LOCUS       NM_015718               1980 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens NADPH oxidase 3 (NOX3), mRNA.
ACCESSION   NM_015718
VERSION     NM_015718.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1980)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1980)
  AUTHORS   Zhao,T., Wang,Y., Li,Z., Xu,X., Lei,S., Huang,L., Xu,L., Zhang,M.
            and Yang,L.
  TITLE     Associations of noise kurtosis, genetic variations in NOX3 and
            lifestyle factors with noise-induced hearing loss
  JOURNAL   Environ Health 19 (1), 13 (2020)
   PUBMED   32014026
  REMARK    GeneRIF: Associations of noise kurtosis, genetic variations in NOX3
            and lifestyle factors with noise-induced hearing loss.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1980)
  AUTHORS   Yin,C., Li,K., Yu,Y., Huang,H., Yu,Y., Wang,Z., Yan,J., Pu,Y.,
            Li,Z., Li,D., Chen,P. and Chen,F.
  TITLE     Genome-wide association study identifies loci and candidate genes
            for non-idiopathic pulmonary hypertension in Eastern Chinese Han
            population
  JOURNAL   BMC Pulm Med 18 (1), 158 (2018)
   PUBMED   30290780
  REMARK    GeneRIF: The results suggested that rs6557421 variant in Nox3 and
            rs3744439 variant in Tbx4 might have potential effect on individual
            susceptibility to pulmonary hypertension.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1980)
  AUTHORS   Plantinga,T.S., Arts,P., Knarren,G.H., Mulder,A.H., Wakelkamp,I.M.,
            Hermus,A.R., Joosten,L.A., Netea,M.G., Bisschop,P.H., de
            Herder,W.W., Beijers,H.J., de Bruin,I.J., Gilissen,C.,
            Veltman,J.A., Hoischen,A., Smit,J.W. and Netea-Maier,R.T.
  TITLE     Rare NOX3 Variants Confer Susceptibility to Agranulocytosis During
            Thyrostatic Treatment of Graves' Disease
  JOURNAL   Clin Pharmacol Ther 102 (6), 1017-1024 (2017)
   PUBMED   28486791
  REMARK    GeneRIF: genetic variants in NOX3 may confer susceptibility to
            antithyroid drug-induced apoptosis of granulocytes.
REFERENCE   5  (bases 1 to 1980)
  AUTHORS   Cantu,E., Shah,R.J., Lin,W., Daye,Z.J., Diamond,J.M., Suzuki,Y.,
            Ellis,J.H., Borders,C.F., Andah,G.A., Beduhn,B., Meyer,N.J.,
            Ruschefski,M., Aplenc,R., Feng,R. and Christie,J.D.
  CONSRTM   Lung Transplant Outcomes Group Investigators
  TITLE     Oxidant stress regulatory genetic variation in recipients and
            donors contributes to risk of primary graft dysfunction after lung
            transplantation
  JOURNAL   J Thorac Cardiovasc Surg 149 (2), 596-602 (2015)
   PUBMED   25439478
  REMARK    GeneRIF: In lung transplants, our study highlights a
            donor-recipient interaction of NOX3 and NFE2L2 that increases the
            risk of PGD.
REFERENCE   6  (bases 1 to 1980)
  AUTHORS   Ueno,N., Takeya,R., Miyano,K., Kikuchi,H. and Sumimoto,H.
  TITLE     The NADPH oxidase Nox3 constitutively produces superoxide in a
            p22phox-dependent manner: its regulation by oxidase organizers and
            activators
  JOURNAL   J Biol Chem 280 (24), 23328-23339 (2005)
   PUBMED   15824103
  REMARK    GeneRIF: Nox3 functions together with p22(phox) as an enzyme
            constitutively producing superoxide
REFERENCE   7  (bases 1 to 1980)
  AUTHORS   Cheng,G., Ritsick,D. and Lambeth,J.D.
  TITLE     Nox3 regulation by NOXO1, p47phox, and p67phox
  JOURNAL   J Biol Chem 279 (33), 34250-34255 (2004)
   PUBMED   15181005
  REMARK    GeneRIF: Nox3 is regulated by NOXO1, p47phox, and p67phox
REFERENCE   8  (bases 1 to 1980)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   9  (bases 1 to 1980)
  AUTHORS   Cheng,G., Cao,Z., Xu,X., van Meir,E.G. and Lambeth,J.D.
  TITLE     Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4,
            and Nox5
  JOURNAL   Gene 269 (1-2), 131-140 (2001)
   PUBMED   11376945
REFERENCE   10 (bases 1 to 1980)
  AUTHORS   Kikuchi,H., Hikage,M., Miyashita,H. and Fukumoto,M.
  TITLE     NADPH oxidase subunit, gp91(phox) homologue, preferentially
            expressed in human colon epithelial cells
  JOURNAL   Gene 254 (1-2), 237-243 (2000)
   PUBMED   10974555
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031773.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_015718.2.
            
            Summary: This gene encodes a member of the NOX family of NADPH
            oxidases. These enzymes have the capacity to generate superoxide
            and other reactive oxygen species (ROS) and transport electrons
            across the plasma membrane. The ROS generated by family members
            have been implicated in numerous biological functions including
            host defense, posttranlational processing of proteins, cellular
            signaling, regulation of gene expression, and cell differentiation.
            The protein encoded by this gene is expressed predominantly in the
            inner ear and is involved in the biogenesis of otoconia/otolith,
            which are crystalline structures of the inner ear involved in the
            perception of gravity.[provided by RefSeq, May 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF190122.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2142680,
                                           SAMEA2144333 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000159060.3/ ENSP00000159060.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AL031773.1         83725-83811         c
            88-183              AL031773.1         83006-83101         c
            184-294             AL031773.1         82783-82893         c
            295-379             AL031773.1         81376-81460         c
            380-525             AL031773.1         71245-71390         c
            526-707             AL031773.1         67928-68109         c
            708-837             AL031773.1         64390-64519         c
            838-930             AL031773.1         58815-58907         c
            931-1184            AL031773.1         56766-57019         c
            1185-1347           AL031773.1         50666-50828         c
            1348-1494           AL031773.1         39186-39332         c
            1495-1619           AL031773.1         35102-35226         c
            1620-1773           AL031773.1         24781-24934         c
            1774-1980           AL031773.1         23340-23546         c
FEATURES             Location/Qualifiers
     source          1..1980
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     gene            1..1980
                     /gene="NOX3"
                     /gene_synonym="GP91-3; MOX-2"
                     /note="NADPH oxidase 3"
                     /db_xref="GeneID:50508"
                     /db_xref="HGNC:HGNC:7890"
                     /db_xref="MIM:607105"
     exon            1..87
                     /gene="NOX3"
                     /gene_synonym="GP91-3; MOX-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1746
                     /gene="NOX3"
                     /gene_synonym="GP91-3; MOX-2"
                     /note="NADPH oxidase catalytic subunit-like 3; gp91phox
                     homolog 3; mitogenic oxidase 2"
                     /codon_start=1
                     /product="NADPH oxidase 3"
                     /protein_id="NP_056533.1"
                     /db_xref="CCDS:CCDS5250.1"
                     /db_xref="GeneID:50508"
                     /db_xref="HGNC:HGNC:7890"
                     /db_xref="MIM:607105"
                     /translation="MMGCWILNEGLSTILVLSWLGINFYLFIDTFYWYEEEESFHYTR
                     VILGSTLAWARASALCLNFNCMLILIPVSRNLISFIRGTSICCRGPWRRQLDKNLRFH
                     KLVAYGIAVNATIHIVAHFFNLERYHWSQSEEAQGLLAALSKLGNTPNESYLNPVRTF
                     PTNTTTELLRTIAGVTGLVISLALVLIMTSSTEFIRQASYELFWYTHHVFIVFFLSLA
                     IHGTGRIVRGQTQDSLSLHNITFCRDRYAEWQTVAQCPVPQFSGKEPSAWKWILGPVV
                     LYACERIIRFWRFQQEVVITKVVSHPSGVLELHMKKRGFKMAPGQYILVQCPAISSLE
                     WHPFTLTSAPQEDFFSVHIRAAGDWTAALLEAFGAEGQALQEPWSLPRLAVDGPFGTA
                     LTDVFHYPVCVCVAAGIGVTPFAALLKSIWYKCSEAQTPLKLSKVYFYWICRDARAFE
                     WFADLLLSLETRMSEQGKTHFLSYHIFLTGWDENQALHIALHWDENTDVITGLKQKTF
                     YGRPNWNNEFKQIAYNHPSSSIGVFFCGPKALSRTLQKMCHLYSSADPRGVHFYYNKE
                     SF"
     exon            88..183
                     /gene="NOX3"
                     /gene_synonym="GP91-3; MOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            184..294
                     /gene="NOX3"
                     /gene_synonym="GP91-3; MOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            295..379
                     /gene="NOX3"
                     /gene_synonym="GP91-3; MOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            380..525
                     /gene="NOX3"
                     /gene_synonym="GP91-3; MOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            526..707
                     /gene="NOX3"
                     /gene_synonym="GP91-3; MOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..837
                     /gene="NOX3"
                     /gene_synonym="GP91-3; MOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            838..930
                     /gene="NOX3"
                     /gene_synonym="GP91-3; MOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1184
                     /gene="NOX3"
                     /gene_synonym="GP91-3; MOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1347
                     /gene="NOX3"
                     /gene_synonym="GP91-3; MOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1494
                     /gene="NOX3"
                     /gene_synonym="GP91-3; MOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1619
                     /gene="NOX3"
                     /gene_synonym="GP91-3; MOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1773
                     /gene="NOX3"
                     /gene_synonym="GP91-3; MOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1980
                     /gene="NOX3"
                     /gene_synonym="GP91-3; MOX-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaagaaat ttcctgacag ccgaagagca acaagtatca tgatggggtg ctggattttg
       61 aatgagggtc tctccaccat attagtactc tcatggctgg gaataaattt ttatctgttt
      121 attgacacgt tctactggta tgaagaggag gagtctttcc attacacacg agttattttg
      181 ggttcaacac tggcttgggc acgagcatcc gcactgtgcc tgaattttaa ctgcatgcta
      241 attctaatac ctgtcagtcg aaaccttatt tcattcataa gaggaacaag tatttgctgc
      301 agaggaccgt ggaggaggca attagacaaa aacctcagat ttcacaaact ggtcgcctat
      361 gggatagctg ttaatgcaac catccacatc gtggcgcatt tcttcaacct ggaacgctac
      421 cactggagcc agtccgagga ggcccaggga cttctggccg cactttccaa gctgggcaac
      481 acccctaacg agagctacct caaccctgtc cggaccttcc ccacaaacac aaccactgaa
      541 ttgctaagga caatagcagg cgtcaccggt ctggtgatct ctctggcttt agtcttgatc
      601 atgacctcgt caactgagtt catcagacag gcctcctatg agttgttctg gtacacacac
      661 catgttttca tcgtcttctt tctcagcctg gccatccatg ggacgggtcg gattgttcga
      721 ggccaaaccc aagacagtct ctctctgcac aacatcacct tctgtagaga ccgctatgca
      781 gaatggcaga cagtggccca atgccccgtg cctcaatttt ctggcaagga accctcggct
      841 tggaaatgga ttttaggccc tgtggtcttg tatgcatgtg aaagaataat taggttctgg
      901 cgatttcaac aagaagttgt cattaccaag gtggtaagcc acccctctgg agtcctggaa
      961 cttcacatga aaaagcgtgg ctttaaaatg gcgccagggc agtacatctt ggtgcagtgc
     1021 ccagccatat cttcgctgga gtggcacccc ttcaccctta cctctgcccc ccaggaggac
     1081 tttttcagcg tgcacatccg ggcagcagga gactggacag cagcgctact ggaggccttt
     1141 ggggcagagg gacaggccct ccaggagccc tggagcctgc caaggctggc agtggacggg
     1201 ccctttggaa ctgccctgac agatgtattt cactacccag tgtgtgtgtg cgttgccgcg
     1261 gggatcggag tcactccctt cgctgctctt ctgaaatcta tatggtacaa atgcagtgag
     1321 gcacagaccc cactgaagct gagcaaggtg tatttctact ggatttgccg ggatgcaaga
     1381 gcttttgagt ggtttgctga tctcttactc tccctggaaa cacggatgag tgagcagggg
     1441 aaaactcact ttctgagtta tcatatattt cttaccggct gggatgaaaa tcaggctctt
     1501 cacatagctt tacactggga cgaaaatact gacgtgatta caggcttaaa gcagaagacc
     1561 ttctatggga ggcccaactg gaacaatgag ttcaagcaga ttgcctacaa tcaccccagc
     1621 agcagtattg gcgtgttctt ctgtggacct aaagctctct cgaggacact tcaaaagatg
     1681 tgccacttgt attcatcagc tgaccccaga ggtgttcatt tctattacaa caaggagagc
     1741 ttctagactt tggaggtcaa gtccaggcat tgtgttttca atcaagttat tgattccaaa
     1801 gaactccacc aggaattcct gtgacggcct gttgatatga gctcccagtt gggaactggt
     1861 gaataataat taactattgt gaacagtaca ctataccata cttccttagc ttataaataa
     1921 catgtcatat acaacagaac aaaaacattt actgaaatta aaatatatta tgtttctcaa
//
