LOCUS       NM_148896                575 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens neuropeptide B (NPB), mRNA.
ACCESSION   NM_148896 XM_934478
VERSION     NM_148896.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 575)
  AUTHORS   Patra,M.C., Maharana,J., Pradhan,S.K. and Rath,S.N.
  TITLE     Molecular dynamics simulation of neuropeptide B and neuropeptide W
            in the dipalmitoylphosphatidylcholine membrane bilayer
  JOURNAL   J Biomol Struct Dyn 32 (7), 1118-1131 (2014)
   PUBMED   23815761
REFERENCE   2  (bases 1 to 575)
  AUTHORS   Sakurai,T.
  TITLE     NPBWR1 and NPBWR2: Implications in Energy Homeostasis, Pain, and
            Emotion
  JOURNAL   Front Endocrinol (Lausanne) 4, 23 (2013)
   PUBMED   23515889
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 575)
  AUTHORS   Kanesaka,M., Matsuda,M., Hirano,A., Tanaka,K., Kanatani,A. and
            Tokita,S.
  TITLE     Development of a potent and selective GPR7 (NPBW1) agonist: a
            systematic structure-activity study of neuropeptide B
  JOURNAL   J Pept Sci 13 (6), 379-385 (2007)
   PUBMED   17486669
REFERENCE   4  (bases 1 to 575)
  AUTHORS   Singh,G. and Davenport,A.P.
  TITLE     Neuropeptide B and W: neurotransmitters in an emerging
            G-protein-coupled receptor system
  JOURNAL   Br J Pharmacol 148 (8), 1033-1041 (2006)
   PUBMED   16847439
  REMARK    Review article
REFERENCE   5  (bases 1 to 575)
  AUTHORS   Andreis,P.G., Rucinski,M., Neri,G., Conconi,M.T., Petrelli,L.,
            Parnigotto,P.P., Malendowicz,L.K. and Nussdorfer,G.G.
  TITLE     Neuropeptides B and W enhance the growth of human adrenocortical
            carcinoma-derived NCI-H295 cells by exerting MAPK p42/p44-mediated
            proliferogenic and antiapoptotic effects
  JOURNAL   Int J Mol Med 16 (6), 1021-1028 (2005)
   PUBMED   16273281
REFERENCE   6  (bases 1 to 575)
  AUTHORS   Lucyk,S., Miskolzie,M. and Kotovych,G.
  TITLE     NMR conformational analyses on (des-bromo) neuropeptide B [1-23]
            and neuropeptide W [1-23]: the importance of alpha-helices, a
            cation-pi interaction and a beta-turn
  JOURNAL   J Biomol Struct Dyn 23 (1), 77-90 (2005)
   PUBMED   15918679
REFERENCE   7  (bases 1 to 575)
  AUTHORS   Tanaka,H., Yoshida,T., Miyamoto,N., Motoike,T., Kurosu,H.,
            Shibata,K., Yamanaka,A., Williams,S.C., Richardson,J.A.,
            Tsujino,N., Garry,M.G., Lerner,M.R., King,D.S., O'Dowd,B.F.,
            Sakurai,T. and Yanagisawa,M.
  TITLE     Characterization of a family of endogenous neuropeptide ligands for
            the G protein-coupled receptors GPR7 and GPR8
  JOURNAL   Proc Natl Acad Sci U S A 100 (10), 6251-6256 (2003)
   PUBMED   12719537
REFERENCE   8  (bases 1 to 575)
  AUTHORS   Davenport,A.P.
  TITLE     Peptide and trace amine orphan receptors: prospects for new
            therapeutic targets
  JOURNAL   Curr Opin Pharmacol 3 (2), 127-134 (2003)
   PUBMED   12681233
  REMARK    Review article
REFERENCE   9  (bases 1 to 575)
  AUTHORS   Brezillon,S., Lannoy,V., Franssen,J.D., Le Poul,E., Dupriez,V.,
            Lucchetti,J., Detheux,M. and Parmentier,M.
  TITLE     Identification of natural ligands for the orphan G protein-coupled
            receptors GPR7 and GPR8
  JOURNAL   J Biol Chem 278 (2), 776-783 (2003)
   PUBMED   12401809
REFERENCE   10 (bases 1 to 575)
  AUTHORS   Fujii,R., Yoshida,H., Fukusumi,S., Habata,Y., Hosoya,M.,
            Kawamata,Y., Yano,T., Hinuma,S., Kitada,C., Asami,T., Mori,M.,
            Fujisawa,Y. and Fujino,M.
  TITLE     Identification of a neuropeptide modified with bromine as an
            endogenous ligand for GPR7
  JOURNAL   J Biol Chem 277 (37), 34010-34016 (2002)
   PUBMED   12118011
  REMARK    GeneRIF: identified a neuropeptide modified with bromine; an
            endogenous ligand for GPR7
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC126128.1 and BM978256.1.
            
            On Nov 22, 2018 this sequence version replaced NM_148896.4.
            
            Summary: This gene encodes a member of the neuropeptide B/W family
            of proteins and preproprotein that is proteolytically processed to
            generate multiple protein products. The encoded products include
            neuropeptide B-23 and a C-terminally extended form, neuropeptide
            B-29, which are characterized by an N-terminal brominated
            tryptophan amino acid. Both of the encoded peptides bind with
            higher affinity to neuropeptide B/W (NPB/W) receptor 1 compared to
            the related NPB/W receptor 2. These peptides may regulate feeding,
            pain perception, and stress in rodents. [provided by RefSeq, Jul
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM978256.1, SRR1803612.301958.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333383.8/ ENSP00000332766.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-477               BC126128.1         43-519
            478-575             BM978256.1         18-115              c
FEATURES             Location/Qualifiers
     source          1..575
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..575
                     /gene="NPB"
                     /gene_synonym="L7; PPL7; PPNPB"
                     /note="neuropeptide B"
                     /db_xref="GeneID:256933"
                     /db_xref="HGNC:HGNC:30099"
                     /db_xref="MIM:607996"
     exon            1..289
                     /gene="NPB"
                     /gene_synonym="L7; PPL7; PPNPB"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..418
                     /gene="NPB"
                     /gene_synonym="L7; PPL7; PPNPB"
                     /note="preproneuropeptide B; preproprotein L7; prepro-NPB"
                     /codon_start=1
                     /product="neuropeptide B preproprotein"
                     /protein_id="NP_683694.1"
                     /db_xref="CCDS:CCDS11790.1"
                     /db_xref="GeneID:256933"
                     /db_xref="HGNC:HGNC:30099"
                     /db_xref="MIM:607996"
                     /translation="MARSATLAAAALALCLLLAPPGLAWYKPAAGHSSYSVGRAAGLL
                     SGLRRSPYARRSQPYRGAEPPGGAGASPELQLHPRLRSLAVCVQDVAPNLQRCERLPD
                     GRGTYQCKANVFLSLRAADCLAA"
     exon            290..575
                     /gene="NPB"
                     /gene_synonym="L7; PPL7; PPNPB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      551..556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPB"
                     /gene_synonym="L7; PPL7; PPNPB"
                     /note="hexamer: AATAAA"
     regulatory      555..560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPB"
                     /gene_synonym="L7; PPL7; PPNPB"
                     /note="hexamer: AATAAA"
     polyA_site      569
                     /gene="NPB"
                     /gene_synonym="L7; PPL7; PPNPB"
     polyA_site      575
                     /gene="NPB"
                     /gene_synonym="L7; PPL7; PPNPB"
                     /note="major polyA site"
ORIGIN      
        1 gagcccggac gccgccgccc accagtcagc cggcgtcccc atggcccggt ccgcgacact
       61 ggcggccgcc gccctggcgc tgtgcctgct gctggcgccg cctggcctcg cgtggtacaa
      121 gccagcggcg gggcacagct cctactcggt gggccgcgcc gcggggctgc tgtccggcct
      181 ccgcaggtcc ccgtacgcgc ggcgctccca gccctacaga ggggcggaac ccccgggcgg
      241 ggccggcgcc tccccggagc tgcaactgca ccccaggctg cggagcctcg ctgtgtgcgt
      301 ccaggacgtc gccccaaacc tgcagaggtg cgagcggctc cccgacggcc gcgggaccta
      361 ccagtgcaag gcgaacgtct tcctgtccct gcgcgcagcc gactgcctcg ccgcctgagc
      421 ccggacctct cctggcaccg ctgggggccc cccgccccca ccgtcccact cggtgacccc
      481 aggcccctcc ggcgcgggat ggcgccccag gtctccccta ctccgctcac cccgcagtta
      541 atggcaaacg aataaataaa tgaggcggcc tcgga
//
