LOCUS       NM_006491               1481 bp    mRNA    linear   PRI 13-DEC-2024
DEFINITION  Homo sapiens NOVA alternative splicing regulator 1 (NOVA1),
            transcript variant 3, mRNA.
ACCESSION   NM_006491
VERSION     NM_006491.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1481)
  AUTHORS   Zhang,B., Liu,Y., Yu,J. and Lin,X.
  TITLE     Upregulation of FGF9 and NOVA1 in cancer-associated fibroblasts
            promotes cell proliferation, invasion and migration of triple
            negative breast cancer
  JOURNAL   Drug Dev Res 85 (3), e22185 (2024)
   PUBMED   38657094
  REMARK    GeneRIF: Upregulation of FGF9 and NOVA1 in cancer-associated
            fibroblasts promotes cell proliferation, invasion and migration of
            triple negative breast cancer.
REFERENCE   2  (bases 1 to 1481)
  AUTHORS   Saito,Y., Yang,Y., Saito,M., Park,C.Y., Funato,K., Tabar,V. and
            Darnell,R.B.
  TITLE     NOVA1 acts as an oncogenic RNA-binding protein to regulate
            cholesterol homeostasis in human glioblastoma cells
  JOURNAL   Proc Natl Acad Sci U S A 121 (10), e2314695121 (2024)
   PUBMED   38416679
  REMARK    GeneRIF: NOVA1 acts as an oncogenic RNA-binding protein to regulate
            cholesterol homeostasis in human glioblastoma cells.
REFERENCE   3  (bases 1 to 1481)
  AUTHORS   Zhang,B., Sun,R., Gu,M., Jiang,Z., Wang,Y., Zhang,L., Liu,X. and
            Chi,Z.
  TITLE     RNA-binding protein NOVA1 promotes acute T-lymphocyte leukemia
            progression by stabilizing USP44 mRNA
  JOURNAL   Biochem Cell Biol 102 (1), 60-72 (2024)
   PUBMED   37816258
  REMARK    GeneRIF: RNA-binding protein NOVA1 promotes acute T-lymphocyte
            leukemia progression by stabilizing USP44 mRNA.
REFERENCE   4  (bases 1 to 1481)
  AUTHORS   Liu,Z.Y., Zhai,F.F., Liu,J.Y., Zhou,Y.J., Shu,M.J., Huang,X.H.,
            Han,F., Li,M.L., Zhou,L.X., Ni,J., Yao,M., Zhang,S.Y., Cui,L.Y.,
            Jin,Z.Y. and Zhu,Y.C.
  TITLE     Pattern of Brain Parenchymal Damage Related to Cerebral Small
            Vessel Disease in Carriers of Rare NOTCH3 Variants
  JOURNAL   Neurology 101 (20), e1979-e1991 (2023)
   PUBMED   37775315
  REMARK    GeneRIF: Pattern of Brain Parenchymal Damage Related to Cerebral
            Small Vessel Disease in Carriers of Rare NOTCH3 Variants.
REFERENCE   5  (bases 1 to 1481)
  AUTHORS   Fu,R.H., Chen,H.J. and Hong,S.Y.
  TITLE     Interaction of the C9orf72-Amyotrophic Lateral Sclerosis-Related
            Proline-Arginine Dipeptide Repeat Protein with the RNA-Binding
            Protein NOVA1 Causes Decreased Expression of UNC13A Due to Enhanced
            Inclusion of Cryptic Exons, Which Is Reversed by Betulin Treatment
  JOURNAL   Cells 12 (20), 2476 (2023)
   PUBMED   37887320
  REMARK    GeneRIF: Interaction of the C9orf72-Amyotrophic Lateral
            Sclerosis-Related Proline-Arginine Dipeptide Repeat Protein with
            the RNA-Binding Protein NOVA1 Causes Decreased Expression of UNC13A
            Due to Enhanced Inclusion of Cryptic Exons, Which Is Reversed by
            Betulin Treatment.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1481)
  AUTHORS   Jensen,K.B., Dredge,B.K., Stefani,G., Zhong,R., Buckanovich,R.J.,
            Okano,H.J., Yang,Y.Y. and Darnell,R.B.
  TITLE     Nova-1 regulates neuron-specific alternative splicing and is
            essential for neuronal viability
  JOURNAL   Neuron 25 (2), 359-371 (2000)
   PUBMED   10719891
REFERENCE   7  (bases 1 to 1481)
  AUTHORS   Lewis,H.A., Chen,H., Edo,C., Buckanovich,R.J., Yang,Y.Y.,
            Musunuru,K., Zhong,R., Darnell,R.B. and Burley,S.K.
  TITLE     Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding
            domains
  JOURNAL   Structure 7 (2), 191-203 (1999)
   PUBMED   10368286
REFERENCE   8  (bases 1 to 1481)
  AUTHORS   Buckanovich,R.J. and Darnell,R.B.
  TITLE     The neuronal RNA binding protein Nova-1 recognizes specific RNA
            targets in vitro and in vivo
  JOURNAL   Mol Cell Biol 17 (6), 3194-3201 (1997)
   PUBMED   9154818
REFERENCE   9  (bases 1 to 1481)
  AUTHORS   Buckanovich,R.J., Yang,Y.Y. and Darnell,R.B.
  TITLE     The onconeural antigen Nova-1 is a neuron-specific RNA-binding
            protein, the activity of which is inhibited by paraneoplastic
            antibodies
  JOURNAL   J Neurosci 16 (3), 1114-1122 (1996)
   PUBMED   8558240
REFERENCE   10 (bases 1 to 1481)
  AUTHORS   Buckanovich,R.J., Posner,J.B. and Darnell,R.B.
  TITLE     Nova, the paraneoplastic Ri antigen, is homologous to an
            RNA-binding protein and is specifically expressed in the developing
            motor system
  JOURNAL   Neuron 11 (4), 657-672 (1993)
   PUBMED   8398153
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL079343.4, AI569678.1,
            CN409914.1, U04840.1, BE644739.1 and AL132716.6.
            
            On Aug 13, 2020 this sequence version replaced NM_006491.2.
            
            Summary: This gene encodes a neuron-specific RNA-binding protein, a
            member of the Nova family of paraneoplastic disease antigens, that
            is recognized and inhibited by paraneoplastic antibodies. These
            antibodies are found in the sera of patients with paraneoplastic
            opsoclonus-ataxia, breast cancer, and small cell lung cancer.
            Alternatively spliced transcripts encoding distinct isoforms have
            been described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon in the 3' coding region, and differs in the 3' UTR, compared
            to variant 1. The resulting protein (isoform 3) is shorter and has
            a distinct C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289639.1, DA163131.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               AL079343.4         152924-153202
            280-293             AI569678.1         212-225             c
            294-526             CN409914.1         16-248
            527-1013            CN409914.1         251-737
            1014-1116           U04840.1           486-588
            1117-1338           BE644739.1         155-376             c
            1339-1481           AL132716.6         111887-112029
FEATURES             Location/Qualifiers
     source          1..1481
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..1481
                     /gene="NOVA1"
                     /gene_synonym="Nova-1"
                     /note="NOVA alternative splicing regulator 1"
                     /db_xref="GeneID:4857"
                     /db_xref="HGNC:HGNC:7886"
                     /db_xref="MIM:602157"
     exon            1..733
                     /gene="NOVA1"
                     /gene_synonym="Nova-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             598..1143
                     /gene="NOVA1"
                     /gene_synonym="Nova-1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     paraneoplastic Ri antigen; ventral neuron-specific protein
                     1; RNA-binding protein Nova-1; onconeural ventral antigen
                     1; neuro-oncological ventral antigen 1"
                     /codon_start=1
                     /product="RNA-binding protein Nova-1 isoform 3"
                     /protein_id="NP_006482.1"
                     /db_xref="CCDS:CCDS9635.1"
                     /db_xref="GeneID:4857"
                     /db_xref="HGNC:HGNC:7886"
                     /db_xref="MIM:602157"
                     /translation="MMAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNT
                     GEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKDFYPGTTERVCLI
                     QGTVEALNAVHGFIAEKIREMPQNVAKTEPVSILQPQTTVNPDRIKQTLPSSPTTTKS
                     SPSDPMTTSRANQKHNISWIS"
     exon            734..877
                     /gene="NOVA1"
                     /gene_synonym="Nova-1"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1044
                     /gene="NOVA1"
                     /gene_synonym="Nova-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1116
                     /gene="NOVA1"
                     /gene_synonym="Nova-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1481
                     /gene="NOVA1"
                     /gene_synonym="Nova-1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1481
                     /gene="NOVA1"
                     /gene_synonym="Nova-1"
                     /note="major polyA site"
ORIGIN      
        1 agaaccgctc cggcagcggc ggcggcggca gcaccagcag cgggagcgag cgcaacgcta
       61 gcgcggcgcg gggaccgccg cgctccttcc cggctcctgc cctcctctgc cgctcgctcc
      121 tctctcggca tccacctcct tcccctcctc ctgctcattc actctttccc tcactctccc
      181 ctcctcctcg gcttctcccc gcgccccgcc agccctcgcg ctctcccact ccctctgcct
      241 gtcctccccg gtcccctcct cccgctcatt cactcgcccc tctcccttct ccactctctc
      301 cccctgtctc ctttcttctt cttctttcac cctccgtctc tcacaccccc tccattcccc
      361 tgtctccttt ctgacactgc actgcagctg ctcctcagcc ctgccccctc cccagtgaga
      421 acaaaccagc aacattgctt tttttcctaa agagatttat attgatccga ttaaaaaaaa
      481 aaaaccttaa gaaaccccaa acgcaaaaaa aaaaaaaaaa aaaaaagaaa aaagaaaaga
      541 aaaagccaaa acaaaaggga gaaccttctc ccggtagcag cggcaggaac tgcaaacatg
      601 atggcggcag ctcccatcca gcagaacggg acccacactg gggttcccat agacctggac
      661 ccgccggact cgcggaaaag gccgctggaa gccccccctg aagccggcag caccaagagg
      721 accaatacgg gcgaagacgg ccagtatttt ctaaaggttc tcatacctag ttatgctgct
      781 ggatctataa ttgggaaggg aggacagaca attgttcagt tgcaaaaaga aactggagcc
      841 accatcaagc tgtctaagtc caaagatttt tacccaggta ctactgagcg agtgtgcttg
      901 atccagggaa cggttgaagc actgaatgca gttcatggat tcattgcaga aaaaattcga
      961 gaaatgcccc aaaatgtggc caagacagaa ccagtcagca ttctacaacc ccagaccacc
     1021 gttaatccag atcgcatcaa acaaacattg ccatcttccc caactaccac caagtcctct
     1081 ccatctgatc ccatgaccac ctccagagct aatcagaagc ataatatctc ctggatatca
     1141 tgaagcaaga tataagagaa gaacaaaaca aaatccgtaa ttcattgaaa gaattgtaat
     1201 catcaatctt tcatattatt aatactttgt aattattttc tccccaacag tattttccag
     1261 tagattctaa tcatgtggta gggcagaagg aaatgtgttt tttgttgttc atttgtttct
     1321 tgtcaatagt cctgattaat ttagctttgc tatactgact tatatctgga agtatataac
     1381 caagataaga aaataggttt taatatgatc atcttaagct aattgtaatg aaaagaacta
     1441 atggactgtc aatattcaga aaaccaaaaa taaaaaatac a
//
