LOCUS       NM_005285               4209 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens neuropeptides B and W receptor 1 (NPBWR1), mRNA.
ACCESSION   NM_005285
VERSION     NM_005285.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4209)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4209)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   3  (bases 1 to 4209)
  AUTHORS   Sandoval,J., Mendez-Gonzalez,J., Nadal,E., Chen,G., Carmona,F.J.,
            Sayols,S., Moran,S., Heyn,H., Vizoso,M., Gomez,A.,
            Sanchez-Cespedes,M., Assenov,Y., Muller,F., Bock,C., Taron,M.,
            Mora,J., Muscarella,L.A., Liloglou,T., Davies,M., Pollan,M.,
            Pajares,M.J., Torre,W., Montuenga,L.M., Brambilla,E., Field,J.K.,
            Roz,L., Lo Iacono,M., Scagliotti,G.V., Rosell,R., Beer,D.G. and
            Esteller,M.
  TITLE     A prognostic DNA methylation signature for stage I non-small-cell
            lung cancer
  JOURNAL   J Clin Oncol 31 (32), 4140-4147 (2013)
   PUBMED   24081945
  REMARK    GeneRIF: hypermethylation of HIST1H4F, PCDHGB6, NPBWR1, ALX1, and
            HOXA9 was significantly associated with shorter survival in stage 1
            Non-small-cell lung cancer
REFERENCE   4  (bases 1 to 4209)
  AUTHORS   Pelosini,C., Maffei,M., Ceccarini,G., Marchi,M., Marsili,A.,
            Galli,G., Scartabelli,G., Tamberi,A., Latrofa,F., Fierabracci,P.,
            Vitti,P., Pinchera,A. and Santini,F.
  TITLE     Frequency of the GPR7 Tyr135Phe allelic variant in lean and obese
            subjects
  JOURNAL   J Endocrinol Invest 36 (9), 712-715 (2013)
   PUBMED   23563248
  REMARK    GeneRIF: screening of GPR7 gene mutations among lean and obese
            subjects revealed a Tyr135Phe allelic variant that is fairly common
            in the study population. This variant is unlikely to cause a
            functional derangement of the receptor
REFERENCE   5  (bases 1 to 4209)
  AUTHORS   Watanabe,N., Wada,M., Irukayama-Tomobe,Y., Ogata,Y., Tsujino,N.,
            Suzuki,M., Furutani,N., Sakurai,T. and Yamamoto,M.
  TITLE     A single nucleotide polymorphism of the neuropeptide B/W receptor-1
            gene influences the evaluation of facial expressions
  JOURNAL   PLoS One 7 (4), e35390 (2012)
   PUBMED   22545105
  REMARK    GeneRIF: A single nucleotide polymorphism of NPBWR1 changed the
            receptor function of this molecule at the cellular level, and, at
            the behavioral level, could influence personality difference in the
            context of social interaction.
REFERENCE   6  (bases 1 to 4209)
  AUTHORS   Tanaka,H., Yoshida,T., Miyamoto,N., Motoike,T., Kurosu,H.,
            Shibata,K., Yamanaka,A., Williams,S.C., Richardson,J.A.,
            Tsujino,N., Garry,M.G., Lerner,M.R., King,D.S., O'Dowd,B.F.,
            Sakurai,T. and Yanagisawa,M.
  TITLE     Characterization of a family of endogenous neuropeptide ligands for
            the G protein-coupled receptors GPR7 and GPR8
  JOURNAL   Proc Natl Acad Sci U S A 100 (10), 6251-6256 (2003)
   PUBMED   12719537
  REMARK    GeneRIF: characterization of a family of endogenous neuropeptide
            ligands for this G protein-coupled receptor
REFERENCE   7  (bases 1 to 4209)
  AUTHORS   Brezillon,S., Lannoy,V., Franssen,J.D., Le Poul,E., Dupriez,V.,
            Lucchetti,J., Detheux,M. and Parmentier,M.
  TITLE     Identification of natural ligands for the orphan G protein-coupled
            receptors GPR7 and GPR8
  JOURNAL   J Biol Chem 278 (2), 776-783 (2003)
   PUBMED   12401809
  REMARK    GeneRIF: distribution in central nervous system and peripheral
            tissues with precursor peptides
REFERENCE   8  (bases 1 to 4209)
  AUTHORS   Shimomura,Y., Harada,M., Goto,M., Sugo,T., Matsumoto,Y., Abe,M.,
            Watanabe,T., Asami,T., Kitada,C., Mori,M., Onda,H. and Fujino,M.
  TITLE     Identification of neuropeptide W as the endogenous ligand for
            orphan G-protein-coupled receptors GPR7 and GPR8
  JOURNAL   J Biol Chem 277 (39), 35826-35832 (2002)
   PUBMED   12130646
REFERENCE   9  (bases 1 to 4209)
  AUTHORS   Fujii,R., Yoshida,H., Fukusumi,S., Habata,Y., Hosoya,M.,
            Kawamata,Y., Yano,T., Hinuma,S., Kitada,C., Asami,T., Mori,M.,
            Fujisawa,Y. and Fujino,M.
  TITLE     Identification of a neuropeptide modified with bromine as an
            endogenous ligand for GPR7
  JOURNAL   J Biol Chem 277 (37), 34010-34016 (2002)
   PUBMED   12118011
  REMARK    GeneRIF: neuropeptide B, a neuropeptide modified with bromine is an
            endogenous ligand for GPR7
REFERENCE   10 (bases 1 to 4209)
  AUTHORS   O'Dowd,B.F., Scheideler,M.A., Nguyen,T., Cheng,R., Rasmussen,J.S.,
            Marchese,A., Zastawny,R., Heng,H.H., Tsui,L.C., Shi,X. et al.
  TITLE     The cloning and chromosomal mapping of two novel human
            opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed
            in discrete areas of the brain
  JOURNAL   Genomics 28 (1), 84-91 (1995)
   PUBMED   7590751
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087348.6.
            
            On Dec 2, 2019 this sequence version replaced NM_005285.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.12042.1,
                                           SRR14038193.59720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMN03465403
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000674939.1/ ENSP00000501711.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               AC087348.6         34101-34285         c
            186-4209            AC087348.6         29733-33756         c
FEATURES             Location/Qualifiers
     source          1..4209
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11.23"
     gene            1..4209
                     /gene="NPBWR1"
                     /gene_synonym="GPR7"
                     /note="neuropeptides B and W receptor 1"
                     /db_xref="GeneID:2831"
                     /db_xref="HGNC:HGNC:4522"
                     /db_xref="MIM:600730"
     exon            1..185
                     /gene="NPBWR1"
                     /gene_synonym="GPR7"
                     /inference="alignment:Splign:2.1.0"
     exon            186..4209
                     /gene="NPBWR1"
                     /gene_synonym="GPR7"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..1369
                     /gene="NPBWR1"
                     /gene_synonym="GPR7"
                     /note="opioid-somatostatin-like receptor 7; G-protein
                     coupled receptor 7; neuropeptide B/W receptor 1;
                     neuropeptides B/W receptor 1"
                     /codon_start=1
                     /product="neuropeptides B/W receptor type 1"
                     /protein_id="NP_005276.2"
                     /db_xref="CCDS:CCDS6151.1"
                     /db_xref="GeneID:2831"
                     /db_xref="HGNC:HGNC:4522"
                     /db_xref="MIM:600730"
                     /translation="MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVY
                     AVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQW
                     PFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSL
                     AVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVST
                     ICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALT
                     TDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA"
     regulatory      4181..4186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPBWR1"
                     /gene_synonym="GPR7"
                     /note="hexamer: AATAAA"
     polyA_site      4209
                     /gene="NPBWR1"
                     /gene_synonym="GPR7"
                     /note="major polyA site"
ORIGIN      
        1 atccctgcac ttccaggcgc gcgggaggga ccggcgggga cgcgagctgc ggactctggc
       61 gaactcgggg gaggcagaca gggggaggcg gacacccagc cggcaggcgt ctcagcctcc
      121 ccgcagccgg cgggcttttc tcctgacagc tccaggaaag gcagacccct tccccagcca
      181 gccagccccg tgagtccgcg gcgacattgg gccgtggggt ggctgggaac ggtcccctcc
      241 tccggaaaaa ccagagaacg gcttggagag ctgaaacgag cgtccgcgag caggtccgtg
      301 cagaaccggg cttcaggacc gctgagctcc gtagggcgtc cttgggggac gccaggtcgc
      361 cggctcctct gccctcgttg agatggacaa cgcctcgttc tcggagccct ggcccgccaa
      421 cgcatcgggc ccggacccgg cgctgagctg ctccaacgcg tcgactctgg cgccgctgcc
      481 ggcgccgctg gcggtggctg taccagttgt ctacgcggtg atctgcgccg tgggtctggc
      541 gggcaactcc gccgtgctgt acgtgttgct gcgggcgccc cgcatgaaga ccgtcaccaa
      601 cctgttcatc ctcaacctgg ccatcgccga cgagctcttc acgctggtgc tgcccatcaa
      661 catcgccgac ttcctgctgc ggcagtggcc cttcggggag ctcatgtgca agctcatcgt
      721 ggctatcgac cagtacaaca ccttctccag cctctacttc ctcaccgtca tgagcgccga
      781 ccgctacctg gtggtgttgg ccactgcgga gtcgcgccgg gtggccggcc gcacctacag
      841 cgccgcgcgc gcggtgagcc tggccgtgtg ggggatcgtc acactcgtcg tgctgccctt
      901 cgcagtcttc gcccggctag acgacgagca gggccggcgc cagtgcgtgc tagtctttcc
      961 gcagcccgag gccttctggt ggcgcgcgag ccgcctctac acgctcgtgc tgggcttcgc
     1021 catccccgtg tccaccatct gtgtcctcta taccaccctg ctgtgccggc tgcatgccat
     1081 gcggctggac agccacgcca aggccctgga gcgcgccaag aagcgggtga ccttcctggt
     1141 ggtggcaatc ctggcggtgt gcctcctctg ctggacgccc taccacctga gcaccgtggt
     1201 ggcgctcacc accgacctcc cgcagacgcc gctggtcatc gctatctcct acttcatcac
     1261 cagcctgagc tacgccaaca gctgcctcaa ccccttcctc tacgccttcc tggacgccag
     1321 cttccgcagg aacctccgcc agctgataac ttgccgcgcg gcagcctgac tcccccagcg
     1381 tccggctccg caactgcccg ccactcctgg ccagcgaggg aggagccggc gccagagtgc
     1441 gggaccagac aggccgccta ggcctcctgg ggaaaccgac tcgcgcccca tacccgacct
     1501 agcagatcgg aagcgctgcg actgtgcccg caggttgacc ttgccaagcc ctccaggtga
     1561 tgcgcggcca tgccgggtga ggagaactga ggctgagatc gccacactga gggctcccta
     1621 aagccgaggt ggaggaagag gagggtagag gaggagggcg gtattgctgg gaaccgcccc
     1681 ctccctgccc tgctccctgc tgccccaccc gagccctggc agtctggaac ctggctggag
     1741 tcggaactct ccgcgccttc gaagggaggc ccgaggacgc tgccggcgcc cccaggcgtc
     1801 ggctccgcgc ggcccctgct gtagctggcg cacagccccg gcgggtcccc ttgtcctccg
     1861 cgcgctctgg gaagacggtc aggcgcgcgc gtttggcgcc cacccctgtg agacccgctt
     1921 ggcctggcgc cgcgggcggg gaccgctgcc gaggccgcca gcgcctcttc aactggggaa
     1981 aacacaacaa ctcgggatgc cccatcggag tgtgtataca cctgtgtgtg tgtgtgtgtg
     2041 gtgtgcgcgc gtttgcggag gcatgaaatg cggggaaaga ggctggcgct tggcagtgac
     2101 tgcctagaat atgatacgaa tagtgatcct tctttctgtc tgcccctact ccttttcttt
     2161 gccttttccc tttcctatcc gtgatctccc ctgaaaatgt cagactcccg gagcaaggaa
     2221 cccggagtag cccgggcgcg cggttccggc gccccctgga ggagccagcg gccgagtgct
     2281 tagcgtcgga ggatcgcggg gctttgtggt ggagcactcc ggctgagcgc gcttcacagc
     2341 gctgtggcac actggtcatc gttgcttata gaggatgcca agccccaccc ccattccccc
     2401 aattggcctc gtctcttgtc ttacttagat cagtttgttg taactgttca tgtgtgtact
     2461 gtttttcagg actgaaaact ttataaataa tgtacatgtc ctaatctcac gagttgccat
     2521 gaagatcaaa taagataaaa agaaatgcga tctattctct tgtgttccct ttctcctctg
     2581 cttccttggc tccgccttag ggagagcagg aagcagggat gaccgacggc ttcaggtttt
     2641 ctctgctgta cttttcacag ggagctgtgg attacctggg ctttattcct tacttgtaga
     2701 cggcatccgg taggtagtcc cggtaaaccg ggtaaatact ggtcctggag tcaccaggga
     2761 gattggccag catcctacct gtgtttttgt ctctgcatat ggaagacaaa gtggattaag
     2821 agagaggact ggcattgggt ttgcccaatc ctctgcagtt tagccttaga catgagggcc
     2881 gaaccctaag caaagtctgg taattgatta tggtgtttta aaaggtatta atctttagga
     2941 tgaagtccaa acaggatgaa aatttctaca aatgtttgtt tcctatgtca tgtgtgagaa
     3001 aaaaaaatgt gagtgttgca gcacattttg tttgcttagt ttggcatctt caatcaattt
     3061 ctcaattatt taggttgaaa atagctttta ataaatattt ggaaggaaaa aactccccct
     3121 tggaatgggg ggaagcaaac cccctctcta attttggtga ataagaattg ctttcttagc
     3181 tctcagagtt tttaggaaca ttgaaataat tcatagccat cagtttagaa aatatacatt
     3241 aaaaaacctt ctgtcttggg tggcaaataa tagtaaattg tttaaaagaa agttttcatc
     3301 tacaatgagt ttcgagtggt ggacctcatg gcatttgaac aggcctctct ctgctggccg
     3361 gcttcggagg cttcttggaa ttcattttaa tatctttcga atttctagga aacattctat
     3421 tgattttcct taaactctca aaattatctc atgaatcctc tgtaactttt caaaattaaa
     3481 gttttaaact tagagtaact tctagattac ctaaggtgat ggacaaagag taaggtgaac
     3541 atttggctac aaacacagct ggagtgattg tctggattca gtatctcatc tgtcttaata
     3601 agctcagtaa ctggactcag atgggggaca gctgagtgat ccatctgtcc actgtttcat
     3661 ccctacagta gattgacctc gagccttctt ggaatctatg gagatgactg ctggaaaaat
     3721 acacgggctg acattgctgt tcatccccag caaggcatgg actggcttct gagtatgcct
     3781 gtgggattaa tcaggtctca gcagttgagt tcctcctggg ctttctgatc actggataaa
     3841 ctgttgtatc attatttcta ggtcgttgcc cttcatacga gcatgtagac tgtatatctc
     3901 aggcttcctt tttatgtctt gggtaatcgg ttgaataaat acacacataa gccaggcaaa
     3961 agtagaattt attcacatca ttgtattgca aaggttttaa cactgtgttg aattcttgca
     4021 gtttctgtgt aaactctatg gtttggtttt accactttga atagttaaaa atgtctattt
     4081 gcttttactt aatttagtgc agttatgtaa tgtgtatgct tatgttttct cttgacaaac
     4141 gcagaaactc tgtagtccat tgtagaggag ctcagtttaa aataaaagct gaaacattct
     4201 gtgtgataa
//
