LOCUS       NM_002516               8122 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens NOVA alternative splicing regulator 2 (NOVA2), mRNA.
ACCESSION   NM_002516
VERSION     NM_002516.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8122)
  AUTHORS   Xia,F., Xie,M., He,J. and Cheng,D.
  TITLE     Circ_0004140 promotes lung adenocarcinoma progression by
            upregulating NOVA2 via sponging miR-330-5p
  JOURNAL   Thorac Cancer 14 (35), 3483-3494 (2023)
   PUBMED   37920146
  REMARK    GeneRIF: Circ_0004140 promotes lung adenocarcinoma progression by
            upregulating NOVA2 via sponging miR-330-5p.
REFERENCE   2  (bases 1 to 8122)
  AUTHORS   Liu,J., Yu,Q. and Yang,X.
  TITLE     Circ_0102231 inactivates the PI3K/AKT signaling pathway by
            regulating the miR-635/NOVA2 pathway to promote the progression of
            non-small cell lung cancer
  JOURNAL   Thorac Cancer 14 (35), 3453-3464 (2023)
   PUBMED   37864285
  REMARK    GeneRIF: Circ_0102231 inactivates the PI3K/AKT signaling pathway by
            regulating the miR-635/NOVA2 pathway to promote the progression of
            non-small cell lung cancer.
REFERENCE   3  (bases 1 to 8122)
  AUTHORS   Hou,X., Li,Y., Song,J., Peng,L., Zhang,W., Liu,R., Yuan,H.,
            Feng,T., Li,J., Li,W. and Zhu,C.
  TITLE     METTL14 reverses liver fibrosis by inhibiting NOVA2 through an
            m6A-YTHDF2-dependent mechanism
  JOURNAL   Hepatol Commun 7 (8), e0199 (2023)
   PUBMED   37534933
  REMARK    GeneRIF: METTL14 reverses liver fibrosis by inhibiting NOVA2
            through an m6A-YTHDF2-dependent mechanism.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8122)
  AUTHORS   Di Matteo,A., Belloni,E., Pradella,D., Chiaravalli,A.M., Pini,G.M.,
            Bugatti,M., Alfieri,R., Barzan,C., Franganillo Tena,E., Bione,S.,
            Terenzani,E., Sessa,F., Wyatt,C.D.R., Vermi,W. and Ghigna,C.
  TITLE     Alternative Splicing Changes Promoted by NOVA2 Upregulation in
            Endothelial Cells and Relevance for Gastric Cancer
  JOURNAL   Int J Mol Sci 24 (9), 8102 (2023)
   PUBMED   37175811
  REMARK    GeneRIF: Alternative Splicing Changes Promoted by NOVA2
            Upregulation in Endothelial Cells and Relevance for Gastric Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8122)
  AUTHORS   Kremer,V., Oppelaar,J.J., Gimbel,T., Koziarek,S., Ganzevoort,W.,
            van Pampus,M.G., van den Born,B.J., Vogt,L., de Groot,C. and
            Boon,R.A.
  TITLE     Neuro-oncological Ventral Antigen 2 Regulates Splicing of Vascular
            Endothelial Growth Factor Receptor 1 and Is Required for
            Endothelial Function
  JOURNAL   Reprod Sci 30 (2), 678-689 (2023)
   PUBMED   35927413
  REMARK    GeneRIF: Neuro-oncological Ventral Antigen 2 Regulates Splicing of
            Vascular Endothelial Growth Factor Receptor 1 and Is Required for
            Endothelial Function.
REFERENCE   6  (bases 1 to 8122)
  AUTHORS   Lewis,H.A., Musunuru,K., Jensen,K.B., Edo,C., Chen,H., Darnell,R.B.
            and Burley,S.K.
  TITLE     Sequence-specific RNA binding by a Nova KH domain: implications for
            paraneoplastic disease and the fragile X syndrome
  JOURNAL   Cell 100 (3), 323-332 (2000)
   PUBMED   10676814
REFERENCE   7  (bases 1 to 8122)
  AUTHORS   Lewis,H.A., Chen,H., Edo,C., Buckanovich,R.J., Yang,Y.Y.,
            Musunuru,K., Zhong,R., Darnell,R.B. and Burley,S.K.
  TITLE     Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding
            domains
  JOURNAL   Structure 7 (2), 191-203 (1999)
   PUBMED   10368286
REFERENCE   8  (bases 1 to 8122)
  AUTHORS   Yang,Y.Y., Yin,G.L. and Darnell,R.B.
  TITLE     The neuronal RNA-binding protein Nova-2 is implicated as the
            autoantigen targeted in POMA patients with dementia
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 13254-13259 (1998)
   PUBMED   9789075
REFERENCE   9  (bases 1 to 8122)
  AUTHORS   Fletcher,C.F., Okano,H.J., Gilbert,D.J., Yang,Y., Yang,C.,
            Copeland,N.G., Jenkins,N.A. and Darnell,R.B.
  TITLE     Mouse chromosomal locations of nine genes encoding homologs of
            human paraneoplastic neurologic disorder antigens
  JOURNAL   Genomics 45 (2), 313-319 (1997)
   PUBMED   9344654
REFERENCE   10 (bases 1 to 8122)
  AUTHORS   Ueki,K., Ramaswamy,S., Billings,S.J., Mohrenweiser,H.W. and
            Louis,D.N.
  TITLE     ANOVA, a putative astrocytic RNA-binding protein gene that maps to
            chromosome 19q13.3
  JOURNAL   Neurogenetics 1 (1), 31-36 (1997)
   PUBMED   10735272
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011545.4, AF083898.1,
            BQ631784.1, AI990298.1, U70477.1, AC008623.4 and BM666426.1.
            
            On Nov 28, 2018 this sequence version replaced NM_002516.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF083898.1, U70477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162328 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000263257.6/
                                                ENSP00000263257.4
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-466               AC011545.4         5321-5786           c
            467-1227            AF083898.1         1-761
            1228-1234           BQ631784.1         343-349
            1235-1374           AF083898.1         769-908
            1375-1494           AI990298.1         76-195
            1495-2343           U70477.1           1000-1848
            2344-8042           AC008623.4         16805-22503
            8043-8122           BM666426.1         18-97               c
FEATURES             Location/Qualifiers
     source          1..8122
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..8122
                     /gene="NOVA2"
                     /gene_synonym="ANOVA; NEDASB; NOVA-2; NOVA3"
                     /note="NOVA alternative splicing regulator 2"
                     /db_xref="GeneID:4858"
                     /db_xref="HGNC:HGNC:7887"
                     /db_xref="MIM:601991"
     exon            1..599
                     /gene="NOVA2"
                     /gene_synonym="ANOVA; NEDASB; NOVA-2; NOVA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             515..1993
                     /gene="NOVA2"
                     /gene_synonym="ANOVA; NEDASB; NOVA-2; NOVA3"
                     /note="neuro-oncological ventral antigen 3; astrocytic
                     NOVA1-like RNA-binding protein; neuro-oncological ventral
                     antigen 2"
                     /codon_start=1
                     /product="RNA-binding protein Nova-2"
                     /protein_id="NP_002507.1"
                     /db_xref="CCDS:CCDS12679.1"
                     /db_xref="GeneID:4858"
                     /db_xref="HGNC:HGNC:7887"
                     /db_xref="MIM:601991"
                     /translation="MEPEAPDSRKRPLETPPEVVCTKRSNTGEEGEYFLKVLIPSYAA
                     GSIIGKGGQTIVQLQKETGATIKLSKSKDFYPGTTERVCLVQGTAEALNAVHSFIAEK
                     VREIPQAMTKPEVVNILQPQTTMNPDRAKQAKLIVPNSTAGLIIGKGGATVKAVMEQS
                     GAWVQLSQKPEGINLQERVVTVSGEPEQVHKAVSAIVQKVQEDPQSSSCLNISYANVA
                     GPVANSNPTGSPYASPADVLPAAAAASAAAASGLLGPAGLAGVGAFPAALPAFSGTDL
                     LAISTALNTLASYGYNTNSLGLGLNSAAASGVLAAVAAGANPAAAAAANLLASYAGEA
                     GAGPAGGAAPPPPPPPGALGSFALAAAANGYLGAGAGGGAGGGGGPLVAAAAAAGAAG
                     GFLTAEKLAAESAKELVEIAVPENLVGAILGKGGKTLVEYQELTGARIQISKKGEFLP
                     GTRNRRVTITGSPAATQAAQYLISQRVTYEQGVRASNPQKVG"
     exon            600..743
                     /gene="NOVA2"
                     /gene_synonym="ANOVA; NEDASB; NOVA-2; NOVA3"
                     /inference="alignment:Splign:2.1.0"
     exon            744..910
                     /gene="NOVA2"
                     /gene_synonym="ANOVA; NEDASB; NOVA-2; NOVA3"
                     /inference="alignment:Splign:2.1.0"
     exon            911..8122
                     /gene="NOVA2"
                     /gene_synonym="ANOVA; NEDASB; NOVA-2; NOVA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2321..2326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOVA2"
                     /gene_synonym="ANOVA; NEDASB; NOVA-2; NOVA3"
                     /note="hexamer: AACAAA"
     polyA_site      2332
                     /gene="NOVA2"
                     /gene_synonym="ANOVA; NEDASB; NOVA-2; NOVA3"
     regulatory      8104..8109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOVA2"
                     /gene_synonym="ANOVA; NEDASB; NOVA-2; NOVA3"
                     /note="hexamer: GATAAA"
     polyA_site      8122
                     /gene="NOVA2"
                     /gene_synonym="ANOVA; NEDASB; NOVA-2; NOVA3"
                     /note="major polyA site"
ORIGIN      
        1 gctcggccct cttgccccag ggagccaaga agaagcgggg agtcccgtcc ccccagtggc
       61 gcgtccagtc cccagcctct gtggtcccag gagagacccc acctctcagt tctttcccgg
      121 ccctatcgga gacccccctc ggccctgcca tcctgctcac ggccgctctc caggctctgt
      181 cagccccccg agaaccggct cccccctacc cccgccttcc ctctccgggg ctccccctcc
      241 cccatccctc caccgccccc tccccctccc acctcccctc ccctccccct cccccgcccc
      301 ccgccccccg ccccccccca ccatgaggat gatggccgcc ggcgcggtgc acggcctctt
      361 cacggcctcc gcggccccgc agccgccgcc gcccccgccg ccgccgccgc cgcaacccca
      421 gcctccccag cagccgtcgc cgccgccaca gcagccgccg ccgccgccgc cgcagccgcc
      481 gcagcagcag cagccgccgc cccaggcccc ccccatggag cccgaggccc cggattcccg
      541 caagaggccc ctcgaaacgc cccccgaggt ggtctgcacc aagcgcagca acacgggaga
      601 ggaaggcgaa tacttcctga aggtgctgat ccccagctac gcggcgggct ccatcattgg
      661 caagggcggg cagaccatcg tgcagctgca gaaggagacc ggagccacca tcaagctctc
      721 caagtccaaa gacttctacc ccggaaccac agagcgggta tgcctagtac agggcacggc
      781 agaggccttg aatgctgtgc acagctttat tgccgagaag gtccgagaaa tcccacaagc
      841 gatgaccaag cctgaggtgg tcaacatcct tcaaccccaa accacgatga accccgacag
      901 agccaagcag gccaagctga tcgtccccaa cagcacggcg ggcctgatca tcggcaaggg
      961 aggcgccacg gtgaaagccg tgatggaaca gtcaggagca tgggtgcagc tgtcccagaa
     1021 gccggagggc atcaacctgc aggagcgcgt ggtgacggtc agcggcgagc ccgagcaggt
     1081 gcacaaggcc gtgagcgcca tcgtgcagaa ggtacaagaa gacccccaga gcagcagctg
     1141 cctcaacatc agctacgcca acgtggcagg ccccgtggcc aactccaacc ccaccggctc
     1201 tccgtacgcc agccccgcgg atgtgctgcc agccgcggcc gcagcgtcgg ccgccgccgc
     1261 ctccggcctg ctgggccccg ccgggctggc tggcgtgggg gcctttcccg ccgcgctgcc
     1321 cgccttctca ggcaccgacc tgctggccat cagcacggcg cttaacacgc tggcaagtta
     1381 cggctacaac accaactccc tgggcctggg cctcaactcg gccgcagctt ccggcgtcct
     1441 ggccgccgtg gccgccgggg ccaacccagc agccgccgcc gccgccaacc tcctggcatc
     1501 ctacgcgggc gaggccgggg ccgggccagc cggaggggcc gccccgccgc cgcccccgcc
     1561 tcccggagcc ctggggtcct ttgcgttggc cgcagccgcc aacggctacc tcggggccgg
     1621 ggcgggcggc ggggcgggcg gagggggcgg cccgctggtg gccgctgcag ccgcggccgg
     1681 ggcggccggg ggcttcctga cggcggagaa gctggcggct gagagtgcca aggagctggt
     1741 ggagattgcg gtgcctgaga acctggtggg agccatcctg gggaaggggg gcaagacgtt
     1801 ggtggagtac caggagctga cgggcgctcg catccagatc tccaagaagg gcgagttcct
     1861 gccaggcacg cggaaccggc gggtcaccat cacgggcagc cccgcggcca cgcaagccgc
     1921 tcaatacctc atcagtcagc gggtcaccta cgagcaggga gtgagggcct caaaccccca
     1981 gaaagtggga tgaggcctgt ggtgtgtgct cccacccttt tctctcctcc catctcctcc
     2041 tcttccctct cctcctcccc cccaactcct gacctcagct tggtgtagtc ctgctcctct
     2101 tgggatgggg ctggggtagg cccgactgca ccctcccctt ctggtagtca taggcaggat
     2161 tgagtgacgg ttgggaaggg ggctcagaag ccccctcccc agcccggaac tgacccctcc
     2221 ttcctccctc cctgtgcttg gctgggcctg acccttcctg tcccagggcc caggtctgtg
     2281 tgatatctgt atatattgca ttttgttgat tttaatagaa aacaaagcgt tattttctct
     2341 ttctttccct cctttttttt tttttttttt tttttggtaa ggattttttc cccctttata
     2401 agtttttgtt tccatatggg aggaggggag ggagcctctg ggtcacccag aatgaggggc
     2461 cttcccaaaa cacaacaccc cacctctctg ctttcagttc tagatctgag ggaagccatg
     2521 ggagtagagg tagcagaggc gtctgagctg aaatggggca tttggagcaa ggaccccaga
     2581 gttcccagat cttctcagct actctcctcc cactggagct gtccctccta ggtgggaatg
     2641 ttcactcttt tgttgtcagg ttgtatgggg gggcagggac agtgctgctg ggaaggatgc
     2701 cagctctggg attgggccag tcctgtgggc aagacttgca agaggctgga tcaacttggt
     2761 gtggtatctc tgatggctta gagtaatggc aatgagggtc tctgttgtga tgtcactgag
     2821 tactttctgg ggtgcttctg ggcacccctt atgatgtcac aggaagcagt tcctcagagg
     2881 ttacttcctg tgaacataag ggagcaggta cttcctgtga tgtctcaatg agttcttcct
     2941 tgaaggtcac tttggtgata tcatgggaag gtgtacttcc ggtgatgcct agaggtcacg
     3001 tcctgtgatg tcattaggct gaagcatgta cttcctgtat tggacagtga ccagtctctg
     3061 acctgccttc tccctccaca cccttctttg gtgggtgttg gcctgggggt cttcctagga
     3121 agagaataag gcacgggact tggatccaat ctggaggact ctaacggaaa aaaaccaata
     3181 ttgtcagggt catctccatt caaacacgtc aagtctgcga actcgccctg gagggagggg
     3241 tgggagatgg acctagtgca aactactgtt aaagacctcc cttcccaccc ctgccttttg
     3301 tgtgcatgcc tgtgtctgcg tggctttgtt tcattgaatc gggtgagcca agtgtgtggt
     3361 ggctctgtca ggccagtatg gccaggtgta gagttcagtg agccatagta gggtcccttg
     3421 ggccagaatg cttcgtgtgg tctgataggt tagattggtt tggtggcttc cagcaagctg
     3481 gcatacttcg gtgatgtctg atggatcaga atgttttggt gtgctcacca ggggctctgg
     3541 agaactagaa tgttctgatg gagtctgaca agccaggcgg ccttgagagt tggtttagga
     3601 gtggctccct gagtgctgtg gctgtggtca gctctaagga cctgttggca gactgagatt
     3661 tcagggcctg acaaccatgt agactaggat agctgagacc tccctctacc cccacccatc
     3721 tccctctctt ccttggagac cacctccact ttctccaacc caaagcaggg cgcccagtgc
     3781 cctggttcca tcatcagcat ctctggggga ggggcgcccc atgcccaccc tctcccccat
     3841 ttgtccgcct cctaggtctt ccaaaccctt ttcttctcta tgactttggg ggaaatccag
     3901 cctccttgtc tctctcctaa aaaaggaggg aagaaaagcc acagagacaa ttcctgcccc
     3961 taaagcctag gagatccctc tcccttgcta gagagccacc cccaaatcaa aatgtgaaaa
     4021 tccctagaaa gcaatagcct tcgaggtacc ttgcactgaa tttcccaccc cagcccttcc
     4081 acccgatggg aggctgtaac ttgggcactg gggtgacttt ttccatgccc ttgtcatctc
     4141 cagggtggga ggcaggcccc acttcccctc ccctatcccc cacttcccat tgttgttgcc
     4201 ccacccctaa tctccagact gaacccagat ggagatctga gtgccaaaac aattcttgat
     4261 gtaactttgt acatatcttc tactaccgtt gggggctctt ggggttagag gtgggggcgg
     4321 ctctgtgggc cattgctccc ctccacctct caaaagacct tacagtattt cacagtatct
     4381 ctacccgcac gcgagtatta cagtatctag ctggaatatc cccctacagc cccccaggac
     4441 cctatgagga agggaaggag ccagggagag tgaagtaagg tctgggactg gggaggtggg
     4501 atctgaatga actcatttgc atatcatttg catcctccgc ttggcagccg ctttctacaa
     4561 actcattcac tggagtctgg gtcccaatca gccgggtcca ggactcctct cacacagaca
     4621 catctccgga ggctgggcct cctgaaaagt gtttgcttgg ggtgtctgtg taacaacccc
     4681 tccctattca tatttcttgg ggacccccta cccagccagc cagggtgatc tgaaaggtat
     4741 actttgctag ctcagtgagc tagttcactc accatgttgg tgagcagaga gccacacctt
     4801 tccccatttt accttgggaa actcactcca ccatctttgc catctcttga aagtcccttc
     4861 tgcaatctga cctcaatctt ttgtgctgca gtttgtccag aggggacaca gatgtggggt
     4921 cagggatgag gattattgaa aaacccatca tctctttttt tttccccgtc tccctattag
     4981 ccaatccgat ctcagagtct ctgagtggcc tccttgcacc cttctcttca gcacccagta
     5041 ggtgcttaat aagtgtttgc tgcattggat tatctcccta ttccttctca tttgccctct
     5101 agcttcccat accttctcca agtgtcttcc tccctttctt tgtctggctc cctatgactt
     5161 tctatttttt tttcctccgt gtggttccca ttgttttctg tcctgtctct atcttagtct
     5221 ttgtctgtct tcctcctttc ctcaaatgtc tcaactctct ctccccaatt tccccattta
     5281 aaaaaaaaaa aaagtgccaa acttccttgg aactgagccg ctctgggggg agaggacctt
     5341 ggatagaggg gaggaaatgg gaccatttct ctttgaggag gtccctaaga ggcattgcaa
     5401 aagtgtggac atggagctaa attgggtccc ccttccacag ccctcccacc ctgagttttt
     5461 cttagaatct ttgtaagaaa aaaaaaaaaa gacagaaaaa agctctcctt ttcaacttac
     5521 ccctatcctt ttgggtcccc ccaaattcca ccagccaagg agaatcccac ttgccaactt
     5581 cctggcaaat ctatggaaac tggggaggag gagacaagct caactcctcc tctgctagcc
     5641 caaggggcgg taccaactgg attcaagaga aggacctcaa agctcctatg agaagagggg
     5701 gttcgatgtg ccaaattaac ctccttcatc ccccatctca gggggctctg agccaacctg
     5761 cccagccacc ttcttctgcc ctgtcccagc cacctctaca tgggcaagga ggcttcactg
     5821 caataattag taggggtggt gatcagaaga caatgatttt gccgtttcta tctgccctaa
     5881 cgcctaccct ggacttgtag ttgggaatta tgggtatccc aagtggatgt tgataaaagc
     5941 cgacctatag atggttgggg acctctactt ggaacaccag ggtgtcgctt atctccgagg
     6001 tgtatttcct ctcccctctg gaccaccaaa tccttcaata tcccctcatt ctgtttctcc
     6061 tccctgttcc tccatcccac atcctccttc ttactttgtt ttgattggtg gccaattgtt
     6121 tggaaaatga gaggagtccc cctgaatgga tgattgctgt ttcaggaccg ggattagagg
     6181 ctgtgataga ctgtgcagtg gcaaaagtat taacaagagt ggcgatgagg atggcagttg
     6241 gggcgtccag gctgctgact gagtgcccgc ctgtcggtac agccagccag gccttcgaca
     6301 agcacctgcc tggaaaccgg gctcgctgtc ctgaaagcct ggactggatg tcacgatggg
     6361 gagaacggga tcgcgatacc caagctgggg cacaggcgag ccagggacac tggtttactg
     6421 gggtgataac acccagccct gctatcgcga tccgtttgca ctgtggtcag ctgtctccac
     6481 gccgtggttg gagagggctt gtctccgggc gccactgctg gtgtgtatgg tctgtcttag
     6541 tgtcccctgc aagttgcatt ggagattgct gggtggcagg gagggaaatg ggaagagaat
     6601 ctgtggggtc atggtggtga aggctgctgg tttttaatcc cttctcaacc agtccaggac
     6661 acttgtctcc cagagataac tgggggggga ctgcctaacc ccccctcccc cacccctttc
     6721 cctaccccac ctctcccccc aaaaccacca acctctcatc ttctaagtga ctccatcacc
     6781 accggccacc gggacctgcg gcctcattgc tccagcccgc cccactcgac cgtcagactc
     6841 gctcatcgaa ctctttttga ttaacccttt ctgtgttcat cccacggaaa actgtgtgtc
     6901 cggcaggggg gaggggggag gctaggggca gttgctacct ttcctccatc tcctcccacc
     6961 acccatgcct ccccacccgc accccatccc atgccccacc cccatccctc acccctaggg
     7021 tctgccccac cctggggatt gacatcctct ataaatatct atgctatttg gctttgtccc
     7081 tttaaaaggc gggtccaggg gcgtggcctc cctcaaatgg agcgctcact ctgaccccct
     7141 ccttcgtgtg ccccccacac actccccacg ccttcattgt aaatagtcac ttttgtactg
     7201 ggtttgagcc aggggacgtg gggagtcatt tttcttttct ttatgttggc atctcaggcc
     7261 actggaggca tggcccacat cccgggtcga tttgggagaa ttttaaggta tgtcccctca
     7321 cctgtcccca tcgctaagga tttcaagcta tcagtattac tctagaggga tggggtgcat
     7381 agattccccg gcagggtggt gggagaggtg tggaaaggtg tagtctggga ggatgcctcc
     7441 gttttcccct tctgtgaaat ggattcatcc tccaatttcc ctgaggagcc tcagtgagat
     7501 aatggtggag tcagaggagc tagaacctct cttccccctt tctctgttgg agacagggta
     7561 gcagaagaat gggggacagg ggaggctgca gggccatctt tggagaaccg attgctaaat
     7621 ccttcttagg accttaaggt agcctcctct ccaggcttgt tctccctctt ggaatatggg
     7681 gaggactgga ggacctctaa ggtcccttgg ttctccccag tccttagatt aaaaggccca
     7741 ggccccaggc tggccccctg cctgctgtcc cactccttca ttccatttct tggaatgtgg
     7801 ccatgcctcc agtgcctcca ttcaaccccc tctaactgat tccttccatc ctctgcgacc
     7861 agagacgccg cccgcctcct gcccaccacc tccagaagct cctggctggg gtgcactgcc
     7921 gtctcctccc actccccaca ttgccatgcc tgggccacgc ccaccccacc cactcaccca
     7981 cccccagtgt ccgttgtgtg acctagtgca ccatgtatta gcttccatgg cccccacccc
     8041 agcccccacc acaccccctt tccccacccc tttcccctcg gcgacttcac ctttttttgc
     8101 cgcgataaac gccatctcag ca
//
