LOCUS       NM_002518               4020 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens neuronal PAS domain protein 2 (NPAS2), mRNA.
ACCESSION   NM_002518 NM_032235
VERSION     NM_002518.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4020)
  AUTHORS   Karuga,F.F., Jaromirska,J., Sochal,M., Bialasiewicz,P. and
            Gabryelska,A.
  TITLE     Association between glucose metabolism, the circadian cycle and
            hypoxia: Evaluation of the NPAS2 and Rev-Erb-alpha protein serum
            levels in obstructive sleep apnea patients - a pilot study
  JOURNAL   Dent Med Probl 61 (3), 465-469 (2024)
   PUBMED   38804230
  REMARK    GeneRIF: Association between glucose metabolism, the circadian
            cycle and hypoxia: Evaluation of the NPAS2 and Rev-Erb-alpha
            protein serum levels in obstructive sleep apnea patients - a pilot
            study.
REFERENCE   2  (bases 1 to 4020)
  AUTHORS   Cao,X.M., Kang,W.D., Xia,T.H., Yuan,S.B., Guo,C.A., Wang,W.J. and
            Liu,H.B.
  TITLE     High expression of the circadian clock gene NPAS2 is associated
            with progression and poor prognosis of gastric cancer: A
            single-center study
  JOURNAL   World J Gastroenterol 29 (23), 3645-3657 (2023)
   PUBMED   37398880
  REMARK    GeneRIF: High expression of the circadian clock gene NPAS2 is
            associated with progression and poor prognosis of gastric cancer: A
            single-center study.
REFERENCE   3  (bases 1 to 4020)
  AUTHORS   Huang,Y., Xiao,L., Daba,M.Y., Xu,D., Wang,Y., Li,L., Li,Q., Liu,B.,
            Qin,W., Zhang,H. and Yuan,X.
  TITLE     Characterization of molecular subtypes based on chromatin
            regulators and identification of the role of NPAS2 in lung
            adenocarcinoma
  JOURNAL   Clin Epigenetics 15 (1), 72 (2023)
   PUBMED   37120564
  REMARK    GeneRIF: Characterization of molecular subtypes based on chromatin
            regulators and identification of the role of NPAS2 in lung
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4020)
  AUTHORS   Ma,S., Chen,Y., Quan,P., Zhang,J., Han,S., Wang,G., Qi,R.,
            Zhang,X., Wang,F., Yuan,J., Yang,X., Jia,W. and Qin,W.
  TITLE     NPAS2 promotes aerobic glycolysis and tumor growth in prostate
            cancer through HIF-1A signaling
  JOURNAL   BMC Cancer 23 (1), 280 (2023)
   PUBMED   36978001
  REMARK    GeneRIF: NPAS2 promotes aerobic glycolysis and tumor growth in
            prostate cancer through HIF-1A signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4020)
  AUTHORS   Yao,R., Zhou,L., Guo,Z., Zhang,D. and Zhang,T.
  TITLE     Integrative Molecular Analyses of an Individual Transcription
            Factor-Based Genomic Model for Lung Cancer Prognosis
  JOURNAL   Dis Markers 2021, 5125643 (2021)
   PUBMED   34925645
  REMARK    GeneRIF: Integrative Molecular Analyses of an Individual
            Transcription Factor-Based Genomic Model for Lung Cancer Prognosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4020)
  AUTHORS   Michel,A.M., Choudhury,K.R., Firth,A.E., Ingolia,N.T., Atkins,J.F.
            and Baranov,P.V.
  TITLE     Observation of dually decoded regions of the human genome using
            ribosome profiling data
  JOURNAL   Genome Res 22 (11), 2219-2229 (2012)
   PUBMED   22593554
REFERENCE   7  (bases 1 to 4020)
  AUTHORS   Garcia,J.A., Zhang,D., Estill,S.J., Michnoff,C., Rutter,J.,
            Reick,M., Scott,K., Diaz-Arrastia,R. and McKnight,S.L.
  TITLE     Impaired cued and contextual memory in NPAS2-deficient mice
  JOURNAL   Science 288 (5474), 2226-2230 (2000)
   PUBMED   10864874
REFERENCE   8  (bases 1 to 4020)
  AUTHORS   Hogenesch,J.B., Gu,Y.Z., Jain,S. and Bradfield,C.A.
  TITLE     The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally
            active complexes with circadian and hypoxia factors
  JOURNAL   Proc Natl Acad Sci U S A 95 (10), 5474-5479 (1998)
   PUBMED   9576906
REFERENCE   9  (bases 1 to 4020)
  AUTHORS   Hogenesch,J.B., Chan,W.K., Jackiw,V.H., Brown,R.C., Gu,Y.Z.,
            Pray-Grant,M., Perdew,G.H. and Bradfield,C.A.
  TITLE     Characterization of a subset of the basic-helix-loop-helix-PAS
            superfamily that interacts with components of the dioxin signaling
            pathway
  JOURNAL   J Biol Chem 272 (13), 8581-8593 (1997)
   PUBMED   9079689
REFERENCE   10 (bases 1 to 4020)
  AUTHORS   Zhou,Y.D., Barnard,M., Tian,H., Li,X., Ring,H.Z., Francke,U.,
            Shelton,J., Richardson,J., Russell,D.W. and McKnight,S.L.
  TITLE     Molecular characterization of two mammalian bHLH-PAS domain
            proteins selectively expressed in the central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 94 (2), 713-718 (1997)
   PUBMED   9012850
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092168.4, U77970.1,
            BC072383.1, BM724652.1, AK128586.1, AK095806.1 and AC016738.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002518.3.
            
            Summary: The protein encoded by this gene is a member of the basic
            helix-loop-helix (bHLH)-PAS family of transcription factors. A
            similar mouse protein may play a regulatory role in the acquisition
            of specific types of memory. It also may function as a part of a
            molecular clock operative in the mammalian forebrain. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051351.1, U77970.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335681.10/ ENSP00000338283.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC092168.4         145135-145146
            13-255              U77970.1           1-243
            256-1477            BC072383.1         211-1432
            1478-1547           BM724652.1         561-630
            1548-2427           BC072383.1         1503-2382
            2428-4013           AK128586.1         2249-3834
            4014-4016           AK095806.1         2031-2033
            4017-4020           AC016738.6         89099-89102
FEATURES             Location/Qualifiers
     source          1..4020
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..4020
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /note="neuronal PAS domain protein 2"
                     /db_xref="GeneID:4862"
                     /db_xref="HGNC:HGNC:7895"
                     /db_xref="MIM:603347"
     exon            1..276
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /inference="alignment:Splign:2.1.0"
     exon            277..330
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..2773
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /note="neuronal PAS2; member of PAS superfamily 4; member
                     of PAS protein 4; PAS domain-containing protein 4;
                     basic-helix-loop-helix-PAS protein MOP4; class E basic
                     helix-loop-helix protein 9"
                     /codon_start=1
                     /product="neuronal PAS domain-containing protein 2"
                     /protein_id="NP_002509.2"
                     /db_xref="CCDS:CCDS2048.1"
                     /db_xref="GeneID:4862"
                     /db_xref="HGNC:HGNC:7895"
                     /db_xref="MIM:603347"
                     /translation="MDEDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLPGNTRKMD
                     KTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTT
                     DGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYL
                     KSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRV
                     PLGKEVCFIATVRLATPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLP
                     FEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITY
                     HQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEALHSSALKDKGSSLEPRQHF
                     NTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPALPRSATLPQ
                     ELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFSAQFSMFQTIKDQ
                     LEQRTRILQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQ
                     LQQRSAAVTQPQLGAGPQLPGQISSAQVTSQHLLRESSVISTQGPKPMRSSQLMQSSG
                     RSGSSLVSPFSSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQPIQP
                     MMPGSCDARQPSEVSRTGRQVKYAQSQTVFQNPDAHPANSSSAPMPVLLMGQAVLHPS
                     FPASQPSPLQPAQARQQPPQHYLQVQAPTSLHSEQQDSLLLSTYSQQPGTLGYPQPPP
                     AQPQPLRPPRRVSSLSESSGLQQPPR"
     exon            331..479
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /inference="alignment:Splign:2.1.0"
     exon            480..571
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /inference="alignment:Splign:2.1.0"
     exon            572..661
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /inference="alignment:Splign:2.1.0"
     exon            662..782
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /inference="alignment:Splign:2.1.0"
     exon            783..896
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1015
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1098
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1205
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1353
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1438
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1580
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1690
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1780
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1927
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2125
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2316
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2409
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2590
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..4020
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3216..3221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /note="hexamer: AATAAA"
     polyA_site      3246
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /note="major polyA site"
     regulatory      3882..3887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /note="hexamer: AATAAA"
     polyA_site      3908
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
     regulatory      3996..4001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
                     /note="hexamer: AATAAA"
     polyA_site      4020
                     /gene="NPAS2"
                     /gene_synonym="bHLHe9; MOP4; PASD4"
ORIGIN      
        1 gcgtgcggaa gagtttgccg cgcgagcagc cggcctctcg caggagccga gggacccgcg
       61 cggctgcggc ccaggagcgg cggccgcgga gcccggagac ccgcagccgc ggcggcggcg
      121 gcggcggcgg cagcagctag agcagcgcct cccgccgccg cccgggagga gctcgccgcg
      181 cccgctcgcc gcctcgtctc ccagcggcgg cgggaggcgc gtctccccgg cccagtccgc
      241 gcccggcccc gcggggccgc tccggcccgc tccgaggaaa aactgcatag aaaatctaat
      301 ggatgaagat gagaaagaca gagccaagag agcttctcga aacaagtctg agaagaagcg
      361 tcgggaccag ttcaatgttc tcatcaaaga gctcagttcc atgctccctg gcaacacgcg
      421 gaaaatggac aaaaccaccg tgttggaaaa ggtcatcgga tttttgcaga aacacaatga
      481 agtctcagcg caaacggaaa tctgtgacat tcagcaagac tggaagcctt cattcctcag
      541 taatgaagaa ttcacccagc tgatgttgga ggcattagat ggcttcatta tcgcagtgac
      601 aacagacggc agcatcatct atgtctctga cagtatcacg cctctccttg ggcatttacc
      661 gtcggatgtc atggatcaga atttgttaaa tttcctccca gaacaagaac attcagaagt
      721 ttataaaatc ctttcttccc atatgcttgt gacggattcc ccctccccag aatacttaaa
      781 atctgacagc gatttagagt tttattgcca tcttctcaga ggcagcttga acccaaagga
      841 atttccaact tatgaataca taaaatttgt aggaaatttt cgctcttaca acaatgtgcc
      901 tagcccctcc tgtaatggtt ttgacaacac cctttcaaga ccttgccggg tgccactagg
      961 aaaggaggtt tgcttcattg ccaccgttcg tctggcaaca ccacaattct taaaggaaat
     1021 gtgcatagtt gacgaacctt tagaggaatt cacttcaagg catagcttgg aatggaaatt
     1081 tttatttctg gatcacagag cacctccaat cataggatac ctgccttttg aagtgctggg
     1141 aacctcaggc tatgactact accacattga tgacctggag ctcctggcca ggtgtcacca
     1201 gcacctgatg cagtttggca aagggaagtc gtgttgctac cggtttctga ccaaaggtca
     1261 gcagtggatc tggctgcaga ctcactacta catcacctac catcagtgga actccaagcc
     1321 cgagttcatc gtgtgcacac actcggtggt cagttacgca gatgtccggg tggaaaggag
     1381 gcaggagctg gctctggaag acccgccatc cgaggccctc cactcctcag cactaaagga
     1441 caagggctca agcctggaac ctcggcagca ctttaacaca ctcgacgtgg gtgcctcggg
     1501 ccttaatacc agtcattcgc catcggcgtc ctcaagaagt tcccacaaat cctcgcacac
     1561 agccatgtca gaacccacct ccactcccac caagctgatg gcagaggcca gcaccccggc
     1621 tttgccaaga tcagccaccc tgccccaaga gttacctgtc cccgggctca gccaggcagc
     1681 caccatgccg gcccctctgc cttccccatc gtcctgcgac ctcacacagc agctcctgcc
     1741 tcagaccgtt ctgcagagca cgcccgctcc catggcacag ttttcggcac agttcagcat
     1801 gttccagacc atcaaagacc agctagagca gcggacgcgg atcctgcagg ccaatatccg
     1861 gtggcaacag gaagagctcc acaagatcca ggagcagctc tgcctggtcc aggactccaa
     1921 cgtccagatg ttcctgcagc agccagctgt atccctgagc ttcagcagca cccagcgacc
     1981 tgaggctcag cagcagctac agcaaaggtc agctgcagtg actcagcccc agctcggggc
     2041 gggcccccaa cttccagggc agatctcctc tgcccaggtc acaagccagc acctgctcag
     2101 agaatcaagt gtgatatcaa cccagggtcc aaagccaatg agaagctcac agctaatgca
     2161 gagcagcggc cgctctggaa gcagcctagt gtccccgttc agcagcgcca cagctgcgct
     2221 cccgccaagt ctgaatctga ccacacctgc ttccacctcc caggatgcca gccagtgcca
     2281 gcccagccca gacttcagcc atgatcggca gctcaggctg ttgctgagcc agcccatcca
     2341 gcccatgatg cccgggtcct gtgacgcaag gcagccctcg gaagtcagca ggacgggacg
     2401 gcaagtcaag tacgcccaga gccagaccgt gtttcaaaat ccagacgcac accccgccaa
     2461 cagcagcagc gccccgatgc ccgtcctgct gatggggcag gcggtgctcc accccagctt
     2521 ccctgcctcc caaccatcgc ccctgcagcc tgcacaggcc cggcagcagc caccgcagca
     2581 ctacctgcag gtacaggcac caacctcttt gcacagtgag cagcaggact cgctacttct
     2641 ctccacctac tcacaacagc cagggaccct gggctacccc caaccacccc cagcacagcc
     2701 ccagccccta cgtcctcccc gaagggtcag cagtctgtct gagtcgtcag gcctccagca
     2761 gccgccccga taatgccccg gcactgaagt cgggacacaa tcagctttaa ccaatggatg
     2821 aggggggtgg ccacaggaga tggggagagg agtctgaact aaacccctgg cttttgtgca
     2881 cactgcatac gtttcagaac tcctggatgg taaccatctc tggagtgcag cgcttgctgc
     2941 agtggaaatg atcaggaata ctgaccgtgt ttctcttgcc tccgaggttc ttgggcacac
     3001 tctatagcca tactggacag gaaccaggtg ccccgtgtag gcatcgtcgg tcggtttgcc
     3061 gtcagagatg gcgcatctcg ctgcatcccc cgagagtaca ccggttgctc tagccacctg
     3121 cggcccgccc atctgcgcta gctggccttc acgctcttga tcgtctttcc tttgtattgg
     3181 agaaggactg ggtcagagat ctgttggaga gagagaataa agagattatt tttcattatt
     3241 tttaaatggt tgtttttgtt ttaatttgca cagctacaca gaggaaataa cttaggcact
     3301 ttctgttttt tttaaaaaaa taataaggtc tcatggcttc atttagagac cacagtaaca
     3361 acagcagccc accaatcaga gaagctggtt gttattaacc aagctacaga ttcacacttt
     3421 ctggcctaaa ccctaatggg atgaggcttt tcaccccagg ccatgctggt ggtgattttt
     3481 tagcccctaa ataaaacact ggactatttc ctgtttactt cattgattgc aactacaaag
     3541 gtggactcaa agcaaagcac aatcatgcca gccaacattc cagaattctg ctgagaactc
     3601 caagtctgtg aggggagagg ttttacaagc cagacaggcc tgggggactg cagtccccaa
     3661 ggagaccctg ccacatgctg gccctttgag tgagaatgct gcatctttct acatatcttc
     3721 atgagaatac tgagaattgg attttccttt tcaaaatgca ctttgctttt tttgtatgtt
     3781 ttgttatgtt gagatgtttc taaagaaaag attttatgta attataagat gaagcgtagt
     3841 gaattgtaca gctgttgtaa taatgaccta tttctatata aaataaaatt gtatggctta
     3901 tgtgtaaatt attttgtatc tgagatacca gttccttttc ccaaatataa aagtataaaa
     3961 gttttcttgt gtttttctgt gagtgaaaat tttgtaataa attaacaaat ttgtacaatt
//
