LOCUS       NM_000271               4760 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens NPC intracellular cholesterol transporter 1 (NPC1),
            mRNA.
ACCESSION   NM_000271
VERSION     NM_000271.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4760)
  AUTHORS   Huang,Y., Mei,H., Deng,C., Wang,W., Yuan,C., Nie,Y., Li,J.D. and
            Liu,J.
  TITLE     EXTL3 and NPC1 are mammalian host factors for Autographa
            californica multiple nucleopolyhedrovirus infection
  JOURNAL   Nat Commun 15 (1), 7711 (2024)
   PUBMED   39231976
  REMARK    GeneRIF: EXTL3 and NPC1 are mammalian host factors for Autographa
            californica multiple nucleopolyhedrovirus infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4760)
  AUTHORS   Lopergolo,D., Bianchi,S., Gallus,G.N., Locci,S., Pucci,B.,
            Leoni,V., Gasparini,D., Tardelli,E., Chincarini,A., Sestini,S.,
            Santorelli,F.M., Zetterberg,H., De Stefano,N. and Mignarri,A.
  TITLE     Familial Alzheimer's disease associated with heterozygous NPC1
            mutation
  JOURNAL   J Med Genet 61 (4), 332-339 (2024)
   PUBMED   37989569
  REMARK    GeneRIF: Familial Alzheimer's disease associated with heterozygous
            NPC1 mutation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4760)
  AUTHORS   Xu,J., Chen,F., Zhu,W. and Zhang,W.
  TITLE     NPC1 promotes autophagy with tumor promotion and acts as a
            prognostic model for hepatocellular carcinoma
  JOURNAL   Gene 897, 148050 (2024)
   PUBMED   38042211
  REMARK    GeneRIF: NPC1 promotes autophagy with tumor promotion and acts as a
            prognostic model for hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 4760)
  AUTHORS   Casas,M., Murray,K.D., Hino,K., Vierra,N.C., Simo,S., Trimmer,J.S.,
            Dixon,R.E. and Dickson,E.J.
  TITLE     NPC1-dependent alterations in KV2.1-CaV1.2 nanodomains drive
            neuronal death in models of Niemann-Pick Type C disease
  JOURNAL   Nat Commun 14 (1), 4553 (2023)
   PUBMED   37507375
  REMARK    GeneRIF: NPC1-dependent alterations in KV2.1-CaV1.2 nanodomains
            drive neuronal death in models of Niemann-Pick Type C disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4760)
  AUTHORS   Loftus,S.K., Morris,J.A., Carstea,E.D., Gu,J.Z., Cummings,C.,
            Brown,A., Ellison,J., Ohno,K., Rosenfeld,M.A., Tagle,D.A.,
            Pentchev,P.G. and Pavan,W.J.
  TITLE     Murine model of Niemann-Pick C disease: mutation in a cholesterol
            homeostasis gene
  JOURNAL   Science 277 (5323), 232-235 (1997)
   PUBMED   9211850
REFERENCE   6  (bases 1 to 4760)
  AUTHORS   Carstea,E.D., Morris,J.A., Coleman,K.G., Loftus,S.K., Zhang,D.,
            Cummings,C., Gu,J., Rosenfeld,M.A., Pavan,W.J., Krizman,D.B.,
            Nagle,J., Polymeropoulos,M.H., Sturley,S.L., Ioannou,Y.A.,
            Higgins,M.E., Comly,M., Cooney,A., Brown,A., Kaneski,C.R.,
            Blanchette-Mackie,E.J., Dwyer,N.K., Neufeld,E.B., Chang,T.Y.,
            Liscum,L., Strauss,J.F. 3rd, Ohno,K., Zeigler,M., Carmi,R.,
            Sokol,J., Markie,D., O'Neill,R.R., van Diggelen,O.P., Elleder,M.,
            Patterson,M.C., Brady,R.O., Vanier,M.T., Pentchev,P.G. and
            Tagle,D.A.
  TITLE     Niemann-Pick C1 disease gene: homology to mediators of cholesterol
            homeostasis
  JOURNAL   Science 277 (5323), 228-231 (1997)
   PUBMED   9211849
REFERENCE   7  (bases 1 to 4760)
  AUTHORS   Greer,W.L., Riddell,D.C., Byers,D.M., Welch,J.P., Girouard,G.S.,
            Sparrow,S.M., Gillan,T.L. and Neumann,P.E.
  TITLE     Linkage of Niemann-Pick disease type D to the same region of human
            chromosome 18 as Niemann-Pick disease type C
  JOURNAL   Am J Hum Genet 61 (1), 139-142 (1997)
   PUBMED   9245994
REFERENCE   8  (bases 1 to 4760)
  AUTHORS   Carstea,E.D., Polymeropoulos,M.H., Parker,C.C.,
            Detera-Wadleigh,S.D., O'Neill,R.R., Patterson,M.C., Goldin,E.,
            Xiao,H., Straub,R.E., Vanier,M.T. et al.
  TITLE     Linkage of Niemann-Pick disease type C to human chromosome 18
  JOURNAL   Proc Natl Acad Sci U S A 90 (5), 2002-2004 (1993)
   PUBMED   8446622
REFERENCE   9  (bases 1 to 4760)
  AUTHORS   Patterson,M.
  TITLE     Niemann-Pick Disease Type C
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301473
REFERENCE   10 (bases 1 to 4760)
  AUTHORS   Klein,C., Lohmann,K., Marras,C. and Munchau,A.
  TITLE     Hereditary Dystonia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301334
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR159421.1, AF002020.1,
            AB209048.1, BC063302.1 and AC010853.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000271.4.
            
            Summary: This gene encodes a large protein that resides in the
            limiting membrane of endosomes and lysosomes and mediates
            intracellular cholesterol trafficking via binding of cholesterol to
            its N-terminal domain. It is predicted to have a cytoplasmic
            C-terminus, 13 transmembrane domains, and 3 large loops in the
            lumen of the endosome - the last loop being at the N-terminus. This
            protein transports low-density lipoproteins to late
            endosomal/lysosomal compartments where they are hydrolized and
            released as free cholesterol. Defects in this gene cause
            Niemann-Pick type C disease, a rare autosomal recessive
            neurodegenerative disorder characterized by over accumulation of
            cholesterol and glycosphingolipids in late endosomal/lysosomal
            compartments.[provided by RefSeq, Aug 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB209048.1, BC063302.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269228.10/ ENSP00000269228.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                DR159421.1         393-434
            43-2088             AF002020.1         3-2048
            2089-4701           AB209048.1         1961-4573
            4702-4703           BC063302.1         4636-4637
            4704-4760           AC010853.11        139910-139966
FEATURES             Location/Qualifiers
     source          1..4760
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q11.2"
     gene            1..4760
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /note="NPC intracellular cholesterol transporter 1"
                     /db_xref="GeneID:4864"
                     /db_xref="HGNC:HGNC:7897"
                     /db_xref="MIM:607623"
     exon            1..220
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..4000
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /note="Niemann-Pick C1 protein"
                     /codon_start=1
                     /product="NPC intracellular cholesterol transporter 1
                     precursor"
                     /protein_id="NP_000262.2"
                     /db_xref="CCDS:CCDS11878.1"
                     /db_xref="GeneID:4864"
                     /db_xref="HGNC:HGNC:7897"
                     /db_xref="MIM:607623"
                     /translation="MTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEY
                     SGPPKPLPKDGYDLVQELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFY
                     NLLNLFCELTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNAC
                     RDVEAPSSNDKALGLLCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHGME
                     PMNNATKGCDESVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITY
                     MAFLLVFFGAFFAVWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGC
                     LRRLFTRWGSFCVRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEK
                     EYFDQHFGPFFRTEQLIIRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAI
                     ENITASYDNETVTLQDICLAPLSPYNTNCTILSVLNYFQNSHSVLDHKKGDDFFVYAD
                     YHTHFLYCVRAPASLNDTSLLHDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFP
                     VNNYYNDTEKLQRAQAWEKEFINFVKNYKNPNLTISFTAERSIEDELNRESDSDVFTV
                     VISYAIMFLYISLALGHMKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPL
                     TLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSF
                     SETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIF
                     CCVRGAEDGTSVQASESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKV
                     DIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGC
                     NNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDWVKPQSSCCRVDNITDQFCNASVV
                     DPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILLGHG
                     TRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYRVFPYSVFYVFY
                     EQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFGVMWLWG
                     ISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSGITL
                     TKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAKSCA
                     TEERYKGTERERLLNF"
     exon            221..343
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..450
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..626
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..794
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1044
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1118
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1489
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1716
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1817
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1920
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2110
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2293
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2408
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2536
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2677
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2767
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2958
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3074
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3204
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3408
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3640
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3641..3754
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3755..3917
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3918..4760
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4686..4691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /note="hexamer: AATACA"
     polyA_site      4703
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /note="major polyA site"
     regulatory      4737..4742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
                     /note="hexamer: AATACA"
     polyA_site      4760
                     /gene="NPC1"
                     /gene_synonym="NPC; POGZ; SLC65A1"
ORIGIN      
        1 cttcctgacc ggcgcgcgca gcctgctgcc gcggtcagcg cctgctcctg ctcctccgct
       61 cctcctgcgc ggggtgctga aacagcccgg ggaagtagag ccgcctccgg ggagcccaac
      121 cagccgaacg ccgccggcgt cagcagcctt gcgcggccac agcatgaccg ctcgcggcct
      181 ggcccttggc ctcctcctgc tgctactgtg tccagcgcag gtgttttcac agtcctgtgt
      241 ttggtatgga gagtgtggaa ttgcatatgg ggacaagagg tacaattgcg aatattctgg
      301 cccaccaaaa ccattgccaa aggatggata tgacttagtg caggaactct gtccaggatt
      361 cttctttggc aatgtcagtc tctgttgtga tgttcggcag cttcagacac taaaagacaa
      421 cctgcagctg cctctacagt ttctgtccag atgtccatcc tgtttttata acctactgaa
      481 cctgttttgt gagctgacat gtagccctcg acagagtcag tttttgaatg ttacagctac
      541 tgaagattat gttgatcctg ttacaaacca gacgaaaaca aatgtgaaag agttacaata
      601 ctacgtcgga cagagttttg ccaatgcaat gtacaatgcc tgccgggatg tggaggcccc
      661 ctcaagtaat gacaaggccc tgggactcct gtgtgggaag gacgctgacg cctgtaatgc
      721 caccaactgg attgaataca tgttcaataa ggacaatgga caggcacctt ttaccatcac
      781 tcctgtgttt tcagattttc cagtccatgg gatggagccc atgaacaatg ccaccaaagg
      841 ctgtgacgag tctgtggatg aggtcacagc accatgtagc tgccaagact gctctattgt
      901 ctgtggcccc aagccccagc ccccacctcc tcctgctccc tggacgatcc ttggcttgga
      961 cgccatgtat gtcatcatgt ggatcaccta catggcgttt ttgcttgtgt tttttggagc
     1021 attttttgca gtgtggtgct acagaaaacg gtattttgtc tccgagtaca ctcccatcga
     1081 tagcaatata gctttttctg ttaatgcaag tgacaaagga gaggcgtcct gctgtgaccc
     1141 tgtcagcgca gcatttgagg gctgcttgag gcggctgttc acacgctggg ggtctttctg
     1201 cgtccgaaac cctggctgtg tcattttctt ctcgctggtc ttcattactg cgtgttcgtc
     1261 aggcctggtg tttgtccggg tcacaaccaa tccagttgac ctctggtcag cccccagcag
     1321 ccaggctcgc ctggaaaaag agtactttga ccagcacttt gggcctttct tccggacgga
     1381 gcagctcatc atccgggccc ctctcactga caaacacatt taccagccat acccttcggg
     1441 agctgatgta ccctttggac ctccgcttga catacagata ctgcaccagg ttcttgactt
     1501 acaaatagcc atcgaaaaca ttactgcctc ttatgacaat gagactgtga cacttcaaga
     1561 catctgcttg gcccctcttt caccgtataa cacgaactgc accattttga gtgtgttaaa
     1621 ttacttccag aacagccatt ccgtgctgga ccacaagaaa ggggacgact tctttgtgta
     1681 tgccgattac cacacgcact ttctgtactg cgtacgggct cctgcctctc tgaatgatac
     1741 aagtttgctc catgaccctt gtctgggtac gtttggtgga ccagtgttcc cgtggcttgt
     1801 gttgggaggc tatgatgatc aaaactacaa taacgccact gcccttgtga ttaccttccc
     1861 tgtcaataat tactataatg atacagagaa gctccagagg gcccaggcct gggaaaaaga
     1921 gtttattaat tttgtgaaaa actacaagaa tcccaatctg accatttcct tcactgctga
     1981 acgaagtatt gaagatgaac taaatcgtga aagtgacagt gatgtcttca ccgttgtaat
     2041 tagctatgcc atcatgtttc tatatatttc cctagccttg gggcacatga aaagctgtcg
     2101 caggcttctg gtggattcga aggtctcact aggcatcgcg ggcatcttga tcgtgctgag
     2161 ctcggtggct tgctccttgg gtgtcttcag ctacattggg ttgcccttga ccctcattgt
     2221 gattgaagtc atcccgttcc tggtgctggc tgttggagtg gacaacatct tcattctggt
     2281 gcaggcctac cagagagatg aacgtcttca aggggaaacc ctggatcagc agctgggcag
     2341 ggtcctagga gaagtggctc ccagtatgtt cctgtcatcc ttttctgaga ctgtagcatt
     2401 tttcttagga gcattgtccg tgatgccagc cgtgcacacc ttctctctct ttgcgggatt
     2461 ggcagtcttc attgactttc ttctgcagat tacctgtttc gtgagtctct tggggttaga
     2521 cattaaacgt caagagaaaa atcggctaga catcttttgc tgtgtcagag gtgctgaaga
     2581 tggaacaagc gtccaggcct cagagagctg tttgtttcgc ttcttcaaaa actcctattc
     2641 tccacttctg ctaaaggact ggatgagacc aattgtgata gcaatatttg tgggtgttct
     2701 gtcattcagc atcgcagtcc tgaacaaagt agatattgga ttggatcagt ctctttcgat
     2761 gccagatgac tcctacatgg tggattattt caaatccatc agtcagtacc tgcatgcggg
     2821 tccgcctgtg tactttgtcc tggaggaagg gcacgactac acttcttcca aggggcagaa
     2881 catggtgtgc ggcggcatgg gctgcaacaa tgattccctg gtgcagcaga tatttaacgc
     2941 ggcgcagctg gacaactata cccgaatagg cttcgccccc tcgtcctgga tcgacgatta
     3001 tttcgactgg gtgaagccac agtcgtcttg ctgtcgagtg gacaatatca ctgaccagtt
     3061 ctgcaatgct tcagtggttg accctgcctg cgttcgctgc aggcctctga ctccggaagg
     3121 caaacagagg cctcaggggg gagacttcat gagattcctg cccatgttcc tttcggataa
     3181 ccctaacccc aagtgtggca aagggggaca tgctgcctat agttctgcag ttaacatcct
     3241 ccttggccat ggcaccaggg tcggagccac gtacttcatg acctaccaca ccgtgctgca
     3301 gacctctgct gactttattg acgctctgaa gaaagcccga cttatagcca gtaatgtcac
     3361 cgaaaccatg ggcattaacg gcagtgccta ccgagtattt ccttacagtg tgttttatgt
     3421 cttctacgaa cagtacctga ccatcattga cgacactatc ttcaacctcg gtgtgtccct
     3481 gggcgcgata tttctggtga ccatggtcct cctgggctgt gagctctggt ctgcagtcat
     3541 catgtgtgcc accatcgcca tggtcttggt caacatgttt ggagttatgt ggctctgggg
     3601 catcagtctg aacgctgtat ccttggtcaa cctggtgatg agctgtggca tctccgtgga
     3661 gttctgcagc cacataacca gagcgttcac ggtgagcatg aaaggcagcc gcgtggagcg
     3721 cgcggaagag gcacttgccc acatgggcag ctccgtgttc agtggaatca cacttacaaa
     3781 atttggaggg attgtggtgt tggcttttgc caaatctcaa attttccaga tattctactt
     3841 caggatgtat ttggccatgg tcttactggg agccactcac ggattaatat ttctccctgt
     3901 cttactcagt tacatagggc catcagtaaa taaagccaaa agttgtgcca ctgaagagcg
     3961 atacaaagga acagagcgcg aacggcttct aaatttctag ccctctcgca gggcatcctg
     4021 actgaactgt gtctaagggt cggtcggttt accactggac gggtgctgca tcggcaaggc
     4081 caagttgaac accggatggt gccaaccatc ggttgtttgg cagcagcttt gaacgtagcg
     4141 cctgtgaact caggaatgca cagttgactt gggaagcagt attactagat ctggaggcaa
     4201 ccacaggaca ctaaacttct cccagcctct tcaggaaaga aacctcattc tttggcaagc
     4261 aggaggtgac actagatggc tgtgaatgtg atccgctcac tgacactctg taaaggccaa
     4321 tcaatgcact gtctgtctct ccttttagga gtaagccatc ccacaagttc tataccatat
     4381 ttttagtgac agttgaggtt gtagatacac tttataacat tttatagttt aaagagcttt
     4441 attaatgcaa taaattaact ttgtacacat ttttatataa aaaaacagca agtgatttca
     4501 gaatgttgta ggcctcatta gagcttggtc tccaaaaatc tgtttgaaaa aagcaacatg
     4561 ttcttcacag tgttccccta gaaaggaaga gatttaattg ccagttagat gtggcatgaa
     4621 atgagggaca aagaaagcat ctcgtaggtg tgtctactgg gttttaactt atttttcttt
     4681 aataaaatac attgttttcc taagttttgg ggttacccta tctgctttga gagacaaata
     4741 caaaagctaa atggaagaga
//
