of NPDC-1, gene involved in the control of
            proliferation and differentiation of neural and glial precursors]
  JOURNAL   C R Seances Soc Biol Fil 191 (1), 95-104 (1997)
   PUBMED   9181131
  REMARK    Review article
REFERENCE   10 (bases 1 to 1475)
  AUTHORS   Galiana,E., Vernier,P., Dupont,E., Evrard,C. and Rouget,P.
  TITLE     Identification of a neural-specific cDNA, NPDC-1, able to
            down-regulate cell proliferation and to suppress transformation
  JOURNAL   Proc Natl Acad Sci U S A 92 (5), 1560-1564 (1995)
   PUBMED   7878019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807752.10 and BC004217.2.
            
            On Nov 23, 2018 this sequence version replaced NM_015392.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074793.1, SRR3476690.813417.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371601.5/ ENSP00000360660.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AL807752.10        116071-116139       c
            70-1475             BC004217.2         1-1406
FEATURES             Location/Qualifiers
     source          1..1475
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..1475
                     /gene="NPDC1"
                     /gene_synonym="CAB; CAB-; CAB-1; CAB1; NPDC-1"
                     /note="neural proliferation, differentiation and control
                     1"
                     /db_xref="GeneID:56654"
                     /db_xref="HGNC:HGNC:7899"
                     /db_xref="MIM:605798"
     exon            1..300
                     /gene="NPDC1"
                     /gene_synonym="CAB; CAB-; CAB-1; CAB1; NPDC-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1166
                     /gene="NPDC1"
                     /gene_synonym="CAB; CAB-; CAB-1; CAB1; NPDC-1"
                     /note="neural proliferation differentiation and control
                     protein 1"
                     /codon_start=1
                     /product="neural proliferation differentiation and control
                     protein 1 precursor"
                     /protein_id="NP_056207.3"
                     /db_xref="CCDS:CCDS7024.1"
                     /db_xref="GeneID:56654"
                     /db_xref="HGNC:HGNC:7899"
                     /db_xref="MIM:605798"
                     /translation="MATPLPPPSPRHLRLLRLLLSGLVLGAALRGAAAGHPDVAACPG
                     SLDCALKRRARCPPGAHACGPCLQPFQEDQQGLCVPRMRRPPGGGRPQPRLEDEIDFL
                     AQELARKESGHSTPPLPKDRQRLPEPATLGFSARGQGLELGLPSTPGTPTPTPHTSLG
                     SPVSSDPVHMSPLEPRGGQGDGLALVLILAFCVAGAAALSVASLCWCRLQREIRLTQK
                     ADYATAKAPGSPAAPRISPGDQRLAQSAEMYHYQHQRQQMLCLERHKEPPKELDTASS
                     DEENEDGDFTVYECPGLAPTGEMEVRNPLFDHAALSAPLPAPSSPPALP"
     exon            301..447
                     /gene="NPDC1"
                     /gene_synonym="CAB; CAB-; CAB-1; CAB1; NPDC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..573
                     /gene="NPDC1"
                     /gene_synonym="CAB; CAB-; CAB-1; CAB1; NPDC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..744
                     /gene="NPDC1"
                     /gene_synonym="CAB; CAB-; CAB-1; CAB1; NPDC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..811
                     /gene="NPDC1"
                     /gene_synonym="CAB; CAB-; CAB-1; CAB1; NPDC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            812..896
                     /gene="NPDC1"
                     /gene_synonym="CAB; CAB-; CAB-1; CAB1; NPDC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            897..976
                     /gene="NPDC1"
                     /gene_synonym="CAB; CAB-; CAB-1; CAB1; NPDC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1073
                     /gene="NPDC1"
                     /gene_synonym="CAB; CAB-; CAB-1; CAB1; NPDC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1475
                     /gene="NPDC1"
                     /gene_synonym="CAB; CAB-; CAB-1; CAB1; NPDC-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1451..1456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPDC1"
                     /gene_synonym="CAB; CAB-; CAB-1; CAB1; NPDC-1"
                     /note="hexamer: ATTAAA"
     polyA_site      1475
                     /gene="NPDC1"
                     /gene_synonym="CAB; CAB-; CAB-1; CAB1; NPDC-1"
                     /note="major polyA site"
ORIGIN      
        1 ggatccttgc tgcagcgtca gcgccgccgc ccgtgccttt cctcttcctc ctcctcctcc
       61 ttggcatccg cctcttcttc ctcctgcgtc ctcccccgct gcctccgctg ctcccgacgc
      121 ggagcccgga gcccgcgccg agcccctggc ctcgcggtgc catgctgccc cggcggcggc
      181 gctgaaggat ggcgacgccg ctgcctccgc cctccccgcg gcacctgcgg ctgctgcggc
      241 tgctgctctc cggcctcgtc ctcggcgccg ccctgcgtgg agccgccgcc ggccacccgg
      301 atgtagccgc ctgtcccggg agcctggact gtgccctgaa gaggcgggca aggtgtcctc
      361 ctggtgcaca tgcctgtggg ccctgccttc agcccttcca ggaggaccag caagggctct
      421 gtgtgcccag gatgcgccgg cctccaggcg ggggccggcc ccagcccaga ctggaagatg
      481 agattgactt cctggcccag gagcttgccc ggaaggagtc tggacactca actccgcccc
      541 tacccaagga ccgacagcgg ctcccggagc ctgccaccct gggcttctcg gcacgggggc
      601 aggggctgga gctgggcctc ccctccactc caggaacccc cacgcccacg ccccacacct
      661 ccctgggctc ccctgtgtca tccgacccgg tgcacatgtc gcccctggag ccccggggag
      721 ggcaaggcga cggcctcgcc cttgtgctga tcctggcgtt ctgtgtggcc ggtgcagccg
      781 ccctctccgt agcctccctc tgctggtgca ggctgcagcg tgagatccgc ctgactcaga
      841 aggccgacta cgccactgcg aaggcccctg gctcacctgc agctccccgg atctcgcctg
      901 gggaccagcg gctggcacag agcgcggaga tgtaccacta ccagcaccaa cggcaacaga
      961 tgctgtgcct ggagcggcat aaagagccac ccaaggagct ggacacggcc tcctcggatg
     1021 aggagaatga ggacggagac ttcacggtgt acgagtgccc gggcctggcc ccgaccgggg
     1081 aaatggaggt gcgcaaccct ctgttcgacc acgccgcact gtccgcgccc ctgccggccc
     1141 ccagctcacc gcctgcactg ccatgacctg gaggcagaca gacgcccacc tgctccccga
     1201 cctcgaggcc cccggggagg ggcagggcct ggagcttccc actaaaaaca tgttttgatg
     1261 ctgtgtgctt ttggctgggc ctcgggctcc aggccctggg accccttgcc agggagaccc
     1321 ccgaaccttt gtgccaggac acctcctggt cccctgcacc tctcctgttc ggtttagacc
     1381 cccaaactgg agggggcatg gagaaccgta gagcgcagga acgggtgggt aattctagag
     1441 acaaaagcca attaaagtcc atttcagacc tgcgg
//
