LOCUS       NM_172167               1541 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens NADPH oxidase organizer 1 (NOXO1), transcript variant
            b, mRNA.
ACCESSION   NM_172167
VERSION     NM_172167.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1541)
  AUTHORS   Zhu,Y., Shi,W., Han,W., Wang,M., Chen,J. and Zhou,J.
  TITLE     DNA methylation of ICAM4 and NOXO1 participate in the formation of
            uterine fibroids via regulating immune cell infiltration
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (11), 173-179 (2023)
   PUBMED   38015525
  REMARK    GeneRIF: DNA methylation of ICAM4 and NOXO1 participate in the
            formation of uterine fibroids via regulating immune cell
            infiltration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1541)
  AUTHORS   Benssouina,F.Z., Parat,F., Villard,C., Leloup,L., Garrouste,F.,
            Sabatier,J.M., Ferhat,L. and Kovacic,H.
  TITLE     Overexpression of a Novel Noxo1 Mutant Increases Ros Production and
            Noxo1 Relocalisation
  JOURNAL   Int J Mol Sci 24 (5), 4663 (2023)
   PUBMED   36902094
  REMARK    GeneRIF: Overexpression of a Novel Noxo1 Mutant Increases Ros
            Production and Noxo1 Relocalisation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1541)
  AUTHORS   Haq,S., Sarodaya,N., Karapurkar,J.K., Suresh,B., Jo,J.K., Singh,V.,
            Bae,Y.S., Kim,K.S. and Ramakrishna,S.
  TITLE     CYLD destabilizes NoxO1 protein by promoting ubiquitination and
            regulates prostate cancer progression
  JOURNAL   Cancer Lett 525, 146-157 (2022)
   PUBMED   34742871
  REMARK    GeneRIF: CYLD destabilizes NoxO1 protein by promoting
            ubiquitination and regulates prostate cancer progression.
REFERENCE   4  (bases 1 to 1541)
  AUTHORS   Liu,D., Marie,J.C., Pelletier,A.L., Song,Z., Ben-Khemis,M.,
            Boudiaf,K., Pintard,C., Leger,T., Terrier,S., Chevreux,G.,
            El-Benna,J. and Dang,P.M.
  TITLE     Protein Kinase CK2 Acts as a Molecular Brake to Control NADPH
            Oxidase 1 Activation and Colon Inflammation
  JOURNAL   Cell Mol Gastroenterol Hepatol 13 (4), 1073-1093 (2022)
   PUBMED   35031518
REFERENCE   5  (bases 1 to 1541)
  AUTHORS   Cheng,G. and Lambeth,J.D.
  TITLE     Alternative mRNA splice forms of NOXO1: differential tissue
            expression and regulation of Nox1 and Nox3
  JOURNAL   Gene 356, 118-126 (2005)
   PUBMED   15949904
  REMARK    GeneRIF: Data suggest different tissue localizations and functions
            for NOXO1beta and NOXO1gamma in regulating Nox family members.
REFERENCE   6  (bases 1 to 1541)
  AUTHORS   Cheng,G., Ritsick,D. and Lambeth,J.D.
  TITLE     Nox3 regulation by NOXO1, p47phox, and p67phox
  JOURNAL   J Biol Chem 279 (33), 34250-34255 (2004)
   PUBMED   15181005
  REMARK    GeneRIF: NOXO1, p47phox, and p67phox regulate Nox3
REFERENCE   7  (bases 1 to 1541)
  AUTHORS   Cheng,G. and Lambeth,J.D.
  TITLE     NOXO1, regulation of lipid binding, localization, and activation of
            Nox1 by the Phox homology (PX) domain
  JOURNAL   J Biol Chem 279 (6), 4737-4742 (2004)
   PUBMED   14617635
  REMARK    GeneRIF: NOXO1 and NOXA1 activate Nox1 without the need for agonist
            activation, and this is mediated in part by binding of the NOXO1 PX
            domain to membrane lipids.
REFERENCE   8  (bases 1 to 1541)
  AUTHORS   Takeya,R., Ueno,N., Kami,K., Taura,M., Kohjima,M., Izaki,T.,
            Nunoi,H. and Sumimoto,H.
  TITLE     Novel human homologues of p47phox and p67phox participate in
            activation of superoxide-producing NADPH oxidases
  JOURNAL   J Biol Chem 278 (27), 25234-25246 (2003)
   PUBMED   12716910
  REMARK    Erratum:[J Biol Chem. 2015 Mar 6;290(10):6003. doi:
            10.1074/jbc.A114.212856.. PMID: 25750260]
REFERENCE   9  (bases 1 to 1541)
  AUTHORS   Geiszt,M., Lekstrom,K., Witta,J. and Leto,T.L.
  TITLE     Proteins homologous to p47phox and p67phox support superoxide
            production by NAD(P)H oxidase 1 in colon epithelial cells
  JOURNAL   J Biol Chem 278 (22), 20006-20012 (2003)
   PUBMED   12657628
REFERENCE   10 (bases 1 to 1541)
  AUTHORS   Banfi,B., Clark,R.A., Steger,K. and Krause,K.H.
  TITLE     Two novel proteins activate superoxide generation by the NADPH
            oxidase NOX1
  JOURNAL   J Biol Chem 278 (6), 3510-3513 (2003)
   PUBMED   12473664
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292197.1 and AF532984.1.
            
            On Jun 2, 2019 this sequence version replaced NM_172167.2.
            
            Summary: This gene encodes an NADPH oxidase (NOX) organizer, which
            positively regulates NOX1 and NOX3. The protein contains a PX
            domain and two SH3 domains. Alternatively spliced transcript
            variants encoding multiple isoforms have been observed for this
            gene. [provided by RefSeq, Jun 2012].
            
            Transcript Variant: This variant (b) uses an alternate splice site
            in the coding region, but maintains the reading frame, compared to
            variant a. The encoded isoform (b) is longer than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292197.1, AB097667.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356120.9/ ENSP00000348435.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               AK292197.1         81-366
            287-1418            AF532984.1         1-1132
            1419-1541           AK292197.1         1499-1621
FEATURES             Location/Qualifiers
     source          1..1541
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1541
                     /gene="NOXO1"
                     /gene_synonym="P41NOX; P41NOXA; P41NOXB; P41NOXC; SH3PXD5;
                     SNX28"
                     /note="NADPH oxidase organizer 1"
                     /db_xref="GeneID:124056"
                     /db_xref="HGNC:HGNC:19404"
                     /db_xref="MIM:611256"
     exon            1..356
                     /gene="NOXO1"
                     /gene_synonym="P41NOX; P41NOXA; P41NOXB; P41NOXC; SH3PXD5;
                     SNX28"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..1406
                     /gene="NOXO1"
                     /gene_synonym="P41NOX; P41NOXA; P41NOXB; P41NOXC; SH3PXD5;
                     SNX28"
                     /note="isoform b is encoded by transcript variant b;
                     regulatory protein P41NOX; Nox organizer 1; nox-organizing
                     protein 1; NADPH oxidase regulatory protein; SH3 and PX
                     domain-containing protein 5"
                     /codon_start=1
                     /product="NADPH oxidase organizer 1 isoform b"
                     /protein_id="NP_751907.1"
                     /db_xref="CCDS:CCDS10455.1"
                     /db_xref="GeneID:124056"
                     /db_xref="HGNC:HGNC:19404"
                     /db_xref="MIM:611256"
                     /translation="MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDE
                     FRQLKKTLKETFPVEAGLLRRSDRVLPKLLDAPLLGRVGRTSRGLARLQLLETYSRRL
                     LATAERVARSPTITGFFAPQPLDLEPALPPGSRVILPTPEEQPLSRAAGRLSIHSLEA
                     QSLRCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEA
                     APGQGREGGPSLGSSGPQFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGD
                     RAGLLPAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGA
                     IQSRCCTVTRRALERRPRRQGRPRGCVDSVPHPTTEQ"
     exon            357..437
                     /gene="NOXO1"
                     /gene_synonym="P41NOX; P41NOXA; P41NOXB; P41NOXC; SH3PXD5;
                     SNX28"
                     /inference="alignment:Splign:2.1.0"
     exon            438..513
                     /gene="NOXO1"
                     /gene_synonym="P41NOX; P41NOXA; P41NOXB; P41NOXC; SH3PXD5;
                     SNX28"
                     /inference="alignment:Splign:2.1.0"
     exon            514..691
                     /gene="NOXO1"
                     /gene_synonym="P41NOX; P41NOXA; P41NOXB; P41NOXC; SH3PXD5;
                     SNX28"
                     /inference="alignment:Splign:2.1.0"
     exon            692..876
                     /gene="NOXO1"
                     /gene_synonym="P41NOX; P41NOXA; P41NOXB; P41NOXC; SH3PXD5;
                     SNX28"
                     /inference="alignment:Splign:2.1.0"
     exon            877..990
                     /gene="NOXO1"
                     /gene_synonym="P41NOX; P41NOXA; P41NOXB; P41NOXC; SH3PXD5;
                     SNX28"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1108
                     /gene="NOXO1"
                     /gene_synonym="P41NOX; P41NOXA; P41NOXB; P41NOXC; SH3PXD5;
                     SNX28"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1541
                     /gene="NOXO1"
                     /gene_synonym="P41NOX; P41NOXA; P41NOXB; P41NOXC; SH3PXD5;
                     SNX28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1521..1526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOXO1"
                     /gene_synonym="P41NOX; P41NOXA; P41NOXB; P41NOXC; SH3PXD5;
                     SNX28"
                     /note="hexamer: AGTAAA"
     polyA_site      1541
                     /gene="NOXO1"
                     /gene_synonym="P41NOX; P41NOXA; P41NOXB; P41NOXC; SH3PXD5;
                     SNX28"
                     /note="major polyA site"
ORIGIN      
        1 agtcttgcac gcctccaggg ctggaaagct cattcttctt cttcctccca gcagctctgc
       61 ctggaagtcc cccaatccct gtgctcctgc ccccagatcg tgggcttggg ggacagcaag
      121 aaagctgcaa aggactcagc tggggcggct ccacaaggac cccacaggct tgaggtgttg
      181 ccaggattct atcccagggg gttttctggg tcccccagag ccctctcaag cacggggagg
      241 cagaagggtc ctcgcccatt tcaggaatct gcagcctgga agccacagcc atggcaggcc
      301 cccgataccc agtttcagtg caaggggcag ccctggtgca gatcaagagg ctccaaacgt
      361 ttgccttctc tgtgcgctgg tcagacggca gcgacacctt cgtgcgcagg agttgggacg
      421 aattcaggca gctcaagaag accctcaagg agaccttccc ggtggaggcg ggcctgctgc
      481 ggagatctga ccgcgttctc ccaaagcttc tcgatgcacc actgttggga cgcgtggggc
      541 gcacgagccg cggcctggcg cgcctgcagc tgttggaaac ctattctcgg aggctgctgg
      601 cgactgcaga gcgcgtggca cggagcccga cgatcactgg cttcttcgca ccgcaacccc
      661 tggacctgga gcccgcgctg ccacccggca gccgggtgat cctgcccacc ccagaggagc
      721 agcctctttc tcgcgctgcg ggccgcctct ccatccacag tctggaggct cagagcctgc
      781 gctgcctgca gcccttctgt acccaggaca cgcgggatag gccttttcag gcgcaggccc
      841 aggagagcct ggacgtgctg ctgcggcacc cctcaggctg gtggctggtg gagaacgaag
      901 accggcagac cgcctggttt ccagcgccct acctggagga ggcggccccg ggccaaggcc
      961 gggagggagg cccgtcccta gggagcagcg gtccccagtt ctgtgcttcc cgcgcctacg
     1021 agagcagccg cgcagatgag ctgtccgtgc ccgcgggggc gcgcgtgcgc gtgttggaaa
     1081 cgtcagaccg cggctggtgg ctatgcaggt acggcgaccg ggcgggccta ctccccgcgg
     1141 tgctgctgcg gccggaaggg ctgggcgctc tcctgagcgg gacggggttc cgtggaggag
     1201 acgacccggc gggtgaggcc cggggcttcc ctgaaccctc ccaggccacc gcccctcccc
     1261 ccaccgtgcc cacccgacct tcgccgggcg ccatccagag ccgctgctgc accgtcacac
     1321 gcagggccct ggagcggcgc ccacggcgcc agggccgccc tcgagggtgc gtggactctg
     1381 tgccgcaccc cacgacggag cagtgagcgc gaggatcccg atgaggggat ggaccgcgcc
     1441 atcccagggc tggggaggag cggggagggc ggatctccct ggccagcagg gatgggaggg
     1501 ggccatttgc tgttcctctg agtaaagctt gttctgcatg a
//
