LOCUS       NM_001134462            2433 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens notochord homeobox (NOTO), mRNA.
ACCESSION   NM_001134462 XM_001719354 XM_292889 XM_941998
VERSION     NM_001134462.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2433)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (bases 1 to 2433)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2433)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   4  (bases 1 to 2433)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   5  (bases 1 to 2433)
  AUTHORS   Abdelkhalek,H.B., Beckers,A., Schuster-Gossler,K., Pavlova,M.N.,
            Burkhardt,H., Lickert,H., Rossant,J., Reinhardt,R., Schalkwyk,L.C.,
            Muller,I., Herrmann,B.G., Ceolin,M., Rivera-Pomar,R. and Gossler,A.
  TITLE     The mouse homeobox gene Not is required for caudal notochord
            development and affected by the truncate mutation
  JOURNAL   Genes Dev 18 (14), 1725-1736 (2004)
   PUBMED   15231714
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK295936.1 and AC010913.9.
            
            On May 17, 2019 this sequence version replaced NM_001134462.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK316410.1, AK295936.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2161674
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398468.4/ ENSP00000381486.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1132              AK295936.1         317-1448
            1133-2433           AC010913.9         123485-124785
FEATURES             Location/Qualifiers
     source          1..2433
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.2"
     gene            1..2433
                     /gene="NOTO"
                     /note="notochord homeobox"
                     /db_xref="GeneID:344022"
                     /db_xref="HGNC:HGNC:31839"
                     /db_xref="MIM:620695"
     exon            1..475
                     /gene="NOTO"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..849
                     /gene="NOTO"
                     /note="notochord homolog"
                     /codon_start=1
                     /product="homeobox protein notochord"
                     /protein_id="NP_001127934.1"
                     /db_xref="CCDS:CCDS46335.1"
                     /db_xref="GeneID:344022"
                     /db_xref="HGNC:HGNC:31839"
                     /db_xref="MIM:620695"
                     /translation="MPSPRPRGSPPPAPSGSRVRPPRSGRSPAPRSPTGPNTPRAPGR
                     FESPFSVEAILARPDPCAPAASQPSGSACVHPAFWTAASLCATGGLPWACPTSWLPAY
                     LSVGFYPVPGPRVAPVCGLLGFGVTGLELAHCSGLWAFPDWAPTEDLQDTERQQKRVR
                     TMFNLEQLEELEKVFAKQHNLVGKKRAQLAARLKLTENQVRVWFQNRRVKYQKQQKLR
                     AAVTSAEAASLDEPSSSSIASIQSDDAESGVDG"
     exon            476..690
                     /gene="NOTO"
                     /inference="alignment:Splign:2.1.0"
     exon            691..2433
                     /gene="NOTO"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccagacaac cggtcttgct cgctgccttt tgcagaatct tctcacttct cccgagctcc
       61 cttccttgcg tccgtccggg caacggccgc gtcatgccta gccccaggcc gcgaggcagc
      121 ccgccacccg ctccctcggg ctctcgggtc cgacctccgc gctctggccg ctctccggcg
      181 cccaggtccc ctactggccc gaacacgccc cgcgctcccg gacgcttcga gtcccctttc
      241 tcggtcgagg ccatcctggc gaggcccgac ccctgcgcgc cggcggcctc ccagccgtcg
      301 ggctccgcct gcgtccaccc ggccttctgg accgctgctt ccctgtgcgc caccgggggt
      361 ctgccctggg cttgcccgac atcgtggctg cccgcctacc tgagcgtagg tttttaccct
      421 gtgccagggc cgcgcgtggc tcccgtctgc ggcctgctgg gcttcggcgt cacagggttg
      481 gagctggctc actgctcagg actctgggcc ttcccagact gggccccaac ggaggaccta
      541 caggacactg agagacagca aaagagagtc cgaactatgt ttaacttgga gcagctggaa
      601 gagttggaga aagtgtttgc aaaacagcac aatctggtgg ggaagaagag agcccagctg
      661 gcagctcggc tcaaacttac agagaaccag gtgagagtct ggttccagaa ccgcagggtc
      721 aagtatcaga agcagcaaaa gctgagggca gcagttacat ctgccgaggc tgcctccctg
      781 gatgagcctt ccagcagctc catcgccagt atccagagtg atgatgccga gtcaggagtg
      841 gacggctgaa gactgggaca gaggccctag ccaggctgcc tggactagtt cctcctgggg
      901 gtacccactg gagctccctg cctcacacct caacgaaaag cctcctcaac cagaagaatc
      961 tgagctgtca agcagggacc cccttttcta tactgattcc tggaaactgg aataatgtaa
     1021 tgattggagg cacagactct ggccttcagc tatgtccttg gccaacctat ggaacttccg
     1081 agcctttttt ctttatctgt ataatgggtg cattcataac ttagatcacc caggggtgag
     1141 aagatgtctg taaagcaata atgtgccatg cacagtgcaa agtgtgtggt tactgttaag
     1201 gcttgtaggc ccctgagtag agaagaccaa ctggaaaaaa aaaagttttt ttcttctgct
     1261 gtcaccccac aacaatcaac acagaacact tctgtgacca aacgtatagg ggtgtacccc
     1321 acattccaac ctccagttca gcaaattctg acatgatcta cctgcaggta gtgtctgacc
     1381 ccacagattc agggctcatt ccacatggca gcccctcctt tctttttttt ttgagacaga
     1441 ctgcagtggc gcgatcttgg ctcaccgcca cctccgcctc ccgggttcaa gcgattctcc
     1501 tgcctcagcc tcccgagcag ctgggactat aggcgcatgc caccatgcct ggctaatttt
     1561 tatattttta gtagagacgg ggtttcatca tatggtcagg ctggtcttga actgctgacc
     1621 ttgtgatcca cccacctcgg cctcccaaag tgctgggatt acatgtgtga gccaccaccc
     1681 ggcccaaccc tgcccttttt gttttttatg gagtcttaag gtctaccagt catcagtcaa
     1741 ctcattagca tatgaaaaga catcacttca gagattctag ggattttagg agttctatgc
     1801 caggaaatcg agatgaagac caaatatata tttcataata tcacagctcc cctcacctgg
     1861 gggagtaata cctgtaccag caattaatat tttcctggcc tggctgtgga gaaggaacct
     1921 ctttgaataa gcatctgggc atagaagact cttcaccatc agaaggagtt gagagcaaag
     1981 aagagaaggt agactgttta gcccacttca caaagtttcc caacgttttc ttgttttgtc
     2041 tgaactgtta ccattctcag aagaagctca ggcccagcag caaagacaag gactcgctct
     2101 gtcacccaga ctggagtgca gtggtgcaat catagctcac ggcagcctca acctcctggg
     2161 ctctagtgat cctcccacct tagcctccta agcagctggg actacaggcg cgtgacacca
     2221 cgcctggcta atttttaaca ttttttgtag agacaacgtc cacttgttgc ccaggctggt
     2281 cttgaattcc aggcttcaag tggttctcct gccttggcct cccaaagccc catcttttta
     2341 tagaataatt tgtgtatgcc aaggctggca ttttgtcata aactctgctg tgttttcaca
     2401 ggacagttat aatttccccc tttcatgact ctg
//
