LOCUS       NM_001394988            6259 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens neuronal PAS domain protein 3 (NPAS3), transcript
            variant 5, mRNA.
ACCESSION   NM_001394988 XM_011537070
VERSION     NM_001394988.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6259)
  AUTHORS   Pavesic Radonja,A., Blazevic Zelic,S., Rubesa,G. and Bradshaw,N.J.
  TITLE     SYMPTOM SEVERITY IN SCHIZOPHRENIA PATIENTS WITH NPAS3, DYSBINDIN-1
            AND/OR TRIOBP PROTEIN PATHOLOGY IN THEIR BLOOD SERUM: A PANSS-BASED
            FOLLOW UP STUDY
  JOURNAL   Psychiatr Danub 35 (2), 180-186 (2023)
   PUBMED   37480305
  REMARK    GeneRIF: SYMPTOM SEVERITY IN SCHIZOPHRENIA PATIENTS WITH NPAS3,
            DYSBINDIN-1 AND/OR TRIOBP PROTEIN PATHOLOGY IN THEIR BLOOD SERUM: A
            PANSS-BASED FOLLOW UP STUDY.
REFERENCE   2  (bases 1 to 6259)
  AUTHORS   Li,Y., Fan,T., Li,X., Liu,L., Mao,F., Li,Y., Miao,Z., Zeng,C.,
            Song,W., Pan,J., Zhou,S., Wang,H., Wang,Y. and Sun,Z.S.
  TITLE     Npas3 deficiency impairs cortical astrogenesis and induces
            autistic-like behaviors
  JOURNAL   Cell Rep 40 (9), 111289 (2022)
   PUBMED   36044858
  REMARK    GeneRIF: Npas3 deficiency impairs cortical astrogenesis and induces
            autistic-like behaviors.
            Erratum:[Cell Rep. 2022 Nov 8;41(6):111551. doi:
            10.1016/j.celrep.2022.111551.. PMID: 36351396]
REFERENCE   3  (bases 1 to 6259)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6259)
  AUTHORS   Rossi,J.J., Rosenfeld,J.A., Chan,K.M., Streff,H., Nankivell,V.,
            Peet,D.J., Whitelaw,M.L. and Bersten,D.C.
  TITLE     Molecular characterisation of rare loss-of-function NPAS3 and NPAS4
            variants identified in individuals with neurodevelopmental
            disorders
  JOURNAL   Sci Rep 11 (1), 6602 (2021)
   PUBMED   33758288
  REMARK    GeneRIF: Molecular characterisation of rare loss-of-function NPAS3
            and NPAS4 variants identified in individuals with
            neurodevelopmental disorders.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6259)
  AUTHORS   Luoma,L.M. and Berry,F.B.
  TITLE     Molecular analysis of NPAS3 functional domains and variants
  JOURNAL   BMC Mol Biol 19 (1), 14 (2018)
   PUBMED   30509165
  REMARK    GeneRIF: NPAS3 is a true transcription factor capable of regulating
            expression of target genes through their promoters by directly
            cooperating with ARNT.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6259)
  AUTHORS   Pickard,B.S., Christoforou,A., Thomson,P.A., Fawkes,A., Evans,K.L.,
            Morris,S.W., Porteous,D.J., Blackwood,D.H. and Muir,W.J.
  TITLE     Interacting haplotypes at the NPAS3 locus alter risk of
            schizophrenia and bipolar disorder
  JOURNAL   Mol Psychiatry 14 (9), 874-884 (2009)
   PUBMED   18317462
  REMARK    GeneRIF: This study demonstrated that these risk and protective
            effects act combinatorially, potentially multiplicatively, to
            determine NPAS3 gene-wide susceptibility in bipolar disorder and
            schizophrenia.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 6259)
  AUTHORS   Uhl,G.R., Liu,Q.R., Drgon,T., Johnson,C., Walther,D., Rose,J.E.,
            David,S.P., Niaura,R. and Lerman,C.
  TITLE     Molecular genetics of successful smoking cessation: convergent
            genome-wide association study results
  JOURNAL   Arch Gen Psychiatry 65 (6), 683-693 (2008)
   PUBMED   18519826
  REMARK    GeneRIF: Clinical trial and genome-wide association study of
            gene-disease association, gene-environment interaction, and
            pharmacogenomic / toxicogenomic. (HuGE Navigator)
REFERENCE   8  (bases 1 to 6259)
  AUTHORS   Pickard,B.S., Pieper,A.A., Porteous,D.J., Blackwood,D.H. and
            Muir,W.J.
  TITLE     The NPAS3 gene--emerging evidence for a role in psychiatric illness
  JOURNAL   Ann Med 38 (6), 439-448 (2006)
   PUBMED   17008307
  REMARK    Review article
REFERENCE   9  (bases 1 to 6259)
  AUTHORS   Kamnasaran,D., Chen,C.P., Devriendt,K., Mehta,L. and Cox,D.W.
  TITLE     Defining a holoprosencephaly locus on human chromosome 14q13 and
            characterization of potential candidate genes
  JOURNAL   Genomics 85 (5), 608-621 (2005)
   PUBMED   15820313
REFERENCE   10 (bases 1 to 6259)
  AUTHORS   Kamnasaran,D., Muir,W.J., Ferguson-Smith,M.A. and Cox,D.W.
  TITLE     Disruption of the neuronal PAS3 gene in a family affected with
            schizophrenia
  JOURNAL   J Med Genet 40 (5), 325-332 (2003)
   PUBMED   12746393
  REMARK    GeneRIF: haploinsufficiency of NPAS3 contributes to the cause of
            schizophrenia
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL109769.5, AL139296.4,
            AL158802.1, AL161851.4 and AL157689.3.
            
            On May 13, 2021 this sequence version replaced XM_011537070.2.
            
            Summary: This gene encodes a member of the basic helix-loop-helix
            and PAS domain-containing family of transcription factors. The
            encoded protein is localized to the nucleus and may regulate genes
            involved in neurogenesis. Chromosomal abnormalities that affect the
            coding potential of this gene are associated with schizophrenia and
            cognitive disability. Alternate splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KJ534897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155371, SAMEA2156099
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-488               AL109769.5         62489-62976         c
            489-733             AL139296.4         91923-92167         c
            734-784             AL139296.4         91762-91812         c
            785-861             AL158802.1         36002-36078         c
            862-951             AL161851.4         9294-9383
            952-1126            AL161851.4         125384-125558
            1127-1245           AL161851.4         184387-184505
            1246-1439           AL157689.3         64948-65141
            1440-1546           AL157689.3         69077-69183
            1547-1694           AL157689.3         84508-84655
            1695-1819           AL157689.3         88068-88192
            1820-6259           AL157689.3         90345-94784
FEATURES             Location/Qualifiers
     source          1..6259
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q13.1"
     gene            1..6259
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /note="neuronal PAS domain protein 3"
                     /db_xref="GeneID:64067"
                     /db_xref="HGNC:HGNC:19311"
                     /db_xref="MIM:609430"
     exon            1..488
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..3195
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /note="isoform 5 is encoded by transcript variant 5;
                     neuronal PAS domain-containing protein 3; member of PAS
                     protein 6; neuronal PAS3; PAS domain-containing protein 6;
                     basic-helix-loop-helix-PAS protein MOP6; class E basic
                     helix-loop-helix protein 12"
                     /codon_start=1
                     /product="neuronal PAS domain-containing protein 3 isoform
                     5"
                     /protein_id="NP_001381917.1"
                     /db_xref="GeneID:64067"
                     /db_xref="HGNC:HGNC:19311"
                     /db_xref="MIM:609430"
                     /translation="MAPTKPSFQQDPSRRERLQALRKEKSRDAARSRRGKENFEFYEL
                     AKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPNTSVKGIQM
                     WKSELCMRKTPCEGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYIS
                     ETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSA
                     SSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGR
                     LRLRVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENR
                     ISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIW
                     IQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPEKTSESSETSDSE
                     SDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCNDDGHSSSNP
                     DSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCESLTSDSAK
                     DSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPGGLDAGLVEPPRLLSS
                     PNSASVLKIKTEISEPINFDNDSSIWNYPPNREISRNESPYSMTKPPSSEHFPSPQGG
                     GGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGASATAALAPVASDPLSPPLSASP
                     RDKHPGNGGGGGGGGGGAGGGGPSASNSLLYTGDLEALQRLQAGNVVLPLVHRVTGTL
                     AATSTAAQRVYTTGTIRYAPAEVTLAMQSNLLPNAHAVNFVDVNSPGFGLDPKTPMEM
                     LYHHVHRLNMSGPFGGAVSAASLTQMPAGNVFTTAEGLFSTLPFPVYSNGIHAAQTLE
                     RKED"
     exon            489..733
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     exon            734..784
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     exon            785..861
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     exon            862..951
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1126
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1245
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1439
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1546
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1694
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1819
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..6259
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6236..6241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /note="hexamer: AATAAA"
     polyA_site      6259
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /note="major polyA site"
ORIGIN      
        1 gccggtcgcc tgtctccgcg ccgggcatgc ctcgggagcc ggggcggccc gggccgcggg
       61 cgctctgcgg cgcatggacg gcggcggcgc cgggcgagca gcgggaggag aaggcgcagg
      121 cggcggcgga agcggcgacc cacggctggg agcaccggcg gcgcgagggg acggccggcc
      181 gcccgcgagg ctccggcccc actacttttc cgtagcctcc ccacctcagc agcacggccg
      241 ccgccgccgc cgccgccgcc gccacggcca cggccacggc cccggccccg gccaccgccc
      301 gccgggcagc ccagagcgcc gcgcacggcc gcactctccc gccaccccac gcacacgcac
      361 acccccgccc gcccacgccc cccacccggg aggggggaga gaggcaaaaa gtaagagagg
      421 aaaaaaaata gcaggaagat ggcgcccacc aagcccagct ttcagcagga tccttccagg
      481 cgagaacgtt tacaagcatt gagaaaggag aaatcccgag atgctgctcg ctcccgccgg
      541 ggaaaagaaa actttgagtt ctatgaattg gccaagttgt tgcctcttcc tgcagccatt
      601 accagccagc tcgacaaggc atccatcatt cgacttacaa ttagctatct gaaaatgagg
      661 gactttgcta accaggggga ccctccgtgg aacttgcgaa tggaaggccc tccacctaac
      721 acatcagtaa aagggataca aatgtggaaa tctgaactct gcatgagaaa gacaccatgt
      781 gaaggtgcac agcgaaggag aagccccagt gcactagcca ttgaagtatt tgaagcacat
      841 ttgggaagcc acattttgca gtccctggat ggctttgtat ttgcactaaa tcaggaagga
      901 aaatttttgt acatttccga aacagtctcc atctacctag gcctctcaca agtggagctg
      961 acaggcagca gtgtctttga ctatgtccac cccggagatc acgtggagat ggctgagcag
     1021 ctgggcatga agctcccccc tgggcggggt ctcctgtcac agggcactgc tgaggacgga
     1081 gccagctcag catcttcctc ctctcagtcg gagacccccg agccagtgga gtcaaccagc
     1141 cccagtctgc taaccactga caacactctt gagcgttcct ttttcatccg aatgaaatct
     1201 actctgacca aacgcggtgt gcacatcaaa tcatcaggat ataaggtgat tcacataaca
     1261 ggccggctac gcctgagagt gtcgctgtcc cacgggagga ccgtccccag ccaaatcatg
     1321 ggtctcgtgg ttgttgcgca tgccttgcct ccccctacga tcaatgaagt cagaattgac
     1381 tgccatatgt tcgtcactcg agtaaatatg gacctcaata tcatttactg tgaaaatagg
     1441 attagtgatt atatggatct gacccctgta gatatcgtag ggaagagatg ctaccacttc
     1501 atccatgctg aagacgtgga gggcatcagg cacagtcact tggacttgct gaataagggt
     1561 cagtgtgtga caaagtacta tcgctggatg cagaagaacg gaggatatat ttggatacag
     1621 tccagtgcca ccatagctat taatgccaag aatgcaaatg aaaagaatat catctgggtg
     1681 aattaccttc ttagcaatcc tgagtacaag gacacaccca tggacatcgc acagctcccc
     1741 catctgccgg agaaaacttc cgaatcctcg gagacatccg actctgagtc agactctaaa
     1801 gacacctcag gtattacaga ggacaacgag aactccaagt ccgacgagaa ggggaaccag
     1861 tccgagaaca gcgaagaccc ggagcccgac cggaagaagt cgggcaacgc gtgtgacaac
     1921 gacatgaact gcaacgacga cggccacagc tccagtaacc cggacagccg cgacagcgac
     1981 gacagcttcg agcactcgga ctttgagaac cccaaggcgg gcgaggacgg cttcggtgct
     2041 ctgggcgcga tgcagatcaa ggtggagcgc tacgtggaga gcgagtcgga cctgcggctg
     2101 cagaactgcg agtcactcac gtccgacagc gccaaggact cggacagcgc aggcgaggcg
     2161 ggcgcgcagg cctccagcaa gcaccagaag cgcaagaaaa ggcggaaacg gcaaaagggc
     2221 ggcagcgcca gccgccggcg cctgtccagc gcgtcgagcc caggcggcct ggacgcgggc
     2281 ctggtggagc ccccgcggct gctgtcctcc cccaacagtg cctcggtgct caagatcaag
     2341 acggagatct cagaacccat caatttcgac aatgacagca gcatctggaa ctacccgccc
     2401 aaccgggaga tctccaggaa cgagtccccc tacagcatga ccaagccccc cagctctgag
     2461 cacttcccgt ccccgcaggg cggcggcggt gggggtggcg gtggcggggg gctgcacgtg
     2521 gccattcccg actcggtcct caccccgccc ggcgccgacg gcgcggccgc ccgcaagact
     2581 cagttcggcg cctcggccac cgcggccctg gcccccgtcg cctccgaccc gctgtcaccc
     2641 ccgctctcgg cgtccccgcg ggacaagcac cccgggaacg gcggcggggg cgggggcggg
     2701 ggcggcggcg cggggggcgg cggccccagc gcgtccaact ccttgctgta cactggggac
     2761 ctggaggcgc tgcagaggtt gcaggcgggc aacgtcgtgc tcccgctggt gcacagggtg
     2821 accgggaccc tggccgccac cagcacggcc gcgcagaggg tctacaccac gggcaccatc
     2881 cgctacgcgc ccgccgaggt gaccctggcc atgcagagca acctgctgcc caacgcgcac
     2941 gctgttaact tcgtggacgt taacagcccc ggctttggcc tcgaccccaa gacgcccatg
     3001 gagatgctct accaccacgt gcaccggctc aacatgtcag gaccgttcgg cggcgcagtg
     3061 agcgcagcta gcctgacgca gatgcccgcc ggcaacgtgt tcaccacggc cgagggactc
     3121 ttctccacgc tgcccttccc cgtctacagc aacggcatcc acgcggcaca gactctggag
     3181 cgcaaggagg actgaggcgc cgcccgtcct gggcccggcc aggccccgct tggaggaggc
     3241 atcgtcggca ttttcgttta gacctttaat tctagcactt tgaattcgag caggtcagcg
     3301 tcttctctcg ccacgacggt ccccattcca ccccctcttt ctttcacctg acttattctt
     3361 tcgtgtaaag atatgtttat tttttgcctt cagagggtca gacgaccagt tgcctgccgt
     3421 tttgtcttct tctaaggtgt gtgttgggtt gttttgcttt cctttgcatc tttattaaga
     3481 tgtctttcat gtgtatatgc ctctgccata gaatactcag tcttgtggtc aagagagttc
     3541 tcaagtgaca accattgggg tttcttcata aagatcttga tatgatcaag atggaaagag
     3601 acaagcataa acaatgtgcc ctgtttgact aagtcaaatg aaatagggtg gtttttgttt
     3661 ctgttcctaa ttcctttaaa aaataggggg aatagtattt tagaatttta tgcagaattt
     3721 aattctcttt ttacggttaa gattttaaga ttttcttact tgcacataaa aataatttgg
     3781 gttcttaaac ttaatttctg gcctgtgact agaatgttta aaaaaaaaaa agtcggacta
     3841 aatgttaatt actgaaacat taacttaatt tctaaaacca tggtgctatc atttattaat
     3901 ctgtaatgtc ttcatacaaa atgcagctcc tgggctgggt tttgggggaa aaaaaaaaaa
     3961 tgtgttctgt cctggtctgg agtccgttgc tgcagtctcc ttggttagtt aagacaaagc
     4021 cctcattaac gtttgctgca ggacttaaaa ttttttacct cccaactaac aaacatagcc
     4081 tcacattaaa tttaatgggt cagtaaagcc ccttttaaag gggctgctgg aaaactcaat
     4141 caaactgatt tgaggagcag tttaggtaca tactgccttt tgtttagctt tttgttttcc
     4201 ttactcagtc taactgaggc taattttgca acttcaataa cacttcggag taaaagaagg
     4261 aaaatattta acatgttttt ggtttttttc atttcttgct taaaacaaaa aggaaggttg
     4321 tatttggggg gactggtttg atttgatgga atttctttcc ctttggttct tatttctggg
     4381 ttgaaaccaa taagttttaa aactaaagaa tgggttaata agcttcagac agataactgc
     4441 aactgaaaac tgcacattaa gtaaaaaaaa aaaaaaagaa aaaaaaaaga aaaagaaaaa
     4501 gaaaaaaaat cctattttgt ctttgttgcc agaaatcagt gtggtgtcaa acactccaaa
     4561 tgactgtcaa gtataaattc ttcttccact tcatttttgg cagctgtttg ttaaggcatc
     4621 taataacaga tgtgagaact gtaatgtgta caatgtgtat gtgtccttgg ctgtcagtcc
     4681 cattgcagtt tcaatgtgtg tttctatatg cagtatatac taagctaatg tagttgtttt
     4741 gtcctttgtc ttatctgtgc tctatctcta gtccggagtg gtacagtccc attcctgcag
     4801 tcctagtgaa tcagtgattc ttgggggtta gtgggttttg tgtggtggcc ttcctctgta
     4861 atgtcaccct atgctgcttc tactgtctgt gaatcttccg ttttaccttt taaaattcct
     4921 gctgttgctt tgctggtgta tattctccct acctctcctc tctttccctc cctttcccat
     4981 ctccccctct ccctcctctt cattccttcc ccatccccaa aatctctttc attctcagag
     5041 ataaaaagac tcttaactag ctcaaggtta atggagccat ttttcccaca acggaattct
     5101 gggtatgact ctgtcttctg gagtgcaaca caaagcactg aagaataatg ctcagatata
     5161 ttaaataaat tgatgccata tagcctcagt tgttaacatt cccagagtcc cttgtgctct
     5221 acctataagc agtgggtgct tttctttggt ttcctttcag gttggctgat ggagcaatat
     5281 ataaagcaat taccagtgag acagaaaatt ctttcaaagg tcaaccaaca tttttaagaa
     5341 acaaaatggg aggggataat ggaatctaga attgtcatat atatttgttt acttgtgcaa
     5401 tgctaatata gtaactcggc tgtcctttga atatcactgt gttgagtaga ttcctctagg
     5461 acctttgatt tcatgagttg ggcccaaacc gtggtggaat aataacaaaa agaagttaaa
     5521 tgccacaaat tttaatagtg agcttacttg aaggatttaa gtaggtttag gaggtgaaga
     5581 aggccgatgg agaaatttac agattaattt tggaagctct actctagcta tcgaacaatc
     5641 aaaggaatgc acctatcagc tacaaagaac agctagacag ctgttttttt tcttttataa
     5701 atgtttctgt gttgtgtcaa aatgatttct ggtgatttaa actaacagat aatcacagct
     5761 gctgtctaaa ttcatagtgt tgaaaattac aaaatgaaaa aaaaaaaaaa aacacttcat
     5821 tacctgtgaa gactgtgtct gtgtttttaa ctatttcttg tacaaatata tgaaaacttt
     5881 tatgaggaga ctggtgccaa gtagctgaat aatggggaaa gggatattct gttcgtaaaa
     5941 atcttagcag tgttaccaac tctacgatat atatataaaa aaataattaa aacgttacaa
     6001 agcgacagct atggtacatt tgttttgtgt gaagctaacc ggacctaact tcctgagtgc
     6061 ctggcttatt ttgaaacatt ttttttcatt gaccattgat aatgctgcaa atcagaaatg
     6121 tacatacttc atttacaaca gggttctttt tatacttttg tagattctca tacatgtcac
     6181 atacatggtt gtctttatgt aacttaattt tttcatccgc aggtgccatt ttcataataa
     6241 acttctcttg gatttgtta
//
