LOCUS       NM_004557               6745 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens notch receptor 4 (NOTCH4), transcript variant 1, mRNA.
ACCESSION   NM_004557
VERSION     NM_004557.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6745)
  AUTHORS   Zhu,R., Shirley,C.M., Chu,S.H., Li,L., Nguyen,B.H., Seo,J., Wu,M.,
            Seale,T., Duffield,A.S., Staudt,L.M., Levis,M., Hu,Y. and Small,D.
  TITLE     Inhibition of NOTCH4 sensitizes FLT3/ITD acute myeloid leukemia
            cells to FLT3 tyrosine kinase inhibition
  JOURNAL   Leukemia 38 (7), 1581-1591 (2024)
   PUBMED   38811818
  REMARK    GeneRIF: Inhibition of NOTCH4 sensitizes FLT3/ITD acute myeloid
            leukemia cells to FLT3 tyrosine kinase inhibition.
REFERENCE   2  (bases 1 to 6745)
  AUTHORS   Lopez-Lopez,S., Romero de Avila,M.J., Gonzalez-Gomez,M.J.,
            Nueda,M.L., Baladron,V., Monsalve,E.M., Garcia-Ramirez,J.J. and
            Diaz-Guerra,M.J.M.
  TITLE     NOTCH4 potentiates the IL-13 induced genetic program in M2
            alternative macrophages through the AP1 and IRF4-JMJD3 axis
  JOURNAL   Int Immunol 35 (10), 497-509 (2023)
   PUBMED   37478314
  REMARK    GeneRIF: NOTCH4 potentiates the IL-13 induced genetic program in M2
            alternative macrophages through the AP1 and IRF4-JMJD3 axis.
REFERENCE   3  (bases 1 to 6745)
  AUTHORS   Budhbhatti,U., Chauhan,A., Bhatt,D., Parmar,C., Damani,V., Patel,A.
            and Joshi,C.
  TITLE     Association of NOTCH4 and ACHE gene polymorphism in Alzheimer's
            disease of Gujarat cohort
  JOURNAL   Neurosci Lett 814, 137428 (2023)
   PUBMED   37544578
  REMARK    GeneRIF: Association of NOTCH4 and ACHE gene polymorphism in
            Alzheimer's disease of Gujarat cohort.
REFERENCE   4  (bases 1 to 6745)
  AUTHORS   Zhang,B., Dong,S., Wang,J., Huang,T., Zhao,P., Xu,J., Liu,D.,
            Fu,L., Wang,L., Wang,G. and Zou,C.
  TITLE     NOTCH4DeltaL12_16 sensitizes lung adenocarcinomas to EGFR-TKIs
            through transcriptional down-regulation of HES1
  JOURNAL   Nat Commun 14 (1), 3183 (2023)
   PUBMED   37268635
  REMARK    GeneRIF: NOTCH4[DeltaL12_16] sensitizes lung adenocarcinomas to
            EGFR-TKIs through transcriptional down-regulation of HES1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6745)
  AUTHORS   Yamamoto,S., Schulze,K.L. and Bellen,H.J.
  TITLE     Introduction to Notch signaling
  JOURNAL   Methods Mol Biol 1187, 1-14 (2014)
   PUBMED   25053477
  REMARK    Review article
REFERENCE   6  (bases 1 to 6745)
  AUTHORS   Li,L., Huang,G.M., Banta,A.B., Deng,Y., Smith,T., Dong,P.,
            Friedman,C., Chen,L., Trask,B.J., Spies,T., Rowen,L. and Hood,L.
  TITLE     Cloning, characterization, and the complete 56.8-kilobase DNA
            sequence of the human NOTCH4 gene
  JOURNAL   Genomics 51 (1), 45-58 (1998)
   PUBMED   9693032
REFERENCE   7  (bases 1 to 6745)
  AUTHORS   Sugaya,K., Sasanuma,S., Nohata,J., Kimura,T., Fukagawa,T.,
            Nakamura,Y., Ando,A., Inoko,H., Ikemura,T. and Mita,K.
  TITLE     Gene organization of human NOTCH4 and (CTG)n polymorphism in this
            human counterpart gene of mouse proto-oncogene Int3
  JOURNAL   Gene 189 (2), 235-244 (1997)
   PUBMED   9168133
REFERENCE   8  (bases 1 to 6745)
  AUTHORS   Uyttendaele,H., Marazzi,G., Wu,G., Yan,Q., Sassoon,D. and
            Kitajewski,J.
  TITLE     Notch4/int-3, a mammary proto-oncogene, is an endothelial
            cell-specific mammalian Notch gene
  JOURNAL   Development 122 (7), 2251-2259 (1996)
   PUBMED   8681805
REFERENCE   9  (bases 1 to 6745)
  AUTHORS   Matsuno,K., Diederich,R.J., Go,M.J., Blaumueller,C.M. and
            Artavanis-Tsakonas,S.
  TITLE     Deltex acts as a positive regulator of Notch signaling through
            interactions with the Notch ankyrin repeats
  JOURNAL   Development 121 (8), 2633-2644 (1995)
   PUBMED   7671825
REFERENCE   10 (bases 1 to 6745)
  AUTHORS   Sugaya,K., Fukagawa,T., Matsumoto,K., Mita,K., Takahashi,E.,
            Ando,A., Inoko,H. and Ikemura,T.
  TITLE     Three genes in the human MHC class III region near the junction
            with the class II: gene for receptor of advanced glycosylation end
            products, PBX2 homeobox gene and a notch homolog, human counterpart
            of mouse mammary tumor gene int-3
  JOURNAL   Genomics 23 (2), 408-419 (1994)
   PUBMED   7835890
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL705928.1, U95299.1, D63395.1
            and BQ023880.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004557.3.
            
            Summary: This gene encodes a member of the NOTCH family of
            proteins. Members of this Type I transmembrane protein family share
            structural characteristics including an extracellular domain
            consisting of multiple epidermal growth factor-like (EGF) repeats,
            and an intracellular domain consisting of multiple different domain
            types. Notch signaling is an evolutionarily conserved intercellular
            signaling pathway that regulates interactions between physically
            adjacent cells through binding of Notch family receptors to their
            cognate ligands. The encoded preproprotein is proteolytically
            processed in the trans-Golgi network to generate two polypeptide
            chains that heterodimerize to form the mature cell-surface
            receptor. This receptor may play a role in vascular, renal and
            hepatic development. Mutations in this gene may be associated with
            schizophrenia. Alternative splicing results in multiple transcript
            variants, at least one of which encodes an isoform that is
            proteolytically processed. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC140782.1, U95299.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375023.3/ ENSP00000364163.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AL705928.1         1-64
            65-4281             U95299.1           16-4232
            4282-4430           D63395.1           1419-1567
            4431-5823           U95299.1           4382-5774
            5824-6740           D63395.1           2961-3877
            6741-6745           BQ023880.1         18-22               c
FEATURES             Location/Qualifiers
     source          1..6745
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..6745
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /note="notch receptor 4"
                     /db_xref="GeneID:4855"
                     /db_xref="HGNC:HGNC:7884"
                     /db_xref="MIM:164951"
     exon            1..212
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..6151
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /note="Notch homolog 4; notch 4"
                     /codon_start=1
                     /product="neurogenic locus notch homolog protein 4
                     preproprotein"
                     /protein_id="NP_004548.3"
                     /db_xref="CCDS:CCDS34420.1"
                     /db_xref="GeneID:4855"
                     /db_xref="HGNC:HGNC:7884"
                     /db_xref="MIM:164951"
                     /translation="MQPPSLLLLLLLLLLLCVSVVRPRGLLCGSFPEPCANGGTCLSL
                     SLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFL
                     CTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFC
                     SANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSF
                     QCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVN
                     PDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQN
                     SAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHL
                     EDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGG
                     SCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQ
                     LCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQC
                     QDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLC
                     EVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVG
                     WTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLN
                     GGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQ
                     GPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRN
                     SHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSY
                     FCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDAC
                     QSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAF
                     YCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRA
                     PSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSC
                     SETTGLGGPGFRCSCPHSSPGPRCQKPGAKGCEGRSGDGACDAGCSGPGGNWDGGDCS
                     LGVPDPWKGCPSHSRCWLLFRDGQCHPQCDSEECLFDGYDCETPPACTPAYDQYCHDH
                     FHNGHCEKGCNTAECGWDGGDCRPEDGDPEWGPSLALLVVLSPPALDQQLFALARVLS
                     LTLRVGLWVRKDRDGRDMVYPYPGARAEEKLGGTRDPTYQERAAPQTQPLGKETDSLS
                     AGFVVVMGVDLSRCGPDHPASRCPWDPGLLLRFLAAMAAVGALEPLLPGPLLAVHPHA
                     GTAPPANQLPWPVLCSPVAGVILLALGALLVLQLIRRRRREHGALWLPPGFTRRPRTQ
                     SAPHRRRPPLGEDSIGLKALKPKAEVDEDGVVMCSGPEEGEEVGQAEETGPPSTCQLW
                     SLSGGCGALPQAAMLTPPQESEMEAPDLDTRGPDGVTPLMSAVCCGEVQSGTFQGAWL
                     GCPEPWEPLLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGR
                     TPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQAD
                     VGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQ
                     LLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAGPPEARHKATPGREAGPFPR
                     ARTVSVSVPPHGGGALPRCRTLSAGAGPRGGGACLQARTWSVDLAARGGGAYSHCRSL
                     SGVGAGGGPTPRGRRFSAGMRGPRPNPAIMRGRYGVAAGRGGRVSTDDWPCDWVALGA
                     CGSASNIPIPPPCLTPSPERGSPQLDCGPPALQEMPINQGGEGKK"
     exon            213..294
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            295..590
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            591..938
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1061
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1298
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1454
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1649
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1763
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1877
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2000
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2160
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2306
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2459
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2577
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2578..2665
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2819
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..3004
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..3257
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            3258..3370
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            3371..3894
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            3895..4278
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            4279..4454
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            4455..4674
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            4675..4756
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            4757..4895
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            4896..5191
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            5192..5339
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            5340..5437
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     exon            5438..6745
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6723..6728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /note="hexamer: AATAAA"
     polyA_site      6745
                     /gene="NOTCH4"
                     /gene_synonym="INT3"
                     /note="major polyA site"
ORIGIN      
        1 agacgtgagg cttgcagcag gccgaggagg aagaagaggg gcagtgggag cagaggaggt
       61 ggctcctgcc ccagtgagag ctctgagggt ccctgcctga agagggacag ggaccggggc
      121 ttggagaagg ggctgtggaa tgcagccccc ttcactgctg ctgctgctgc tgctgctgct
      181 gctgctatgt gtctcagtgg tcagacccag agggctgctg tgtgggagtt tcccagaacc
      241 ctgtgccaat ggaggcacct gcctgagcct gtctctggga caagggacct gccagtgtgc
      301 ccctggcttc ctgggtgaga cgtgccagtt tcctgacccc tgccagaacg cccagctctg
      361 ccaaaatgga ggcagctgcc aagccctgct tcccgctccc ctagggctcc ccagctctcc
      421 ctctccattg acacccagct tcttgtgcac ttgcctccct ggcttcactg gtgagagatg
      481 ccaggccaag cttgaagacc cttgtcctcc ctccttctgt tccaaaaggg gccgctgcca
      541 catccaggcc tcgggccgcc cacagtgctc ctgcatgcct ggatggacag gtgagcagtg
      601 ccagcttcgg gacttctgtt cagccaaccc atgtgttaat ggaggggtgt gtctggccac
      661 atacccccag atccagtgcc actgcccacc gggcttcgag ggccatgcct gtgaacgtga
      721 tgtcaacgag tgcttccagg acccaggacc ctgccccaaa ggcacctcct gccataacac
      781 cctgggctcc ttccagtgcc tctgccctgt ggggcaggag ggtccacgtt gtgagctgcg
      841 ggcaggaccc tgccctccta ggggctgttc gaatgggggc acctgccagc tgatgccaga
      901 gaaagactcc acctttcacc tctgcctctg tcccccaggt ttcataggcc cagactgtga
      961 ggtgaatcca gacaactgtg tcagccacca gtgtcagaat gggggcactt gccaggatgg
     1021 gctggacacc tacacctgcc tctgcccaga aacctggaca ggctgggact gctccgaaga
     1081 tgtggatgag tgtgagaccc agggtccccc tcactgcaga aacgggggca cctgccagaa
     1141 ctctgctggt agctttcact gcgtgtgtgt gagtggctgg ggcggcacaa gctgtgagga
     1201 gaacctggat gactgtattg ctgccacctg tgccccggga tccacctgca ttgaccgggt
     1261 gggctctttc tcctgcctct gcccacctgg acgcacagga ctcctgtgcc acttggaaga
     1321 catgtgtctg agccagccgt gccatgggga tgcccaatgc agcaccaacc ccctcacagg
     1381 ctccacactc tgcctgtgtc agcctggcta ttcggggccc acctgccacc aggacctgga
     1441 cgagtgtctg atggcccagc aaggcccaag tccctgtgaa catggcggtt cctgcctcaa
     1501 cactcctggc tccttcaact gcctctgtcc acctggctac acaggctccc gttgtgaggc
     1561 tgatcacaat gagtgcctct cccagccctg ccacccagga agcacctgtc tggacctact
     1621 tgccaccttc cactgcctct gcccgccagg cttagaaggg cagctctgtg aggtggagac
     1681 caacgagtgt gcctcagctc cctgcctgaa ccacgcggat tgccatgacc tgctcaacgg
     1741 cttccagtgc atctgcctgc ctggattctc cggcacccga tgtgaggagg atatcgatga
     1801 gtgcagaagc tctccctgtg ccaatggtgg gcagtgccag gaccagcctg gagccttcca
     1861 ctgcaagtgt ctcccaggct ttgaagggcc acgctgtcaa acagaggtgg atgagtgcct
     1921 gagtgaccca tgtcccgttg gagccagctg ccttgatctt ccaggagcct tcttttgcct
     1981 ctgcccctct ggtttcacag gccagctctg tgaggttccc ctgtgtgctc ccaacctgtg
     2041 ccagcccaag cagatatgta aggaccagaa agacaaggcc aactgcctct gtcctgatgg
     2101 aagccctggc tgtgccccac ctgaggacaa ctgcacctgc caccacgggc actgccagag
     2161 atcctcatgt gtgtgtgacg tgggttggac ggggccagag tgtgaggcag agctaggggg
     2221 ctgcatctct gcaccctgtg cccatggggg gacctgctac ccccagccct ctggctacaa
     2281 ctgcacctgc cctacaggct acacaggacc cacctgtagt gaggagatga cagcttgtca
     2341 ctcagggcca tgtctcaatg gcggctcctg caaccctagc cctggaggct actactgcac
     2401 ctgccctcca agccacacag ggccccagtg ccaaaccagc actgactact gtgtgtctgc
     2461 cccgtgcttc aatgggggta cctgtgtgaa caggcctggc accttctcct gcctctgtgc
     2521 catgggcttc cagggcccgc gctgtgaggg aaagctccgc cccagctgtg cagacagccc
     2581 ctgtaggaat agggcaacct gccaggacag ccctcagggt ccccgctgcc tctgccccac
     2641 tggctacacc ggaggcagct gccagactct gatggactta tgtgcccaga agccctgccc
     2701 acgcaattcc cactgcctcc agactgggcc ctccttccac tgcttgtgcc tccagggatg
     2761 gaccgggcct ctctgcaacc ttccactgtc ctcctgccag aaggctgcac tgagccaagg
     2821 catagacgtc tcttcccttt gccacaatgg aggcctctgt gtcgacagcg gcccctccta
     2881 tttctgccac tgcccccctg gattccaagg cagcctgtgc caggatcacg tgaacccatg
     2941 tgagtccagg ccttgccaga acggggccac ctgcatggcc cagcccagtg ggtatctctg
     3001 ccagtgtgcc ccaggctacg atggacagaa ctgctcaaag gaactcgatg cttgtcagtc
     3061 ccaaccctgt cacaaccatg gaacctgtac tcccaaacct ggaggattcc actgtgcctg
     3121 ccctccaggc tttgtggggc tacgctgtga gggagacgtg gacgagtgtc tggaccagcc
     3181 ctgccacccc acaggcactg cagcctgcca ctctctggcc aatgccttct actgccagtg
     3241 tctgcctgga cacacaggcc agtggtgtga ggtggagata gacccctgcc acagccaacc
     3301 ctgctttcat ggagggacct gtgaggccac agcaggatca cccctgggtt tcatctgcca
     3361 ctgccccaag ggttttgaag gccccacctg cagccacagg gccccttcct gcggcttcca
     3421 tcactgccac cacggaggcc tgtgtctgcc ctcccctaag ccaggcttcc caccacgctg
     3481 tgcctgcctc agtggctatg ggggtcctga ctgcctgacc ccaccagctc ctaaaggctg
     3541 tggccctccc tccccatgcc tatacaatgg cagctgctca gagaccacgg gcttgggggg
     3601 cccaggcttt cgatgctcct gccctcacag ctctccaggg ccccggtgtc agaaacccgg
     3661 agccaagggg tgtgagggca gaagtggaga tggggcctgc gatgctggct gcagtggccc
     3721 gggaggaaac tgggatggag gggactgctc tctgggagtc ccagacccct ggaagggctg
     3781 cccctcccac tctcggtgct ggcttctctt ccgggacggg cagtgccacc cacagtgtga
     3841 ctctgaagag tgtctgtttg atggctacga ctgtgagacc cctccagcct gcactccagc
     3901 ctatgaccag tactgccatg atcacttcca caacgggcac tgtgagaaag gctgcaacac
     3961 tgcagagtgt ggctgggatg gaggtgactg caggcctgaa gatggggacc cagagtgggg
     4021 gccctccctg gccctgctgg tggtactgag ccccccagcc ctagaccagc agctgtttgc
     4081 cctggcccgg gtgctgtccc tgactctgag ggtaggactc tgggtaagga aggatcgtga
     4141 tggcagggac atggtgtacc cctatcctgg ggcccgggct gaagaaaagc taggaggaac
     4201 tcgggacccc acctatcagg agagagcagc ccctcaaacg cagcccctgg gcaaggagac
     4261 cgactccctc agtgctgggt ttgtggtggt catgggtgtg gatttgtccc gctgtggccc
     4321 tgaccacccg gcatcccgct gtccctggga ccctgggctt ctactccgct tccttgctgc
     4381 gatggctgca gtgggagccc tggagcccct gctgcctgga ccactgctgg ctgtccaccc
     4441 tcatgcaggg accgcacccc ctgccaacca gcttccctgg cctgtgctgt gctccccagt
     4501 ggccggggtg attctcctgg ccctaggggc tcttctcgtc ctccagctca tccggcgtcg
     4561 acgccgagag catggagctc tctggctgcc ccctggtttc actcgacggc ctcggactca
     4621 gtcagctccc caccgacgcc ggcccccact aggcgaggac agcattggtc tcaaggcact
     4681 gaagccaaag gcagaagttg atgaggatgg agttgtgatg tgctcaggcc ctgaggaggg
     4741 agaggaggtg ggccaggctg aagaaacagg cccaccctcc acgtgccagc tctggtctct
     4801 gagtggtggc tgtggggcgc tccctcaggc agccatgcta actcctcccc aggaatctga
     4861 gatggaagcc cctgacctgg acacccgtgg acctgatggg gtgacacccc tgatgtcagc
     4921 agtttgctgt ggggaagtac agtccgggac cttccaaggg gcatggttgg gatgtcctga
     4981 gccctgggaa cctctgctgg atggaggggc ctgtccccag gctcacaccg tgggcactgg
     5041 ggagaccccc ctgcacctgg ctgcccgatt ctcccggcca accgctgccc gccgcctcct
     5101 tgaggctgga gccaacccca accagccaga ccgggcaggg cgcacacccc ttcatgctgc
     5161 tgtggctgct gatgctcggg aggtctgcca gcttctgctc cgtagcagac aaactgcagt
     5221 ggacgctcgc acagaggacg ggaccacacc cttgatgctg gctgccaggc tggcggtgga
     5281 agacctggtt gaagaactga ttgcagccca agcagacgtg ggggccagag ataaatgggg
     5341 gaaaactgcg ctgcactggg ctgctgccgt gaacaacgcc cgagccgccc gctcgcttct
     5401 ccaggccgga gccgataaag atgcccagga caacagggag cagacgccgc tattcctggc
     5461 ggcgcgggaa ggagcggtgg aagtagccca gctactgctg gggctggggg cagcccgaga
     5521 gctgcgggac caggctgggc tagcgccggc ggacgtcgct caccaacgta accactggga
     5581 tctgctgacg ctgctggaag gggctgggcc accagaggcc cgtcacaaag ccacgccggg
     5641 ccgcgaggct gggcccttcc cgcgcgcacg gacggtgtca gtaagcgtgc ccccgcatgg
     5701 gggcggggct ctgccgcgct gccggacgct gtcagccgga gcaggccctc gtgggggcgg
     5761 agcttgtctg caggctcgga cttggtccgt agacttggct gcgcgggggg gcggggccta
     5821 ttctcattgc cggagcctct cgggagtagg agcaggagga ggcccgaccc ctcgcggccg
     5881 taggttttct gcaggcatgc gcgggcctcg gcccaaccct gcgataatgc gaggaagata
     5941 cggagtggct gccgggcgcg gaggcagggt ctcaacggat gactggccct gtgattgggt
     6001 ggccctggga gcttgcggtt ctgcctccaa cattccgatc ccgcctcctt gccttactcc
     6061 gtccccggag cggggatcac ctcaacttga ctgtggtccc ccagccctcc aagaaatgcc
     6121 cataaaccaa ggaggagagg gtaaaaaata gaagaataca tggtagggag gaattccaaa
     6181 aatgattacc cattaaaagg caggctggaa ggccttcctg gttttaagat ggatccccca
     6241 aaatgaaggg ttgtgagttt agtttctctc ctaaaatgaa tgtatgccca ccagagcaga
     6301 catcttccac gtggagaagc tgcagctctg gaaagagggt ttaagatgct aggatgaggc
     6361 aggcccagtc ctcctccaga aaataagaca ggccacagga gggcagagtg gagtggaaat
     6421 acccctaagt tggaaccaag aattgcaggc atatgggatg taagatgttc tttcctatat
     6481 atggtttcca aagggtgccc ctatgatcca ttgtccccac tgcccacaaa tggctgacaa
     6541 atatttattg ggcacctact atgtgccagg cactgtgtag gtgctgaaaa gtggccaagg
     6601 gccacccccg ctgatgactc cttgcattcc ctcccctcac aacaaagaac tccactgtgg
     6661 ggatgaagcg cttcttctag ccactgctat cgctatttaa gaaccctaaa tctgtcaccc
     6721 ataataaagc tgatttgaag tgtta
//
