LOCUS       NM_000435               8680 bp    mRNA    linear   PRI 13-NOV-2024
DEFINITION  Homo sapiens notch receptor 3 (NOTCH3), mRNA.
ACCESSION   NM_000435
VERSION     NM_000435.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8680)
  AUTHORS   Rodriguez-Flores,J.L., Khalid,S., Parikshak,N., Rasheed,A., Ye,B.,
            Kapoor,M., Backman,J., Sepehrband,F., Gioia,S.A.D., Gelfman,S.,
            De,T., Banerjee,N., Sharma,D., Martinez,H., Castaneda,S.,
            D'Ambrosio,D., Zhang,X.A., Xun,P., Tsai,E., Tsai,I.C., Khan,M.Z.,
            Jahanzaib,M., Mian,M.R., Liaqat,M.B., Mahmood,K., Salam,T.U.,
            Hussain,M., Iqbal,J., Aslam,F., Cantor,M.N., Tzoneva,G.,
            Overton,J., Marchini,J., Reid,J.G., Baras,A., Verweij,N.,
            Lotta,L.A., Coppola,G., Karalis,K., Economides,A., Fazio,S.,
            Liedtke,W., Danesh,J., Kamal,A., Frossard,P., Coleman,T.,
            Shuldiner,A.R. and Saleheen,D.
  CONSRTM   Regeneron Genetics Center
  TITLE     NOTCH3 p.Arg1231Cys is markedly enriched in South Asians and
            associated with stroke
  JOURNAL   Nat Commun 15 (1), 8029 (2024)
   PUBMED   39271666
  REMARK    GeneRIF: NOTCH3 p.Arg1231Cys is markedly enriched in South Asians
            and associated with stroke.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8680)
  AUTHORS   Shen,K., Zhu,C., Wu,J., Yan,J., Li,P., Cao,S., Zhou,X. and Yao,G.
  TITLE     Exploiting branched-chain amino acid metabolism and NOTCH3
            expression to predict and target colorectal cancer progression
  JOURNAL   Front Immunol 15, 1430352 (2024)
   PUBMED   39286249
  REMARK    GeneRIF: Exploiting branched-chain amino acid metabolism and NOTCH3
            expression to predict and target colorectal cancer progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8680)
  AUTHORS   Iruzubieta,P., Alves,C.A.P.F., Al Shamsi,A.M., ElGhazali,G.,
            Zaki,M.S., Pinelli,L., Lopergolo,D., Cho,B.P.H., Jolly,A.A., Al
            Futaisi,A., Al-Amrani,F., Galli,J., Fazzi,E., Vulin,K.,
            Barajas-Olmos,F., Hengel,H., Aljamal,B.M., Nasr,V.,
            Assarzadegan,F., Ragno,M., Trojano,L., Ojeda,N.M., Cakar,A.,
            Bianchi,S., Pescini,F., Poggesi,A., Al Tenalji,A., Aziz,M.,
            Mohammad,R., Chedrawi,A., De Stefano,N., Zifarelli,G., Schols,L.,
            Haack,T.B., Rebelo,A., Zuchner,S., Koc,F., Griffiths,L.R.,
            Orozco,L., Helmes,K.G., Babaei,M., Bauer,P., Chan Jeong,W.,
            Karimiani,E.G., Schmidts,M., Gleeson,J.G., Chung,W.K.,
            Alkuraya,F.S., Shalbafan,B., Markus,H.S., Houlden,H. and
            Maroofian,R.
  TITLE     Clinical and neuroradiological spectrum of biallelic variants in
            NOTCH3
  JOURNAL   EBioMedicine 107, 105297 (2024)
   PUBMED   39191170
  REMARK    GeneRIF: Clinical and neuroradiological spectrum of biallelic
            variants in NOTCH3.
REFERENCE   4  (bases 1 to 8680)
  AUTHORS   Cao,Y., Zhang,D.D., Han,F., Jiang,N., Yao,M. and Zhu,Y.C.
  TITLE     Phenotypes Associated with NOTCH3 Cysteine-Sparing Mutations in
            Patients with Clinical Suspicion of CADASIL: A Systematic Review
  JOURNAL   Int J Mol Sci 25 (16), 8796 (2024)
   PUBMED   39201482
  REMARK    GeneRIF: Phenotypes Associated with NOTCH3 Cysteine-Sparing
            Mutations in Patients with Clinical Suspicion of CADASIL: A
            Systematic Review.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8680)
  AUTHORS   Larsson,C., Lardelli,M., White,I. and Lendahl,U.
  TITLE     The human NOTCH1, 2, and 3 genes are located at chromosome
            positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of
            neoplasia-associated translocation
  JOURNAL   Genomics 24 (2), 253-258 (1994)
   PUBMED   7698746
REFERENCE   6  (bases 1 to 8680)
  AUTHORS   Sugaya,K., Fukagawa,T., Matsumoto,K., Mita,K., Takahashi,E.,
            Ando,A., Inoko,H. and Ikemura,T.
  TITLE     Three genes in the human MHC class III region near the junction
            with the class II: gene for receptor of advanced glycosylation end
            products, PBX2 homeobox gene and a notch homolog, human counterpart
            of mouse mammary tumor gene int-3
  JOURNAL   Genomics 23 (2), 408-419 (1994)
   PUBMED   7835890
REFERENCE   7  (bases 1 to 8680)
  AUTHORS   Tournier-Lasserve,E., Joutel,A., Melki,J., Weissenbach,J.,
            Lathrop,G.M., Chabriat,H., Mas,J.L., Cabanis,E.A., Baudrimont,M.,
            Maciazek,J. et al.
  TITLE     Cerebral autosomal dominant arteriopathy with subcortical infarcts
            and leukoencephalopathy maps to chromosome 19q12
  JOURNAL   Nat Genet 3 (3), 256-259 (1993)
   PUBMED   8485581
REFERENCE   8  (bases 1 to 8680)
  AUTHORS   Ejaz,R., Carter,M. and Gripp,K.
  TITLE     NOTCH3-Related Lateral Meningocele Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   27336130
REFERENCE   9  (bases 1 to 8680)
  AUTHORS   Hack,R.J., Rutten,J. and Lesnik Oberstein,S.A.J.
  TITLE     CADASIL
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301673
REFERENCE   10 (bases 1 to 8680)
  AUTHORS   Beleil,O.M., Mickey,M.R. and Terasaki,P.I.
  TITLE     Comparison of male and female kidney transplant survival rates
  JOURNAL   Transplantation 13 (5), 493-500 (1972)
   PUBMED   4557798
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004257.1, U97669.1 and
            AC004663.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000435.2.
            
            Summary: This gene encodes the third discovered human homologue of
            the Drosophilia melanogaster type I membrane protein notch. In
            Drosophilia, notch interaction with its cell-bound ligands (delta,
            serrate) establishes an intercellular signalling pathway that plays
            a key role in neural development. Homologues of the notch-ligands
            have also been identified in human, but precise interactions
            between these ligands and the human notch homologues remains to be
            determined. Mutations in NOTCH3 have been identified as the
            underlying cause of cerebral autosomal dominant arteriopathy with
            subcortical infarcts and leukoencephalopathy (CADASIL). [provided
            by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U97669.1, SRR14038197.924655.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263388.7/ ENSP00000263388.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC004257.1         8292-8305           c
            15-695              U97669.1           3-683
            696-696             AC004663.1         35190-35190         c
            697-1013            U97669.1           685-1001
            1014-1014           AC004663.1         34693-34693         c
            1015-2627           U97669.1           1003-2615
            2628-2628           AC004663.1         27480-27480         c
            2629-2831           U97669.1           2617-2819
            2832-2832           AC004663.1         24783-24783         c
            2833-4652           U97669.1           2821-4640
            4653-4653           AC004663.1         17398-17398         c
            4654-6527           U97669.1           4642-6515
            6528-7946           AC004663.1         2929-4347           c
            7947-8085           U97669.1           7935-8073
            8086-8680           AC004663.1         2195-2789           c
FEATURES             Location/Qualifiers
     source          1..8680
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..8680
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /note="notch receptor 3"
                     /db_xref="GeneID:4854"
                     /db_xref="HGNC:HGNC:7883"
                     /db_xref="MIM:600276"
     exon            1..208
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..7056
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /note="neurogenic locus notch homolog protein 3; Notch
                     homolog 3; notch 3"
                     /codon_start=1
                     /product="neurogenic locus notch homolog protein 3
                     precursor"
                     /protein_id="NP_000426.2"
                     /db_xref="CCDS:CCDS12326.1"
                     /db_xref="GeneID:4854"
                     /db_xref="HGNC:HGNC:7883"
                     /db_xref="MIM:600276"
                     /translation="MGPGARGRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAPPCL
                     DGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTA
                     RFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVD
                     ECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDL
                     TYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVD
                     ECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVA
                     SFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDV
                     DECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRI
                     GQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDV
                     DECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASF
                     SCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDC
                     ASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCL
                     CPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACES
                     QPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSC
                     PQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPN
                     PCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPP
                     GYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCL
                     HGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSG
                     RLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPC
                     LAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLC
                     SCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEA
                     DINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCR
                     PSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLS
                     GPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAA
                     PEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRL
                     FNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECG
                     WDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHGQ
                     AMVFPYHRPSPGSEPRARRELAPEVIGSVVMLEIDNRLCLQSPENDHCFPDAQSAADY
                     LGALSAVERLDFPYPLRDVRGEPLEPPEPSVPLLPLLVAGAVLLLVILVLGVMVARRK
                     REHSTLWFPEGFSLHKDVASGHKGRREPVGQDALGMKNMAKGESLMGEVATDWMDTEC
                     PEAKRLKVEEPGMGAEEAVDCRQWTQHHLVAADIRVAPAMALTPPQGDADADGMDVNV
                     RGPDGFTPLMLASFCGGALEPMPTEEDEADDTSASIISDLICQGAQLGARTDRTGETA
                     LHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLD
                     ARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLAL
                     LKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERL
                     HQDIVRLLDQPSGPRSPPGPHGLGPLLCPPGAFLPGLKAAQSGSKKSRRPPGKAGLGP
                     QGPRGRGKKLTLACPGPLADSSVTLSPVDSLDSPRPFGGPPASPGGFPLEGPYAAATA
                     TAVSLAQLGGPGRAGLGRQPPGGCVLSLGLLNPVAVPLDWARLPPPAPPGPSFLLPLA
                     PGPQLLNPGTPVSPQERPPPYLAVPGHGEEYPAAGAHSSPPKARFLRVPSEHPYLTPS
                     PESPEHWASPSPPSLSDWSESTPSPATATGAMATTTGALPAQPLPLSVPSSLAQAQTQ
                     LGPQPEVTPKRQVLA"
     exon            209..287
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            288..430
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            431..769
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            770..892
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1126
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1282
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1468
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1582
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1696
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1930
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2041
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2234
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2386
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2500
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2656
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2882
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..3084
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3232
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            3233..3417
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            3418..3550
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            3551..3808
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            3809..3927
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            3928..4493
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            4494..4826
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            4827..4981
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            4982..5204
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            5205..5289
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            5290..5452
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            5453..5757
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            5758..5905
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            5906..6003
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     exon            6004..8680
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8063..8068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /note="hexamer: AATAAA"
     polyA_site      8085
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /note="major polyA site"
     regulatory      8656..8661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
                     /note="hexamer: AATAAA"
     polyA_site      8680
                     /gene="NOTCH3"
                     /gene_synonym="CADASIL; CADASIL1; CASIL; IMF2; LMNS"
ORIGIN      
        1 cttcggcgaa gttggcggcg cggaggctgg cccgggacgc gcccggagcc cagggaagga
       61 gggaggaggg gagggtcgcg gccggccgcc atggggccgg gggcccgtgg ccgccgccgc
      121 cgccgtcgcc cgatgtcgcc gccaccgcca ccgccacccg tgcgggcgct gcccctgctg
      181 ctgctgctag cggggccggg ggctgcagcc cccccttgcc tggacggaag cccgtgtgca
      241 aatggaggtc gttgcaccca gctgccctcc cgggaggctg cctgcctgtg cccgcctggc
      301 tgggtgggtg agcggtgtca gctggaggac ccctgtcact caggcccctg tgctggccgt
      361 ggtgtctgcc agagttcagt ggtggctggc accgcccgat tctcatgccg gtgcccccgt
      421 ggcttccgag gccctgactg ctccctgcca gatccctgcc tcagcagccc ttgtgcccac
      481 ggtgcccgct gctcagtggg gcccgatgga cgcttcctct gctcctgccc acctggctac
      541 cagggccgca gctgccgaag cgacgtggat gagtgccggg tgggtgagcc ctgccgccat
      601 ggtggcacct gcctcaacac acctggctcc ttccgctgcc agtgtccagc tggctacaca
      661 gggccactat gtgagaaccc cgcggtgccc tgtgcaccct caccatgccg taacgggggc
      721 acctgcaggc agagtggcga cctcacttac gactgtgcct gtcttcctgg gtttgagggt
      781 cagaattgtg aagtgaacgt ggacgactgt ccaggacacc gatgtctcaa tggggggaca
      841 tgcgtggatg gcgtcaacac ctataactgc cagtgccctc ctgagtggac aggccagttc
      901 tgcacggagg acgtggatga gtgtcagctg cagcccaacg cctgccacaa tgggggtacc
      961 tgcttcaaca cgctgggtgg ccacagctgc gtgtgtgtca atggctggac aggcgagagc
     1021 tgcagtcaga atatcgatga ctgtgccaca gccgtgtgct tccatggggc cacctgccat
     1081 gaccgcgtgg cttctttcta ctgtgcctgc cccatgggca agactggcct cctgtgtcac
     1141 ctggatgacg cctgtgtcag caacccctgc cacgaggatg ctatctgtga cacaaatccg
     1201 gtgaacggcc gggccatttg cacctgtcct cccggcttca cgggtggggc atgtgaccag
     1261 gatgtggacg agtgctctat cggcgccaac ccctgcgagc acttgggcag gtgcgtgaac
     1321 acgcagggct ccttcctgtg ccagtgcggt cgtggctaca ctggacctcg ctgtgagacc
     1381 gatgtcaacg agtgtctgtc ggggccctgc cgaaaccagg ccacgtgcct cgaccgcata
     1441 ggccagttca cctgtatctg tatggcaggc ttcacaggaa cctattgcga ggtggacatt
     1501 gacgagtgtc agagtagccc ctgtgtcaac ggtggggtct gcaaggaccg agtcaatggc
     1561 ttcagctgca cctgcccctc gggcttcagc ggctccacgt gtcagctgga cgtggacgaa
     1621 tgcgccagca cgccctgcag gaatggcgcc aaatgcgtgg accagcccga tggctacgag
     1681 tgccgctgtg ccgagggctt tgagggcacg ctgtgtgatc gcaacgtgga cgactgctcc
     1741 cctgacccat gccaccatgg tcgctgcgtg gatggcatcg ccagcttctc atgtgcctgt
     1801 gctcctggct acacgggcac acgctgcgag agccaggtgg acgaatgccg cagccagccc
     1861 tgccgccatg gcggcaaatg cctagacctg gtggacaagt acctctgccg ctgcccttct
     1921 gggaccacag gtgtgaactg cgaagtgaac attgacgact gtgccagcaa cccctgcacc
     1981 tttggagtct gccgtgatgg catcaaccgc tacgactgtg tctgccaacc tggcttcaca
     2041 gggccccttt gtaacgtgga gatcaatgag tgtgcttcca gcccatgcgg cgagggaggt
     2101 tcctgtgtgg atggggaaaa tggcttccgc tgcctctgcc cgcctggctc cttgccccca
     2161 ctctgcctcc ccccgagcca tccctgtgcc catgagccct gcagtcacgg catctgctat
     2221 gatgcacctg gcgggttccg ctgtgtgtgt gagcctggct ggagtggccc ccgctgcagc
     2281 cagagcctgg cccgagacgc ctgtgagtcc cagccgtgca gggccggtgg gacatgcagc
     2341 agcgatggaa tgggtttcca ctgcacctgc ccgcctggtg tccagggacg tcagtgtgaa
     2401 ctcctctccc cctgcacccc gaacccctgt gagcatgggg gccgctgcga gtctgcccct
     2461 ggccagctgc ctgtctgctc ctgcccccag ggctggcaag gcccacgatg ccagcaggat
     2521 gtggacgagt gtgctggccc cgcaccctgt ggccctcatg gtatctgcac caacctggca
     2581 gggagtttca gctgcacctg ccatggaggg tacactggcc cttcctgcga tcaggacatc
     2641 aatgactgtg accccaaccc atgcctgaac ggtggctcgt gccaagacgg cgtgggctcc
     2701 ttttcctgct cctgcctccc tggtttcgcc ggcccacgat gcgcccgcga tgtggatgag
     2761 tgcctgagca acccctgcgg cccgggcacc tgtaccgacc acgtggcctc cttcacctgc
     2821 acctgcccgc caggctacgg aggcttccac tgcgaacagg acctgcccga ctgcagcccc
     2881 agctcctgct tcaatggcgg gacctgtgtg gacggcgtga actcgttcag ctgcctgtgc
     2941 cgtcccggct acacaggagc ccactgccaa catgaggcag acccctgcct ctcgcggccc
     3001 tgcctacacg ggggcgtctg cagcgccgcc caccctggct tccgctgcac ctgcctcgag
     3061 agcttcacgg gcccgcagtg ccagacgctg gtggattggt gcagccgcca gccttgtcaa
     3121 aacgggggtc gctgcgtcca gactggggcc tattgccttt gtccccctgg atggagcgga
     3181 cgcctctgtg acatccgaag cttgccctgc agggaggccg cagcccagat cggggtgcgg
     3241 ctggagcagc tgtgtcaggc gggtgggcag tgtgtggatg aagacagctc ccactactgc
     3301 gtgtgcccag agggccgtac tggtagccac tgtgagcagg aggtggaccc ctgcttggcc
     3361 cagccctgcc agcatggggg gacctgccgt ggctatatgg ggggctacat gtgtgagtgt
     3421 cttcctggct acaatggtga taactgtgag gacgacgtgg acgagtgtgc ctcccagccc
     3481 tgccagcacg ggggttcatg cattgacctc gtggcccgct atctctgctc ctgtccccca
     3541 ggaacgctgg gggtgctctg cgagattaat gaggatgact gcggcccagg cccaccgctg
     3601 gactcagggc cccggtgcct acacaatggc acctgcgtgg acctggtggg tggtttccgc
     3661 tgcacctgtc ccccaggata cactggtttg cgctgcgagg cagacatcaa tgagtgtcgc
     3721 tcaggtgcct gccacgcggc acacacccgg gactgcctgc aggacccagg cggaggtttc
     3781 cgttgccttt gtcatgctgg cttctcaggt cctcgctgtc agactgtcct gtctccctgc
     3841 gagtcccagc catgccagca tggaggccag tgccgtccta gcccgggtcc tgggggtggg
     3901 ctgaccttca cctgtcactg tgcccagccg ttctggggtc cgcgttgcga gcgggtggcg
     3961 cgctcctgcc gggagctgca gtgcccggtg ggcgtcccat gccagcagac gccccgcggg
     4021 ccgcgctgcg cctgcccccc agggttgtcg ggaccctcct gccgcagctt cccggggtcg
     4081 ccgccggggg ccagcaacgc cagctgcgcg gccgccccct gtctccacgg gggctcctgc
     4141 cgccccgcgc cgctcgcgcc cttcttccgc tgcgcttgcg cgcagggctg gaccgggccg
     4201 cgctgcgagg cgcccgccgc ggcacccgag gtctcggagg agccgcggtg cccgcgcgcc
     4261 gcctgccagg ccaagcgcgg ggaccagcgc tgcgaccgcg agtgcaacag cccaggctgc
     4321 ggctgggacg gcggcgactg ctcgctgagc gtgggcgacc cctggcggca atgcgaggcg
     4381 ctgcagtgct ggcgcctctt caacaacagc cgctgcgacc ccgcctgcag ctcgcccgcc
     4441 tgcctctacg acaacttcga ctgccacgcc ggtggccgcg agcgcacttg caacccggtg
     4501 tacgagaagt actgcgccga ccactttgcc gacggccgct gcgaccaggg ctgcaacacg
     4561 gaggagtgcg gctgggatgg gctggattgt gccagcgagg tgccggccct gctggcccgc
     4621 ggcgtgctgg tgctcacagt gctgctgccg ccagaggagc tactgcgttc cagcgccgac
     4681 tttctgcagc ggctcagcgc catcctgcgc acctcgctgc gcttccgcct ggacgcgcac
     4741 ggccaggcca tggtcttccc ttaccaccgg cctagtcctg gctccgaacc ccgggcccgt
     4801 cgggagctgg cccccgaggt gatcggctcg gtagtaatgc tggagattga caaccggctc
     4861 tgcctgcagt cgcctgagaa tgatcactgc ttccccgatg cccagagcgc cgctgactac
     4921 ctgggagcgt tgtcagcggt ggagcgcctg gacttcccgt acccactgcg ggacgtgcgg
     4981 ggggagccgc tggagcctcc agaacccagc gtcccgctgc tgccactgct agtggcgggc
     5041 gctgtcttgc tgctggtcat tctcgtcctg ggtgtcatgg tggcccggcg caagcgcgag
     5101 cacagcaccc tctggttccc tgagggcttc tcactgcaca aggacgtggc ctctggtcac
     5161 aagggccggc gggaacccgt gggccaggac gcgctgggca tgaagaacat ggccaagggt
     5221 gagagcctga tgggggaggt ggccacagac tggatggaca cagagtgccc agaggccaag
     5281 cggctaaagg tagaggagcc aggcatgggg gctgaggagg ctgtggattg ccgtcagtgg
     5341 actcaacacc atctggttgc tgctgacatc cgcgtggcac cagccatggc actgacacca
     5401 ccacagggcg acgcagatgc tgatggcatg gatgtcaatg tgcgtggccc agatggcttc
     5461 accccgctaa tgctggcttc cttctgtggg ggggctctgg agccaatgcc aactgaagag
     5521 gatgaggcag atgacacatc agctagcatc atctccgacc tgatctgcca gggggctcag
     5581 cttggggcac ggactgaccg tactggcgag actgctttgc acctggctgc ccgttatgcc
     5641 cgtgctgatg cagccaagcg gctgctggat gctggggcag acaccaatgc ccaggaccac
     5701 tcaggccgca ctcccctgca cacagctgtc acagccgatg cccagggtgt cttccagatt
     5761 ctcatccgaa accgctctac agacttggat gcccgcatgg cagatggctc aacggcactg
     5821 atcctggcgg cccgcctggc agtagagggc atggtggaag agctcatcgc cagccatgct
     5881 gatgtcaatg ctgtggatga gcttgggaaa tcagccttac actgggctgc ggctgtgaac
     5941 aacgtggaag ccactttggc cctgctcaaa aatggagcca ataaggacat gcaggatagc
     6001 aaggaggaga cccccctatt cctggccgcc cgcgagggca gctatgaggc tgccaagctg
     6061 ctgttggacc actttgccaa ccgtgagatc accgaccacc tggacaggct gccgcgggac
     6121 gtagcccagg agagactgca ccaggacatc gtgcgcttgc tggatcaacc cagtgggccc
     6181 cgcagccccc ccggtcccca cggcctgggg cctctgctct gtcctccagg ggccttcctc
     6241 cctggcctca aagcggcaca gtcggggtcc aagaagagca ggaggccccc cgggaaggcg
     6301 gggctggggc cgcaggggcc ccgggggcgg ggcaagaagc tgacgctggc ctgcccgggc
     6361 cccctggctg acagctcggt cacgctgtcg cccgtggact cgctggactc cccgcggcct
     6421 ttcggtgggc cccctgcttc ccctggtggc ttcccccttg aggggcccta tgcagctgcc
     6481 actgccactg cagtgtctct ggcacagctt ggtggcccag gccgggcggg tctagggcgc
     6541 cagccccctg gaggatgtgt actcagcctg ggcctgctga accctgtggc tgtgcccctc
     6601 gattgggccc ggctgccccc acctgcccct ccaggcccct cgttcctgct gccactggcg
     6661 ccgggacccc agctgctcaa cccagggacc cccgtctccc cgcaggagcg gcccccgcct
     6721 tacctggcag tcccaggaca tggcgaggag tacccggcgg ctggggcaca cagcagcccc
     6781 ccaaaggccc gcttcctgcg ggttcccagt gagcaccctt acctgacccc atcccccgaa
     6841 tcccctgagc actgggccag cccctcacct ccctccctct cagactggtc cgaatccacg
     6901 cctagcccag ccactgccac tggggccatg gccaccacca ctggggcact gcctgcccag
     6961 ccacttccct tgtctgttcc cagctccctt gctcaggccc agacccagct ggggccccag
     7021 ccggaagtta cccccaagag gcaagtgttg gcctgagacg ctcgtcagtt cttagatctt
     7081 gggggcctaa agagaccccc gtcctgcctc ctttctttct ctgtctcttc cttcctttta
     7141 gtctttttca tcctcttctc tttccaccaa ccctcctgca tccttgcctt gcagcgtgac
     7201 cgagataggt catcagccca gggcttcagt cttcctttat ttataatggg tgggggctac
     7261 cacccaccct ctcagtcttg tgaagagtct gggacctcct tcttccccac ttctctcttc
     7321 cctcattcct ttctctctcc ttctggcctc tcatttcctt acactctgac atgaatgaat
     7381 tattattatt tttatttttc tttttttttt tacattttgt atagaaacaa attcatttaa
     7441 acaaacttat tattattatt ttttacaaaa tatatatatg gagatgctcc ctccccctgt
     7501 gaacccccca gtgcccccgt ggggctgagt ctgtgggccc attcggccaa gctggattct
     7561 gtgtacctag tacacaggca tgactgggat cccgtgtacc gagtacacga cccaggtatg
     7621 taccaagtag gcacccttgg gcgcacccac tggggccagg ggtcggggga gtgttgggag
     7681 cctcctcccc accccacctc cctcacttca ctgcattcca gatgggacat gttccatagc
     7741 cttgctgggg aagggcccac tgccaactcc ctctgcccca gccccaccct tggccatctc
     7801 cctttgggaa ctagggggct gctggtggga aatgggagcc agggcagatg tatgcattcc
     7861 tttgtgtccc tgtaaatgtg ggactacaag aagaggagct gcctgagtgg tactttctct
     7921 tcctggtaat cctctggccc agcctcatgg cagaatagag gtatttttag gctatttttg
     7981 taatatggct tctggtcaaa atccctgtgt agctgaattc ccaagccctg cattgtacag
     8041 ccccccactc ccctcaccac ctaataaagg aatagttaac actcagtgtt gttggtctgt
     8101 gtctaggtaa ggtggggagt ggtggcagtg ggacttctat ctcccccacc cagggctaac
     8161 ttgagctccc atcttggggt aaatacattt gacttgccag tctacttatg cttcctcttt
     8221 tggcagatga ctaccgattg gattagtggt tgtcacctga cttaagctga gccaatcaga
     8281 ttcttttgct cgagaacttt ctttaatgga gaggctaaga aagttgtcag ttggtggagc
     8341 tcttaaggtc acaatcagat ttagaaatat cagtggccaa ttcgaggtgg tgggcaaaga
     8401 gacaagcaaa cagggcagaa gaatgaagct aatattcagg gagaatcaga aatgagagct
     8461 caaatggctc cttgagggct gggggggtta tctcggctcc cagtgcagtt atcaattcca
     8521 gttaattgag tgttcattcc attgagatca acaggtattt attaattgct ttctaagtat
     8581 ctgatcatgg ttctgcatga atttcacttt tacttcatgc tcctatgggt tttggagata
     8641 accttggacc catgtaataa atacttcttt acttgtgcca
//
