LOCUS       NM_001364013            8729 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens notch 2 N-terminal like C (NOTCH2NLC), transcript
            variant 2, mRNA.
ACCESSION   NM_001364013
VERSION     NM_001364013.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8729)
  AUTHORS   Ruffo,P., De Amicis,F., La Bella,V. and Conforti,F.L.
  TITLE     Investigating Repeat Expansions in NIPA1, NOP56, and NOTCH2NLC
            Genes: A Closer Look at Amyotrophic Lateral Sclerosis Patients from
            Southern Italy
  JOURNAL   Cells 13 (8), 677 (2024)
   PUBMED   38667292
  REMARK    GeneRIF: Investigating Repeat Expansions in NIPA1, NOP56, and
            NOTCH2NLC Genes: A Closer Look at Amyotrophic Lateral Sclerosis
            Patients from Southern Italy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8729)
  AUTHORS   Liu,Q., Chen,J., Xue,J., Zhou,X., Tian,Y., Xiao,Q., Huang,W.,
            Pan,Y., Zhou,X., Li,J., Zhao,Y., Pan,H., Wang,Y., He,R., Xiang,Y.,
            Tu,T., Xu,Q., Sun,Q., Tan,J., Yan,X., Li,J., Guo,J., Shen,L.,
            Duan,R., Tang,B. and Liu,Z.
  TITLE     GGC expansions in NOTCH2NLC contribute to Parkinson disease and
            dopaminergic neuron degeneration
  JOURNAL   Eur J Neurol 31 (2), e16145 (2024)
   PUBMED   37975799
  REMARK    GeneRIF: GGC expansions in NOTCH2NLC contribute to Parkinson
            disease and dopaminergic neuron degeneration.
REFERENCE   3  (bases 1 to 8729)
  AUTHORS   Ando,M., Higuchi,Y., Yuan,J.H., Yoshimura,A., Dozono,M., Hobara,T.,
            Kojima,F., Noguchi,Y., Takeuchi,M., Takei,J., Hiramatsu,Y.,
            Nozuma,S., Nakamura,T., Sakiyama,Y., Hashiguchi,A., Matsuura,E.,
            Okamoto,Y., Sone,J. and Takashima,H.
  TITLE     Clinical phenotypic diversity of NOTCH2NLC-related disease in the
            largest case series of inherited peripheral neuropathy in Japan
  JOURNAL   J Neurol Neurosurg Psychiatry 94 (8), 622-630 (2023)
   PUBMED   36948577
  REMARK    GeneRIF: Clinical phenotypic diversity of NOTCH2NLC-related disease
            in the largest case series of inherited peripheral neuropathy in
            Japan.
REFERENCE   4  (bases 1 to 8729)
  AUTHORS   Liu,M., Wang,Y., Shi,C., Yuan,Y., Li,L., Zhang,X., Xu,Y. and
            Yang,J.
  TITLE     Genetic spectrum and clinical features of adult
            leukoencephalopathies in a Chinese cohort
  JOURNAL   Ann Clin Transl Neurol 10 (7), 1119-1135 (2023)
   PUBMED   37237429
  REMARK    GeneRIF: Genetic spectrum and clinical features of adult
            leukoencephalopathies in a Chinese cohort.
REFERENCE   5  (bases 1 to 8729)
  AUTHORS   Sone,J., Mitsuhashi,S., Fujita,A., Mizuguchi,T., Hamanaka,K.,
            Mori,K., Koike,H., Hashiguchi,A., Takashima,H., Sugiyama,H.,
            Kohno,Y., Takiyama,Y., Maeda,K., Doi,H., Koyano,S., Takeuchi,H.,
            Kawamoto,M., Kohara,N., Ando,T., Ieda,T., Kita,Y., Kokubun,N.,
            Tsuboi,Y., Katoh,K., Kino,Y., Katsuno,M., Iwasaki,Y., Yoshida,M.,
            Tanaka,F., Suzuki,I.K., Frith,M.C., Matsumoto,N. and Sobue,G.
  TITLE     Long-read sequencing identifies GGC repeat expansions in NOTCH2NLC
            associated with neuronal intranuclear inclusion disease
  JOURNAL   Nat Genet 51 (8), 1215-1221 (2019)
   PUBMED   31332381
  REMARK    GeneRIF: GGC repeat expansions in NOTCH2NLC gene is associated with
            neuronal intranuclear inclusion disease.
REFERENCE   6  (bases 1 to 8729)
  AUTHORS   Tian,Y., Wang,J.L., Huang,W., Zeng,S., Jiao,B., Liu,Z., Chen,Z.,
            Li,Y., Wang,Y., Min,H.X., Wang,X.J., You,Y., Zhang,R.X., Chen,X.Y.,
            Yi,F., Zhou,Y.F., Long,H.Y., Zhou,C.J., Hou,X., Wang,J.P., Xie,B.,
            Liang,F., Yang,Z.Y., Sun,Q.Y., Allen,E.G., Shafik,A.M., Kong,H.E.,
            Guo,J.F., Yan,X.X., Hu,Z.M., Xia,K., Jiang,H., Xu,H.W., Duan,R.H.,
            Jin,P., Tang,B.S. and Shen,L.
  TITLE     Expansion of Human-Specific GGC Repeat in Neuronal Intranuclear
            Inclusion Disease-Related Disorders
  JOURNAL   Am J Hum Genet 105 (1), 166-176 (2019)
   PUBMED   31178126
  REMARK    GeneRIF: Expansion of NOTCH2NLC GGC Repeat is associated with
            Neuronal Intranuclear Inclusion Disease-Related Disorders.
REFERENCE   7  (bases 1 to 8729)
  AUTHORS   Dougherty,M.L., Underwood,J.G., Nelson,B.J., Tseng,E., Munson,K.M.,
            Penn,O., Nowakowski,T.J., Pollen,A.A. and Eichler,E.E.
  TITLE     Transcriptional fates of human-specific segmental duplications in
            brain
  JOURNAL   Genome Res 28 (10), 1566-1576 (2018)
   PUBMED   30228200
REFERENCE   8  (bases 1 to 8729)
  AUTHORS   Suzuki,I.K., Gacquer,D., Van Heurck,R., Kumar,D., Wojno,M.,
            Bilheu,A., Herpoel,A., Lambert,N., Cheron,J., Polleux,F.,
            Detours,V. and Vanderhaeghen,P.
  TITLE     Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through
            Delta/Notch Regulation
  JOURNAL   Cell 173 (6), 1370-1384 (2018)
   PUBMED   29856955
REFERENCE   9  (bases 1 to 8729)
  AUTHORS   Fiddes,I.T., Lodewijk,G.A., Mooring,M., Bosworth,C.M., Ewing,A.D.,
            Mantalas,G.L., Novak,A.M., van den Bout,A., Bishara,A.,
            Rosenkrantz,J.L., Lorig-Roach,R., Field,A.R., Haeussler,M.,
            Russo,L., Bhaduri,A., Nowakowski,T.J., Pollen,A.A., Dougherty,M.L.,
            Nuttle,X., Addor,M.C., Zwolinski,S., Katzman,S., Kriegstein,A.,
            Eichler,E.E., Salama,S.R., Jacobs,F.M.J. and Haussler,D.
  TITLE     Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical
            Neurogenesis
  JOURNAL   Cell 173 (6), 1356-1369 (2018)
   PUBMED   29856954
  REMARK    GeneRIF: the emergence of human-specific NOTCH2NL genes may have
            contributed to the rapid evolution of the larger human neocortex,
            accompanied by loss of genomic stability at the 1q21.1 locus and
            resulting recurrent neurodevelopmental disorders
REFERENCE   10 (bases 1 to 8729)
  AUTHORS   Florio,M., Heide,M., Pinson,A., Brandl,H., Albert,M., Winkler,S.,
            Wimberger,P., Huttner,W.B. and Hiller,M.
  TITLE     Evolution and cell-type specificity of human-specific genes
            preferentially expressed in progenitors of fetal neocortex
  JOURNAL   Elife 7, e32332 (2018)
   PUBMED   29561261
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC242843.2 and AC242842.3.
            
            On Dec 14, 2020 this sequence version replaced NM_001364013.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            at a 5' exon compared to variant 1. This difference is predicted to
            result in the use of an upstream start codon and an isoform (2)
            with a longer N-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138524.1063694.1,
                                           SRR7410570.24765.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000650865.2/ ENSP00000499085.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               AC242843.2         69046-69347         c
            303-376             AC242843.2         28953-29026         c
            377-636             AC242843.2         4391-4650           c
            637-972             AC242842.3         66306-66641
            973-8729            AC242842.3         66892-74648
FEATURES             Location/Qualifiers
     source          1..8729
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..8729
                     /gene="NOTCH2NLC"
                     /gene_synonym="ETM6; N2N; NIID; NOTCH2NL; NOTCH2NLA;
                     OPDM3"
                     /note="notch 2 N-terminal like C"
                     /db_xref="GeneID:100996717"
                     /db_xref="HGNC:HGNC:53924"
                     /db_xref="MIM:618025"
     exon            1..302
                     /gene="NOTCH2NLC"
                     /gene_synonym="ETM6; N2N; NIID; NOTCH2NL; NOTCH2NLA;
                     OPDM3"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1049
                     /gene="NOTCH2NLC"
                     /gene_synonym="ETM6; N2N; NIID; NOTCH2NL; NOTCH2NLA;
                     OPDM3"
                     /note="isoform 2 is encoded by transcript variant 2; notch
                     homolog 2 N-terminal-like protein C; Notch homolog 2
                     N-terminal-like protein A"
                     /codon_start=1
                     /product="notch homolog 2 N-terminal-like protein C
                     isoform 2"
                     /protein_id="NP_001350942.1"
                     /db_xref="CCDS:CCDS91047.1"
                     /db_xref="GeneID:100996717"
                     /db_xref="HGNC:HGNC:53924"
                     /db_xref="MIM:618025"
                     /translation="MWICPGGGGGGGGGGGGGDREDARPAPLCCGRCWRSGCAARPPR
                     MCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAM
                     LGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC
                     QWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLN
                     LPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPETVRRGTE
                     LWERDREVWNGKEHDEN"
     exon            303..376
                     /gene="NOTCH2NLC"
                     /gene_synonym="ETM6; N2N; NIID; NOTCH2NL; NOTCH2NLA;
                     OPDM3"
                     /inference="alignment:Splign:2.1.0"
     exon            377..636
                     /gene="NOTCH2NLC"
                     /gene_synonym="ETM6; N2N; NIID; NOTCH2NL; NOTCH2NLA;
                     OPDM3"
                     /inference="alignment:Splign:2.1.0"
     exon            637..972
                     /gene="NOTCH2NLC"
                     /gene_synonym="ETM6; N2N; NIID; NOTCH2NL; NOTCH2NLA;
                     OPDM3"
                     /inference="alignment:Splign:2.1.0"
     exon            973..8729
                     /gene="NOTCH2NLC"
                     /gene_synonym="ETM6; N2N; NIID; NOTCH2NL; NOTCH2NLA;
                     OPDM3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8706..8711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOTCH2NLC"
                     /gene_synonym="ETM6; N2N; NIID; NOTCH2NL; NOTCH2NLA;
                     OPDM3"
                     /note="hexamer: AATAAA"
     polyA_site      8729
                     /gene="NOTCH2NLC"
                     /gene_synonym="ETM6; N2N; NIID; NOTCH2NL; NOTCH2NLA;
                     OPDM3"
                     /note="major polyA site"
ORIGIN      
        1 ccaaacttcg ggcggcggct gaggcggcgg ccgaggagcg gcggactcgg ggcgcgggga
       61 gtcgaggcat ttgcgcctgt gcttcggacc gtagcgccag ggcctgagcc tttgaagcag
      121 gaggagggga ggagagagtg gggctcctct atcgggaccc cctccccatg tggatctgcc
      181 caggcggcgg cggcggcggc ggcggcggcg gaggaggcgg cgaccgagaa gatgcccgcc
      241 ctgcgccgct ctgctgtggg cgctgctggc gctctggctg tgctgcgcga cccccgcgca
      301 tgtgtcgaga tggctatgaa ccctgtgtaa atgaaggaat gtgtgttacc taccacaatg
      361 gcacaggata ctgcaaatgt ccagaaggct tcttggggga atattgtcaa catcgagacc
      421 cctgtgagaa gaaccgctgc cagaatggtg ggacttgtgt ggcccaggcc atgctgggga
      481 aagccacgtg ccgatgtgcc tcagggttta caggagagga ctgccagtac tcgacatctc
      541 atccatgctt tgtgtctcga ccttgcctga atggcggcac atgccatatg ctcagccggg
      601 atacctatga gtgcacctgt caagtcgggt ttacaggtaa ggagtgccaa tggaccgatg
      661 cctgcctgtc tcatccctgt gcaaatggaa gtacctgtac cactgtggcc aaccagttct
      721 cctgcaaatg cctcacaggc ttcacagggc agaagtgtga gactgatgtc aatgagtgtg
      781 acattccagg acactgccag catggtggca cctgcctcaa cctgcctggt tcctaccagt
      841 gccagtgcct tcagggcttc acaggccagt actgtgacag cctgtatgtg ccctgtgcac
      901 cctcgccttg tgtcaatgga ggcacctgtc ggcagactgg tgacttcact tttgagtgca
      961 actgccttcc agaaacagtg agaagaggaa cagagctctg ggaaagagac agggaagtct
     1021 ggaatggaaa agaacacgat gagaattaga cactggaaaa tatgtatgtg tggttaataa
     1081 agtgctttaa actgaattga cattaacagt aggtgatcaa ctttactatg tgcttgtgct
     1141 tttgcttttg atggagtaat tcattgtttt cttatccacc taaatgcacc cagctgccct
     1201 tgattttctc tgggctactg gccttcacaa ccctctccca tgtaccctct ctgactttgg
     1261 ggtaaccctc ccctaactta aagctagaga attctgaaac tgaggagggg atcctctgtt
     1321 aatcagtgag cactttttga tgagctgata gatgatatat gagagactat gcgtggcaca
     1381 atactttgtt acactcttca ctgatacaag tgttctagag tgcacacaca acccaaagat
     1441 agaaataaaa agaggagcag tgtcggggag cttggggcct ggtgttccat ggagagggag
     1501 aaaggaacaa gcttggccaa ttcattcaac tccttataaa aatgatgagg aggctgaaaa
     1561 ccaagaattt tgattgggaa cagaatacaa gcagctgaag cagatgaatt actaagcaac
     1621 aaagatcctg tttttataca aatatcctta gtacaaaaac aaaagaagga aaactgtagg
     1681 ggggagtaat gtgctaagta agcagaattg cctccaaaag aagttgttct agttactctt
     1741 tcagagtggg aatcttagat tctggtattg tggatatggt tcacatataa tgggattgtg
     1801 tgttttattt tggaggaatt aaaggtcata gtttggtcct cagtataaaa tcaactggta
     1861 atttgttcat ttcatttggt aaaaatgtat tgactgcctg ctatgttcta ggcaccatgc
     1921 tgtgtatttg gaatacagct atacaaagca ttgtcacata attgaaatga aaattttata
     1981 ttatttaagt cacaagaaca agctatttaa ttatattact tttagtttct cttttaataa
     2041 agaatagata atgctatcat tctagatact aaataagtat tttcttaaca taatattact
     2101 atccacttta tcttgtagaa gaaataacta aaatacatct gtcttcactc ctgtatttgt
     2161 ttgcatttta aggattaaag acagaaatag aaatgtaaac aactttattt tgaaaatatt
     2221 tcaacactgc aaatatctct gggtctgata ttctagtaat ctaattggct agtaattgat
     2281 gttagtgtga tttattgttg aaggctaaat gtgtttttca gtttcaagaa aattgctttt
     2341 aataattgcc tagaacaaga ggttgatttg gcagcaagat gttgacggga agttagagaa
     2401 gtcaataaag gaagttttta gctgagagag agtgattatt cactcccata gcctctgcat
     2461 tgttatccat tagccacgat aagaacctta gggaattctg agagtgtgtc caggaaagga
     2521 tctgtcaaac tagaatagta tctcctcctt gagaaaggaa ataaccaagg attccgcagc
     2581 tgagaggctg ccagggctag tgaaatagag taaggaaatc ttggctgtct cttattctct
     2641 ggttgtagtt taacgcaaga cacttattta ctcactgatg gtgtgtgtgt gtgtgggagg
     2701 ggagattagc atgaggggtg ggaatgggga gatttgatga agagaaaact aacatttttt
     2761 tggtgactca ggaactgtgc caggtacttc catgcttatt agctcaatta cacaaaaatc
     2821 ttgggaccag gtattatttt tcaagtcttc ccacatgaag taactgaagt ttggagatgt
     2881 taagtgattc acccaaagtt gtacagctaa tatgtggtta ggctgggtcc tgaaaccgag
     2941 gcagtttatt ttcaaagcct ttgctttgtg catcttactg cgccacattg cactgcacat
     3001 ctgcttcctg aaagcacttt gtaggtgtgt aaaacttttc gttaaatgct ttaagctgtt
     3061 tgggttaaaa atatatgttc atgttataag aaaaccaaga cactcctaat tataatcaaa
     3121 tagtacttgt tacatatcaa tatgtgtgtg tgtgtgtgtg tgtgtgtgtg tggtatatat
     3181 atatatatcg cattgtgcag atgtttaaaa gtagttacat agactagttc ttgcttttca
     3241 gggtcccata atctaaacca gatgacttca gctttggata aatatataga aggaaattta
     3301 aagagaattc aaaacaatag atgatgcagt gacactgtga ataaatgtta tttatacagt
     3361 ttgtaagatt tcatgctcat tgttcgtatg tcccaggtgg agttcagaaa atattcagtt
     3421 catttccaca aagggaaata gtgcctagag atggttttct tttaaaaagt ccttttcata
     3481 atgcagtgcc cttccttcca ttgcccttca ttccattgct tcccatgctt gtcaagagac
     3541 taaaatgtta cttatagtaa tagtcactat ctcaatgtaa atagcaccct tatttgatga
     3601 gaattattat ttcagttcta aaaatgggga aacaaagtca gcaggaggca aagtagcttg
     3661 ttaaagtatt ctgcaacttt caaatggttg cttccactgc atttcacgtc ttggcacttc
     3721 taattgaggg ttactctaac caccctattt aaaattgtaa ctgtccccca cccccttaat
     3781 tactaaccct ggtctacttt ttgttttctt tttctgtaac tcttatcttc ttactatata
     3841 atttatacta tataatttac ttcattatgt ctattgttta ttgtctgtct tttccaaatt
     3901 ctactgcctc ttaccctctc cagaatgaaa actagtatct ttgtttttgt ttactgatgt
     3961 aacccaaaca cctacaaaca gtgcccagta tatactaggc ccgcaaatat atattggctg
     4021 actgactgta tggtttagta tcatgtcata gtattgagac tgtaactttg gtcttctcat
     4081 tttcttcttt gtattgtgcg tcctagactt agtttggcct ctccttttgt ccttgtatac
     4141 tctaatactg gataagaatt ttggagtctt tttcaactct gagtcagtga atgccacata
     4201 acttagtgac tatatttaaa tggttaattt acaatttttt ccctgcaaag gatactgtag
     4261 tcactgtgag tattttagta ttactgtagg actcaagagg gaattaaaac tacaaaaatg
     4321 acgcgtcttg tatgacacag aaagaaatgt ttcttcacag agggaggaga aaaatatctt
     4381 caagagagaa ctaatagaat caaatcaatg aaccatgtct catctttttg gataagtaac
     4441 tgttagtaat ccagacactt catgagcttt cattatgtaa agtctttagc agaagctaaa
     4501 ggaggggcac caaccacagt aattttaact taagaacaaa atggagcatg aaaataaatt
     4561 attaaatcat ttactcccac tatttttggg ttagggccaa taatggggag agaaagaggt
     4621 agactagttt tgtgtttgtg gctattttaa tagagtagca caagtaatca aaaaacagta
     4681 ggctgttttg aatttactgg ctgtccctta tgagttcaca gttagattgg actgtcctca
     4741 atgtactttc ttttttttct ttctttccca catctcttta tttctctgat tttgtttaaa
     4801 cttcataaag agctctctga tctttccttt ccaaacaatg aaggtttatc ctttgtaaac
     4861 tacctctgta ctccacaggc tgatgatatg tgatatccct atatcattaa agtaaagcct
     4921 aagcacattc tgtggctttt gtgtctactc tgttgttgct gagcttatga actattagaa
     4981 ataactccct cttgcatttt cacacatggg gaatgtgatg ttctcttggg tattatgcta
     5041 atcatatttt ggcaggtttc tctggagcag atgcagaaat gatcatacca ctttccaggg
     5101 tgtattattt tagctccttt gacttgggcc ctaagtctgt tttacctgat gttcctgaaa
     5161 gatgttcctg atgtccttca ctgttctttc atgctggatg ttcttgccta tgctgcctcc
     5221 tcagctatca ccctctcttc ccctttttaa tgtagaactc attcttaatg atttgtcaaa
     5281 ggcaccctat ttcactgaaa tgccttctat attccctacc ctccaagtgg attgtagacc
     5341 ttctaaggtc ttttgacatc tgcatatctc tagcacagca cttaccacgg tgattattta
     5401 tctgttcatc tttccaagta gacactctca ttttaactcc ctaccctagt cgccagcatc
     5461 cccagcatag tgcctgtcat aaaatggtgc cacaatgaaa atttgaaaaa tgaatgaacg
     5521 tgataaacat agatgagaat cctatattct acaatttttt aaatgtactg aaattattct
     5581 ttttgaatcc tcctatttat ttctgtgact tctttggtga caaagttaga aaaaagtgga
     5641 ggtcagtagg gagatatgaa gggacgcaag tggaagcagt gagcctgggc gggtgatgga
     5701 gtgggagata cgtggcacag gggtcagtga gttaatctgg gctcattcag agaatggaag
     5761 gtgtgtgcca agaaaactgg ttggataggg ataggtcagg gattccctct tgcattctca
     5821 cacttggggg catgtgtcat tttcttttct tttctttttt tttttttttt ttttttttga
     5881 gacggagcat cgctctttct cccaggctgg agtgcaatgg tgctatctcg gctcactgca
     5941 acctccacct cccgggttca agctattctc atgtctcagc cttccaagta gctgggacta
     6001 caggtgcctg ccaccatgct cagctaattt ttgtattttt agtaaagatg gggtttcacc
     6061 atgttggtca ggttggcctc gaactcctga tctcaggtga tccacctgcc tcggcttctc
     6121 aaagtgctgg gattccaggc atgagccacc atgcctggcc gcatgtgtca ttttcttggg
     6181 tgttatactg atcgtatatt tgcaggtttg cttttgtgac agacttcttc tgggggaaaa
     6241 aaagtatcct tctatctttt tacttttgtc cagttccagg tatccctgtt tttttcttca
     6301 ctcttccttc cttgttcatg ggagtttttc ttgaggactt caagcccagc ttcggagaat
     6361 cctggttgtg tcatctcatc tcctttctgc tctcttctct acctagcctt tccaccctca
     6421 cacctcccgg ggtctgaaaa tggaaagata agggtgtttc cctgaaagtt gctcttctgt
     6481 gtggggatga caggttctaa agactctttt ctggtccctg ccctcattgc catgattaat
     6541 cagttaagtg gcccgaggtt ttgtaacagc acagtcttaa aatgcttctc ccaagtttaa
     6601 tttctctcca tttgaccttt taaggatgtg aattggcttt aagcagtaga ctccctttag
     6661 tacggcgctg tgagcctctc agtgaatctg ctacatccat tccacccacg ggtctggaaa
     6721 cttgtctgtt tacctttccc taaaaaccta agatatattt ttaagaagtg ccttgtaact
     6781 tttcatatag cctttcccct actttgggta gactgtttct tacaggaatt tggtagatct
     6841 ttccaaagag aattctgtat ctctattttt aaagcataaa tcctgtcaac tttggaggag
     6901 aactgatttg gcttgagttt tctcagacat gggaactttt gacctaagtt tgtattttac
     6961 attgttgaaa gggaactccg ggatcccaga aaacatatgg actgcaattg ggtaaagttt
     7021 ctgtttcagt acttattcct acttactagc cgtttaatct tggtcaagtc agccatgtgg
     7081 ctctcaactt cctcatctgt aacataaaag gattagagca gacaatctct aacaaatgct
     7141 ataataccac tgacaaataa taatattagc taatatgtgt aaggcactgt gtttagtgct
     7201 ttttccctta atacaatagc tttgagatat aatttatata ccatacaatt tacttcttaa
     7261 aaaagtacac aattcagtaa ttttaataga taggagtaac catcaccaca gtcaattcta
     7321 gaatattttt atacatcaga agaaaccctt tacccattat caattactct ccattcctcc
     7381 taactccctc ccagccctag gcaactacta gtctactttc tgtctttatt tgcctcttct
     7441 ggacatttca tacaaatgga aacatgcagc atgtagtaat ttatgacagc ttctttcact
     7501 tagcatgagg ttttcaaagt tcattgatgt ggtagcattt atcagtactc tgtgcctttt
     7561 tatggctgaa taatatttta tcatatggat ttaccacatt ttatcatttt atttatccat
     7621 catcagttga ttgacatttg agttgcttct actttttgag tattatcaat aattctgtta
     7681 tgaacattct tgtataattt tttggtagac atttatcttc atatttcttg gatatatacc
     7741 taggagcaga attgctgcgt cagatggtaa tgctgtttaa ccttttcagg aactgtcaga
     7801 ctgttctgaa gtgggtacat tattttacat tccaaccagc agtgtatgag aattccagtt
     7861 tatccacatc ctcatcaaca gttgttattg tctgtctttt ttattatatt catctgtaat
     7921 gtgaagtgtt tatctcattg tggttttgat ttacatttcc ctgatggttg atgattttca
     7981 acatcttttc atatacttat tagtcattat gtatcttctt tggagaatgt ctgttcagat
     8041 cctttaccta ctttataatt ggtttatctt tttaatattg aactgtaata gttttaaaaa
     8101 aatatatcct aaatacaagt ctcttatcag ataatatgac ttgcagatat tttctgtcat
     8161 tctatgtact gtcttttcac attcttgatg atatactttt cagcccaaat gtttttaact
     8221 tgatggaata caatttattt tttcttttgt tgcttgtgct ttcagtcata tttgtgaaaa
     8281 ctttgcttat cccacattac aaagatttac tacttctaag tgatttataa ttttaccacc
     8341 tacctttagg tctctgatcc attttgagtt aatttttatg tgcaaggagg gagtctaact
     8401 tgattctttt acatgtggat atttagttgt cccaggacca tttgttgaat taagtgccca
     8461 gaacaagtac atctatatat agagaaagta gattagtggt tgtcagagac tgcaagaagt
     8521 ggggaattgg agagtgactg cccataggta caggcatgct ttttggcatt atgaaaatat
     8581 tctggaatta ggtagtggtg atggttgcag aacttttgga atatggtaaa agacactgaa
     8641 atatatgctt aaaaatggtg atttttgtga tatatgaatt atactatgga actaataata
     8701 acagtaataa agcaaggtgt ctttccaca
//
