LOCUS       NM_203458               8356 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens notch 2 N-terminal like A (NOTCH2NLA), transcript
            variant 1, mRNA.
ACCESSION   NM_203458
VERSION     NM_203458.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8356)
  AUTHORS   Lodewijk,G.A., Fernandes,D.P., Vretzakis,I., Savage,J.E. and
            Jacobs,F.M.J.
  TITLE     Evolution of Human Brain Size-Associated NOTCH2NL Genes Proceeds
            toward Reduced Protein Levels
  JOURNAL   Mol Biol Evol 37 (9), 2531-2548 (2020)
   PUBMED   32330268
  REMARK    GeneRIF: Evolution of Human Brain Size-Associated NOTCH2NL Genes
            Proceeds toward Reduced Protein Levels.
REFERENCE   2  (bases 1 to 8356)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8356)
  AUTHORS   Dougherty,M.L., Underwood,J.G., Nelson,B.J., Tseng,E., Munson,K.M.,
            Penn,O., Nowakowski,T.J., Pollen,A.A. and Eichler,E.E.
  TITLE     Transcriptional fates of human-specific segmental duplications in
            brain
  JOURNAL   Genome Res 28 (10), 1566-1576 (2018)
   PUBMED   30228200
REFERENCE   4  (bases 1 to 8356)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 8356)
  AUTHORS   Suzuki,I.K., Gacquer,D., Van Heurck,R., Kumar,D., Wojno,M.,
            Bilheu,A., Herpoel,A., Lambert,N., Cheron,J., Polleux,F.,
            Detours,V. and Vanderhaeghen,P.
  TITLE     Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through
            Delta/Notch Regulation
  JOURNAL   Cell 173 (6), 1370-1384 (2018)
   PUBMED   29856955
REFERENCE   6  (bases 1 to 8356)
  AUTHORS   Fiddes,I.T., Lodewijk,G.A., Mooring,M., Bosworth,C.M., Ewing,A.D.,
            Mantalas,G.L., Novak,A.M., van den Bout,A., Bishara,A.,
            Rosenkrantz,J.L., Lorig-Roach,R., Field,A.R., Haeussler,M.,
            Russo,L., Bhaduri,A., Nowakowski,T.J., Pollen,A.A., Dougherty,M.L.,
            Nuttle,X., Addor,M.C., Zwolinski,S., Katzman,S., Kriegstein,A.,
            Eichler,E.E., Salama,S.R., Jacobs,F.M.J. and Haussler,D.
  TITLE     Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical
            Neurogenesis
  JOURNAL   Cell 173 (6), 1356-1369 (2018)
   PUBMED   29856954
  REMARK    GeneRIF: the emergence of human-specific NOTCH2NL genes may have
            contributed to the rapid evolution of the larger human neocortex,
            accompanied by loss of genomic stability at the 1q21.1 locus and
            resulting recurrent neurodevelopmental disorders
REFERENCE   7  (bases 1 to 8356)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 8356)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   9  (bases 1 to 8356)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 8356)
  AUTHORS   Duan,Z., Li,F.Q., Wechsler,J., Meade-White,K., Williams,K.,
            Benson,K.F. and Horwitz,M.
  TITLE     A novel notch protein, N2N, targeted by neutrophil elastase and
            implicated in hereditary neutropenia
  JOURNAL   Mol Cell Biol 24 (1), 58-70 (2004)
   PUBMED   14673143
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC239799.2.
            
            On Jun 15, 2021 this sequence version replaced NM_203458.5.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.2569023.1,
                                           SRR14038197.1268083.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000362074.8/ ENSP00000354929.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-313               AC239799.2         43344-43656
            314-395             AC239799.2         82984-83065
            396-655             AC239799.2         107355-107614
            656-991             AC239799.2         115550-115885
            992-8356            AC239799.2         116136-123500
FEATURES             Location/Qualifiers
     source          1..8356
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.1"
     gene            1..8356
                     /gene="NOTCH2NLA"
                     /gene_synonym="N2N; NOTCH2NL"
                     /note="notch 2 N-terminal like A"
                     /db_xref="GeneID:388677"
                     /db_xref="HGNC:HGNC:31862"
                     /db_xref="MIM:618023"
     exon            1..313
                     /gene="NOTCH2NLA"
                     /gene_synonym="N2N; NOTCH2NL"
                     /inference="alignment:Splign:2.1.0"
     exon            314..395
                     /gene="NOTCH2NLA"
                     /gene_synonym="N2N; NOTCH2NL"
                     /inference="alignment:Splign:2.1.0"
     CDS             358..1068
                     /gene="NOTCH2NLA"
                     /gene_synonym="N2N; NOTCH2NL"
                     /note="isoform 1 is encoded by transcript variant 1; Notch
                     homolog 2 N-terminal like protein; notch homolog 2
                     N-terminal-like protein A"
                     /codon_start=1
                     /product="notch homolog 2 N-terminal-like protein A
                     isoform 1"
                     /protein_id="NP_982283.2"
                     /db_xref="CCDS:CCDS72880.1"
                     /db_xref="GeneID:388677"
                     /db_xref="HGNC:HGNC:31862"
                     /db_xref="MIM:618023"
                     /translation="MCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQA
                     MLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKE
                     CQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCL
                     NLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPETVRRGT
                     ELWERDREVWNGKEHDEN"
     exon            396..655
                     /gene="NOTCH2NLA"
                     /gene_synonym="N2N; NOTCH2NL"
                     /inference="alignment:Splign:2.1.0"
     exon            656..991
                     /gene="NOTCH2NLA"
                     /gene_synonym="N2N; NOTCH2NL"
                     /inference="alignment:Splign:2.1.0"
     exon            992..8356
                     /gene="NOTCH2NLA"
                     /gene_synonym="N2N; NOTCH2NL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8333..8338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOTCH2NLA"
                     /gene_synonym="N2N; NOTCH2NL"
                     /note="hexamer: AATAAA"
     polyA_site      8356
                     /gene="NOTCH2NLA"
                     /gene_synonym="N2N; NOTCH2NL"
                     /note="major polyA site"
ORIGIN      
        1 acacccgaga aagtttcagc caaacttcgg gcggcggctg aggcggcggc cgaggagcgg
       61 cggactcggg gcgcggggag tcgaggcatt tgcgctgggc ttcggagcgt agcgccaggg
      121 cctgagcctt tgaagcagga ggaggggagg agagagtggg gctcctctat cgggaccccc
      181 tccccatgtg gatctgccca ggcggccgcg gcggcggcgg cggaggaggc gaccgagaag
      241 atacccgccc tgcgccccgc tctgctgtgg gcgctgctgg cgctctggct gtgctgcgcg
      301 acccccgcgc atgcattgca gtgtcgagat ggctatgaac cctgtgtaaa tgaaggaatg
      361 tgtgttacct accacaatgg cacaggatac tgcaaatgtc cagaaggctt cttgggggaa
      421 tattgtcaac atcgagaccc ctgtgagaag aaccgctgcc agaatggtgg gacttgtgtg
      481 gcccaggcca tgctggggaa agccacgtgc cgatgtgcct cagggtttac aggagaggac
      541 tgccagtact cgacatctca tccatgcttt gtgtctcgac cttgcctgaa tggcggcaca
      601 tgccatatgc tcagccggga tacctatgag tgcacctgtc aagtcgggtt tacaggtaag
      661 gagtgccaat ggaccgatgc ctgcctgtct catccctgtg caaatggaag tacctgtacc
      721 actgtggcca accagttctc ctgcaaatgc ctcacaggct tcacagggca gaagtgtgag
      781 actgatgtca atgagtgtga cattccagga cactgccagc atggtggcac ctgcctcaac
      841 ctgcctggtt cctaccagtg ccagtgcctt cagggcttca caggccagta ctgtgacagc
      901 ctgtatgtgc cctgtgcacc ctcgccttgt gtcaatggag gcacctgtcg gcagactggt
      961 gacttcactt ttgagtgcaa ctgccttcca gaaacagtga gaagaggaac agagctctgg
     1021 gaaagagaca gggaagtctg gaatggaaaa gaacacgatg agaattagac actggaaaat
     1081 atgtatgtgt ggttaataaa gtgctttaaa ctgaattgac attaacagtg ggtgatcaac
     1141 tttactatgt gcttgtgctt ttgcttttga tggagtaatt cattgttttc ttatccacct
     1201 aaatgcaccc agctgccctt gattttctct gggctactgg ccttcacaac cctctcccat
     1261 gtaccctctc tgactttggg gtaaccctcc cctaacttaa agctagagaa ttctgaaact
     1321 gaggagggga tcctctgtta atcagtgagc actttttgat gagctgatag atgatatatg
     1381 agagactatg cgtggcacaa tactttgtta cactcttcac tgatacaagt gttctagagt
     1441 gtacacacaa cccaaagata gaaataaaaa gaggagcagt gtcggggagc ttggggcctg
     1501 gtgttccatg gagagggaga aaggaacaag cttgaccaat tcattcaact ccttataaaa
     1561 atgatgagga ggctgaaaac caagaatttt gattgggaac agaatacaag cagctgaatc
     1621 agatgaatta ctaagcaaca aagatcctgt ttttatacaa atatccttag tacaaaaaca
     1681 aaagaaggaa aactgtaggg gggagtaatg tgctaagtaa gcagaattgc ctcaaaaaga
     1741 agttgttcta gttactcttt cagagtggga atcttagatt ctggtattgt ggatatggtt
     1801 cacatataat gggattgtgt gttttatttt ggagggatta aaggtcatag tttggtcctc
     1861 agtataaaat caactggtaa tttattcatt tcatttggta aaaatgtatt gactgcctgc
     1921 tatgttctag gcaccatgct atgtatttgg aatacagcta tacaaagcat tgtcacataa
     1981 ttgaaatgaa aattttatat tatttaagtc acaagaacaa gctatttaat tatattactt
     2041 ttagtttctc ttttaataaa gaatagataa tgctatcatt ctagatacta aataagtatt
     2101 ttcttaacat aatattacta tccactttat cttgtagaag aaataactaa aatacatctg
     2161 tcttcactcc tgtatttgtt tgcattttaa ggattaaaga cagaaataga aatgtaaaca
     2221 actttatttt gaaaatattt caacactgca aatatctctg ggtctgatat tctagtaatc
     2281 taattggcta gtaattgatg ttagtgtgat ttattgttga aggctaaatg tgtttttcag
     2341 tttcaagaaa attgctttta ataattgcct agaacaagag gttgatttgg cagcaagatg
     2401 ttgacgggaa gttagagaag tcaataaagg aagtttttag ctgagagaga gtgattattc
     2461 actcccatag cctctgcatt gttatccatt agccacgata agaaccttag ggaattctga
     2521 gagtgtgtcc aggaaaggat ctgtcaaact agaatagtat ctcctccttg agaaaggaaa
     2581 taaccaagga ttccgcagct gagaggctgc cagggctagt gaaatagagt aaggaaatct
     2641 tggctgtctc ttattctctg gttgtagttt aacgcaagac acttatttac tcactgatgg
     2701 tgtgtgtgtg tgtgggaggg gagattagca tgaggggtgg gaatggggag attcgatgaa
     2761 gagaaaacta acattttttt ggtgactcag gaactgtgcc aggtacttcc atgcttatta
     2821 gctcaattac acaaaaatct tgggaccagg tattattttt caagtcttcc cacatgaagt
     2881 aactgaagtt tggagatgtt aagtgattca cccaaagttg tacagctaat atgtggttag
     2941 gctgggtcct gaaaccgagg cagtttattt tcaaagcctt tgctttgtgc atcttactgc
     3001 gccacattgc actgcacatc tgcttcctga aagcactttg taggtgtgta aaacttttcg
     3061 ttaaatgctt taagctgttt gggttaaaaa tatatgttca tgttataaga aaaccaagac
     3121 actcctaatt ataatcaaat agtacttgtt acatatcaat atgtgtgtgt gtgtgtgtgt
     3181 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtatggcg ttgtgcagat gtttaaaagt
     3241 agttacatag actagttctt gcttttcagg gtcccataat ctaaaccaga tgacttcagc
     3301 tttggataaa tatatagaag gaaatttaaa gagaattcaa aacaatagat gatgcagtga
     3361 cactgtgaat aaatgttatt tatacagttt gtaagatttc atgctcattg ttcatatgtc
     3421 ccaggtggag ttcagaaaat attctcttca tttccacaaa ggggaatagt gcctggagat
     3481 ggttttcttt taaaaagtcc ttttcataat gcagtgccct tccttccatt gcccttcatt
     3541 ccattgcttc ccatgcttgt caagagacta aaatgttact tatagtaata gtcactatct
     3601 caatgtaaat agcaccctta tttgatgaga attattattt cagttctaaa aatggggaaa
     3661 caaagtcagc aggaggcaaa gtagcttgtt aaagtattct gcaactttca aatggttgct
     3721 tccactgcat ttcacgtctt ggcacttcta attgagggtt actctaacca ccctatttaa
     3781 aattgtaact gtcccccacc cccttaatta ctaaccctgg tctacttttt gttttctttt
     3841 tctgtaactc ttatcttctt actatataat ttatactata taatttactt cattatgtct
     3901 attgttcatt gtctgtcttt tccaaattct actgcctctt accctctcca gaatgaaaac
     3961 tagtatcttt gtttttgttt actgatgtaa cccaaacacc tacaaacagt gcccagtata
     4021 tactaggccc acaaatatat attggctgac tgactgtatg gtttagtatc atgtcatagt
     4081 attgagactg taactttggt cttctcattt tcttctttgt attgtgcgtc ctagacttag
     4141 tttggcctct ccttttgtcc ttgtatactc taatactgga taagaatttt ggagtctttt
     4201 tcaactctga gtcagtgaat gccacataac ttagtgacta tatttaaatg gttaatttac
     4261 aattttttcc ctgcaaagga tactgtagtc actgtgagta ttttagtatt attgtaggac
     4321 tcaagaggga attaaaacta caaaaatgac tcctcttgta tgacacagaa agaaatgttt
     4381 cttcacagag ggaggagaaa aatatcttca agagagaact aatagaatca aatcaatgaa
     4441 ccatgtctca tctttttgga taagtaactg ttagtaatcc agacacttca tgagctttca
     4501 ttatgtaaag tctttagcag aagctaaagg aggggcacca accacagtaa ttttaactta
     4561 agaacaaaat ggagcatgaa aataaattat taaatcattt actcccacta tttttgggtt
     4621 agggccaata atggggagag aaagaggtag actagttttg tgtttgtggc tattttaata
     4681 gagtagcaca agtaatcaaa aaacagtagg ctgttttgaa tttactggct gtcccttatg
     4741 agttcacagt tagattggac tgtcctcaat gtactttctt ttttttcttt ctttcccaca
     4801 tctctttatt tctctgattt tgtttaaact tcataaagag ctctctgatc tttcctttcc
     4861 aaacaatgaa ggtttatcct ttgtaaacta cctctgtact ccacaggctg atgatatgtg
     4921 atatccctat atcattaaag taaagcctaa gcacattcta tggcttttgt gtctactctg
     4981 ttgttgctga gcttatgaac tattagaaat aactccctct tgcattttca cacatgggga
     5041 atgtgatgtt ctcttgggta ttatgctaat catattttgg caggtttctc tggagcagat
     5101 gcagaaatga tcataccact ttccagggtg tattatttta gctcctttga cttgggccct
     5161 aagtctgttt tacctgatgt tcctgaaaga tgttcctgat gtccttcact gttctttcat
     5221 gctggatgtt cttgcctatg ctgcctcctc agctatcacc ctctcttccc ctttttaatg
     5281 tagaactcat tcttaatgat ttgtcaaagg caccctattt cactgaaatg ccttctatat
     5341 tccctaccct ccaagtggat tgtagacctt ctaaggtctt ttgacatctg catatctcta
     5401 gcacagcact tatcacggtg attatttatc tgttcatctt tccaagtaga cactctcatt
     5461 ttaactccct accctagtcg ccagcatccc cagcatagtg cctgtcataa aatggtgcca
     5521 caatgaaaat ttgaaaaatg aatgaacgtg ataaacatag atgagaatcc tatattctac
     5581 aattttttaa atgtactgaa attattcttt ttgaatcctc ctatttattt ctgtgacttc
     5641 tttgatgaca aagttagaaa aaagtggagg tcagtaggga gatatgaagg gacgcaggtg
     5701 gaagcagtga gcctgggcgg gtgatggagt gggagatacg tggcacaggg gtcagtgagt
     5761 taatctgggc tcattcagag aatggaaggt gtgtgccaag aaaactggtt ggatagggat
     5821 aggtcaggga ttccctcttg cattctcaca cttgggggca tgtgtcattt tcttttcttt
     5881 tctttttttt tttttttttt tttgagacgg agcatcgctc tttctcccag gctggagtgc
     5941 aatggtgcta tctcggctca ctgcaacctc cacctcccgg gttcaagcta ttctcatgtc
     6001 tcagccttcc aagtagctgg gactacaggt gcctgccacc atgctcagct aatttttgta
     6061 tttttagtag agatggggtt tcaccatgtt ggtcaggttg gcctcgaact cctgatctca
     6121 ggtgatccac ctgcctcggc ttctcaaagt gctgggattc caggcatgag ccaccatgcc
     6181 tggccgcatg tgtcattttc ttgggtgtta tactgatcgt atatttgcag gtttgctttt
     6241 gtgacagact tcttctgggg gaaaaaaagt atccttctat ctttttactt ttgtccagtt
     6301 ccaggtatcc ctgttttttt cttcactctt ccttccttgt tcatgggagt ttttcttgag
     6361 gacttcaagc ccagcttcgg agaatcctgg ttgtgtcatc tcatctcctt tctgctctct
     6421 tctctaccta gcctttccac cctcacacct cccggggtct gaaaatggaa agataagggt
     6481 gtttccctga aagttgctct tctgtgtggg gatgacaggt tctaaagact cttttctggt
     6541 ccctgccctc attgccatga ttaatcagtt aagtggcccg aggttttata acagcacagt
     6601 cttaaaatgc ttctcccaag tttaatttct ctccatttga ccttttaagg atgtgaattg
     6661 gctttaagca gtagactccc tttagtacgg tgctgtgagc ctctcagtga atctgctaca
     6721 tccattccac ccacgggtct ggaaacttgt ctgtttacct ttccctaaaa acctaagata
     6781 tatttttaag aagtgccttg taacttttca tatagccttt cccctacttt gggtagactg
     6841 tttcttacag gaatttggta gatctttcca aagagaattc tgtatctgta tttttaaagc
     6901 ataaatcctg tcaactttgg aggagaactg atttggcttg agttttctca gacatgggaa
     6961 cttttgacct aagtttgtat tttacattgt tgaaagggaa ctccgggatc ccagaaaaca
     7021 tatggactgc aattgggtaa agtttctgtt ccagaaatgc ctcttctgga catttcatac
     7081 aaatggaaac atgcagcatg tagtaattta tgacagcttc tttcacttag catgaggttt
     7141 tcaaagttca ttgatgtggt agcatttgtc agtactctgt gcctttttat ggctgaataa
     7201 tattttatca tatggattta ccacatttta tcattttatt tatccatcat cagttgattg
     7261 acatttgagt tgcttctact ttttgagtat tatcaataat tctgttatga acattcttgt
     7321 ataatttttt ggtagacatt tatcttcata tttcttggat atatacctag gagcagaatt
     7381 gctgcgtcag atggtaatgc tgtttaacct tttcaggaac tgtcagactg ttctgaagtg
     7441 ggtacattat tttacattcc aaccagcagt gtatgagaat tccagtttct ccacatcctc
     7501 atcaacagtt gttattgtct gtctttttta ttatattcat ctgtaatgtg aagtgtttat
     7561 ctcattgtgg ttttgattta catttccctg atggttgatg attttcaaca tcttttcata
     7621 tacttattag tcattatgta tcttctttgg agaatgtctg ttcagatcct ttacctactt
     7681 tataattggt ttatcttttt aatattgaac tgtaatagtt tttaaaaaat atatcctaaa
     7741 tacaagtctc ttatcagata atatgatttg cagatatttt ctgtcattct atgtactgtc
     7801 ttttcacatt cttgatgata tacttttcag cccaaatgtt tttaacttga tggaatacaa
     7861 tttatttttt cttttgttgc ttgtgctttc agtcatattt gtgaaaactt tgcttatccc
     7921 acattacaaa gatttactat ttctaagtga tttataattt taccacctac ctttaggtct
     7981 ctgatccatt ttgagttaat ttttatgtgc gaggagggag tctaacttga ttcttttaca
     8041 tgtggatatt tagttgtccc aggaccattt gttgaattaa gtgcccagaa caagtacatc
     8101 tatatataga gaaagtagat tagtggttgt cagagactgt aagaagtggg gaattggaga
     8161 gtgactgccc ataggtacag gcatgctttt tggcattatg aaaatattct ggaattaggt
     8221 agtggtgatg gttgcagaac ttttggaata tggtaaaaga cactgaaata tatgcttaaa
     8281 aatggtgatt tttgtgatat atgaattata ctatagaact aataataaca gtaataaagc
     8341 aaggtgtctt tccaca
//
