LOCUS       NM_002515               6990 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens NOVA alternative splicing regulator 1 (NOVA1),
            transcript variant 1, mRNA.
ACCESSION   NM_002515
VERSION     NM_002515.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6990)
  AUTHORS   Zhang,B., Liu,Y., Yu,J. and Lin,X.
  TITLE     Upregulation of FGF9 and NOVA1 in cancer-associated fibroblasts
            promotes cell proliferation, invasion and migration of triple
            negative breast cancer
  JOURNAL   Drug Dev Res 85 (3), e22185 (2024)
   PUBMED   38657094
  REMARK    GeneRIF: Upregulation of FGF9 and NOVA1 in cancer-associated
            fibroblasts promotes cell proliferation, invasion and migration of
            triple negative breast cancer.
REFERENCE   2  (bases 1 to 6990)
  AUTHORS   Saito,Y., Yang,Y., Saito,M., Park,C.Y., Funato,K., Tabar,V. and
            Darnell,R.B.
  TITLE     NOVA1 acts as an oncogenic RNA-binding protein to regulate
            cholesterol homeostasis in human glioblastoma cells
  JOURNAL   Proc Natl Acad Sci U S A 121 (10), e2314695121 (2024)
   PUBMED   38416679
  REMARK    GeneRIF: NOVA1 acts as an oncogenic RNA-binding protein to regulate
            cholesterol homeostasis in human glioblastoma cells.
REFERENCE   3  (bases 1 to 6990)
  AUTHORS   Zhang,B., Sun,R., Gu,M., Jiang,Z., Wang,Y., Zhang,L., Liu,X. and
            Chi,Z.
  TITLE     RNA-binding protein NOVA1 promotes acute T-lymphocyte leukemia
            progression by stabilizing USP44 mRNA
  JOURNAL   Biochem Cell Biol 102 (1), 60-72 (2024)
   PUBMED   37816258
  REMARK    GeneRIF: RNA-binding protein NOVA1 promotes acute T-lymphocyte
            leukemia progression by stabilizing USP44 mRNA.
REFERENCE   4  (bases 1 to 6990)
  AUTHORS   Liu,Z.Y., Zhai,F.F., Liu,J.Y., Zhou,Y.J., Shu,M.J., Huang,X.H.,
            Han,F., Li,M.L., Zhou,L.X., Ni,J., Yao,M., Zhang,S.Y., Cui,L.Y.,
            Jin,Z.Y. and Zhu,Y.C.
  TITLE     Pattern of Brain Parenchymal Damage Related to Cerebral Small
            Vessel Disease in Carriers of Rare NOTCH3 Variants
  JOURNAL   Neurology 101 (20), e1979-e1991 (2023)
   PUBMED   37775315
  REMARK    GeneRIF: Pattern of Brain Parenchymal Damage Related to Cerebral
            Small Vessel Disease in Carriers of Rare NOTCH3 Variants.
REFERENCE   5  (bases 1 to 6990)
  AUTHORS   Fu,R.H., Chen,H.J. and Hong,S.Y.
  TITLE     Interaction of the C9orf72-Amyotrophic Lateral Sclerosis-Related
            Proline-Arginine Dipeptide Repeat Protein with the RNA-Binding
            Protein NOVA1 Causes Decreased Expression of UNC13A Due to Enhanced
            Inclusion of Cryptic Exons, Which Is Reversed by Betulin Treatment
  JOURNAL   Cells 12 (20), 2476 (2023)
   PUBMED   37887320
  REMARK    GeneRIF: Interaction of the C9orf72-Amyotrophic Lateral
            Sclerosis-Related Proline-Arginine Dipeptide Repeat Protein with
            the RNA-Binding Protein NOVA1 Causes Decreased Expression of UNC13A
            Due to Enhanced Inclusion of Cryptic Exons, Which Is Reversed by
            Betulin Treatment.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6990)
  AUTHORS   Jensen,K.B., Dredge,B.K., Stefani,G., Zhong,R., Buckanovich,R.J.,
            Okano,H.J., Yang,Y.Y. and Darnell,R.B.
  TITLE     Nova-1 regulates neuron-specific alternative splicing and is
            essential for neuronal viability
  JOURNAL   Neuron 25 (2), 359-371 (2000)
   PUBMED   10719891
REFERENCE   7  (bases 1 to 6990)
  AUTHORS   Lewis,H.A., Chen,H., Edo,C., Buckanovich,R.J., Yang,Y.Y.,
            Musunuru,K., Zhong,R., Darnell,R.B. and Burley,S.K.
  TITLE     Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding
            domains
  JOURNAL   Structure 7 (2), 191-203 (1999)
   PUBMED   10368286
REFERENCE   8  (bases 1 to 6990)
  AUTHORS   Buckanovich,R.J. and Darnell,R.B.
  TITLE     The neuronal RNA binding protein Nova-1 recognizes specific RNA
            targets in vitro and in vivo
  JOURNAL   Mol Cell Biol 17 (6), 3194-3201 (1997)
   PUBMED   9154818
REFERENCE   9  (bases 1 to 6990)
  AUTHORS   Buckanovich,R.J., Yang,Y.Y. and Darnell,R.B.
  TITLE     The onconeural antigen Nova-1 is a neuron-specific RNA-binding
            protein, the activity of which is inhibited by paraneoplastic
            antibodies
  JOURNAL   J Neurosci 16 (3), 1114-1122 (1996)
   PUBMED   8558240
REFERENCE   10 (bases 1 to 6990)
  AUTHORS   Buckanovich,R.J., Posner,J.B. and Darnell,R.B.
  TITLE     Nova, the paraneoplastic Ri antigen, is homologous to an
            RNA-binding protein and is specifically expressed in the developing
            motor system
  JOURNAL   Neuron 11 (4), 657-672 (1993)
   PUBMED   8398153
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL079343.4, AI569678.1,
            CN409914.1, U04840.1, R60636.1, BX431656.1, BE762927.1 and
            AL132716.6.
            
            On Nov 22, 2018 this sequence version replaced NM_002515.2.
            
            Summary: This gene encodes a neuron-specific RNA-binding protein, a
            member of the Nova family of paraneoplastic disease antigens, that
            is recognized and inhibited by paraneoplastic antibodies. These
            antibodies are found in the sera of patients with paraneoplastic
            opsoclonus-ataxia, breast cancer, and small cell lung cancer.
            Alternatively spliced transcripts encoding distinct isoforms have
            been described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.9615.1,
                                           SRR1803613.203456.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267757 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000539517.7/ ENSP00000438875.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               AL079343.4         152924-153202
            280-293             AI569678.1         212-225             c
            294-526             CN409914.1         16-248
            527-1013            CN409914.1         251-737
            1014-2764           U04840.1           486-2236
            2765-2885           R60636.1           255-375
            2886-2892           R60636.1           377-383
            2893-2899           R60636.1           385-391
            2900-2947           U04840.1           2366-2413
            2948-2955           R60636.1           445-452
            2956-2960           U04840.1           2420-2424
            2961-2962           R60636.1           458-459
            2963-3014           U04840.1           2425-2476
            3015-3020           BX431656.1         10-15
            3021-3477           U04840.1           2482-2938
            3478-3478           U04840.1           2940-2940
            3479-3709           BX431656.1         472-702
            3710-3922           U04840.1           3180-3392
            3923-4175           U04840.1           3394-3646
            4176-4197           BE762927.1         41-62
            4198-6990           AL132716.6         136273-139065
FEATURES             Location/Qualifiers
     source          1..6990
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..6990
                     /gene="NOVA1"
                     /gene_synonym="Nova-1"
                     /note="NOVA alternative splicing regulator 1"
                     /db_xref="GeneID:4857"
                     /db_xref="HGNC:HGNC:7886"
                     /db_xref="MIM:602157"
     exon            1..733
                     /gene="NOVA1"
                     /gene_synonym="Nova-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             598..2121
                     /gene="NOVA1"
                     /gene_synonym="Nova-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     paraneoplastic Ri antigen; ventral neuron-specific protein
                     1; RNA-binding protein Nova-1; onconeural ventral antigen
                     1; neuro-oncological ventral antigen 1"
                     /codon_start=1
                     /product="RNA-binding protein Nova-1 isoform 1"
                     /protein_id="NP_002506.2"
                     /db_xref="CCDS:CCDS32061.1"
                     /db_xref="GeneID:4857"
                     /db_xref="HGNC:HGNC:7886"
                     /db_xref="MIM:602157"
                     /translation="MMAAAPIQQNGTHTGVPIDLDPPDSRKRPLEAPPEAGSTKRTNT
                     GEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKDFYPGTTERVCLI
                     QGTVEALNAVHGFIAEKIREMPQNVAKTEPVSILQPQTTVNPDRIKQTLPSSPTTTKS
                     SPSDPMTTSRANQVKIIVPNSTAGLIIGKGGATVKAVMEQSGAWVQLSQKPDGINLQE
                     RVVTVSGEPEQNRKAVELIIQKIQEDPQSGSCLNISYANVTGPVANSNPTGSPYANTA
                     EVLPTAAAAAGLLGHANLAGVAAFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGL
                     GLSQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGTFALGSLAAAT
                     AATNGYFGAASPLAASAILGTEKSTDGSKDVVEIAVPENLVGAILGKGGKTLVEYQEL
                     TGARIQISKKGEFVPGTRNRKVTITGTPAATQAAQYLITQRITYEQGVRAANPQKVG"
     exon            734..877
                     /gene="NOVA1"
                     /gene_synonym="Nova-1"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1044
                     /gene="NOVA1"
                     /gene_synonym="Nova-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1116
                     /gene="NOVA1"
                     /gene_synonym="Nova-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..6990
                     /gene="NOVA1"
                     /gene_synonym="Nova-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4166..4171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOVA1"
                     /gene_synonym="Nova-1"
                     /note="hexamer: TATAAA"
     polyA_site      4194
                     /gene="NOVA1"
                     /gene_synonym="Nova-1"
                     /note="major polyA site"
     regulatory      6961..6966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOVA1"
                     /gene_synonym="Nova-1"
                     /note="hexamer: AATAAA"
     polyA_site      6990
                     /gene="NOVA1"
                     /gene_synonym="Nova-1"
ORIGIN      
        1 agaaccgctc cggcagcggc ggcggcggca gcaccagcag cgggagcgag cgcaacgcta
       61 gcgcggcgcg gggaccgccg cgctccttcc cggctcctgc cctcctctgc cgctcgctcc
      121 tctctcggca tccacctcct tcccctcctc ctgctcattc actctttccc tcactctccc
      181 ctcctcctcg gcttctcccc gcgccccgcc agccctcgcg ctctcccact ccctctgcct
      241 gtcctccccg gtcccctcct cccgctcatt cactcgcccc tctcccttct ccactctctc
      301 cccctgtctc ctttcttctt cttctttcac cctccgtctc tcacaccccc tccattcccc
      361 tgtctccttt ctgacactgc actgcagctg ctcctcagcc ctgccccctc cccagtgaga
      421 acaaaccagc aacattgctt tttttcctaa agagatttat attgatccga ttaaaaaaaa
      481 aaaaccttaa gaaaccccaa acgcaaaaaa aaaaaaaaaa aaaaaagaaa aaagaaaaga
      541 aaaagccaaa acaaaaggga gaaccttctc ccggtagcag cggcaggaac tgcaaacatg
      601 atggcggcag ctcccatcca gcagaacggg acccacactg gggttcccat agacctggac
      661 ccgccggact cgcggaaaag gccgctggaa gccccccctg aagccggcag caccaagagg
      721 accaatacgg gcgaagacgg ccagtatttt ctaaaggttc tcatacctag ttatgctgct
      781 ggatctataa ttgggaaggg aggacagaca attgttcagt tgcaaaaaga aactggagcc
      841 accatcaagc tgtctaagtc caaagatttt tacccaggta ctactgagcg agtgtgcttg
      901 atccagggaa cggttgaagc actgaatgca gttcatggat tcattgcaga aaaaattcga
      961 gaaatgcccc aaaatgtggc caagacagaa ccagtcagca ttctacaacc ccagaccacc
     1021 gttaatccag atcgcatcaa acaaacattg ccatcttccc caactaccac caagtcctct
     1081 ccatctgatc ccatgaccac ctccagagct aatcaggtaa agattatagt tcccaacagc
     1141 acagcaggtc tgataatagg gaagggaggt gctactgtga aggctgtaat ggagcagtca
     1201 ggggcttggg tgcagctttc ccagaaacct gatgggatca acttgcaaga gagggttgtc
     1261 actgtgagtg gagaacctga acaaaaccga aaagctgttg aacttatcat ccagaagata
     1321 caagaggatc cacaaagtgg cagctgtctc aatatcagtt atgccaatgt gacaggtcca
     1381 gtggcaaatt ccaatccaac cggatctcct tatgcaaaca ctgctgaagt gttaccaact
     1441 gctgcagcag ctgcagggct attaggacat gctaaccttg ctggcgttgc agcctttcca
     1501 gcagttttat ctggcttcac aggcaatgac ctggtggcca tcacctctgc acttaataca
     1561 ttagccagct atggatataa tctcaacact ttaggtttag gtctcagtca agcagcagca
     1621 acaggggctt tggctgcagc agctgccagt gccaacccag cagcagcagc agccaattta
     1681 ttggccacct atgccagtga agcctcagcc agtggcagca cagctggtgg tacggcgggg
     1741 acatttgcat taggtagcct ggctgctgct actgctgcaa ccaatggata ttttggagct
     1801 gcttctcccc tagctgccag tgccattcta ggaacagaaa agtccacaga tggatccaag
     1861 gatgtagttg aaatagcagt gccagaaaac ttagttggtg caatacttgg caaaggaggg
     1921 aaaacattag tggaatacca ggagttgact ggtgcaagga tacagatctc caaaaaagga
     1981 gaattcgtac ctggcacaag gaatcggaag gtaaccatta ctggaacacc agctgcaaca
     2041 caggctgctc aatatttaat tacacaaagg atcacatatg agcaaggagt tcgggctgcc
     2101 aatcctcaga aagtgggttg agtgccccag ttacacatca gattgtttta acccctcctt
     2161 taccccattt tcaagaagga tgtactgtac tttgcagaag tgaagttttt ctgttattaa
     2221 tatataatta tgcaaatgaa tgcgactatg ttgacaatgt gtatatgtaa ataatatgtg
     2281 ttttaccaga tgtttcatag aaagaatttt ttcttgatct gttttgttct ctatactttg
     2341 cttgtgtata tttgtcagag gtgtttctag tgtaagattt aagcctgcca ttttaccagc
     2401 attattgtag tttaatgatt gaatgtagac agggatatgc gtatagtttt cagtattagt
     2461 tctagataac actaaattaa ctactgttag gttgagtatg gtggggtcag tgacctaaaa
     2521 tggagtgagg ccaaagcact gtcctgtaag tcttacttcc tgcttagggc acagtgaagt
     2581 aggaaacaat attttgaaaa taagttttaa atttaaaatg atcaaaaagc aatatagttg
     2641 cataaaagca ctgtaaaata tttaaaaggt taaaactgtg gaaaattata ttggtaagtt
     2701 tacagatcaa taaaagcacc tgttctccat ctgaactaga caatggaaat aatgctgcat
     2761 gctggccatg gcccattctt catcatttgt aagttcaaca aaagttctca catggagtcc
     2821 cacctcttca gaggtttgta catttgtttt taagcactga attcactact gatcccatcg
     2881 cctggccagt agaacagtca ttactccatt aacatcctca ctgtttagac acataactgt
     2941 ggtacagtgt attggaaatt ttataaacaa aagtgaaagt gccaacaaat tattgatagc
     3001 tgataatgtt tcattatctg caactgcttg ataagtatgt tgcattttaa gagcttataa
     3061 ttgtgtataa tttgttaaca ctagaaacct attagtattg tgaatgtaga ttttactgtg
     3121 aagctatctg tgatttagct gtttgctccc atgatggagt ctttgcagca tggcgctagc
     3181 agccaatgca gtttctaata ctcggtaatt tgcatgtttt gtggagcatt tttatgtcac
     3241 caaccagaca gtatttcctg catgcttatt tagaagaggc agcttatctt gagaggtagt
     3301 gttatctacc tttgtcaggc tttttgacag gtcatttcag agtaagcctt tgttcccaag
     3361 acccaacaac tgtcaccctc ttctgtacct ctcctgagtg ccaactgtcc aggccatttg
     3421 acacaccatc tgttaacctc tgagtttgcc cactcaaggc cactcatagg ggcatccatc
     3481 cccaagcacc tcctcatgct gtgcatgcag tcttaaattc aatggacaaa aataaaatgc
     3541 tggctacctc tggatcatct ggctgagcaa ctgaattaca aaagagaatt acttccatct
     3601 caacttcaac ccattgatta cgtccatcct agcaagctaa atggcatccc agctgctcct
     3661 ttctgtgcaa ccaattaaag aacaatgagt gtgatgctcc atgtctgaat ttcgtccagc
     3721 ctctctctga actgtgatct ttgtcctcat gaactttccc ttttgttcat tgaactatat
     3781 ggactcttca tttcatattg atttactgtg caatttactt ttggacattg agaacttgaa
     3841 attatttcct gatcccttcc ccttccacta ttaataattc atttctgtca aactgtaaga
     3901 gtagactcat tttttttttt ttagttttta acattggact gttatttcat ttagagttct
     3961 ctatctctaa atatttattt agagaatgat tttaaaaggg aatgatatgc ttgtttaaat
     4021 gaaagagaaa agctgtagta aactgtgtta attggtaatg actatttatc gtcgatactc
     4081 tgtagctgtg taagttttga caaatagtgt atctcgtgga atcagtggtt agcattgccg
     4141 ctattatatt tactcatttt atcattataa atgtgcttag ttcatcatgt agcatcactt
     4201 gtctcccgtc tcattttttc cttgcatgtc acaagtctca gatcatttat aatacattaa
     4261 cagtaaataa tatctatgta aatttctttc accatgctgt ctcagagtca gcagtgaaca
     4321 aaggcaaaga ttggggcccc acttagtttg aaaaagggaa aggaagtgat ctaggatgtg
     4381 tactagaagc atttcaaatg ttgggtcttt aaaatgtttt gttcagtctt agcaaatctt
     4441 cgatctttta tttcaaaatt ccagtagtcc actgtggagc ccatgcattt catctggaat
     4501 ttaatgttac tttgaagcca aaccatttaa acaattatgt gtgttttatt agctagtgtt
     4561 gctgaaaatg cacttagttc aattttaatt gtaaatggga attttaaact tttcctagtt
     4621 agcatggtta tatgttagtt aaaactgaaa gctaaattga agatattaca ttttaattta
     4681 tggtgacaga taagggtttg tatgcattat gtgtaaatca gcttcatgct gtttaaaaat
     4741 ttattctctg aaatttatag accatgtaga attgatttgt gatgtgatgc tttaatttat
     4801 tgcaagaaaa ttagtatggc ttcaaactgc cacaggtagg catgtaacaa tggctgttca
     4861 gctgtactga tccaaaatgg agaaaactga tgatacaagg gccaaacatc ttatgaaatg
     4921 caactattta tagacttgtt ttgctatagg gaggctggtg aacacgctga atacgaatta
     4981 cctcagttct gcagctttct atgtcttttt aatgcattct gtttcagggt cactttcaat
     5041 caatatttca tttacttact gagattgaat gggcgctctg agacacagtg tgctgtttat
     5101 catacagatt ggacacctca ttctagatcc aagatctttt cctcaacact gggagctgtc
     5161 ctttcagcac cacaaaatta ctgcttgaag ttgcattgca gtttttttgt tttttttttg
     5221 tttgtttgtt tgtttgtttt tttgtttttt tctttatcac tgggagcttt tctttcagca
     5281 ccacaacatt gcacctagac tttttaaacg gctgccttcc tctttgcact gaagaccaat
     5341 ttcgtctgca cttccagtta ttgctattac ctgtaggact ttcaatccta cttcacttca
     5401 cccaccccac tcctgaaaca gttaaatgta tctatttctg tggaagtcat tttctcattg
     5461 aatgattaga aacaaagata aattctaacc tgtaacggct catttcgact cattgcttac
     5521 aatagatcta agctcttttt tctgcttatt cgactccttc cagcttccca tcacatctgt
     5581 aacaaacttt taaaatgata ttgccacacc accatgcaca agcctacctg cacagtagag
     5641 atagattatt ccatcgcatt cagatggtta acagaggtta gcaagtcctg tattatatat
     5701 ttatatcgct ttctaagaaa gtgcatatta atgtttactt taagaatgtg taaatggtgc
     5761 tatcaagaat ctgataaatt ttatccccgt tttttgtgta ccacttctaa tgtatgagat
     5821 ttattttttt attggaaaaa aataaacagt atgaaagcat taaattggta gattttagta
     5881 atttaacaat gaatggaatc cctacgttac aggccctatg tttccttgga aattttaatg
     5941 gtggtaatag atttcaacaa aggtactgat aatcatattc cttttaatcc attcttatat
     6001 ttcagtcttg atttatatgc tgattcctca ctgagtcctt aagtaaagtt tatttactta
     6061 ataattttat ttactgtaag tcttctccaa gaagggaatt cttgctttcg aaggcagcaa
     6121 ttgagagatg aaaatataat ttaatacccc ttacatcaca ggcactattt gagactagtt
     6181 actctgttag taggagaaat attcatcact cattaaatac agggcaagca tggctataca
     6241 caataatttt gagtgcaata cagtcataaa tttaatgtac acacgttact taactgaggc
     6301 aaacagccat acaaaattgc acatgattag aaaacaggat gaactcattt tgccttctgc
     6361 ttggtttctc ataaacatga atacataata ttgttatgca ctgttgttca tagatgtctt
     6421 tttacataaa gggtaagtat catattactt taacagatta tatttggaaa tctgcatgtt
     6481 attttttgtt tcatcagata tgtgccccaa ataaataact tttctttcaa aaaatgaaag
     6541 tattagagaa cttgtcatgt taattttgaa aaatattgag gtatagtact agacaggatg
     6601 tcattccact ggtctatata aacaaaaaaa actgttcttg aaaattgaag cattaccttg
     6661 tataataaag tacatcaaat cagatttgta aataaaatat tgtttaattc taaagtattc
     6721 aatattttga ttagattatt tttttaagga aaaatattta acgtgtatgt gccgaatttt
     6781 ttttaaatag ttttttataa ttgcaatgga aaggcaattg tctcattaca aagtggtaca
     6841 gaagccaata cttgggttac catagatata taaacaagca aaaactgtgg aacacgtttt
     6901 aagctcattt tggaaaatta aaacagttct gtagaaatgc atatttgtat ttgtttctct
     6961 aataaatctg caaatagctt taaacacaaa
//
