LOCUS       XM_011515326            4787 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens NPC1 like intracellular cholesterol
            transporter 1 (NPC1L1), transcript variant X1, mRNA.
ACCESSION   XM_011515326
VERSION     XM_011515326.4
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000007.14) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011515326.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4787
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
     gene            1..4787
                     /gene="NPC1L1"
                     /gene_synonym="LDLCQ7; NPC11L1; SLC65A2"
                     /note="NPC1 like intracellular cholesterol transporter 1;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 18 ESTs, 32 long SRA reads, 2 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 11 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:29881"
                     /db_xref="HGNC:HGNC:7898"
                     /db_xref="MIM:608010"
     CDS             72..3875
                     /gene="NPC1L1"
                     /gene_synonym="LDLCQ7; NPC11L1; SLC65A2"
                     /codon_start=1
                     /product="NPC1-like intracellular cholesterol transporter
                     1 isoform X1"
                     /protein_id="XP_011513628.1"
                     /db_xref="GeneID:29881"
                     /db_xref="HGNC:HGNC:7898"
                     /db_xref="MIM:608010"
                     /translation="MAEAGLRGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPE
                     LSGSLMTLSNVSCLSNTPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEAS
                     LSITKALLTRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAYEAFY
                     QHSFAEQSYDSCSRVRVPAAATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDI
                     TFHLLEPGQAVGSGIQPLNEGVARCNESQGDDVATCSCQDCAASCPAIARPQALDSTF
                     YLGQMPGSLVLIIILCSVFAVVTILLVGFRVAPARDKSKMVDPKKGTSLSDKLSFSTH
                     TLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARS
                     EKAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQER
                     LRHLQVWSPEAQRNISLQDICYAPLNPDNTSLYDCCINSLLQYFQNNRTLLLLTANQT
                     LMGQTSQVDWKDHFLYCANAPLTFKDGTALALSCMADYGAPVFPFLAIGGYKGKDYSE
                     AEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDE
                     INRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMA
                     AMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQMSAFVALLSLDSKRQEAS
                     RLDVCCCVKPQELPPPGQGEGLLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYS
                     MCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICS
                     SAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDWLTPSSCCRLYISGPNKDKF
                     CPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVN
                     LTSDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPY
                     TITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTV
                     GFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSA
                     VFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDV
                     NPALALEQKRAEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEGSIKGAGAISNFLPN
                     NGRQF"
ORIGIN      
        1 aatgtgtgtt cagcccttgg ctgttcctga ggcctggcct ggctccccgc tgaccccttc
       61 ccagacctgg gatggcggag gccggcctga ggggctggct gctgtgggcc ctgctcctgc
      121 gcttggccca gagtgagcct tacacaacca tccaccagcc tggctactgc gccttctatg
      181 acgaatgtgg gaagaaccca gagctgtctg gaagcctcat gacactctcc aacgtgtcct
      241 gcctgtccaa cacgccggcc cgcaagatca caggtgatca cctgatccta ttacagaaga
      301 tctgcccccg cctctacacc ggccccaaca cccaagcctg ctgctccgcc aagcagctgg
      361 tatcactgga agcgagtctg tcgatcacca aggccctcct cacccgctgc ccagcctgct
      421 ctgacaattt tgtgaacctg cactgccaca acacgtgcag ccccaatcag agcctcttca
      481 tcaatgtgac ccgcgtggcc cagctagggg ctggacaact cccagctgtg gtggcctatg
      541 aggccttcta ccagcatagc tttgccgagc agagctatga ctcctgcagc cgtgtgcgcg
      601 tccctgcagc tgccacgctg gctgtgggca ccatgtgtgg cgtgtatggc tctgcccttt
      661 gcaatgccca gcgctggctc aacttccagg gagacacagg caatggtctg gccccactgg
      721 acatcacctt ccacctcttg gagcctggcc aggccgtggg gagtgggatt cagcctctga
      781 atgagggggt tgcacgttgc aatgagtccc aaggtgacga cgtggcgacc tgctcctgcc
      841 aagactgtgc tgcatcctgt cctgccatag cccgccccca ggccctcgac tccaccttct
      901 acctgggcca gatgccgggc agtctggtcc tcatcatcat cctctgctct gtcttcgctg
      961 tggtcaccat cctgcttgtg ggattccgtg tggcccccgc cagggacaaa agcaagatgg
     1021 tggaccccaa gaagggcacc agcctctctg acaagctcag cttctccacc cacaccctcc
     1081 ttggccagtt cttccagggc tggggcacgt gggtggcttc gtggcctctg accatcttgg
     1141 tgctatctgt catcccggtg gtggccttgg cagcgggcct ggtctttaca gaactcacta
     1201 cggaccccgt ggagctgtgg tcggccccca acagccaagc ccggagtgag aaagctttcc
     1261 atgaccagca tttcggcccc ttcttccgaa ccaaccaggt gatcctgacg gctcctaacc
     1321 ggtccagcta caggtatgac tctctgctgc tggggcccaa gaacttcagc ggaatcctgg
     1381 acctggactt gctgctggag ctgctagagc tgcaggagag gctgcggcac ctccaggtat
     1441 ggtcgcccga agcacagcgc aacatctccc tgcaggacat ctgctacgcc cccctcaatc
     1501 cggacaatac cagtctctac gactgctgca tcaacagcct cctgcagtat ttccagaaca
     1561 accgcacgct cctgctgctc acagccaacc agacactgat ggggcagacc tcccaagtcg
     1621 actggaagga ccattttctg tactgtgcca atgccccgct caccttcaag gatggcacag
     1681 ccctggccct gagctgcatg gctgactacg gggcccctgt cttccccttc cttgccattg
     1741 gggggtacaa aggaaaggac tattctgagg cagaggccct gatcatgacg ttctccctca
     1801 acaattaccc tgccggggac ccccgtctgg cccaggccaa gctgtgggag gaggccttct
     1861 tagaggaaat gcgagccttc cagcgtcgga tggctggcat gttccaggtc acgttcatgg
     1921 ctgagcgctc tctggaagac gagatcaatc gcaccacagc tgaagacctg cccatctttg
     1981 ccaccagcta cattgtcata ttcctgtaca tctctctggc cctgggcagc tattccagct
     2041 ggagccgagt gatggtggac tccaaggcca cgctgggcct cggcggggtg gccgtggtcc
     2101 tgggagcagt catggctgcc atgggcttct tctcctactt gggtatccgc tcctccctgg
     2161 tcatcctgca agtggttcct ttcctggtgc tgtccgtggg ggctgataac atcttcatct
     2221 ttgttctcga gtaccagatg tcagcctttg tggccctgct ctccctggac agcaagaggc
     2281 aggaggcctc ccggttggac gtctgctgct gtgtcaagcc ccaggagctg cccccgcctg
     2341 gccagggaga ggggctcctg cttggcttct tccaaaaggc ttatgccccc ttcctgctgc
     2401 actggatcac tcgaggtgtt gtgctgctgc tgtttctcgc cctgttcgga gtgagcctct
     2461 actccatgtg ccacatcagc gtgggactgg accaggagct ggccctgccc aaggactcgt
     2521 acctgcttga ctatttcctc tttctgaacc gctacttcga ggtgggggcc ccggtgtact
     2581 ttgttaccac cttgggctac aacttctcca gcgaggctgg gatgaatgcc atctgctcca
     2641 gtgcaggctg caacaacttc tccttcaccc agaagatcca gtatgccaca gagttccctg
     2701 agcagtctta cctggccatc cctgcctcct cctgggtgga tgacttcatt gactggctga
     2761 ccccgtcctc ctgctgccgc ctttatatat ctggccccaa taaggacaag ttctgcccct
     2821 cgaccgtcaa ctctctgaac tgcctaaaga actgcatgag catcacgatg ggctctgtga
     2881 ggccctcggt ggagcagttc cataagtatc ttccctggtt cctgaacgac cggcccaaca
     2941 tcaaatgtcc caaaggcggc ctggcagcat acagcacctc tgtgaacttg acttcagatg
     3001 gccaggtttt agcctccagg ttcatggcct atcacaagcc cctgaaaaac tcacaggatt
     3061 acacagaagc tctgcgggca gctcgagagc tggcagccaa catcactgct gacctgcgga
     3121 aagtgcctgg aacagacccg gcttttgagg tcttccccta cacgatcacc aatgtgtttt
     3181 atgagcagta cctgaccatc ctccctgagg ggctcttcat gctcagcctc tgccttgtgc
     3241 ccaccttcgc tgtctcctgc ctcctgctgg gcctggacct gcgctccggc ctcctcaacc
     3301 tgctctccat tgtcatgatc ctcgtggaca ctgtcggctt catggccctg tggggcatca
     3361 gttacaatgc tgtgtccctc atcaacctgg tctcggcggt gggcatgtct gtggagtttg
     3421 tgtcccacat tacccgctcc tttgccatca gcaccaagcc cacctggctg gagagggcca
     3481 aagaggccac catctctatg ggaagtgcgg tgtttgcagg tgtggccatg accaacctgc
     3541 ctggcatcct tgtcctgggc ctcgccaagg cccagctcat tcagatcttc ttcttccgcc
     3601 tcaacctcct gatcactctg ctgggcctgc tgcatggctt ggtcttcctg cccgtcatcc
     3661 tcagctacgt ggggcctgac gttaacccgg ctctggcact ggagcagaag cgggctgagg
     3721 aggcggtggc agcagtcatg gtggcctctt gcccaaatca cccctcccga gtctccacag
     3781 ctgacaacat ctatgtcaac cacagctttg aaggttctat caaaggtgct ggtgccatca
     3841 gcaacttctt gcccaacaat gggcggcagt tctgatacag ccagaggccc tgtctaggct
     3901 ctatggccct gaaccaaagg gttatgggga tcttccttgt gactgcccct tgacacacgc
     3961 cctcctcaaa tcctagggga ggccattccc atgagactgc ctgtcactgg aggatggcct
     4021 gctcttgagg tatccaggca gcaccactga tggctcctct gctcccatag tgggtcccca
     4081 gtttccaagt cacctaggcc ttgggcagtg cctcctcctg ggcctgggtc tggaagttgg
     4141 caggaacaga cacactccat gtttgtccca cactcactca ctttcctagg agcccacttc
     4201 tcatccaact tttcccttct cagttcctct ctcgaaagtc ttaattctgt gtcagtaagt
     4261 ctttaacacg tagcagtgtc cctgagaaca cagacaatga ccactaccct gggtgtgata
     4321 tcacaggagg ccagagagag gcaaaggctc aggccaagag ccaacgctgt gggaggccgg
     4381 tcggcagcca ctccctccag ggcgcacctg caggtctgcc atccacggcc ttttctggca
     4441 agagaagggc ccaggaagga tgctctcata aggcccagga aggatgctct cataagcacc
     4501 ttggtcatgg attagcccct cctggaaaat ggtgttgggt ttggtctcca gctccaatac
     4561 ttattaaggc tgttgctgcc agtcaaggcc acccaggagt ctgaaggctg ggagctcttg
     4621 gggctgggct ggtcctccca tcttcacctc gggcctggat cccaggcctc aaaccagccc
     4681 aacccgagct tttggacagc tctccagaag catgaactgc agtggagatg aagatcctgg
     4741 ctctgtgctg tgcacatagg tgtttaataa acatttgttg gcagaaa
//
