LOCUS       NM_024505               8405 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens NADPH oxidase 5 (NOX5), transcript variant 1, mRNA.
ACCESSION   NM_024505
VERSION     NM_024505.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8405)
  AUTHORS   Song,H.K., Kim,J.M., Noh,E.M., Youn,H.J. and Lee,Y.R.
  TITLE     Role of NOX1 and NOX5 in protein kinase C/reactive oxygen
            species-mediated MMP-9 activation and invasion in MCF-7 breast
            cancer cells
  JOURNAL   Mol Med Rep 30 (4) (2024)
   PUBMED   39219290
  REMARK    GeneRIF: Role of NOX1 and NOX5 in protein kinase C/reactive oxygen
            species-mediated MMP-9 activation and invasion in MCF-7 breast
            cancer cells.
REFERENCE   2  (bases 1 to 8405)
  AUTHORS   Cui,C., Jiang,M., Jain,N., Das,S., Lo,Y.H., Kermani,A.A.,
            Pipatpolkai,T. and Sun,J.
  TITLE     Structural basis of human NOX5 activation
  JOURNAL   Nat Commun 15 (1), 3994 (2024)
   PUBMED   38734761
  REMARK    GeneRIF: Structural basis of human NOX5 activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8405)
  AUTHORS   Garcia,J.G., Ansorena,E., Izal,I., Zalba,G., de Miguel,C. and
            Milagro,F.I.
  TITLE     Structure, regulation, and physiological functions of NADPH oxidase
            5 (NOX5)
  JOURNAL   J Physiol Biochem 79 (2), 383-395 (2023)
   PUBMED   36905456
  REMARK    GeneRIF: Structure, regulation, and physiological functions of
            NADPH oxidase 5 (NOX5).
            Review article
REFERENCE   4  (bases 1 to 8405)
  AUTHORS   Miyano,K. and Kajikawa,M.
  TITLE     Ca2+ -binding-region-dependent cell surface localization of NADPH
            oxidase Nox5
  JOURNAL   FEBS Lett 597 (5), 702-713 (2023)
   PUBMED   36653838
  REMARK    GeneRIF: Ca[2+] -binding-region-dependent cell surface localization
            of NADPH oxidase Nox5.
REFERENCE   5  (bases 1 to 8405)
  AUTHORS   Jiang,Z., Wu,L., van der Leeden,B., van Rossum,A.C., Niessen,H.W.M.
            and Krijnen,P.A.J.
  TITLE     NOX2 and NOX5 are increased in cardiac microvascular endothelium of
            deceased COVID-19 patients
  JOURNAL   Int J Cardiol 370, 454-462 (2023)
   PUBMED   36332749
  REMARK    GeneRIF: NOX2 and NOX5 are increased in cardiac microvascular
            endothelium of deceased COVID-19 patients.
REFERENCE   6  (bases 1 to 8405)
  AUTHORS   Brar,S.S., Corbin,Z., Kennedy,T.P., Hemendinger,R., Thornton,L.,
            Bommarius,B., Arnold,R.S., Whorton,A.R., Sturrock,A.B.,
            Huecksteadt,T.P., Quinn,M.T., Krenitsky,K., Ardie,K.G.,
            Lambeth,J.D. and Hoidal,J.R.
  TITLE     NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145
            prostate cancer cells
  JOURNAL   Am J Physiol Cell Physiol 285 (2), C353-C369 (2003)
   PUBMED   12686516
REFERENCE   7  (bases 1 to 8405)
  AUTHORS   Moskwa,P., Dagher,M.C., Paclet,M.H., Morel,F. and Ligeti,E.
  TITLE     Participation of Rac GTPase activating proteins in the deactivation
            of the phagocytic NADPH oxidase
  JOURNAL   Biochemistry 41 (34), 10710-10716 (2002)
   PUBMED   12186557
  REMARK    GeneRIF: we propose that the GTP-bound active form of Rac is
            required for sustained enzyme activity and that membrane-localized
            GAPs have a role in the deactivation of NADPH oxidase
REFERENCE   8  (bases 1 to 8405)
  AUTHORS   Armstrong,J.S., Bivalacqua,T.J., Chamulitrat,W., Sikka,S. and
            Hellstrom,W.J.
  TITLE     A comparison of the NADPH oxidase in human sperm and white blood
            cells
  JOURNAL   Int J Androl 25 (4), 223-229 (2002)
   PUBMED   12121572
  REMARK    GeneRIF: Reactive oxygen species producing activity of NOX5 in
            sperm and NADPH-oxidase of white blood cells; role of protein
            kinase C in NOX5 activation
REFERENCE   9  (bases 1 to 8405)
  AUTHORS   Banfi,B., Molnar,G., Maturana,A., Steger,K., Hegedus,B.,
            Demaurex,N. and Krause,K.H.
  TITLE     A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes
  JOURNAL   J Biol Chem 276 (40), 37594-37601 (2001)
   PUBMED   11483596
  REMARK    GeneRIF: NOX5 is likely to be involved in Ca(2+)-activated,
            redox-dependent processes of spermatozoa and lymphocytes such as
            sperm-oocyte fusion, cell proliferation, and cytokine secretion.
REFERENCE   10 (bases 1 to 8405)
  AUTHORS   Cheng,G., Cao,Z., Xu,X., van Meir,E.G. and Lambeth,J.D.
  TITLE     Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4,
            and Nox5
  JOURNAL   Gene 269 (1-2), 131-140 (2001)
   PUBMED   11376945
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA868876.1, AF353089.1,
            DQ413001.1, AC027088.8 and AI091544.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_024505.3.
            
            Transcript Variant: This variant (1, alternately referred to as
            NOX5 gamma and v3) encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF353089.1, AK314689.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000388866.8/ ENSP00000373518.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DA868876.1         1-21
            22-859              AF353089.1         1-838
            860-1028            DQ413001.1         219-387
            1029-2376           AF353089.1         1008-2355
            2377-2390           AC027088.8         58257-58270         c
            2391-2804           AI091544.1         6-419               c
            2805-8405           AC027088.8         52242-57842         c
FEATURES             Location/Qualifiers
     source          1..8405
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q23"
     gene            1..8405
                     /gene="NOX5"
                     /note="NADPH oxidase 5"
                     /db_xref="GeneID:79400"
                     /db_xref="HGNC:HGNC:14874"
                     /db_xref="MIM:606572"
     exon            1..91
                     /gene="NOX5"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..2339
                     /gene="NOX5"
                     /note="isoform 1 is encoded by transcript variant 1; NADPH
                     oxidase, EF-hand calcium binding domain 5"
                     /codon_start=1
                     /product="NADPH oxidase 5 isoform 1"
                     /protein_id="NP_078781.3"
                     /db_xref="CCDS:CCDS32276.2"
                     /db_xref="GeneID:79400"
                     /db_xref="HGNC:HGNC:14874"
                     /db_xref="MIM:606572"
                     /translation="MNTSGDPAQTGPEGCRGTMSAEEDARWLRWVTQQFKTIAGEDGE
                     ISLQEFKAALHVKESFFAERFFALFDSDRSGTITLQELQEALTLLIHGSPMDKLKFLF
                     QVYDIDVCARQGASAGTEWGAGAGPHWASSPLGTGSGSIDPDELRTVLQSCLRESAIS
                     LPDEKLDQLTLALFESADADGNGAITFEELRDELQRFPGVMENLTISAAHWLTAPAPR
                     PRPRRPRQLTRAYWHNHRSQLFCLATYAGLHVLLFGLAASAHRDLGASVMVAKGCGQC
                     LNFDCSFIAVLMLRRCLTWLRATWLAQVLPLDQNIQFHQLMGYVVVGLSLVHTVAHTV
                     NFVLQAQAEASPFQFWELLLTTRPGIGWVHGSASPTGVALLLLLLLMFICSSSCIRRS
                     GHFEVFYWTHLSYLLVWLLLIFHGPNFWKWLLVPGILFFLEKAIGLAVSRMAAVCIME
                     VNLLPSKVTHLLIKRPPFFHYRPGDYLYLNIPTIARYEWHPFTISSAPEQKDTIWLHI
                     RSQGQWTNRLYESFKASDPLGRGSKRLSRSVTMRKSQRSSKGSEILLEKHKFCNIKCY
                     IDGPYGTPTRRIFASEHAVLIGAGIGITPFASILQSIMYRHQKRKHTCPSCQHSWIEG
                     VQDNMKLHKVDFIWINRDQRSFEWFVSLLTKLEMDQAEEAQYGRFLELHMYMTSALGK
                     NDMKAIGLQMALDLLANKEKKDSITGLQTRTQPGRPDWSKVFQKVAAEKKGKVQVFFC
                     GSPALAKVLKGHCEKFGFRFFQENF"
     exon            92..215
                     /gene="NOX5"
                     /inference="alignment:Splign:2.1.0"
     exon            216..366
                     /gene="NOX5"
                     /inference="alignment:Splign:2.1.0"
     exon            367..661
                     /gene="NOX5"
                     /inference="alignment:Splign:2.1.0"
     exon            662..896
                     /gene="NOX5"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1050
                     /gene="NOX5"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1229
                     /gene="NOX5"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1412
                     /gene="NOX5"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1545
                     /gene="NOX5"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1688
                     /gene="NOX5"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1733
                     /gene="NOX5"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1858
                     /gene="NOX5"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1940
                     /gene="NOX5"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2040
                     /gene="NOX5"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2207
                     /gene="NOX5"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..8405
                     /gene="NOX5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2745..2750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOX5"
                     /note="hexamer: TATAAA"
     polyA_site      2764
                     /gene="NOX5"
                     /note="major polyA site"
     regulatory      6110..6115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOX5"
                     /note="hexamer: TATAAA"
     polyA_site      6131
                     /gene="NOX5"
     regulatory      6788..6793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOX5"
                     /note="hexamer: AGTAAA"
     regulatory      6793..6798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOX5"
                     /note="hexamer: AACAAA"
     polyA_site      6810
                     /gene="NOX5"
     polyA_site      6827
                     /gene="NOX5"
     regulatory      8373..8378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOX5"
                     /note="hexamer: AATAAA"
     polyA_site      8405
                     /gene="NOX5"
ORIGIN      
        1 agcagtcttt ctgggacctg tgatctagaa gacaggagaa gatgaacaca tctggagacc
       61 cagcccagac gggccctgaa ggctgtagag gcaccatgag tgccgaggag gatgccaggt
      121 ggctccggtg ggtgactcag cagtttaaga ccattgcagg agaagatggg gagatcagcc
      181 tgcaagaatt caaagcagct ctgcatgtga aagagtcctt ctttgcagag cgattctttg
      241 ccctatttga ctccgataga agtggcacca tcaccctcca ggagctgcag gaggcactga
      301 ccctgctcat ccatggcagc cccatggaca aactcaaatt cctcttccag gtgtatgaca
      361 tcgatgtgtg tgcacggcag ggggcgtctg caggtacaga gtggggtgct ggggcaggcc
      421 cgcactgggc ttcatcccca ctcgggacag gcagtggctc cattgacccg gatgagctgc
      481 gcactgtgct gcagtcgtgt ctgcgcgaga gcgccatctc gctgcctgac gagaagctgg
      541 accagctgac gctggcgctc ttcgaatcgg ccgacgcgga cggcaacggg gccatcacct
      601 tcgaggagct ccgggacgag ctgcagcgct tccccggagt catggagaac ctgaccatca
      661 gcgctgccca ctggctgacg gcccccgccc cccgcccacg cccgcgccgg ccgcgccagc
      721 tgacccgcgc ctactggcac aaccaccgca gccagctgtt ctgcctggcc acctatgcag
      781 gcctccacgt gctgctcttc gggctggcgg ccagcgcgca ccgggacctc ggcgccagcg
      841 tcatggtggc caagggctgc ggccagtgcc tcaacttcga ctgcagcttc atcgcggtgc
      901 tgatgctcag acgctgcctc acctggctgc gggccacgtg gctggctcaa gtcctaccac
      961 tggaccagaa catccagttc caccagctta tgggctacgt ggtagtgggg ctgtccctcg
     1021 tgcacaccgt ggctcacact gtgaactttg tactccaggc tcaggcggag gccagccctt
     1081 tccagttctg ggagctgctg ctcaccacga ggcctggcat tggctgggta cacggttcgg
     1141 cctccccgac aggtgtcgct ctgctgctgc tgctcctcct catgttcatc tgctccagtt
     1201 cctgcatccg caggagtggc cactttgagg tgttctattg gactcacctg tcctacctcc
     1261 tcgtgtggct tctgctcatc tttcatgggc ccaacttctg gaagtggctg ctggtgcctg
     1321 gaatcttgtt tttcctggag aaggccatcg gactggcagt gtcccgcatg gcagccgtgt
     1381 gcatcatgga agtcaacctc ctcccctcca aggtcactca tctcctcatc aagcggcccc
     1441 ctttttttca ctatagacct ggtgactact tgtatctgaa catccccacc attgctcgct
     1501 atgagtggca ccccttcacc atcagcagtg ctcctgagca gaaagacact atctggctgc
     1561 acattcggtc ccaaggccag tggacaaaca ggctgtatga gtccttcaag gcatcagacc
     1621 cactgggccg tggttctaag aggctgtcga ggagtgtgac aatgagaaag agtcaaaggt
     1681 cgtccaaggg ctctgagata cttttggaga aacacaaatt ctgtaacatc aagtgctaca
     1741 tcgatgggcc ttatgggacc cccacccgca ggatctttgc ctctgagcat gccgtgctca
     1801 tcggggcagg catcggcatc accccctttg cttccattct gcagagtatc atgtacaggc
     1861 accagaaaag aaagcatact tgccccagct gccagcactc ctggatcgaa ggtgtccaag
     1921 acaacatgaa gctccataag gtggacttta tctggatcaa cagagaccag cggtctttcg
     1981 agtggtttgt gagcctgctg actaaactgg agatggacca ggccgaggag gctcaatacg
     2041 gccgcttcct ggagctgcat atgtacatga catctgcact gggcaagaat gacatgaagg
     2101 ccattggcct gcagatggcc cttgacctcc tggccaacaa ggagaagaaa gactccatca
     2161 cggggctgca gacgcgcacc cagcctgggc ggcctgactg gagcaaggtg ttccagaaag
     2221 tggctgctga gaagaagggc aaggtgcagg tcttcttctg tggctcccca gctctggcca
     2281 aggtgctgaa gggccattgt gagaagttcg gcttcagatt tttccaagag aatttctagc
     2341 ctcacctctc caagctctgc cccaagtcca caccatgggt ctgcttcatt gcattagtat
     2401 aaatgccccc acagggacca gcctcagatg acccacccaa taagacaaag cctagggacc
     2461 ccctaatcct gctcaacaga gagaacagga gaccccaagg ggcagatgaa cttcctctag
     2521 aacccagggg aagggacagt gccttgttca gtctgctgta gattctgggg tttctgtgaa
     2581 agtgagggaa ccagaggctg gtcacgggag cttgggggtg gggttcgagg gggcagaggg
     2641 caaccactcc tccaaacatt ttccgacgga gccttccccc acatccatgg tcccaaacct
     2701 gcccaatcat cacagtcatt tggaagctta tttctccggc atcttataaa attgttcaaa
     2761 cctacaaaaa gtgagaagaa tcatacagtg aacagtgtta cctactttct agactcctca
     2821 gttaataatt tgctctgttt atcacatatt atccatcagt tcctcctccc tctttccatc
     2881 tgtcaattta tctgattttt tggatgcatt ttcaagttag gtgcaaatat ctcagcacac
     2941 cttgctactt ggaggagcct tcttcaaatg cacattcctt ggtcccacta ccagaaattc
     3001 tgattctgat gatctgggaa tgaaacctga aatatgtatt ttccaccaaa tccatttgca
     3061 tagggagaaa taagcagcat ctttccctgc ccctccttgt gtctttgtct ccccatctcc
     3121 ctctctcctg gcgcgtccct cagagcctct ctgggctctg tatgctggcc tcttccttct
     3181 ctctgtgtgc tgagtcgctt gagaaacagg atggagacag cctctttgtg tgcctctctc
     3241 tgtcgtggaa aggccaagtg cctggggatg aagcgggcta agcctggaag ctcagctcag
     3301 ccacactctg gctgtgtggc cctggaagct tccccatgtc tgttattttc atctgtgaaa
     3361 taagctgatg ccatccgtca gtcacagttg ctgtgaggtg acatgagacg ccaagtgctc
     3421 aagacattcc acctcagttc agctccttgc tgctccaggc tttcgtgcat ctacatcatt
     3481 tctctttatc ctggctccct ctgtctctgt tttccagcct ctgtttgcgt ctgtccctgt
     3541 ctgggcagga gggaacagca gaggcagcaa aggctctctc agcacatact gtggggagga
     3601 gcggccctgg gcagaggaca gggtgggcct cacctcctcc atctgagctg gacatttcca
     3661 tctgtgccac accatgagct cctgtgagcc ccacatttcc tgggcatcct ccaccttgca
     3721 gtcagtcctg ataggttctc ttcttgacag tgtaaagcac ccttccccaa ggctgccatc
     3781 atggggttgg aaccaggcac tttccaatgg gattgtagct ggcacctttc ttttccatgg
     3841 gttggaagtc catggttgca aagggggagg taaagaagcc ggatcataac ctggatgatg
     3901 atgtccctta tctaaggtgg ggctgggatg cagcagtagg ggtgggtgtg acctgcaggg
     3961 gatgagccag ttgggtggat ggaagaatga aggtggggga aagctctctt ctgaaagggg
     4021 caataggaag gggatggtgg aggaagacgc tgaggcaggc cctgggaagg ggaaggcaaa
     4081 acataccctg aggactggga cagagcagga tgggagtgag gatgtcatct ttaagatgtg
     4141 aggaggaacg ggaagaagaa tacgagagga ggagtggggc ctgcagtcaa ggagaggcta
     4201 attcggtttg ggtgggtgga aagcggggct cgtgcttgca ccaagcctcc atctccctgg
     4261 actgggagtc agcaaggcca ggagacctgg tgttggggcc ttccaaccag atcgtgttta
     4321 atttccagca agcctgggga ggcacacaac tcaccaggga aactcacacc tggagtttta
     4381 ccagcctgag gccacacact cttggaacct ctttccctct gttgagtctg tactttcccc
     4441 tcttcatcag gcttgggaag gcttggacaa aacgctctct ggggcacaga aggaaactaa
     4501 agagggtgtt ctgacttaag gttggaggat gtaaacaggc tgtgccaaat catttggaaa
     4561 cgtggcagaa tctgtttagc acaggatgtc tcacacatgc actcaatgca cacacacaca
     4621 tgcatgtcac cgttttggat tctttcccat ctctgtctac accgccttaa cacatttgag
     4681 ccctgccctc agtcctttgc cctctcgtaa cagatttcca ccaggctccc acccgcatat
     4741 acaaatagtc agctgttcgt ttaggactta ataatatagt gggtgggagc aggtggaagg
     4801 acttggacat acgattctaa aatccgtgaa tgcccacatg tgtgacgacc atatgcccgt
     4861 gtcctgaggt tttctctcca gacagattcc agttgcccac gagagggcgc tgcagaatca
     4921 cggatctcaa gcgggtttgt ttcccaggaa gtgagactgg tccgtgagtg gcagttaatc
     4981 aaagggaaag gggctgggaa gacaacgccc tgttccaaag ctccccacta gaggcaaaac
     5041 ctccaggctc catctctgtg aagtcaagag acttcatgtt caaggtcagt ttctctagct
     5101 ggcagcttct cactgccgct gccttccccc agaaactcta ccctccccat acccagtgtc
     5161 cagttctggg ctttcctctt ttctgcttgc aacaaaatgt ccatcggtga ggtcaagttg
     5221 aactgaacag gcctggcttg gggagagttc acaggtccag gttctgtctg cctcggtgga
     5281 catgtcatcg aaggcagcag gaccacacat gtgagtgtac agcacgcatg gtctgaccat
     5341 ctggatgttt cccagatgtg cagatgggca tcatcggcca tcaacaggaa aatgcatccg
     5401 gatgactggc tgacttttct tctctcacca gatgttgcca atgctgtaga aacatctggg
     5461 cccacgacag ataaggctga cacatgcaaa gagaagagag aaggagcaag gccagttatc
     5521 ggcacgtgtg cccatcctcc cccatgaagc tgcaaactcc ccaaggccag acatggggac
     5581 ccaaagccta gcacagagtg tagaccagat gtcggttcct cccagggcaa ggggttactt
     5641 aaatggaatt atccttacaa agagtctttt gcacctaatt gtcacttgta atttggggaa
     5701 caaaagcaca aacacaagcc cactgaacca ctttgccagg tgccattgca ctgttctgtg
     5761 aggacagcgc tgacggagac agcaggcatt cctgaaatga ccaatcaggc agggccctcc
     5821 tggacgagcg gcacaagtgc aggctattaa tacactgagc tggggcattc gtgggagggg
     5881 agggggcatg ggcaacatgg agagtcacca ggctggcaga caaggttgaa ggtagggagg
     5941 gatgaggaac attagccgag actggctctg ggccaacctg ttggagacac agtggacaaa
     6001 cctttgccct ctgggaggca gggcactgag tcctacactt gcctctgcca cagtctgctg
     6061 tgtgaccttg ggtgtatcat ttgacctctc tgagttctca ctttcttatt ataaagtgaa
     6121 cagatcaagt atgtatgcgt ttaagcactt gtcatttcta aaaggataca tgaaagtata
     6181 tttatctgtg tgctctgggg agtgggaatg gagggataca atgaaggaaa ggattttgtg
     6241 tttttgtttt tgttttactt tttgcccttc tgtaaagttt aagtttttat taatattata
     6301 gttttatttt aaaaagaaac cccaaatagg atgtcatgta aaagaaaaga aaaaacaagt
     6361 accaagtgtt tgatataatc ctatttataa cacagaaaat aaatgacata tgtatatcat
     6421 gtggggataa atagataaaa atacacggaa agacagttag aagccagcct taatctgtct
     6481 tgggcccaga cagcccttat ctgttggggg cccagatgtg tctacagcat tgttaacatc
     6541 tggtgaaagg agaaaagtca gccagccatc ctgatgcgtt ttcttgctga tggccgatga
     6601 tgcccaaatg ctaagcagtt cgcagtggtt aactgtggag gaggcaaagg aggacttgaa
     6661 tgttttcctc ttatctgttt cctgtatttg tgtgttacct gagtaaggtt tcacttcctg
     6721 tattactcat gtgatatttt actttttaat ttatgtactt ttgtatggct tgtatctatt
     6781 ttttaagagt aaaacaaaat gcagagatta tctgcagtgt tgtctaagat cctgaatatt
     6841 gatttggtat caagtgaaag tatttcgggc ctaagccagg ggactggccc tccccgtcag
     6901 gggtcactcc gtgggctctt caataaggga ggctcctata gtgcccatta tcaatatgct
     6961 gctggccctg aatggcctaa gtattaaaat aaaatgccct gtctaggccc aaaactagtc
     7021 cagaaggact gtggaggccg tgggcataca cgtgaaattg tgtgcacagg ggctaagccc
     7081 agcaccagcc cagcctggga gttgagatgc ctcagggcac actgtctgtg ctaaacaaat
     7141 actcatatta accagccttc ctgacagatt gatgcatctt tttatgatct gtctttacaa
     7201 tatgatgact ctctcctttt aaaaataaga ttaattcaga caagacattt attttatgag
     7261 gaaattcatc ccagggggaa aaatactcaa cctgaatggc agaaatggct ggaaagagac
     7321 ttgactctca aggaagcttc cagcctccaa ccttagccac ccagccatgg ccccaaaagg
     7381 gctgccctaa tactactcag ggacaaatgg gccctcttaa actaccctag ctgtgtgagt
     7441 gtagcctgct ggagaaacaa agaaagacag gtagtgagtt ttagtgtggc agggaagaaa
     7501 aggatgcatt ttttggtaaa ggaaaaaaaa attctgagat ttacccaaat ttggctggac
     7561 atgagtttat aaatacagat taagcttgtc tttaaataac cctaaagaat gttcaagaac
     7621 agtgaatgat ttgtctctgt gtccccagtg actagaatag cgtcaccacc tagtaggtgc
     7681 ttggcgtgtt tcatgaatgt ttccactgct atggtctgtt tcagctggtg accccatgag
     7741 gtacccttgg ctcctctatc tcccccatct tcctccttca gccaatcatc aagcctgtca
     7801 acatggcatt ctaaatgctt ctcaagcaca tttccttccc cactggccct gccttggttc
     7861 agtccttaaa ttgcctattg cctgaattgg tgcatcagag acaggctgga gaaaggaaga
     7921 ccagttagcc agaaaggaag cttggaagac cacccagcta actggtcttc ctttctccag
     7981 cctggctctg atccatcctc cacacactgc tgtgggtctg actgcacacc ttctttttgg
     8041 aggactctcc tattatagcc atcaaactcc tgagtctgct acacaaggcc cccccaacat
     8101 aagccctaga tgaagatctg ctaccattac agccagtatt acctggccct tgcctacctc
     8161 tcaggtcttg gcaatgtcca ccttgctttt tttactttaa atagcatcat ttcgtgctcc
     8221 cccaggacac tgtgcagctt cgcacctcca agcctttgct tctgcatcgc ctgacacttg
     8281 gagcaccctt ctccactttc agattgagac ttcggaacac tttatcatca gcctatctgt
     8341 aaagacttcc ttgctggtcc ctcccatcgc agaataaaca gcctgctccg taggattgta
     8401 ctgta
//
