LOCUS       NM_001164749            6304 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens neuronal PAS domain protein 3 (NPAS3), transcript
            variant 1, mRNA.
ACCESSION   NM_001164749
VERSION     NM_001164749.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6304)
  AUTHORS   Pavesic Radonja,A., Blazevic Zelic,S., Rubesa,G. and Bradshaw,N.J.
  TITLE     SYMPTOM SEVERITY IN SCHIZOPHRENIA PATIENTS WITH NPAS3, DYSBINDIN-1
            AND/OR TRIOBP PROTEIN PATHOLOGY IN THEIR BLOOD SERUM: A PANSS-BASED
            FOLLOW UP STUDY
  JOURNAL   Psychiatr Danub 35 (2), 180-186 (2023)
   PUBMED   37480305
  REMARK    GeneRIF: SYMPTOM SEVERITY IN SCHIZOPHRENIA PATIENTS WITH NPAS3,
            DYSBINDIN-1 AND/OR TRIOBP PROTEIN PATHOLOGY IN THEIR BLOOD SERUM: A
            PANSS-BASED FOLLOW UP STUDY.
REFERENCE   2  (bases 1 to 6304)
  AUTHORS   Li,Y., Fan,T., Li,X., Liu,L., Mao,F., Li,Y., Miao,Z., Zeng,C.,
            Song,W., Pan,J., Zhou,S., Wang,H., Wang,Y. and Sun,Z.S.
  TITLE     Npas3 deficiency impairs cortical astrogenesis and induces
            autistic-like behaviors
  JOURNAL   Cell Rep 40 (9), 111289 (2022)
   PUBMED   36044858
  REMARK    GeneRIF: Npas3 deficiency impairs cortical astrogenesis and induces
            autistic-like behaviors.
            Erratum:[Cell Rep. 2022 Nov 8;41(6):111551. doi:
            10.1016/j.celrep.2022.111551.. PMID: 36351396]
REFERENCE   3  (bases 1 to 6304)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6304)
  AUTHORS   Rossi,J.J., Rosenfeld,J.A., Chan,K.M., Streff,H., Nankivell,V.,
            Peet,D.J., Whitelaw,M.L. and Bersten,D.C.
  TITLE     Molecular characterisation of rare loss-of-function NPAS3 and NPAS4
            variants identified in individuals with neurodevelopmental
            disorders
  JOURNAL   Sci Rep 11 (1), 6602 (2021)
   PUBMED   33758288
  REMARK    GeneRIF: Molecular characterisation of rare loss-of-function NPAS3
            and NPAS4 variants identified in individuals with
            neurodevelopmental disorders.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6304)
  AUTHORS   Luoma,L.M. and Berry,F.B.
  TITLE     Molecular analysis of NPAS3 functional domains and variants
  JOURNAL   BMC Mol Biol 19 (1), 14 (2018)
   PUBMED   30509165
  REMARK    GeneRIF: NPAS3 is a true transcription factor capable of regulating
            expression of target genes through their promoters by directly
            cooperating with ARNT.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6304)
  AUTHORS   Pickard,B.S., Christoforou,A., Thomson,P.A., Fawkes,A., Evans,K.L.,
            Morris,S.W., Porteous,D.J., Blackwood,D.H. and Muir,W.J.
  TITLE     Interacting haplotypes at the NPAS3 locus alter risk of
            schizophrenia and bipolar disorder
  JOURNAL   Mol Psychiatry 14 (9), 874-884 (2009)
   PUBMED   18317462
  REMARK    GeneRIF: This study demonstrated that these risk and protective
            effects act combinatorially, potentially multiplicatively, to
            determine NPAS3 gene-wide susceptibility in bipolar disorder and
            schizophrenia.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 6304)
  AUTHORS   Uhl,G.R., Liu,Q.R., Drgon,T., Johnson,C., Walther,D., Rose,J.E.,
            David,S.P., Niaura,R. and Lerman,C.
  TITLE     Molecular genetics of successful smoking cessation: convergent
            genome-wide association study results
  JOURNAL   Arch Gen Psychiatry 65 (6), 683-693 (2008)
   PUBMED   18519826
  REMARK    GeneRIF: Clinical trial and genome-wide association study of
            gene-disease association, gene-environment interaction, and
            pharmacogenomic / toxicogenomic. (HuGE Navigator)
REFERENCE   8  (bases 1 to 6304)
  AUTHORS   Pickard,B.S., Pieper,A.A., Porteous,D.J., Blackwood,D.H. and
            Muir,W.J.
  TITLE     The NPAS3 gene--emerging evidence for a role in psychiatric illness
  JOURNAL   Ann Med 38 (6), 439-448 (2006)
   PUBMED   17008307
  REMARK    Review article
REFERENCE   9  (bases 1 to 6304)
  AUTHORS   Kamnasaran,D., Chen,C.P., Devriendt,K., Mehta,L. and Cox,D.W.
  TITLE     Defining a holoprosencephaly locus on human chromosome 14q13 and
            characterization of potential candidate genes
  JOURNAL   Genomics 85 (5), 608-621 (2005)
   PUBMED   15820313
REFERENCE   10 (bases 1 to 6304)
  AUTHORS   Kamnasaran,D., Muir,W.J., Ferguson-Smith,M.A. and Cox,D.W.
  TITLE     Disruption of the neuronal PAS3 gene in a family affected with
            schizophrenia
  JOURNAL   J Med Genet 40 (5), 325-332 (2003)
   PUBMED   12746393
  REMARK    GeneRIF: haploinsufficiency of NPAS3 contributes to the cause of
            schizophrenia
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL109769.5, AY157302.1,
            AB055962.1, AL157689.3 and AI811363.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001164749.1.
            
            Summary: This gene encodes a member of the basic helix-loop-helix
            and PAS domain-containing family of transcription factors. The
            encoded protein is localized to the nucleus and may regulate genes
            involved in neurogenesis. Chromosomal abnormalities that affect the
            coding potential of this gene are associated with schizophrenia and
            cognitive disability. Alternate splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB055962.1, KJ534894.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMN03465402
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356141.9/ ENSP00000348460.4
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-374               AL109769.5         62603-62976         c
            375-438             AY157302.1         1-64
            439-3240            AB055962.1         1-2802
            3241-5911           AL157689.3         91721-94391
            5912-6304           AI811363.1         10-402              c
FEATURES             Location/Qualifiers
     source          1..6304
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q13.1"
     gene            1..6304
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /note="neuronal PAS domain protein 3"
                     /db_xref="GeneID:64067"
                     /db_xref="HGNC:HGNC:19311"
                     /db_xref="MIM:609430"
     exon            1..488
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..3240
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neuronal PAS domain-containing protein 3; member of PAS
                     protein 6; neuronal PAS3; PAS domain-containing protein 6;
                     basic-helix-loop-helix-PAS protein MOP6; class E basic
                     helix-loop-helix protein 12"
                     /codon_start=1
                     /product="neuronal PAS domain-containing protein 3 isoform
                     1"
                     /protein_id="NP_001158221.1"
                     /db_xref="CCDS:CCDS53891.1"
                     /db_xref="GeneID:64067"
                     /db_xref="HGNC:HGNC:19311"
                     /db_xref="MIM:609430"
                     /translation="MAPTKPSFQQDPSRRERITAQHPLPNQSECRKIYRYDGIYCEST
                     YQNLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLK
                     MRDFANQGDPPWNLRMEGPPPNTSVKVIGAQRRRSPSALAIEVFEAHLGSHILQSLDG
                     FVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGR
                     GLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGV
                     HIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFV
                     TRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCV
                     TKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPH
                     LPEKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACD
                     NDMNCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESD
                     LRLQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPG
                     GLDAGLVEPPRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREISRNESPYSM
                     TKPPSSEHFPSPQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGASATAALA
                     PVASDPLSPPLSASPRDKHPGNGGGGGGGGGGAGGGGPSASNSLLYTGDLEALQRLQA
                     GNVVLPLVHRVTGTLAATSTAAQRVYTTGTIRYAPAEVTLAMQSNLLPNAHAVNFVDV
                     NSPGFGLDPKTPMEMLYHHVHRLNMSGPFGGAVSAASLTQMPAGNVFTTAEGLFSTLP
                     FPVYSNGIHAAQTLERKED"
     exon            489..578
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     exon            579..823
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     exon            824..906
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     exon            907..996
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1171
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1290
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1484
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1591
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1739
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1864
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..6304
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6281..6286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /note="hexamer: AATAAA"
     polyA_site      6304
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /note="major polyA site"
ORIGIN      
        1 gccggtcgcc tgtctccgcg ccgggcatgc ctcgggagcc ggggcggccc gggccgcggg
       61 cgctctgcgg cgcatggacg gcggcggcgc cgggcgagca gcgggaggag aaggcgcagg
      121 cggcggcgga agcggcgacc cacggctggg agcaccggcg gcgcgagggg acggccggcc
      181 gcccgcgagg ctccggcccc actacttttc cgtagcctcc ccacctcagc agcacggccg
      241 ccgccgccgc cgccgccgcc gccacggcca cggccacggc cccggccccg gccaccgccc
      301 gccgggcagc ccagagcgcc gcgcacggcc gcactctccc gccaccccac gcacacgcac
      361 acccccgccc gcccacgccc cccacccggg aggggggaga gaggcaaaaa gtaagagagg
      421 aaaaaaaata gcaggaagat ggcgcccacc aagcccagct ttcagcagga tccttccagg
      481 cgagaacgaa taactgccca gcatcctctg cccaaccaat cagaatgtag gaaaatctac
      541 agatatgacg gaatctactg tgaatctacc taccagaatt tacaagcatt gagaaaggag
      601 aaatcccgag atgctgctcg ctcccgccgg ggaaaagaaa actttgagtt ctatgaattg
      661 gccaagttgt tgcctcttcc tgcagccatt accagccagc tcgacaaggc atccatcatt
      721 cgacttacaa ttagctatct gaaaatgagg gactttgcta accaggggga ccctccgtgg
      781 aacttgcgaa tggaaggccc tccacctaac acatcagtaa aagttatagg tgcacagcga
      841 aggagaagcc ccagtgcact agccattgaa gtatttgaag cacatttggg aagccacatt
      901 ttgcagtccc tggatggctt tgtatttgca ctaaatcagg aaggaaaatt tttgtacatt
      961 tccgaaacag tctccatcta cctaggcctc tcacaagtgg agctgacagg cagcagtgtc
     1021 tttgactatg tccaccccgg agatcacgtg gagatggctg agcagctggg catgaagctc
     1081 ccccctgggc ggggtctcct gtcacagggc actgctgagg acggagccag ctcagcatct
     1141 tcctcctctc agtcggagac ccccgagcca gtggagtcaa ccagccccag tctgctaacc
     1201 actgacaaca ctcttgagcg ttcctttttc atccgaatga aatctactct gaccaaacgc
     1261 ggtgtgcaca tcaaatcatc aggatataag gtgattcaca taacaggccg gctacgcctg
     1321 agagtgtcgc tgtcccacgg gaggaccgtc cccagccaaa tcatgggtct cgtggttgtt
     1381 gcgcatgcct tgcctccccc tacgatcaat gaagtcagaa ttgactgcca tatgttcgtc
     1441 actcgagtaa atatggacct caatatcatt tactgtgaaa ataggattag tgattatatg
     1501 gatctgaccc ctgtagatat cgtagggaag agatgctacc acttcatcca tgctgaagac
     1561 gtggagggca tcaggcacag tcacttggac ttgctgaata agggtcagtg tgtgacaaag
     1621 tactatcgct ggatgcagaa gaacggagga tatatttgga tacagtccag tgccaccata
     1681 gctattaatg ccaagaatgc aaatgaaaag aatatcatct gggtgaatta ccttcttagc
     1741 aatcctgagt acaaggacac acccatggac atcgcacagc tcccccatct gccggagaaa
     1801 acttccgaat cctcggagac atccgactct gagtcagact ctaaagacac ctcaggtatt
     1861 acagaggaca acgagaactc caagtccgac gagaagggga accagtccga gaacagcgaa
     1921 gacccggagc ccgaccggaa gaagtcgggc aacgcgtgtg acaacgacat gaactgcaac
     1981 gacgacggcc acagctccag taacccggac agccgcgaca gcgacgacag cttcgagcac
     2041 tcggactttg agaaccccaa ggcgggcgag gacggcttcg gtgctctggg cgcgatgcag
     2101 atcaaggtgg agcgctacgt ggagagcgag tcggacctgc ggctgcagaa ctgcgagtca
     2161 ctcacgtccg acagcgccaa ggactcggac agcgcaggcg aggcgggcgc gcaggcctcc
     2221 agcaagcacc agaagcgcaa gaaaaggcgg aaacggcaaa agggcggcag cgccagccgc
     2281 cggcgcctgt ccagcgcgtc gagcccaggc ggcctggacg cgggcctggt ggagcccccg
     2341 cggctgctgt cctcccccaa cagtgcctcg gtgctcaaga tcaagacgga gatctcagaa
     2401 cccatcaatt tcgacaatga cagcagcatc tggaactacc cgcccaaccg ggagatctcc
     2461 aggaacgagt ccccctacag catgaccaag ccccccagct ctgagcactt cccgtccccg
     2521 cagggcggcg gcggtggggg tggcggtggc ggggggctgc acgtggccat tcccgactcg
     2581 gtcctcaccc cgcccggcgc cgacggcgcg gccgcccgca agactcagtt cggcgcctcg
     2641 gccaccgcgg ccctggcccc cgtcgcctcc gacccgctgt cacccccgct ctcggcgtcc
     2701 ccgcgggaca agcaccccgg gaacggcggc gggggcgggg gcgggggcgg cggcgcgggg
     2761 ggcggcggcc ccagcgcgtc caactccttg ctgtacactg gggacctgga ggcgctgcag
     2821 aggttgcagg cgggcaacgt cgtgctcccg ctggtgcaca gggtgaccgg gaccctggcc
     2881 gccaccagca cggccgcgca gagggtctac accacgggca ccatccgcta cgcgcccgcc
     2941 gaggtgaccc tggccatgca gagcaacctg ctgcccaacg cgcacgctgt taacttcgtg
     3001 gacgttaaca gccccggctt tggcctcgac cccaagacgc ccatggagat gctctaccac
     3061 cacgtgcacc ggctcaacat gtcaggaccg ttcggcggcg cagtgagcgc agctagcctg
     3121 acgcagatgc ccgccggcaa cgtgttcacc acggccgagg gactcttctc cacgctgccc
     3181 ttccccgtct acagcaacgg catccacgcg gcacagactc tggagcgcaa ggaggactga
     3241 ggcgccgccc gtcctgggcc cggccaggcc ccgcttggag gaggcatcgt cggcattttc
     3301 gtttagacct ttaattctag cactttgaat tcgagcaggt cagcgtcttc tctcgccacg
     3361 acggtcccca ttccaccccc tctttctttc acctgactta ttctttcgtg taaagatatg
     3421 tttatttttt gccttcagag ggtcagacga ccagttgcct gccgttttgt cttcttctaa
     3481 ggtgtgtgtt gggttgtttt gctttccttt gcatctttat taagatgtct ttcatgtgta
     3541 tatgcctctg ccatagaata ctcagtcttg tggtcaagag agttctcaag tgacaaccat
     3601 tggggtttct tcataaagat cttgatatga tcaagatgga aagagacaag cataaacaat
     3661 gtgccctgtt tgactaagtc aaatgaaata gggtggtttt tgtttctgtt cctaattcct
     3721 ttaaaaaata gggggaatag tattttagaa ttttatgcag aatttaattc tctttttacg
     3781 gttaagattt taagattttc ttacttgcac ataaaaataa tttgggttct taaacttaat
     3841 ttctggcctg tgactagaat gtttaaaaaa aaaaaagtcg gactaaatgt taattactga
     3901 aacattaact taatttctaa aaccatggtg ctatcattta ttaatctgta atgtcttcat
     3961 acaaaatgca gctcctgggc tgggttttgg gggaaaaaaa aaaaatgtgt tctgtcctgg
     4021 tctggagtcc gttgctgcag tctccttggt tagttaagac aaagccctca ttaacgtttg
     4081 ctgcaggact taaaattttt tacctcccaa ctaacaaaca tagcctcaca ttaaatttaa
     4141 tgggtcagta aagccccttt taaaggggct gctggaaaac tcaatcaaac tgatttgagg
     4201 agcagtttag gtacatactg ccttttgttt agctttttgt tttccttact cagtctaact
     4261 gaggctaatt ttgcaacttc aataacactt cggagtaaaa gaaggaaaat atttaacatg
     4321 tttttggttt ttttcatttc ttgcttaaaa caaaaaggaa ggttgtattt ggggggactg
     4381 gtttgatttg atggaatttc tttccctttg gttcttattt ctgggttgaa accaataagt
     4441 tttaaaacta aagaatgggt taataagctt cagacagata actgcaactg aaaactgcac
     4501 attaagtaaa aaaaaaaaaa aagaaaaaaa aaagaaaaag aaaaagaaaa aaaatcctat
     4561 tttgtctttg ttgccagaaa tcagtgtggt gtcaaacact ccaaatgact gtcaagtata
     4621 aattcttctt ccacttcatt tttggcagct gtttgttaag gcatctaata acagatgtga
     4681 gaactgtaat gtgtacaatg tgtatgtgtc cttggctgtc agtcccattg cagtttcaat
     4741 gtgtgtttct atatgcagta tatactaagc taatgtagtt gttttgtcct ttgtcttatc
     4801 tgtgctctat ctctagtccg gagtggtaca gtcccattcc tgcagtccta gtgaatcagt
     4861 gattcttggg ggttagtggg ttttgtgtgg tggccttcct ctgtaatgtc accctatgct
     4921 gcttctactg tctgtgaatc ttccgtttta ccttttaaaa ttcctgctgt tgctttgctg
     4981 gtgtatattc tccctacctc tcctctcttt ccctcccttt cccatctccc cctctccctc
     5041 ctcttcattc cttccccatc cccaaaatct ctttcattct cagagataaa aagactctta
     5101 actagctcaa ggttaatgga gccatttttc ccacaacgga attctgggta tgactctgtc
     5161 ttctggagtg caacacaaag cactgaagaa taatgctcag atatattaaa taaattgatg
     5221 ccatatagcc tcagttgtta acattcccag agtcccttgt gctctaccta taagcagtgg
     5281 gtgcttttct ttggtttcct ttcaggttgg ctgatggagc aatatataaa gcaattacca
     5341 gtgagacaga aaattctttc aaaggtcaac caacattttt aagaaacaaa atgggagggg
     5401 ataatggaat ctagaattgt catatatatt tgtttacttg tgcaatgcta atatagtaac
     5461 tcggctgtcc tttgaatatc actgtgttga gtagattcct ctaggacctt tgatttcatg
     5521 agttgggccc aaaccgtggt ggaataataa caaaaagaag ttaaatgcca caaattttaa
     5581 tagtgagctt acttgaagga tttaagtagg tttaggaggt gaagaaggcc gatggagaaa
     5641 tttacagatt aattttggaa gctctactct agctatcgaa caatcaaagg aatgcaccta
     5701 tcagctacaa agaacagcta gacagctgtt ttttttcttt tataaatgtt tctgtgttgt
     5761 gtcaaaatga tttctggtga tttaaactaa cagataatca cagctgctgt ctaaattcat
     5821 agtgttgaaa attacaaaat gaaaaaaaaa aaaaaaacac ttcattacct gtgaagactg
     5881 tgtctgtgtt tttaactatt tcttgtacaa atatatgaaa acttttatga ggagactggt
     5941 gccaagtagc tgaataatgg ggaaagggat attctgttcg taaaaatctt agcagtgtta
     6001 ccaactctac gatatatata taaaaaaata attaaaacgt tacaaagcga cagctatggt
     6061 acatttgttt tgtgtgaagc taaccggacc taacttcctg agtgcctggc ttattttgaa
     6121 acattttttt tcattgacca ttgataatgc tgcaaatcag aaatgtacat acttcattta
     6181 caacagggtt ctttttatac ttttgtagat tctcatacat gtcacataca tggttgtctt
     6241 tatgtaactt aattttttca tccgcaggtg ccattttcat aataaacttc tcttggattt
     6301 gtta
//
