LOCUS       NM_018958               7619 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens nuclear pore associated protein 1 (NPAP1), mRNA.
ACCESSION   NM_018958
VERSION     NM_018958.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7619)
  AUTHORS   Neumann,L.C., Feiner,N., Meyer,A., Buiting,K. and Horsthemke,B.
  TITLE     The imprinted NPAP1 gene in the Prader-Willi syndrome region
            belongs to a POM121-related family of retrogenes
  JOURNAL   Genome Biol Evol 6 (2), 344-351 (2014)
   PUBMED   24482533
  REMARK    GeneRIF: NPAP1 is specific to primate species and absent from the
            15q11q13-orthologous regions in all nonprimate mammals.
REFERENCE   2  (bases 1 to 7619)
  AUTHORS   Teumer,A., Holtfreter,B., Volker,U., Petersmann,A., Nauck,M.,
            Biffar,R., Volzke,H., Kroemer,H.K., Meisel,P., Homuth,G. and
            Kocher,T.
  TITLE     Genome-wide association study of chronic periodontitis in a general
            German population
  JOURNAL   J Clin Periodontol 40 (11), 977-985 (2013)
   PUBMED   24024966
REFERENCE   3  (bases 1 to 7619)
  AUTHORS   Neumann,L.C., Markaki,Y., Mladenov,E., Hoffmann,D., Buiting,K. and
            Horsthemke,B.
  TITLE     The imprinted NPAP1/C15orf2 gene in the Prader-Willi syndrome
            region encodes a nuclear pore complex associated protein
  JOURNAL   Hum Mol Genet 21 (18), 4038-4048 (2012)
   PUBMED   22694955
  REMARK    GeneRIF: C15orf2 is part of the nuclear pore complex or its
            associated molecular networks.
REFERENCE   4  (bases 1 to 7619)
  AUTHORS   Wawrzik,M., Unmehopa,U.A., Swaab,D.F., van de Nes,J., Buiting,K.
            and Horsthemke,B.
  TITLE     The C15orf2 gene in the Prader-Willi syndrome region is subject to
            genomic imprinting and positive selection
  JOURNAL   Neurogenetics 11 (2), 153-161 (2010)
   PUBMED   20020165
  REMARK    GeneRIF: These results indicate that C15orf2 might have an
            important role in human biology and that a deficiency of C15orf2
            might contribute to Prader-Willi syndrome.
REFERENCE   5  (bases 1 to 7619)
  AUTHORS   de Kovel,C.G., Trucks,H., Helbig,I., Mefford,H.C., Baker,C.,
            Leu,C., Kluck,C., Muhle,H., von Spiczak,S., Ostertag,P.,
            Obermeier,T., Kleefuss-Lie,A.A., Hallmann,K., Steffens,M., Gaus,V.,
            Klein,K.M., Hamer,H.M., Rosenow,F., Brilstra,E.H., Trenite,D.K.,
            Swinkels,M.E., Weber,Y.G., Unterberger,I., Zimprich,F., Urak,L.,
            Feucht,M., Fuchs,K., Moller,R.S., Hjalgrim,H., De Jonghe,P.,
            Suls,A., Ruckert,I.M., Wichmann,H.E., Franke,A., Schreiber,S.,
            Nurnberg,P., Elger,C.E., Lerche,H., Stephani,U., Koeleman,B.P.,
            Lindhout,D., Eichler,E.E. and Sander,T.
  TITLE     Recurrent microdeletions at 15q11.2 and 16p13.11 predispose to
            idiopathic generalized epilepsies
  JOURNAL   Brain 133 (Pt 1), 23-32 (2010)
   PUBMED   19843651
  REMARK    GeneRIF: The results from this study show an involvement of
            microdeletions at 15q11.2 that predispose patients to idiopathic
            generalized epilepsies.
REFERENCE   6  (bases 1 to 7619)
  AUTHORS   Kanber,D., Giltay,J., Wieczorek,D., Zogel,C., Hochstenbach,R.,
            Caliebe,A., Kuechler,A., Horsthemke,B. and Buiting,K.
  TITLE     A paternal deletion of MKRN3, MAGEL2 and NDN does not result in
            Prader-Willi syndrome
  JOURNAL   Eur J Hum Genet 17 (5), 582-590 (2009)
   PUBMED   19066619
REFERENCE   7  (bases 1 to 7619)
  AUTHORS   Calounova,G., Hedvicakova,P., Silhanova,E., Kreckova,G. and
            Sedlacek,Z.
  TITLE     Molecular and clinical characterization of two patients with
            Prader-Willi syndrome and atypical deletions of proximal chromosome
            15q
  JOURNAL   Am J Med Genet A 146A (15), 1955-1962 (2008)
   PUBMED   18627056
REFERENCE   8  (bases 1 to 7619)
  AUTHORS   Buiting,K., Nazlican,H., Galetzka,D., Wawrzik,M., Gross,S. and
            Horsthemke,B.
  TITLE     C15orf2 and a novel noncoding transcript from the
            Prader-Willi/Angelman syndrome region show monoallelic expression
            in fetal brain
  JOURNAL   Genomics 89 (5), 588-595 (2007)
   PUBMED   17337158
  REMARK    GeneRIF: C15orf2 gene is imprinted, with monoallelic expression
            from the paternal allele in fetal brain.
REFERENCE   9  (bases 1 to 7619)
  AUTHORS   Farber,C., Gross,S., Neesen,J., Buiting,K. and Horsthemke,B.
  TITLE     Identification of a testis-specific gene (C15orf2) in the
            Prader-Willi syndrome region on chromosome 15
  JOURNAL   Genomics 65 (2), 174-183 (2000)
   PUBMED   10783265
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC100720.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 26, 2019 this sequence version replaced NM_018958.2.
            
            Summary: This intronless retrogene is located in the Prader-Willi
            syndrome region on chromosome 15. This gene exhibits
            tissue-specific imprinting. Expression in adult testis and brain is
            biallelic, while expression in fetal brain is monoallelic and only
            from the paternal chromosome. The encoded protein is associated
            with the nuclear pore complex. [provided by RefSeq, Mar 2021].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on a combination of transcript alignments and
            PubMed IDs 10783265 and 20020165).
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 17337158
            MANE Ensembl match     :: ENST00000329468.5/ ENSP00000333735.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7619              AC100720.8         3273-10891          c
FEATURES             Location/Qualifiers
     source          1..7619
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q11.2"
     gene            1..7619
                     /gene="NPAP1"
                     /gene_synonym="C15orf2"
                     /note="nuclear pore associated protein 1"
                     /db_xref="GeneID:23742"
                     /db_xref="HGNC:HGNC:1190"
                     /db_xref="MIM:610922"
     exon            1..7619
                     /gene="NPAP1"
                     /gene_synonym="C15orf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..3564
                     /gene="NPAP1"
                     /gene_synonym="C15orf2"
                     /note="protein C15orf2"
                     /codon_start=1
                     /product="nuclear pore-associated protein 1"
                     /protein_id="NP_061831.2"
                     /db_xref="CCDS:CCDS10015.1"
                     /db_xref="GeneID:23742"
                     /db_xref="HGNC:HGNC:1190"
                     /db_xref="MIM:610922"
                     /translation="MGNLLSKFRPGCRRRPLPGPGRGAPAPLSRDASPPGRAHSVPTP
                     RPFRGLFRRNARRRPSAASIFVAPKRPCPLPRAAAAPLGVLPAVGWGLAIRKTPMLPA
                     RNPPRFGHPSSVRIPPPSRMFTLLLPSPREPAVKARKPIPATLLEETEVWAQEGPRRV
                     KKDEDPVQIEGEDDEKRTPLSSGEASSTSRSQGTQGDVASFRCSPGPLEGNVYHKFSE
                     NSMSEKAQASPASSCLEGPAMPSTHSQAGCARHLGKPDPDATAPPEPAVGCSLLQQKL
                     AAEVLNEEPPPSSLGLPIPLMSGKRMPDEKPFCIPPRSAAPPRAARNRPCKRKMSIPL
                     LLPLPPSLPLLWDRGELPPPAKLPCLSVEGDLHTLEKSPEYKRNSRILEDKTETMTNS
                     SITQPAPSFSQPVQTTDSLPLTTYTSQVSAPLPIPDLADLATGPLILPIPPLSTTPKM
                     DEKIAFTIPNSPLALPADLVPILGDQSNEKGGSYNSVVGAAPLTSDPPTPPSSTPSFK
                     PPVTRESPISMCVDSPPPLSFLTLLPVPSTGTSVITSKPMNSTSVISTVTTNASAHLT
                     SQTAVDPEVVNMDTTAPSQVVIFTSSLSSRVSSLPNSQIHCSAEQRHPGKTSVYTSPL
                     PFIFHNTTPSFNQLFGKEATPQPKFEAPDGQPQKASLPSACVFLSLPIIPPPDTSTLV
                     NSASTASSSKPPIETNAMHTTPPSKAVILQSASVSKKYLPFYLGLPGSGNTQPSGNTA
                     SVQGSTSLPAQSVRAPATASNHPLNPGATPQPKFGAPDGPQQKTSLPSAHDFLSLPIM
                     VPPDTSTLVSSASAASLSKPAIDTSDMNTTPPSKTVILQSTFVSRKEEYIRFYMGLPG
                     SGNTLHSDSIASAQVSTSFPAQADRRPTTTSSHPLNTGSISHSTLGATDGQQKSDSSF
                     ILGNPATPAPVIGLTSPSVQPLSGSIIPPGFAELTSPYTALGTPVNAEPVEGHNASAF
                     PNGTAKTSGFRIATGMPGTGDSTLLVGNTIPGPQVIMGPGTPMDGGSIGFSMSAPGPS
                     STSGELNIGQGQSGTPSTTSVFPFGQAAWDPTGHSMAAAPQGASNIPVFGYTSAAAYI
                     PGLDPPTQNSCSGMGGDGTRSIVGGPCVPAFQQCILQHTWTERKFYTSSTHYYGQETY
                     VRRHVCFQLP"
     regulatory      7595..7600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NPAP1"
                     /gene_synonym="C15orf2"
                     /note="hexamer: AGTAAA"
     polyA_site      7619
                     /gene="NPAP1"
                     /gene_synonym="C15orf2"
                     /note="major polyA site"
ORIGIN      
        1 agtttgtgct tggtcgccag aggaggcggt ggctgaggag agttgagtcc actgctgacc
       61 ctgttttacg gtaggaggca cggctagctc taaatgggca atttacttag taaatttaga
      121 cccgggtgcc gccgccggcc cctgccaggg ccagggcgtg gcgcccccgc tcccctgtcc
      181 cgggacgcct ccccgcccgg tcgggctcac tctgtaccca ccccgcgccc tttccgcggc
      241 ctgttccgcc ggaacgcccg tcgcaggcct tcagcagcca gcatcttcgt cgcccctaag
      301 aggccgtgtc ctctccctcg ggctgcggcc gcccctctgg gggtcctgcc ggctgtgggt
      361 tgggggctgg ccatcaggaa gacacccatg ctgcctgctc ggaacccccc gaggtttgga
      421 caccccagtt ccgtaaggat ccctcctccc agccgcatgt tcactctcct gctgccttca
      481 ccacgtgagc cggcggtcaa ggccaggaag cccatcccag ccactctcct ggaggagacc
      541 gaggtgtggg cccaagaagg gcccagaaga gtgaagaagg atgaggatcc ggtgcagatc
      601 gaaggggagg atgacgagaa aaggaccccc cttagcagcg gagaagcatc gtccacatcc
      661 aggtcccagg gcacccaggg agacgtggcc tccttcagat gcagccctgg gcctctggag
      721 ggaaatgtct accacaagtt ctcagaaaac agcatgagtg agaaggccca ggcgtctcca
      781 gcgagctcct gcttggaagg ccctgccatg cccagcacac acagccaggc cggatgtgcc
      841 cggcatcttg gaaagcctga tccggatgca acagcgcccc ctgagccagc cgttggctgc
      901 tccctgctgc agcagaagtt ggctgcggaa gtgctgaatg aagagccacc gcccagctcc
      961 ctaggcttgc cgattccgct gatgtccgga aagaggatgc ctgatgagaa gcctttctgt
     1021 attcctccaa ggagcgctgc tcctcccaga gctgcccgca acaggccctg caaaaggaaa
     1081 atgtcgattc cattgctgct gccgctgccc ccttcactgc cattgctgtg ggatcgaggt
     1141 gagcttcccc cacctgctaa gctcccctgc ctgtctgttg agggagacct acacaccttg
     1201 gagaagagcc ctgagtataa aaggaatagc agaatcttgg aggataaaac agagaccatg
     1261 acaaacagca gcatcaccca gcctgcccct tctttctccc aacctgtgca gaccacagac
     1321 tccctgcccc tgaccactta cacttcccag gtctcagctc ctttgcccat ccctgacttg
     1381 gctgacctgg ctactggacc cctcatcctg cctatccctc cactttccac cacaccaaaa
     1441 atggatgaga aaatagcatt cacaatccct aactctcctc tggctcttcc tgctgacctt
     1501 gttcccattt tgggtgatca gtctaatgag aaaggaggct cttataattc agtcgtagga
     1561 gcagcgcctc tcacttctga ccccccaaca cctcctagct ccacaccctc cttcaagcct
     1621 cccgtcacaa gggagtcccc aatatctatg tgtgtggatt cccctcctcc tctttccttc
     1681 ctgactcttc ttccagtccc ttccaccggg acctcagtta tcaccagcaa gcctatgaat
     1741 tccacgtcag tcatttccac tgtcacaaca aacgcatctg cccacctaac ctcacagact
     1801 gcggtagacc ctgaagtagt taatatggat actactgccc catctcaggt tgttattttc
     1861 acatcttccc taagctccag agtgagctct ctcccaaatt cccaaataca ttgcagtgca
     1921 gagcagaggc acccgggaaa gacatcagtc tacacatccc cacttccatt tatattccac
     1981 aataccaccc caagttttaa ccaactcttt ggaaaagaag ccacccctca gcccaaattt
     2041 gaggctcctg atgggcagcc gcagaaagct tctctcccca gtgcctgtgt tttcctgagc
     2101 cttcccatca ttcctcctcc agacacctcc actttagtga acagtgcctc tacagcatca
     2161 tcatccaaac ctcccattga aaccaatgct atgcatacca ctcctccttc caaggctgtc
     2221 atcttgcagt ctgcctctgt ctccaagaag tacctcccat tttacctggg gcttcctggt
     2281 tctgggaaca cacaacccag cggcaacact gcctcagtcc aaggctccac cagtttgcct
     2341 gcacagtcag tcagggcacc agctacagct tccaaccatc ctttaaatcc aggagccacc
     2401 cctcaaccca aatttggggc ccctgatggg ccgcagcaga aaacctctct ccccagtgcc
     2461 catgatttcc tgagccttcc tatcatggtt cctccagaca cctccacttt agtgagcagt
     2521 gcctctgcag catcgttatc caagcctgcc attgacacca gtgacatgaa taccacccct
     2581 ccttccaaaa ctgtcatctt gcagtctacc tttgtctcca ggaaggagga gtacatccga
     2641 ttttatatgg ggcttcctgg ttctgggaac acactacaca gtgacagcat tgcctcagcc
     2701 caagtctcca ccagttttcc tgcacaggca gataggagac caaccacaac ttccagccat
     2761 cctttaaata caggatccat ctctcattcc acacttgggg ccactgatgg gcagcagaag
     2821 tctgacagtt cttttattct ggggaatcca gcaaccccag caccagttat aggcttaaca
     2881 tctccttcag tccagccact gagtggcagc ataattccac caggttttgc agagttaaca
     2941 tcaccatata ctgcattggg cacacctgtt aatgctgagc cagtcgaggg tcacaatgca
     3001 agtgctttcc ccaatggcac agcaaagact tctggattta gaattgccac tgggatgcct
     3061 ggcactggag acagtacctt actggttgga aatactattc caggcccaca agtgattatg
     3121 ggacctggaa cccctatgga tggtgggagc attgggttca gcatgtctgc cccaggcccc
     3181 agttccacat caggagaact caacattgga caaggacaga gtgggacacc cagcaccact
     3241 tctgttttcc catttggtca ggcagcctgg gacccaactg gccacagcat ggctgctgca
     3301 ccacaagggg ctagcaacat tcctgtattt ggatatactt ctgctgccgc ctacattcct
     3361 ggtttagacc cacctaccca gaattcatgc agtggtatgg gaggggatgg caccagatcc
     3421 atagttggag gcccttgtgt tcctgctttt caacagtgca tcctgcagca cacatggaca
     3481 gagagaaaat tctacacttc aagcacccac tactatggac aagaaacata tgttaggaga
     3541 catgtctgtt tccaacttcc gtaagagcac ctgtggttca cctgatcaca ccacatcagt
     3601 tgtggttgta aataccagca ttatcctttt gtatggtcat gcttctagtt tcatcttcat
     3661 gccaagcacc tgccatgtac ctctccagaa ctcaggttgt gcaccaggag gggacaacaa
     3721 catccctgtg ctccctttct ctgtcagtac acatgggtcc cacctggaca aaacacaggt
     3781 ggtgcatctg cagtgaatgg caacatatct ttaattagag gcccttgtgt atccacctac
     3841 caacaaagta cctagggccc acctggacaa aacacagatg gtacctcttc caggagtgtc
     3901 aacattcatt tgatagaagg ccctcatgtg cccatgtatc agcaaagcac ctggggccca
     3961 cctggacaaa gcacaaacca tgcaatgagg gacagcaaca caacggctgt gactggttgt
     4021 acttttggtc ccccatttac acaaagcacc tgaggcccac ctggctaaat gcaggtggtg
     4081 caataggaga tagccccaga tatttgtagg gagaaacctc tagtctccct ttcagtaaaa
     4141 atactatgga cctgcccaac caaggtgctc cttttgactt tagaggaacc agcattgttt
     4201 ttgttttggt ttgtttgttt gtttgtttgt ttgtttgttt gtttttgaga cggagcctta
     4261 gcccaggctg gagtgtagta gcacaatctc ggctcactgc aacctccacc tcctgggttc
     4321 aagcaattct cctgtcttag cctcctgagt agctgggact acaggcatat gccaccacac
     4381 ctggctattt tttataattt tagcagagac agagttccac cttattggcc aggctggtct
     4441 caaactcctg acctcaggtg atccacccac ctcggcctcc caaagtgcta ggatgacagg
     4501 tgtgagccac catgcccagc ctagaggagc cagcattgtt agttaaatac ttgtgtttgg
     4561 atggtcctgg tcagagcacc tgtgcctgtg atggaaagca gccactagtg acacttgtac
     4621 ctgccaaggc cttcatagga gccaccaact cattttttac tcctatcaat ggtcttaaga
     4681 aataagcact ctccctgcac atacagttct cataaattga cattgttcca ggaggaatgg
     4741 gctcagttcc ctcaaggtta aacttaacct gctctcttcc tacagaagct ggaggcccaa
     4801 aaccacagac agagagagag agagtgtgtg tgtttgtgtg tgtgtgtgtg tgtttattgg
     4861 tgagtgtgga gcagatgagc ccagtcagaa ccgcactgta ttttagtggt cttctgcact
     4921 gtggagggta gaggaaacct ggcttgactg ttaacttggc tgaccctacc tctgggccag
     4981 ttctctctag tcatggacag aaaggcaaaa ttcccgactt tgtggaccct atattctagt
     5041 tgaaggggag aaaagaagca aaaacatgga aattatctgg taaattagcc agtaacgaat
     5101 gctatgaaaa ataaagaagt acatggagga ttgagattgt agatagaagc aggtgtttca
     5161 gtttacactg tgaacaagcc tcactgggaa ggtaaattta aacgaagcct agagagaagc
     5221 agttgagcca gatatatgag caaagacctt tccagataat aggagtggtc attgcagagg
     5281 ctcaaaggaa ggatccctgg tgtcctcatg gagcagttag taaggaaatg tggctggaat
     5341 ggagtcagca agtgggaggg agggatagag aagaggacag aggagagatg tgagtggaat
     5401 tccttcctcc actttttact aattgtgtaa taacagttga ctcaaacttc aaaagtctca
     5461 atgaaatcag tacttttact atggcctgtt tatctcataa gatttttgaa aggataaaat
     5521 gaaataatat ggagaaatga cttataagct tttgttgtaa tttgttatat acatagggat
     5581 ggatagacgg atggatagat tagatgatag atagatagat agatagatga taacgttatg
     5641 gactgaatgt ttgtgtaccc ccaaaaattg atattttgaa gcctaacttc cagtgtgatg
     5701 gtattaggag gtgaggcttt ggggaggtga ttaggtttag atgaagtcat gaaaatgaaa
     5761 cccccatgat gggatttgcg cctttatgag aagaaatacc agtgctttct ctaattgcca
     5821 tgtgaaggta taccaacaag gtaacagtct gtaagccagg aaaagagtcc tcacaagaaa
     5881 cagaatttgt ctttatcttg gacttcctaa cctttagaat tgtagaaaat aattgaatgt
     5941 tgtttaagct accagtctgt ggcatttttt gtagcaatca gaactgacta ataaagatag
     6001 atagatgata gatagataca tagatagatg atagagatag atgatagata gatagataga
     6061 tagatagata atatacatat atatgtatgg tcaatgactg agttccttag gcaatggtgc
     6121 cctgattgcc tttattaggc aattcaaata gaagaataga agaaccccct tttttttttg
     6181 agatggagtc ttgctctgtc acccaggctg gagtgcagtg gcgtgatctt ggctcactgc
     6241 acgctccacc tctcggaaga accccttttt attagcataa aagcacttac ttttatgaag
     6301 caaacacatg taaaaatatg ataacagaga ctaaaacatt tatgagatta ggcctgaaag
     6361 aaaacaatca cagagaaatt actgaattcc tcttggcacc ctggggcctg attcattcgc
     6421 tctaaattgt ttagtacagt tccagaggat caaagctcct gtttcctggc cagataatca
     6481 cctaactttt gtaatcagaa ctgcctttca gaagtagagt ggaaatccag ttttcttcta
     6541 atagccctat acccttgcag tattaccagg gacaaatttt ttaaaattca tacttcttga
     6601 cattttttaa aaggcttcaa gctaaatatt atgatcctgg taagacaaac tttgaataaa
     6661 tgtgtgagag atacaaagat aatttttgtt ttcatgtttt gatgcactta cacaactgaa
     6721 actatttcta aatattcttt tattttttat taagataaaa agcaaacata atatcaattt
     6781 aaataatact gaaagtcaac cttcctacca cagttccctc ctccagagat agtgtttagc
     6841 tactttgatg tcactcccat agttctgagt ttgctttttt acttcaacta ttatgttatc
     6901 ttacagatgt cattgttttt cctaaaactt gaagtgcctt cctttttttc tccttgaact
     6961 cttttcccat aaaaaaaaaa tgtttttggt ttctagaatt ttcaaatagt attgtttact
     7021 tgactgaatc ccttcctttt ccagaaacct tgagcctcct ccactggttt gggagtggta
     7081 agaccaaagt aaatgtaaaa agtaaagtag aggttcctct tcaaagactt tcctccctat
     7141 ctaattagaa ataagtagta acttctttta gaagcaaaat gtattcacag acctgtacta
     7201 acattcttaa atatctgcta gtcataataa agaaatcaat gtactttatg ttcttagctc
     7261 ccacaattta gcctaagtat ttgccctggc atgcttatac tggtccaagc attaggtcat
     7321 agcctgttcc tcttccttat ttagaagtgt ttttaccttt ctcagcattc cacaagttac
     7381 ttcctcattc ctttgttctc ctctaccttt gcctctttta aaagttctaa attgctagcc
     7441 aatcgggaca aatacagaat gtgaggtcct gttccagcca atggaaaccg gacacagcag
     7501 tagggtggac gcgtcaggtt ataaatgacc ctgtctcctt tgttcggtgt actcttgtgg
     7561 caaaactgct ggcaagtgta ccctttctgc aggaagtaaa aatggcctta ctaaataaa
//
