LOCUS       NM_001256067            1614 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens NADPH oxidase activator 1 (NOXA1), transcript variant
            2, mRNA.
ACCESSION   NM_001256067
VERSION     NM_001256067.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1614)
  AUTHORS   Liu,D., Marie,J.C., Pelletier,A.L., Song,Z., Ben-Khemis,M.,
            Boudiaf,K., Pintard,C., Leger,T., Terrier,S., Chevreux,G.,
            El-Benna,J. and Dang,P.M.
  TITLE     Protein Kinase CK2 Acts as a Molecular Brake to Control NADPH
            Oxidase 1 Activation and Colon Inflammation
  JOURNAL   Cell Mol Gastroenterol Hepatol 13 (4), 1073-1093 (2022)
   PUBMED   35031518
REFERENCE   2  (bases 1 to 1614)
  AUTHORS   Sugimoto,Y., Katsumi,Y., Iehara,T., Kaneda,D., Tomoyasu,C.,
            Ouchi,K., Yoshida,H., Miyachi,M., Yagyu,S., Kikuchi,K.,
            Tsuchiya,K., Kuwahara,Y., Sakai,T. and Hosoi,H.
  TITLE     The Novel Histone Deacetylase Inhibitor, OBP-801, Induces Apoptosis
            in Rhabdoid Tumors by Releasing the Silencing of NOXA
  JOURNAL   Mol Cancer Ther 19 (10), 1992-2000 (2020)
   PUBMED   32847975
  REMARK    GeneRIF: The Novel Histone Deacetylase Inhibitor, OBP-801, Induces
            Apoptosis in Rhabdoid Tumors by Releasing the Silencing of NOXA.
REFERENCE   3  (bases 1 to 1614)
  AUTHORS   Djajawi,T.M., Liu,L., Gong,J.N., Huang,A.S., Luo,M.J., Xu,Z.,
            Okamoto,T., Call,M.J., Huang,D.C.S. and van Delft,M.F.
  TITLE     MARCH5 requires MTCH2 to coordinate proteasomal turnover of the
            MCL1:NOXA complex
  JOURNAL   Cell Death Differ 27 (8), 2484-2499 (2020)
   PUBMED   32094511
  REMARK    GeneRIF: MARCH5 requires MTCH2 to coordinate proteasomal turnover
            of the MCL1:NOXA complex.
REFERENCE   4  (bases 1 to 1614)
  AUTHORS   Haschka,M.D., Karbon,G., Soratroi,C., O'Neill,K.L., Luo,X. and
            Villunger,A.
  TITLE     MARCH5-dependent degradation of MCL1/NOXA complexes defines
            susceptibility to antimitotic drug treatment
  JOURNAL   Cell Death Differ 27 (8), 2297-2312 (2020)
   PUBMED   32015503
  REMARK    GeneRIF: MARCH5-dependent degradation of MCL1/NOXA complexes
            defines susceptibility to antimitotic drug treatment.
REFERENCE   5  (bases 1 to 1614)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1614)
  AUTHORS   Park,H.S., Park,D. and Bae,Y.S.
  TITLE     Molecular interaction of NADPH oxidase 1 with betaPix and Nox
            Organizer 1
  JOURNAL   Biochem Biophys Res Commun 339 (3), 985-990 (2006)
   PUBMED   16329988
REFERENCE   7  (bases 1 to 1614)
  AUTHORS   Takeya,R., Ueno,N., Kami,K., Taura,M., Kohjima,M., Izaki,T.,
            Nunoi,H. and Sumimoto,H.
  TITLE     Novel human homologues of p47phox and p67phox participate in
            activation of superoxide-producing NADPH oxidases
  JOURNAL   J Biol Chem 278 (27), 25234-25246 (2003)
   PUBMED   12716910
  REMARK    Erratum:[J Biol Chem. 2015 Mar 6;290(10):6003. doi:
            10.1074/jbc.A114.212856.. PMID: 25750260]
REFERENCE   8  (bases 1 to 1614)
  AUTHORS   Geiszt,M., Lekstrom,K., Witta,J. and Leto,T.L.
  TITLE     Proteins homologous to p47phox and p67phox support superoxide
            production by NAD(P)H oxidase 1 in colon epithelial cells
  JOURNAL   J Biol Chem 278 (22), 20006-20012 (2003)
   PUBMED   12657628
REFERENCE   9  (bases 1 to 1614)
  AUTHORS   Banfi,B., Clark,R.A., Steger,K. and Krause,K.H.
  TITLE     Two novel proteins activate superoxide generation by the NADPH
            oxidase NOX1
  JOURNAL   J Biol Chem 278 (6), 3510-3513 (2003)
   PUBMED   12473664
REFERENCE   10 (bases 1 to 1614)
  AUTHORS   Scanlan,M.J., Chen,Y.T., Williamson,B., Gure,A.O., Stockert,E.,
            Gordan,J.D., Tureci,O., Sahin,U., Pfreundschuh,M. and Old,L.J.
  TITLE     Characterization of human colon cancer antigens recognized by
            autologous antibodies
  JOURNAL   Int J Cancer 76 (5), 652-658 (1998)
   PUBMED   9610721
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX322799.22 and AB095031.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001256067.1.
            
            Summary: This gene encodes a protein which activates NADPH
            oxidases, enzymes which catalyze a reaction generating reactive
            oxygen species. The encoded protein contains four N-terminal
            tetratricopeptide domains and a C-terminal Src homology 3 domain.
            Interaction between the encoded protein and proteins in the oxidase
            regulatory complex occur via the tetratricopeptide domains.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region compared to variant 1. The
            resulting protein (isoform 2) is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB095031.1, BC110840.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683555.1/ ENSP00000507846.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BX322799.22        120062-120083
            23-1614             AB095031.1         1-1592
FEATURES             Location/Qualifiers
     source          1..1614
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..1614
                     /gene="NOXA1"
                     /gene_synonym="NY-CO-31; p51NOX; SDCCAG31"
                     /note="NADPH oxidase activator 1"
                     /db_xref="GeneID:10811"
                     /db_xref="HGNC:HGNC:10668"
                     /db_xref="MIM:611255"
     exon            1..314
                     /gene="NOXA1"
                     /gene_synonym="NY-CO-31; p51NOX; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1568
                     /gene="NOXA1"
                     /gene_synonym="NY-CO-31; p51NOX; SDCCAG31"
                     /note="isoform 2 is encoded by transcript variant 2;
                     serologically defined colon cancer antigen 31;
                     p67phox-like factor; Nox activator 1; inhibitory NADPH
                     oxidase activator 1; p51-nox; antigen NY-CO-31; NCF2-like
                     protein"
                     /codon_start=1
                     /product="NADPH oxidase activator 1 isoform 2"
                     /protein_id="NP_001242996.1"
                     /db_xref="CCDS:CCDS94544.1"
                     /db_xref="GeneID:10811"
                     /db_xref="HGNC:HGNC:10668"
                     /db_xref="MIM:611255"
                     /translation="MASLGDLVRAWHLGAQAVDRGDWARALHLFSGVPAPPARLCFNA
                     GCVHLLAGDPEAALRAFDQAVTKDTCMAVGFFQRGVANFQLARFQEALSDFWLALEQL
                     RGHAAIDYTQLGLRFKLQAWEVLHNVASAQCQLGLWTEAASSLREAMSKWPEGSLNGL
                     DSALDQVQRRGSLPPRQVPRGEVFRPHRWHLKHLEPVDFLGKAKVVASAIPDDQGWGV
                     RPQQPQGPGANHDARSLIMDSPRAGTHQGPLDAETEVGADRCTSTAYQEQRPQVEQVG
                     KQAPLSPGLPAMGGPGPGPCEDPAGAGGAGAGGSEPLVTVTVQCAFTVALRARRGADL
                     SSLRALLGQALPHQAQLGQLSYLAPGEDGHWVPIPEEESLQRAWQDAAACPRGLQLQC
                     RGAGGRPVLYQVVAQHSYSAQGPEDLGFRQGDTVDVLCEVDQAWLEGHCDGRIGIFPK
                     CFVVPAGPRMSGAPGRLPRSQQGDQP"
     exon            315..397
                     /gene="NOXA1"
                     /gene_synonym="NY-CO-31; p51NOX; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            398..506
                     /gene="NOXA1"
                     /gene_synonym="NY-CO-31; p51NOX; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            507..641
                     /gene="NOXA1"
                     /gene_synonym="NY-CO-31; p51NOX; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            642..749
                     /gene="NOXA1"
                     /gene_synonym="NY-CO-31; p51NOX; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            750..809
                     /gene="NOXA1"
                     /gene_synonym="NY-CO-31; p51NOX; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            810..835
                     /gene="NOXA1"
                     /gene_synonym="NY-CO-31; p51NOX; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            836..941
                     /gene="NOXA1"
                     /gene_synonym="NY-CO-31; p51NOX; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            942..987
                     /gene="NOXA1"
                     /gene_synonym="NY-CO-31; p51NOX; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1046
                     /gene="NOXA1"
                     /gene_synonym="NY-CO-31; p51NOX; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1201
                     /gene="NOXA1"
                     /gene_synonym="NY-CO-31; p51NOX; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1316
                     /gene="NOXA1"
                     /gene_synonym="NY-CO-31; p51NOX; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1431
                     /gene="NOXA1"
                     /gene_synonym="NY-CO-31; p51NOX; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1614
                     /gene="NOXA1"
                     /gene_synonym="NY-CO-31; p51NOX; SDCCAG31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1593..1598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOXA1"
                     /gene_synonym="NY-CO-31; p51NOX; SDCCAG31"
                     /note="hexamer: AATAAA"
     polyA_site      1614
                     /gene="NOXA1"
                     /gene_synonym="NY-CO-31; p51NOX; SDCCAG31"
                     /note="major polyA site"
ORIGIN      
        1 agcggggttg cacctggcgc ttggcgcccg cacctctgcc cgcctcggag accccgcagc
       61 cccgcgccgc cgcctggccc cggccccggc ccctccgcgg gatcctggcc cctcctcgag
      121 cgccgccacc ggccgccatg gcctctctgg gggacctggt gcgcgcctgg cacctgggcg
      181 cgcaggctgt ggatcgtggg gactgggccc gcgccttgca cctcttctcg ggcgtcccgg
      241 cgccgcccgc caggctgtgc ttcaacgcgg gctgcgtgca cctgctggcc ggggaccccg
      301 aggccgcgct gcgggcattt gaccaagccg tgaccaagga cacctgcatg gcggttggct
      361 tcttccagcg aggagtggcc aacttccagc tggcaaggtt ccaggaggct ctgtctgact
      421 tctggctggc cctggagcag ctgaggggcc acgctgccat cgactacacg cagctgggcc
      481 tgcggttcaa gctgcaagcc tgggaggtgc tacacaatgt ggcgtcggca cagtgccagc
      541 tggggctctg gacagaggcg gccagcagcc taagggaggc catgtccaag tggccggagg
      601 ggtccctgaa tggcctggac tcagccctgg accaagtgca gagacggggc tcactgccgc
      661 cacggcaggt ccccaggggc gaggtcttcc ggccccaccg gtggcacctg aagcacttgg
      721 agcccgtgga tttcctgggc aaggccaagg tggtggcctc tgccatcccc gacgaccagg
      781 gctggggcgt ccgccctcag cagccacagg gaccaggagc gaaccatgat gccaggtccc
      841 taatcatgga ctccccaaga gctggcaccc accagggccc cctcgatgca gagacagagg
      901 tcggtgctga ccgctgcacg tcgactgcct accaggagca gaggccccag gtggagcaag
      961 ttggcaaaca ggctcctctc tccccagggc tgccggcaat gggggggcct ggccccggcc
     1021 cctgtgagga ccccgcgggt gctgggggag caggtgcagg gggctccgag cccctggtga
     1081 ctgtcaccgt gcagtgcgcc ttcacagtgg ccctgagggc acgaagagga gccgacctgt
     1141 ccagcctgcg ggcactgctg ggccaagccc tccctcacca ggcccagctt gggcaactca
     1201 gttacctagc cccaggtgag gacgggcact gggtccccat ccccgaggag gagtcgctgc
     1261 agagggcctg gcaggacgca gctgcctgcc ccagggggct gcagctgcag tgcaggggag
     1321 ccgggggtcg gccggtcctc taccaggtgg tggcccagca cagctactcc gcccaggggc
     1381 cagaggacct gggcttccga cagggggaca cggtggacgt cctgtgtgaa gtggaccagg
     1441 catggctgga gggccactgt gacggccgca tcggcatctt ccccaagtgc ttcgtggtcc
     1501 ccgccggccc tcggatgtca ggagcccccg gccgcctgcc ccgatcccag cagggagatc
     1561 agccctaatg atgctgtgtc catgatgctt ttaataaaaa caacccccac tgca
//
