LOCUS       NM_007052               2543 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens NADPH oxidase 1 (NOX1), transcript variant 1, mRNA.
ACCESSION   NM_007052
VERSION     NM_007052.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2543)
  AUTHORS   Song,H.K., Kim,J.M., Noh,E.M., Youn,H.J. and Lee,Y.R.
  TITLE     Role of NOX1 and NOX5 in protein kinase C/reactive oxygen
            species-mediated MMP-9 activation and invasion in MCF-7 breast
            cancer cells
  JOURNAL   Mol Med Rep 30 (4) (2024)
   PUBMED   39219290
  REMARK    GeneRIF: Role of NOX1 and NOX5 in protein kinase C/reactive oxygen
            species-mediated MMP-9 activation and invasion in MCF-7 breast
            cancer cells.
REFERENCE   2  (bases 1 to 2543)
  AUTHORS   Wang,H., Mao,W., Zhang,Y., Feng,W., Bai,B., Ji,B., Chen,J.,
            Cheng,B. and Yan,F.
  TITLE     NOX1 triggers ferroptosis and ferritinophagy, contributes to
            Parkinson's disease
  JOURNAL   Free Radic Biol Med 222, 331-343 (2024)
   PUBMED   38876456
  REMARK    GeneRIF: NOX1 triggers ferroptosis and ferritinophagy, contributes
            to Parkinson's disease.
REFERENCE   3  (bases 1 to 2543)
  AUTHORS   Zhang,Q., Zhou,J., Zhai,D., Jiang,Q., Yang,M. and Zhou,M.
  TITLE     Gut microbiota regulates the ALK5/NOX1 axis by altering glutamine
            metabolism to inhibit ferroptosis of intrahepatic
            cholangiocarcinoma cells
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167152 (2024)
   PUBMED   38582012
  REMARK    GeneRIF: Gut microbiota regulates the ALK5/NOX1 axis by altering
            glutamine metabolism to inhibit ferroptosis of intrahepatic
            cholangiocarcinoma cells.
REFERENCE   4  (bases 1 to 2543)
  AUTHORS   Ohata,H., Shiokawa,D., Sakai,H., Kanda,Y., Okimoto,Y., Kaneko,S.,
            Hamamoto,R., Nakagama,H. and Okamoto,K.
  TITLE     PROX1 induction by autolysosomal activity stabilizes persister-like
            state of colon cancer via feedback repression of the NOX1-mTORC1
            pathway
  JOURNAL   Cell Rep 42 (6), 112519 (2023)
   PUBMED   37224811
  REMARK    GeneRIF: PROX1 induction by autolysosomal activity stabilizes
            persister-like state of colon cancer via feedback repression of the
            NOX1-mTORC1 pathway.
REFERENCE   5  (bases 1 to 2543)
  AUTHORS   Tyagi,A., Chandrasekaran,B., Navin,A.K., Shukla,V., Baby,B.V.,
            Ankem,M.K. and Damodaran,C.
  TITLE     Molecular interplay between NOX1 and autophagy in cadmium-induced
            prostate carcinogenesis
  JOURNAL   Free Radic Biol Med 199, 44-55 (2023)
   PUBMED   36764624
  REMARK    GeneRIF: Molecular interplay between NOX1 and autophagy in
            cadmium-induced prostate carcinogenesis.
REFERENCE   6  (bases 1 to 2543)
  AUTHORS   Arbiser,J.L., Petros,J., Klafter,R., Govindajaran,B.,
            McLaughlin,E.R., Brown,L.F., Cohen,C., Moses,M., Kilroy,S.,
            Arnold,R.S. and Lambeth,J.D.
  TITLE     Reactive oxygen generated by Nox1 triggers the angiogenic switch
  JOURNAL   Proc Natl Acad Sci U S A 99 (2), 715-720 (2002)
   PUBMED   11805326
REFERENCE   7  (bases 1 to 2543)
  AUTHORS   Arnold,R.S., Shi,J., Murad,E., Whalen,A.M., Sun,C.Q.,
            Polavarapu,R., Parthasarathy,S., Petros,J.A. and Lambeth,J.D.
  TITLE     Hydrogen peroxide mediates the cell growth and transformation
            caused by the mitogenic oxidase Nox1
  JOURNAL   Proc Natl Acad Sci U S A 98 (10), 5550-5555 (2001)
   PUBMED   11331784
REFERENCE   8  (bases 1 to 2543)
  AUTHORS   Kikuchi,H., Hikage,M., Miyashita,H. and Fukumoto,M.
  TITLE     NADPH oxidase subunit, gp91(phox) homologue, preferentially
            expressed in human colon epithelial cells
  JOURNAL   Gene 254 (1-2), 237-243 (2000)
   PUBMED   10974555
REFERENCE   9  (bases 1 to 2543)
  AUTHORS   Banfi,B., Maturana,A., Jaconi,S., Arnaudeau,S., Laforge,T.,
            Sinha,B., Ligeti,E., Demaurex,N. and Krause,K.H.
  TITLE     A mammalian H+ channel generated through alternative splicing of
            the NADPH oxidase homolog NOH-1
  JOURNAL   Science 287 (5450), 138-142 (2000)
   PUBMED   10615049
  REMARK    Erratum:[Science. 2005 Jan 7;307(5706):44]
REFERENCE   10 (bases 1 to 2543)
  AUTHORS   Suh,Y.A., Arnold,R.S., Lassegue,B., Shi,J., Xu,X., Sorescu,D.,
            Chung,A.B., Griendling,K.K. and Lambeth,J.D.
  TITLE     Cell transformation by the superoxide-generating oxidase Mox1
  JOURNAL   Nature 401 (6748), 79-82 (1999)
   PUBMED   10485709
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z83819.1, AF127763.2,
            BX956931.1 and AF166327.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_007052.4.
            
            Summary: This gene encodes a member of the NADPH oxidase family of
            enzymes responsible for the catalytic one-electron transfer of
            oxygen to generate superoxide or hydrogen peroxide. Alternatively
            spliced transcript variants encoding multiple isoforms have been
            observed for this gene. [provided by RefSeq, Nov 2012].
            
            Transcript Variant: This variant (1, alternately referred to as
            NOH-1L per PMID: 10615049) represents the longest transcript and
            encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292201.1, AF127763.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372966.8/ ENSP00000362057.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                Z83819.1           37684-37697         c
            15-48               AF127763.2         1-34
            49-150              BX956931.1         5-106
            151-2031            AF166327.1         1-1881
            2032-2543           Z83819.1           6662-7173           c
FEATURES             Location/Qualifiers
     source          1..2543
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..2543
                     /gene="NOX1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH-1L; NOH1"
                     /note="NADPH oxidase 1"
                     /db_xref="GeneID:27035"
                     /db_xref="HGNC:HGNC:7889"
                     /db_xref="MIM:300225"
     exon            1..265
                     /gene="NOX1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH-1L; NOH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1915
                     /gene="NOX1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH-1L; NOH1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitogenic oxidase (pyridine nucleotide-dependent
                     superoxide-generating); NADPH oxidase homolog-1; mitogenic
                     oxidase 1; NADH/NADPH mitogenic oxidase subunit P65-MOX"
                     /codon_start=1
                     /product="NADPH oxidase 1 isoform 1"
                     /protein_id="NP_008983.2"
                     /db_xref="CCDS:CCDS14474.1"
                     /db_xref="GeneID:27035"
                     /db_xref="HGNC:HGNC:7889"
                     /db_xref="MIM:300225"
                     /translation="MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRK
                     ILGSTLACARASALCLNFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHK
                     LVAYMICLHTAIHIIAHLFNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQS
                     RNTTVEYVTFTSIAGLTGVIMTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGL
                     GIHGIGGIVRGQTEESMNESHPRKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAP
                     VILYICERILRFYRSQQKVVITKVVMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISL
                     LEWHPFTLTSAPEEDFFSIHIRAAGDWTENLIRAFEQQYSPIPRIEVDGPFGTASEDV
                     FQYEVAVLVGAGIGVTPFASILKSIWYKFQCADHNLKTKKIYFYWICRETGAFSWFNN
                     LLTSLEQEMEELGKVGFLNYRLFLTGWDSNIVGHAALNFDKATDIVTGLKQKTSFGRP
                     MWDNEFSTIATSHPKSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF"
     exon            266..361
                     /gene="NOX1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH-1L; NOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            362..472
                     /gene="NOX1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH-1L; NOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..557
                     /gene="NOX1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH-1L; NOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            558..709
                     /gene="NOX1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH-1L; NOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            710..891
                     /gene="NOX1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH-1L; NOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1024
                     /gene="NOX1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH-1L; NOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1117
                     /gene="NOX1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH-1L; NOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1353
                     /gene="NOX1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH-1L; NOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1516
                     /gene="NOX1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH-1L; NOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1663
                     /gene="NOX1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH-1L; NOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1788
                     /gene="NOX1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH-1L; NOH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..2543
                     /gene="NOX1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH-1L; NOH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2387..2392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOX1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH-1L; NOH1"
                     /note="hexamer: CATAAA"
     polyA_site      2404
                     /gene="NOX1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH-1L; NOH1"
                     /note="major polyA site"
     regulatory      2518..2523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOX1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH-1L; NOH1"
                     /note="hexamer: AATAAA"
     polyA_site      2543
                     /gene="NOX1"
                     /gene_synonym="GP91-2; MOX1; NOH-1; NOH-1L; NOH1"
ORIGIN      
        1 gctggtctat ctaagctgat agcacagttc tgtccagaga aggaaggcag aataaactta
       61 ttcattccca ggaactcttg gggtaggtgt gtgtttttca catcttaaag gctcacagac
      121 cctgcgctgg acaaatgttc cattcctgaa ggacctctcc agaatccgga ttgctgaatc
      181 ttccctgttg cctagaaggg ctccaaacca cctcttgaca atgggaaact gggtggttaa
      241 ccactggttt tcagttttgt ttctggttgt ttggttaggg ctgaatgttt tcctgtttgt
      301 ggatgccttc ctgaaatatg agaaggccga caaatactac tacacaagaa aaatccttgg
      361 gtcaacattg gcctgtgccc gagcgtctgc tctctgcttg aattttaaca gcacgctgat
      421 cctgcttcct gtgtgtcgca atctgctgtc cttcctgagg ggcacctgct cattttgcag
      481 ccgcacactg agaaagcaat tggatcacaa cctcaccttc cacaagctgg tggcctatat
      541 gatctgccta catacagcta ttcacatcat tgcacacctg tttaactttg actgctatag
      601 cagaagccga caggccacag atggctccct tgcctccatt ctctccagcc tatctcatga
      661 tgagaaaaag gggggttctt ggctaaatcc catccagtcc cgaaacacga cagtggagta
      721 tgtgacattc accagcattg ctggtctcac tggagtgatc atgacaatag ccttgattct
      781 catggtaact tcagctactg agttcatccg gaggagttat tttgaagtct tctggtatac
      841 tcaccacctt tttatcttct atatccttgg cttagggatt cacggcattg gtggaattgt
      901 ccggggtcaa acagaggaga gcatgaatga gagtcatcct cgcaagtgtg cagagtcttt
      961 tgagatgtgg gatgatcgtg actcccactg taggcgccct aagtttgaag ggcatccccc
     1021 tgagtcttgg aagtggatcc ttgcaccggt cattctttat atctgtgaaa ggatcctccg
     1081 gttttaccgc tcccagcaga aggttgtgat taccaaggtt gttatgcacc catccaaagt
     1141 tttggaattg cagatgaaca agcgtggctt cagcatggaa gtggggcagt atatctttgt
     1201 taattgcccc tcaatctctc tcctggaatg gcatcctttt actttgacct ctgctccaga
     1261 ggaagatttc ttctccattc atatccgagc agcaggggac tggacagaaa atctcataag
     1321 ggctttcgaa caacaatatt caccaattcc caggattgaa gtggatggtc cctttggcac
     1381 agccagtgag gatgttttcc agtatgaagt ggctgtgctg gttggagcag gaattggggt
     1441 cacccccttt gcttctatct tgaaatccat ctggtacaaa ttccagtgtg cagaccacaa
     1501 cctcaaaaca aaaaagatct atttctactg gatctgcagg gagacaggtg ccttttcctg
     1561 gttcaacaac ctgttgactt ccctggaaca ggagatggag gaattaggca aagtgggttt
     1621 tctaaactac cgtctcttcc tcaccggatg ggacagcaat attgttggtc atgcagcatt
     1681 aaactttgac aaggccactg acatcgtgac aggtctgaaa cagaaaacct cctttgggag
     1741 accaatgtgg gacaatgagt tttctacaat agctacctcc caccccaagt ctgtagtggg
     1801 agttttctta tgtggccctc ggactttggc aaagagcctg cgcaaatgct gtcaccgata
     1861 ttccagtctg gatcctagaa aggttcaatt ctacttcaac aaagaaaatt tttgagttat
     1921 aggaataagg acggtaatct gcattttgtc tctttgtatc ttcagtaatt tacttggtct
     1981 cgtcaggttt gagcagtcac tttaggataa gaatgtgcct ctcaagcctt gactccctgg
     2041 tattcttttt ttgattgcat tcaacttcgt tacttgagct tcagcaactt aagaacttct
     2101 gaagttctta aagttctgaa gttcttaaag cccatggatc ctttctcaga aaaataactg
     2161 taaatctttc tggacagcca tgactgtagc aaggcttgat agcagaggtt tggtggttca
     2221 gagttataca actaatccca ggtgatttta tcaattccag tgttaccatc tcctgagttt
     2281 tggtttgtaa tcttttgtcc ctcccacccc cacagaagat ttctaagtag ggtgactttt
     2341 taaataaaaa tttattgaat aattaatgat aaaacataat aataaacata aataataaac
     2401 aaaattaccg agaaccccat ccccatataa caccaacagt gtacatgttt actgtcactt
     2461 ttgatatggt cttatccagt gtgaacagca atttattctt atttttgctc atcaaaaaat
     2521 aaaggatttt cttcttcact tga
//
