LOCUS       NM_001396072            2089 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens notch 2 N-terminal like R (NOTCH2NLR), mRNA.
ACCESSION   NM_001396072
VERSION     NM_001396072.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2089)
  AUTHORS   Fiddes,I.T., Pollen,A.A., Davis,J.M. and Sikela,J.M.
  TITLE     Paired involvement of human-specific Olduvai domains and NOTCH2NL
            genes in human brain evolution
  JOURNAL   Hum Genet 138 (7), 715-721 (2019)
   PUBMED   31087184
REFERENCE   2  (bases 1 to 2089)
  AUTHORS   Dougherty,M.L., Underwood,J.G., Nelson,B.J., Tseng,E., Munson,K.M.,
            Penn,O., Nowakowski,T.J., Pollen,A.A. and Eichler,E.E.
  TITLE     Transcriptional fates of human-specific segmental duplications in
            brain
  JOURNAL   Genome Res 28 (10), 1566-1576 (2018)
   PUBMED   30228200
REFERENCE   3  (bases 1 to 2089)
  AUTHORS   Suzuki,I.K., Gacquer,D., Van Heurck,R., Kumar,D., Wojno,M.,
            Bilheu,A., Herpoel,A., Lambert,N., Cheron,J., Polleux,F.,
            Detours,V. and Vanderhaeghen,P.
  TITLE     Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through
            Delta/Notch Regulation
  JOURNAL   Cell 173 (6), 1370-1384 (2018)
   PUBMED   29856955
REFERENCE   4  (bases 1 to 2089)
  AUTHORS   Fiddes,I.T., Lodewijk,G.A., Mooring,M., Bosworth,C.M., Ewing,A.D.,
            Mantalas,G.L., Novak,A.M., van den Bout,A., Bishara,A.,
            Rosenkrantz,J.L., Lorig-Roach,R., Field,A.R., Haeussler,M.,
            Russo,L., Bhaduri,A., Nowakowski,T.J., Pollen,A.A., Dougherty,M.L.,
            Nuttle,X., Addor,M.C., Zwolinski,S., Katzman,S., Kriegstein,A.,
            Eichler,E.E., Salama,S.R., Jacobs,F.M.J. and Haussler,D.
  TITLE     Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical
            Neurogenesis
  JOURNAL   Cell 173 (6), 1356-1369 (2018)
   PUBMED   29856954
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC247039.2 and AC253572.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: MH721902.1, SRR7410570.22636.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000624419.3/ ENSP00000485259.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               AC247039.2         5940-6245           c
            307-388             AC253572.3         63963-64044
            389-648             AC253572.3         85309-85568
            649-984             AC253572.3         93496-93831
            985-2089            AC253572.3         94082-95186
FEATURES             Location/Qualifiers
     source          1..2089
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p11.2"
     gene            1..2089
                     /gene="NOTCH2NLR"
                     /gene_synonym="NOTCH2NLD"
                     /note="notch 2 N-terminal like R"
                     /db_xref="GeneID:101929796"
                     /db_xref="HGNC:HGNC:53925"
                     /db_xref="MIM:618026"
     exon            1..306
                     /gene="NOTCH2NLR"
                     /gene_synonym="NOTCH2NLD"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1058
                     /gene="NOTCH2NLR"
                     /gene_synonym="NOTCH2NLD"
                     /note="notch homolog 2 N-terminal-like-related; notch 2
                     N-terminal like R (pseudogene)"
                     /codon_start=1
                     /product="notch 2 N-terminal like R (pseudogene)
                     precursor"
                     /protein_id="NP_001383001.1"
                     /db_xref="CCDS:CCDS91030.1"
                     /db_xref="GeneID:101929796"
                     /db_xref="HGNC:HGNC:53925"
                     /db_xref="MIM:618026"
                     /translation="MPALRPALLWALLALWLCWAAPAHALQCRDGYEPCVNKGMCVTY
                     HSGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQ
                     YSTPHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHLCANGSTCT
                     TVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYC
                     DRLYVPCAHSPCVNGGTCRQTGDFTFECNCLPETVRNKRNRALGKRQASLEWKRTR"
     exon            307..388
                     /gene="NOTCH2NLR"
                     /gene_synonym="NOTCH2NLD"
                     /inference="alignment:Splign:2.1.0"
     exon            389..648
                     /gene="NOTCH2NLR"
                     /gene_synonym="NOTCH2NLD"
                     /inference="alignment:Splign:2.1.0"
     exon            649..984
                     /gene="NOTCH2NLR"
                     /gene_synonym="NOTCH2NLD"
                     /inference="alignment:Splign:2.1.0"
     exon            985..2089
                     /gene="NOTCH2NLR"
                     /gene_synonym="NOTCH2NLD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccaaactt ccggcggcgg ctgaggcggc ggccgaggag cggcggactc ggggcgcggg
       61 gagtcgaggc atttgcacct gggcttcgga gcgtagcgcc agggcctgag cctttgaagc
      121 aggaggaggg gaggagagag tggggctcct ctatcgggac cccctcccca tgtggatctg
      181 cccaggcggc ggcggcggcg gcggcggagg aggaggagga ggcgaccgag aagatgcccg
      241 ccctgcgtcc cgctctgctg tgggcgctgc tggcgctctg gctgtgctgg gcggcccccg
      301 cgcatgcatt gcagtgtcga gatggctatg aaccctgtgt aaataaagga atgtgtgtta
      361 cctaccacag tggcacagga tactgcaaat gtccagaagg cttcttgggg gaatattgtc
      421 aacatcgaga cccctgtgag aagaaccgct gccagaatgg tgggacttgt gtggcccagg
      481 ccatgctggg gaaagccacg tgccggtgtg cctcagggtt tacaggagag gactgccagt
      541 actcgacacc tcatccatgc tttgtgtctc gaccttgcct gaatggcggc acatgccata
      601 tgctcagccg ggatacctat gagtgcacct gtcaagtcgg gtttacaggt aaggagtgcc
      661 aatggaccga tgcctgcctg tctcatctct gtgcaaatgg aagtacctgt accactgtgg
      721 ccaaccagtt ctcctgcaaa tgcctcacag gcttcacagg gcagaagtgt gagactgatg
      781 tcaatgagtg tgacattcca ggacactgcc agcatggtgg cacctgcctc aacctgcctg
      841 gttcctacca gtgccagtgc cttcagggct tcacaggcca gtactgtgac agactgtatg
      901 tgccctgtgc acactcgcct tgtgtcaatg gaggcacctg tcggcagact ggtgacttca
      961 cttttgagtg caactgcctt ccagaaacag tgagaaataa gaggaacaga gctctgggaa
     1021 agagacaggc aagtctggaa tggaaaagaa cacgatgaga attagacact ggaaaatatg
     1081 tatgtgtggt taataaagtg ctttaaactg aattgacatt aacagtaggt gatcaacttt
     1141 actatgtgct tgtgcttttg cttttgatgg agtaattcat tgttttctta tccacctaaa
     1201 tgcacccagc tgcccttgat tttctctggg ctactggcct tcacaaccct ctcccatgta
     1261 ccctctctga ctttggggta accctcccct aacttaaagc tagagaattc tgaaactgag
     1321 gaggggatcc tctgttaatc agtgagcact ttttgatgag ctgatagatg atatatgaga
     1381 gactatgtgt ggcacaatac tttgttacac tcttcactga tacaagtgtt gtagagtgca
     1441 cacacaaccc aaagatagaa ataaaaagag gagcagtgtc ggggagcttg gggcctggtg
     1501 ttccatggag agggagaaag gaacaagctt ggccaattca ttcaactcct tataaaaatg
     1561 atgaggaggc tgaaaaccaa gaattttgat tgggaacaga atacaagcag ctgaagcaga
     1621 tgaattacta agcaacaaag atcctgtttt tatacaaata tccttagtac aaaaacaaaa
     1681 gaaggaaaac tgtaggaggg agtaatgtgc taagtaagca gaattgcctc aaaaagaagt
     1741 tgttctagtt actctttcag agtgggaatc ttagattctg gtattgtgga tatggttcac
     1801 atataatggg attgtgtgtt ttattttgga gggattaaag gtcatagttt ggtcctcagt
     1861 ataaaatcaa ctggtaattt attcatttca tttggtaaaa atgtattgac tgcctgctat
     1921 gttctaggca ccatgctatg tatttggaat acagctatac aaagcattgt cacataattg
     1981 aaatgaaaat tttatattat ttaagtcaca agaacaagct atttaattat attactttta
     2041 gtttctcttt taataaagaa tagataatgc tatcattcta gatactaaa
//
