LOCUS       NM_001113475            2324 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens NADP dependent oxidoreductase domain containing 1
            (NOXRED1), transcript variant 1, mRNA.
ACCESSION   NM_001113475
VERSION     NM_001113475.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2324)
  AUTHORS   Chen,K., Liu,H., Liu,Z., Bloomer,W., Amos,C.I., Lee,J.E., Li,X.,
            Nan,H. and Wei,Q.
  TITLE     Genetic variants in glutamine metabolic pathway genes predict
            cutaneous melanoma-specific survival
  JOURNAL   Mol Carcinog 58 (11), 2091-2103 (2019)
   PUBMED   31435991
  REMARK    GeneRIF: In the analysis of the genotype tissue expression (GTEx)
            project datasets, HAL rs17676826 C and NOXRED1 rs8012548 G alleles
            were significantly associated with their mRNA expression levels in
            sun-exposed skin of the lower leg (P = 6.62 x 10(-6) and 1.37 x
            10(-7) , respectively) and in sun-not-exposed suprapubic skin (P <
            .001 and 1.43 x 10(-8) , respectively).
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF111168.2 and AC007954.7.
            
            On May 13, 2021 this sequence version replaced NM_001113475.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066965.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380835.7/ ENSP00000370215.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-789               AF111168.2         25330-26118         c
            790-983             AF111168.2         16529-16722         c
            984-1164            AF111168.2         10060-10240         c
            1165-1316           AF111168.2         9319-9470           c
            1317-1539           AF111168.2         8508-8730           c
            1540-2324           AC007954.7         181000-181784       c
FEATURES             Location/Qualifiers
     source          1..2324
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..2324
                     /gene="NOXRED1"
                     /gene_synonym="C14orf148"
                     /note="NADP dependent oxidoreductase domain containing 1"
                     /db_xref="GeneID:122945"
                     /db_xref="HGNC:HGNC:20487"
     exon            1..789
                     /gene="NOXRED1"
                     /gene_synonym="C14orf148"
                     /inference="alignment:Splign:2.1.0"
     CDS             635..1714
                     /gene="NOXRED1"
                     /gene_synonym="C14orf148"
                     /note="pyrroline-5-carboxylate reductase-like protein
                     C14orf148"
                     /codon_start=1
                     /product="NADP-dependent oxidoreductase domain-containing
                     protein 1"
                     /protein_id="NP_001106946.1"
                     /db_xref="CCDS:CCDS45142.1"
                     /db_xref="GeneID:122945"
                     /db_xref="HGNC:HGNC:20487"
                     /translation="MDMLQDLESLQFEYGVPEEDRIWLYLQGRSRGLMIEACAHATFF
                     CKLLYNLRASLNKNQSSRHLSIGSLNSATPEEFKVGIIGGGHLGKQLAGTLLQLGPIP
                     AESLRISTRRPETLGELQKLGIKCFYHNADLVSWADVIFLCCLPSQLPNICVEIYTSL
                     EKASIVYSFVAAIPLPRLKLLLNHTNILRPQYQYDEDSVSVWGANKGVIAALQDPTIL
                     QATCPYSPAGGIILNIKWLEGVFYAALNICTARNMAHSQVLQLLSELFLSVHFEDCGK
                     DTASCPKLQLTDFVSKAYGKNLSQERPFPWFDLTAVQLKETPFSQHLSSSPVLQDHLT
                     HLYCASFGISLTKEQPVISTGFPSQ"
     exon            790..983
                     /gene="NOXRED1"
                     /gene_synonym="C14orf148"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1164
                     /gene="NOXRED1"
                     /gene_synonym="C14orf148"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1316
                     /gene="NOXRED1"
                     /gene_synonym="C14orf148"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1539
                     /gene="NOXRED1"
                     /gene_synonym="C14orf148"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..2324
                     /gene="NOXRED1"
                     /gene_synonym="C14orf148"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1883..1888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOXRED1"
                     /gene_synonym="C14orf148"
                     /note="hexamer: AACAAG"
     polyA_site      1904
                     /gene="NOXRED1"
                     /gene_synonym="C14orf148"
     regulatory      2304..2309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOXRED1"
                     /gene_synonym="C14orf148"
                     /note="hexamer: AATATA"
     polyA_site      2324
                     /gene="NOXRED1"
                     /gene_synonym="C14orf148"
                     /note="major polyA site"
ORIGIN      
        1 cttaccttcc aggatcagaa gtactgagga gcagagccaa tcttctctgt ttggtgatag
       61 atatatgtag atgggtttat atgactttga gtttagtttg taaaatctag atgtccctgc
      121 cctagacagg ggacaatgat atttagtttg ggttattttg taccctgtgg agaacagagt
      181 ttagtgaaag ggaagcattt ctttgaaatg tggttctatg tgttcagtcc tatttccaaa
      241 acgcaggagg gaatggaagg gaaaacgtcc tggcccaaga atacctgtaa aactcaattg
      301 ctgttgtaaa ttcatctgcc gaaaacagtg cctgtaacct gtgtggagaa acaatacttt
      361 gggtttctgt acaggttttt catgagtcca ggattcatgg gcagccagtg attaggaatc
      421 ctcaaacact cacactctag agtgtgaatt caagagaggt gaattccaaa ttcagaatct
      481 gggagtagag aggtgctgaa gcccatcatc atgagtgctt gtgacctggg cacacacacc
      541 atcatacaca cacctcctac atagacccct cttctaccgg gacagggagc caaattgatt
      601 agtgtctatc actgcaggaa atagtggctt ggaaatggac atgctccagg accttgagtc
      661 cctgcagttt gagtatgggg ttccagagga agatcgtatc tggctgtatt tgcagggccg
      721 ttctcgggga ctgatgatcg aggcttgtgc ccatgcaacc ttcttctgca aactattata
      781 taatttgaga gcatcattaa ataagaatca aagttccaga catctctcaa ttggctccct
      841 taattcagcc actcctgaag agtttaaggt gggcatcatt ggaggtggcc accttgggaa
      901 gcagctggct ggcacactgc tgcagcttgg ccccatccct gctgaaagcc tgcggatctc
      961 cactcggagg ccagagactc tgggtgagct ccagaagctg ggaatcaaat gcttttacca
     1021 taacgctgat ctggtgagtt gggccgatgt gatattcctc tgctgcttgc cgtctcagct
     1081 gcctaatatc tgcgtagaaa tttacaccag ccttgagaag gccagcattg tgtacagctt
     1141 tgtagctgcc atcccactac ccaggctgaa actactgttg aaccacacca atatcttgcg
     1201 gcctcagtat cagtatgatg aagattctgt cagcgtctgg ggggccaata agggagtcat
     1261 agctgctctc caagatccta cgattcttca agctacctgt ccctacagtc ctgctggggg
     1321 aataatcctc aatatcaagt ggttggaggg agtgttctat gcggccctaa acatatgcac
     1381 agcaagaaac atggcccact cccaagtgct gcagcttctg agtgaactct ttctctccgt
     1441 gcactttgaa gactgtggga aagacacagc atcttgccca aagttgcaat taacagattt
     1501 tgtcagcaaa gcctatggca agaatttgtc tcaggaaagg cctttcccct ggtttgatct
     1561 gactgctgtg caactcaagg aaactccgtt tagccagcat ctctcaagta gtcctgttct
     1621 ccaagaccac cttacccatc tatactgtgc ttcatttggc atctccctaa ccaaagaaca
     1681 gccagtcatt tccacaggct ttccatccca ataagagaac tcaggaatca ggattttttc
     1741 ccactcacag attttcccta taatagttgt gccctgatta tcacaattga ctgtgggagt
     1801 cttgtggctg tattgtgttt gccacatgat agacatcagg aattataaaa ctgtactgat
     1861 gactctttaa aatgtagaat aaaacaagtg gtcctatcca tcaatatgta tctggctctc
     1921 agaagcaact agtgaaacta cacaacctaa cttaagtaag ctgctcccgc agaaaagtct
     1981 tgttaataca aattatttct cttctaaaat taaagaagtt ataatgttat aagttttaga
     2041 caattacata ctgcagcttc ttttccaata aatcaagttt caatccattt gccagcagta
     2101 ggtagctgga aaaagataca gtttgatttt ctcacaattt tggacagaga agtgaaggta
     2161 tggtaaacca tcttaattga attatggctt gtatcatgct tattttgact atatatgact
     2221 gttctggtac tatcttattt acagctgttc ccatttaaac catttaaaaa actggtattt
     2281 aatggctaaa actaattttg caaaatatag atctatactg caaa
//
