LOCUS       NM_002519               6113 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens nuclear protein, coactivator of histone transcription
            (NPAT), transcript variant 2, mRNA.
ACCESSION   NM_002519
VERSION     NM_002519.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6113)
  AUTHORS   Terradas,M., Schubert,S.A., Viana-Errasti,J., Ruano,D., Aiza,G.,
            Nielsen,M., Marciel,P., Tops,C.M., Parra,G., Morreau,H.,
            Torrents,D., van Leerdam,M.E., Capella,G., de Miranda,N.F.C.C.,
            Valle,L. and van Wezel,T.
  TITLE     Germline NPAT inactivating variants as cause of hereditary
            colorectal cancer
  JOURNAL   Eur J Hum Genet 32 (7), 871-875 (2024)
   PUBMED   38778081
  REMARK    GeneRIF: Germline NPAT inactivating variants as cause of hereditary
            colorectal cancer.
REFERENCE   2  (bases 1 to 6113)
  AUTHORS   Chen,C., Gallagher,J.R., Tarlton,J., van Aalten,L., Bray,S.E.,
            Ashford,M.L.J., McCrimmon,R.J., Pearson,E.R., McNeilly,A.D. and
            Sutherland,C.
  TITLE     The genetic association of the transcription factor NPAT with
            glycemic response to metformin involves regulation of fuel
            selection
  JOURNAL   PLoS One 16 (7), e0253533 (2021)
   PUBMED   34197485
  REMARK    GeneRIF: The genetic association of the transcription factor NPAT
            with glycemic response to metformin involves regulation of fuel
            selection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6113)
  AUTHORS   Bucholc,K., Skrajna,A., Adamska,K., Yang,X.C., Krajewski,K.,
            Poznanski,J., Dadlez,M., Dominski,Z. and Zhukov,I.
  TITLE     Structural Analysis of the SANT/Myb Domain of FLASH and YARP
            Proteins and Their Complex with the C-Terminal Fragment of NPAT by
            NMR Spectroscopy and Computer Simulations
  JOURNAL   Int J Mol Sci 21 (15), 5268 (2020)
   PUBMED   32722282
  REMARK    GeneRIF: Structural Analysis of the SANT/Myb Domain of FLASH and
            YARP Proteins and Their Complex with the C-Terminal Fragment of
            NPAT by NMR Spectroscopy and Computer Simulations.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6113)
  AUTHORS   Ling Zheng,L., Wang,F.Y., Cong,X.X., Shen,Y., Rao,X.S., Huang,D.S.,
            Fan,W., Yi,P., Wang,X.B., Zheng,L., Zhou,Y.T. and Luo,Y.
  TITLE     Interaction of Heat Shock Protein Cpn10 with the Cyclin E/Cdk2
            Substrate Nuclear Protein Ataxia-Telangiectasia (NPAT) Is Involved
            in Regulating Histone Transcription
  JOURNAL   J Biol Chem 290 (49), 29290-29300 (2015)
   PUBMED   26429916
  REMARK    GeneRIF: Cpn10 has a role in the spatial regulation of NPAT
            signaling
REFERENCE   5  (bases 1 to 6113)
  AUTHORS   Yang,X.C., Sabath,I., Kunduru,L., van Wijnen,A.J., Marzluff,W.F.
            and Dominski,Z.
  TITLE     A conserved interaction that is essential for the biogenesis of
            histone locus bodies
  JOURNAL   J Biol Chem 289 (49), 33767-33782 (2014)
   PUBMED   25339177
  REMARK    GeneRIF: The conserved C-terminal domain shared by FLASH, YARP, and
            Mute recognizes the C-terminal sequence of NPAT orthologues, thus
            acting as a signal targeting proteins to histone locus bodies.
REFERENCE   6  (bases 1 to 6113)
  AUTHORS   Imai,T., Sugawara,T., Nishiyama,A., Shimada,R., Ohki,R., Seki,N.,
            Sagara,M., Ito,H., Yamauchi,M. and Hori,T.
  TITLE     The structure and organization of the human NPAT gene
  JOURNAL   Genomics 42 (3), 388-392 (1997)
   PUBMED   9205109
REFERENCE   7  (bases 1 to 6113)
  AUTHORS   Platzer,M., Rotman,G., Bauer,D., Uziel,T., Savitsky,K.,
            Bar-Shira,A., Gilad,S., Shiloh,Y. and Rosenthal,A.
  TITLE     Ataxia-telangiectasia locus: sequence analysis of 184 kb of human
            genomic DNA containing the entire ATM gene
  JOURNAL   Genome Res 7 (6), 592-605 (1997)
   PUBMED   9199932
REFERENCE   8  (bases 1 to 6113)
  AUTHORS   Byrd,P.J., Cooper,P.R., Stankovic,T., Kullar,H.S., Watts,G.D.,
            Robinson,P.J. and Taylor,M.R.
  TITLE     A gene transcribed from the bidirectional ATM promoter coding for a
            serine rich protein: amino acid sequence, structure and expression
            studies
  JOURNAL   Hum Mol Genet 5 (11), 1785-1791 (1996)
   PUBMED   8923007
REFERENCE   9  (bases 1 to 6113)
  AUTHORS   Imai,T., Yamauchi,M., Seki,N., Sugawara,T., Saito,T., Matsuda,Y.,
            Ito,H., Nagase,T., Nomura,N. and Hori,T.
  TITLE     Identification and characterization of a new gene physically linked
            to the ATM gene
  JOURNAL   Genome Res 6 (5), 439-447 (1996)
   PUBMED   8743993
REFERENCE   10 (bases 1 to 6113)
  AUTHORS   Byrd,P.J., McConville,C.M., Cooper,P., Parkhill,J., Stankovic,T.,
            McGuire,G.M., Thick,J.A. and Taylor,A.M.
  TITLE     Mutations revealed by sequencing the 5' half of the gene for ataxia
            telangiectasia
  JOURNAL   Hum Mol Genet 5 (1), 145-149 (1996)
   PUBMED   8789452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA338219.1, BC050561.2, BC094769.1, X97186.1 and AP002433.5.
            
            On Nov 23, 2018 this sequence version replaced NM_002519.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290020.1, SRR1660803.14079.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278612.9/ ENSP00000278612.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                DA338219.1         1-27
            28-962              BC050561.2         13-947
            963-2887            BC094769.1         968-2892
            2888-3749           BC050561.2         2873-3734
            3750-5809           X97186.1           3682-5741
            5810-5811           AP002433.5         142095-142096       c
            5812-5938           X97186.1           5745-5871
            5939-6113           AP002433.5         141793-141967       c
FEATURES             Location/Qualifiers
     source          1..6113
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     gene            1..6113
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /note="nuclear protein, coactivator of histone
                     transcription"
                     /db_xref="GeneID:4863"
                     /db_xref="HGNC:HGNC:7896"
                     /db_xref="MIM:601448"
     exon            1..139
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..4386
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein NPAT; nuclear protein of the ATM locus; nuclear
                     protein of the ataxia telangiectasia mutated locus;
                     nuclear protein, ataxia-telangiectasia locus; nuclear
                     protein, co-activator of histone transcription"
                     /codon_start=1
                     /product="protein NPAT isoform 2"
                     /protein_id="NP_002510.2"
                     /db_xref="CCDS:CCDS41710.1"
                     /db_xref="GeneID:4863"
                     /db_xref="HGNC:HGNC:7896"
                     /db_xref="MIM:601448"
                     /translation="MLLPSDVARLVLGYLQQENLISTCQTFILESSDLKEYAEHCTDE
                     GFIPACLLSLFGKNLTTILNEYVAMKTKETSNNVPAIMSSLWKKLDHTLSQIRSMQSS
                     PRFAGSQRARTRTGIAEIKRQRKLASQTAPASAELLTLPYLSGQFTTPPSTGTQVTRP
                     SGQISDPSRSYFVVVNHSQSQDTVTTGEALNVIPGAQEKKAHASLMSPGRRKSESQRK
                     STTLSGPHSTIRNFQDPNAFAVEKQMVIENAREKILSNKSLQEKLAENINKFLTSDNN
                     IAQVPKQTDNNPTEPETSIDEFLGLPSEIHMSEEAIQDILEQTESDPAFQALFDLFDY
                     GKTKNNKNISQSISSQPMESNPSIVLADETNLAVKGSFETEESDGQSGQPAFCTSYQN
                     DDPLNALKNSNNHDVLRQEDQENFSQISTSIQKKAFKTAVPTEQKCDIDITFESVPNL
                     NDFNQRGNSNAECNPHCAELYTNQMSTETEMAIGIEKNSLSSNVPSESQLQPDQPDIP
                     ITSFVSLGCEANNENLILSGKSSQLLSQDTSLTGKPSKKSQFCENSNDTVKLKINFHG
                     SKSSDSSEVHKSKIEINVLEPVMSQLSNCQDNSCLQSEILPVSVESSHLNVSGQVEIH
                     LGDSLSSTKQPSNDSASVELNHTENEAQASKSENSQEPSSSVKEENTIFLSLGGNANC
                     EKVALTPPEGTPVENSHSLPPESVCSSVGDSHPESQNTDDKPSSNNSAEIDASNIVSL
                     KVIISDDPFVSSDTELTSAVSSINGENLPTIILSSPTKSPTKNAELVKCLSSEETVGA
                     VVYAEVGDSASMEQSLLTFKSEDSAVNNTQNEDGIAFSANVTPCVSKDGGYIQLMPAT
                     STAFGNSNNILIATCVTDPTALGTSVSQSNVVVLPGNSAPMTAQPLPPQLQTPPRSNS
                     VFAVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNNFSTPPRQVLHMP
                     LTAPVCNRSIPQFPVPPKSQKAQGLRNKPCIGKQVNNLVDSSGHSVGCHAQKTEVSDK
                     SIATDLGKKSEETTVPFPEESIVPAAKPCHRRVLCFDSTTAPVANTQGPNHKMVSQNK
                     ERNAVSFPNLDSPNVSSTLKPPSNNAIKREKEKPPLPKILSKSESAISRHTTIRETQS
                     EKKVSPTEIVLESFHKATANKENELCSDVERQKNPENSKLSIGQQNGGLRSEKSIASL
                     QEMTKKQGTSSNNKNVLSVGTAVKDLKQEQTKSASSLITTEMLQDIQRHSSVSRLADS
                     SDLPVPRTPGSGAGEKHKEEPIDIIKAPSSRRFSEDSSTSKVMVPPVTPDLPACSPAS
                     ETGSENSVNMAAHTLMILSRAAISRTTSATPLKDNTQQFRASSRSTTKKRKIEELDER
                     ERNSRPSSKNLTNSSIPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE"
     exon            140..258
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /inference="alignment:Splign:2.1.0"
     exon            259..319
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /inference="alignment:Splign:2.1.0"
     exon            320..392
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /inference="alignment:Splign:2.1.0"
     exon            393..433
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /inference="alignment:Splign:2.1.0"
     exon            434..658
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /inference="alignment:Splign:2.1.0"
     exon            659..740
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /inference="alignment:Splign:2.1.0"
     exon            741..828
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /inference="alignment:Splign:2.1.0"
     exon            829..920
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1008
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1105
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1234
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..2887
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /inference="alignment:Splign:2.1.0"
     exon            2888..3003
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3112
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3173
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /inference="alignment:Splign:2.1.0"
     exon            3174..4308
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /inference="alignment:Splign:2.1.0"
     exon            4309..6113
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4680..4685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /note="hexamer: AATAGA"
     polyA_site      4701
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /note="major polyA site"
     regulatory      5720..5725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /note="hexamer: AATAAA"
     polyA_site      5747
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
     regulatory      5913..5918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /note="hexamer: AATAAA"
     polyA_site      5938
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /note="major polyA site"
     regulatory      5979..5984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /note="hexamer: ATTAAA"
     polyA_site      5999
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
     regulatory      6094..6099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
                     /note="hexamer: AATAAA"
     polyA_site      6113
                     /gene="NPAT"
                     /gene_synonym="E14; E14/NPAT; p220"
ORIGIN      
        1 agtgccgcca ctggaaccag gagatgcggc gcaggagctg tcgctgtgtt tgctttaacc
       61 tgagtcttgt tccttattgt ggttcctgct gtggttttga tcatgttgtt accctcggac
      121 gtagcccggc ttgtattggg ttacttacag caagaaaacc tcatttctac ctgccagact
      181 tttattttgg aaagttcaga tttaaaagaa tatgcagaac attgtacaga tgaagggttt
      241 attccagcct gcttactgtc cttatttgga aaaaacttga caacaatttt aaatgagtat
      301 gtagctatga aaacaaaaga aacatcaaat aatgtcccag caataatgtc atctctatgg
      361 aagaaattgg accatacact ttctcagatc aggagcatgc aaagttcccc aaggtttgct
      421 ggcagtcaga gagcccgaac gagaactgga attgcagaaa tcaaacggca gagaaagctt
      481 gcatctcaaa cagctccagc cagtgcagag ttgctcactt taccttacct ttcaggacag
      541 tttaccactc ctccttccac aggtacacag gttactcgac caagtggcca aatttcagat
      601 ccatcgaggt catattttgt agtggtcaac cactcacagt cacaagatac tgtaaccact
      661 ggagaagctt taaatgtcat tcctggtgct caggaaaaga aagcacatgc cagtttaatg
      721 tctcccggta gacgcaaaag tgaatctcag agaaaaagta ccactttgtc tggccctcat
      781 tcaacaatac ggaatttcca agatccaaac gcttttgcag tagaaaaaca aatggttatt
      841 gaaaatgcac gagaaaaaat actaagcaac aaatctcttc aagaaaagct agcagaaaac
      901 ataaataaat ttttaactag tgataacaat attgcccaag tacctaagca aacagataac
      961 aaccctacgg agccagagac ttcaattgat gaattcctag gacttccgag tgaaattcac
     1021 atgtctgaag aagctataca ggacatattg gaacagacag aatcagaccc agcatttcag
     1081 gcactctttg atctctttga ctatggcaaa acaaagaata ataaaaatat atcacaaagt
     1141 atttccagtc aacctatgga atccaatccc agtatagtct tagcagatga aactaatcta
     1201 gcagttaaag gttcttttga aacagaagaa tctgatggtc agtctggtca gcccgctttt
     1261 tgtacatcct atcagaatga tgacccatta aatgctttga agaatagcaa caaccatgat
     1321 gtgcttagac aagaagacca ggaaaatttt tcccaaataa gtaccagcat acagaaaaag
     1381 gcctttaaaa cagctgtacc cactgaacag aagtgtgaca ttgacattac ctttgagtcc
     1441 gtgcctaatt tgaatgactt taaccaaaga gggaattcta atgctgaatg taatccacat
     1501 tgtgctgaat tatacaccaa tcagatgtcc actgaaactg aaatggctat agggattgaa
     1561 aagaactctt tgtcttcaaa tgtaccgagt gaatctcagt tacagcctga tcagcctgat
     1621 ataccaataa cttcatttgt ttcacttggt tgtgaagcta acaatgaaaa cttaattctc
     1681 tctgggaaga gttctcaact tttatcccaa gatacttcat taactggaaa gccatctaaa
     1741 aaaagtcaat tttgtgaaaa ttctaatgat acagtaaaac ttaaaattaa ttttcatggt
     1801 tccaagtcat cagattctag tgaagttcac aagagtaaaa tagaaattaa tgtgttagaa
     1861 ccagttatgt cacagctatc aaattgccaa gataattctt gtcttcaaag tgaaatacta
     1921 cctgtgtctg ttgaaagttc acatttaaat gtatctggac aagtagaaat tcatcttgga
     1981 gattcgctgt cttctactaa acaaccatct aatgattcag catctgttga gttaaatcat
     2041 acagaaaatg aagctcaggc atccaagtct gagaattcac aggagccttc atcttctgta
     2101 aaagaagaga atactatttt tctctcttta ggtggaaatg ctaactgtga gaaagttgca
     2161 ctgacgcctc cagaaggcac tcctgtagaa aacagtcact ctcttcctcc agaatctgtg
     2221 tgttcttcag tgggagattc tcaccctgag tcccaaaata ctgatgataa accttctagc
     2281 aacaactcag cagagataga tgcatcaaat atcgtctctc tcaaagttat cattagtgat
     2341 gatccatttg tttcctcaga tactgaactt accagtgctg tttctagtat taatggagaa
     2401 aacctgccaa ctataatctt gtcttctcct actaaatcac ctactaaaaa tgcagaacta
     2461 gttaaatgcc tatcttcaga agaaactgta ggtgctgttg tatatgccga agtaggggat
     2521 tcagcctcaa tggaacagag tcttttaaca ttcaaatctg aagactctgc agtaaacaat
     2581 actcagaatg aagatggcat tgctttttca gctaatgtta caccatgtgt ttccaaggat
     2641 ggaggatata tacagttgat gccagccaca agcacagctt ttggcaattc aaataacatt
     2701 ctgatagcta cctgtgtgac tgatccaaca gcgttaggaa catctgtaag tcagtctaat
     2761 gtagtggtgt tgcctggaaa ttctgcacct atgactgctc aacctctacc acctcagtta
     2821 cagacaccac caaggtcaaa cagtgtattt gctgtcaacc aagctgtgtc accaaacttt
     2881 tcacaaggat ctgccataat aattgcctct ccagtccagc ctgtactcca aggaatggta
     2941 gggatgatcc cagtatctgt ggttggacag aatggaaata acttttctac tcctcctcgg
     3001 caggttcttc atatgccttt gacagcacct gtatgcaata gaagtatccc tcaattcccc
     3061 gtccctccaa aatctcagaa ggctcaggga ctaagaaaca agccttgtat aggaaaacaa
     3121 gtaaataatt tggtggattc gtcaggtcat tcagttggat gtcatgcaca aaaaactgaa
     3181 gtttctgaca aaagtattgc cacagatctt gggaaaaaat cagaagaaac cacagttccc
     3241 ttcccagaag agagtatagt tccagctgct aaaccatgcc acagacgtgt actctgtttc
     3301 gacagcacta ctgctcctgt ggcaaatacg caggggccaa accataagat ggtgtcccaa
     3361 aacaaagaaa ggaatgcagt ctcttttcct aatcttgact cacccaatgt gtcctccacc
     3421 ttaaaacccc cttctaataa tgctatcaaa agagagaaag agaagcctcc tctgcctaag
     3481 attttatcta aatcggaaag tgccattagc cggcatacca ccataagaga aactcaatca
     3541 gaaaagaaag tttcaccaac agaaattgtg cttgaatctt tccataaagc aacagctaat
     3601 aaggagaatg aattatgcag cgatgtagaa agacagaaaa atccagaaaa ttcaaaacta
     3661 tctattgggc agcaaaatgg gggtttgcga agtgagaaat ctatagcttc actgcaagaa
     3721 atgaccaaaa aacaaggcac atcttcaaac aataaaaatg tactttcagt aggtacagct
     3781 gtgaaggatc taaaacaaga acaaactaaa tccgccagtt ctttgattac cacagaaatg
     3841 ttacaggata tacagaggca cagctcagta agtaggcttg ctgatagtag tgatttacct
     3901 gtgccccgga cacctggctc aggggcaggg gaaaaacata aagaagaacc tatagatatt
     3961 atcaaggccc cctctagtag gcgtttcagt gaagacagta gtacatcaaa agtaatggtc
     4021 cctcctgtca ccccagactt gcctgcctgc agccctgcca gtgaaacagg aagtgaaaac
     4081 agtgtaaata tggctgccca cacattaatg attctctcca gggcagccat ttctaggact
     4141 acttcagcaa ctcctctgaa agataacaca caacagttta gagcatcttc aaggagcacc
     4201 acaaaaaagc ggaaaattga ggaattagat gaacgtgagc gaaactctcg tccttctagt
     4261 aaaaatctta caaattcatc aataccaatg aaaaagaaga aaattaagaa aaagaagctt
     4321 cccagttcat ttccagcagg aatggatgta gacaaatttt tgttatcatt gcattatgat
     4381 gagtaaacat tctggacaca taagaacagt aggtgttaaa aactcatatc ccttaaactg
     4441 agtgtaggga atgggatatt gacagaatct gaaagcatga cctgcacttt cattgtactg
     4501 aaacttcact ttatatctaa atcatgctgt ttctgaaaca gcttcctagt ttgtaaatag
     4561 acttacttgg tatattttta ttttgggaaa aacgtttgca gaaatgtaag taaagccaat
     4621 ctgcaaaact gtatagcttt gacaattcca tattgtaaat actgtgtaaa tcttgttgaa
     4681 atagaggtta aatcaaccta atgttcttac actgtgtttt ttgacttctt atgatcccta
     4741 attctgagac ttactcatct ggaatagttt ctcacttgtt ttggaggaaa atgatgctta
     4801 ttcttataaa ttaccttcag taactattca ataagacatt taaatacaca atcactaagt
     4861 actacaaaat aataaccacc tcaactgata gcaaaatatc taattagaaa tcaacagttt
     4921 gatgagtttt tttcctagag tgaatactac ccctttctta taattgctgt aagtattata
     4981 tttctggaat ttcacacttt acctactctg atcactctgt tctctttgtt ttaaagagag
     5041 aattttgtaa accatttatt gaatgttctg atctttcatt tataacttaa gattttttac
     5101 agaactttaa gtggttagac tattgagcca taaaattttg gtttgtagta gagatttctc
     5161 ggtatgtact tttcccctaa atgctgggga tttaaagaat tgcactaatt catagaactc
     5221 tttacattgt agtgaccaat gcacatataa tttaaatctt gtgttctatg tgagagttta
     5281 tgtggaggat tatcttctgg tgttgtgtcc atcataagat gtaaaaagag aaatcatagt
     5341 tttatatttt agtttctcct acaatgggta tgttaaataa ctatatctat acttagatat
     5401 agtgcattgt ctgtgtccct taaagtgtta caaagagttt ctctcaaaag gtccttaagg
     5461 agagtgagag atgagagagg tgccttctct gtattagact cacacacatc agtccagttg
     5521 aagaattggt ttaaactttt aaatgagaac agaaattata attagtacct gaccaattgt
     5581 gcctagatat taaagtatgt tctctttagt actttccgtt caattaaata tcagtatatt
     5641 agggattttt ttctacaggt gtatattttg ttgaagagtc actttcctca accatttttt
     5701 tgtactgggc ctttaaaaaa ataaatccat ccaactttaa cacaacattt ctcagtgtag
     5761 aaatcatgtc ttcttaattg ctgaacctta ctgcaaaaac ttgtgatgta agaaatttgt
     5821 atggtgtggc agtggtctat tcctaaggaa ctaaatatca tatagttaat gtttatttaa
     5881 ctcagcttga gactgtacta cagttaggtt tgaataaata ttttcattaa cttcaaaagt
     5941 ttgaattact ttacattggc agtcttgttt agaaactgat taaattcctt tgcaagtcag
     6001 ttctttttgg gagtttgtac aatgctgaaa atcacagttt tcttcttatt caattcatag
     6061 ttgtatgtac taagcactga aaattcatat acaaataaaa taagtttact ttc
//
