LOCUS       NM_024408              11425 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens notch receptor 2 (NOTCH2), transcript variant 1, mRNA.
ACCESSION   NM_024408 XM_941698 XM_945379
VERSION     NM_024408.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11425)
  AUTHORS   Zhou,X., Zhang,C., Yu,H., Feng,Z., Bai,X., Mei,Y., Li,L., Li,X.,
            Gou,X. and Deng,Y.
  TITLE     The MEF2A/SNHG16/miR-425-5p/NOTCH2 axis induces gemcitabine
            resistance by inhibiting ferroptosis in the starving bladder tumor
            microenvironment
  JOURNAL   Cell Signal 122, 111337 (2024)
   PUBMED   39121977
  REMARK    GeneRIF: The MEF2A/SNHG16/miR-425-5p/NOTCH2 axis induces
            gemcitabine resistance by inhibiting ferroptosis in the starving
            bladder tumor microenvironment.
REFERENCE   2  (bases 1 to 11425)
  AUTHORS   Yang,S., Xiong,L., Yang,G., Xiang,J., Li,L., Kang,L. and Liang,Z.
  TITLE     KLF13 restrains Dll4-muscular Notch2 axis to improve the muscle
            atrophy
  JOURNAL   J Cachexia Sarcopenia Muscle 15 (5), 1869-1882 (2024)
   PUBMED   38973459
  REMARK    GeneRIF: KLF13 restrains Dll4-muscular Notch2 axis to improve the
            muscle atrophy.
REFERENCE   3  (bases 1 to 11425)
  AUTHORS   Ferrandino,M., Cardiero,G., Di Dato,F., Cerrato,Y., Vitagliano,L.,
            Mandato,C., Morisco,F., Spagnuolo,M.I., Iorio,R., Di Taranto,M.D.
            and Fortunato,G.
  TITLE     Association of Very Rare NOTCH2 Variants with Clinical Features of
            Alagille Syndrome
  JOURNAL   Genes (Basel) 15 (8), 1034 (2024)
   PUBMED   39202394
  REMARK    GeneRIF: Association of Very Rare NOTCH2 Variants with Clinical
            Features of Alagille Syndrome.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11425)
  AUTHORS   Lin,H., Fu,L., Zhou,X., Yu,A., Chen,Y., Liao,W., Shu,G., Zhang,L.,
            Tan,L., Liang,H., Wang,Z., Deng,Q., Wang,J., Jin,M., Chen,Z.,
            Wei,J., Cao,J., Chen,W., Li,X., Li,P., Lu,J. and Luo,J.
  TITLE     LRP1 induces anti-PD-1 resistance by modulating the
            DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage
            polarisation in bladder cancer
  JOURNAL   Cancer Lett 593, 216807 (2024)
   PUBMED   38462037
  REMARK    GeneRIF: LRP1 induces anti-PD-1 resistance by modulating the
            DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage
            polarisation in bladder cancer.
REFERENCE   5  (bases 1 to 11425)
  AUTHORS   Li,M., He,W., Wang,F., Zhang,P., Zhang,X., Li,Q., Liu,T. and Li,Y.
  TITLE     High expression of NOTCH2 in gastric adenocarcinoma: A novel early
            diagnostic target
  JOURNAL   J Gastroenterol Hepatol 39 (6), 1115-1122 (2024)
   PUBMED   38577711
  REMARK    GeneRIF: High expression of NOTCH2 in gastric adenocarcinoma: A
            novel early diagnostic target.
REFERENCE   6  (bases 1 to 11425)
  AUTHORS   Hsieh,J.J., Nofziger,D.E., Weinmaster,G. and Hayward,S.D.
  TITLE     Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and
            blocks differentiation
  JOURNAL   J Virol 71 (3), 1938-1945 (1997)
   PUBMED   9032325
REFERENCE   7  (bases 1 to 11425)
  AUTHORS   Katsanis,N., Fitzgibbon,J. and Fisher,E.M.
  TITLE     Paralogy mapping: identification of a region in the human MHC
            triplicated onto human chromosomes 1 and 9 allows the prediction
            and isolation of novel PBX and NOTCH loci
  JOURNAL   Genomics 35 (1), 101-108 (1996)
   PUBMED   8661110
REFERENCE   8  (bases 1 to 11425)
  AUTHORS   Larsson,C., Lardelli,M., White,I. and Lendahl,U.
  TITLE     The human NOTCH1, 2, and 3 genes are located at chromosome
            positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of
            neoplasia-associated translocation
  JOURNAL   Genomics 24 (2), 253-258 (1994)
   PUBMED   7698746
REFERENCE   9  (bases 1 to 11425)
  AUTHORS   Spinner,N.B., Loomes,K.M., Krantz,I.D. and Gilbert,M.A.
  TITLE     Alagille Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301450
REFERENCE   10 (bases 1 to 11425)
  AUTHORS   Stifani,S., Blaumueller,C.M., Redhead,N.J., Hill,R.E. and
            Artavanis-Tsakonas,S.
  TITLE     Human homologs of a Drosophila Enhancer of split gene product
            define a novel family of nuclear proteins
  JOURNAL   Nat Genet 2 (2), 119-127 (1992)
   PUBMED   1303260
  REMARK    Erratum:[Nat Genet. 1992 Dec;2(4):343. doi: 10.1038/ng1292-343a.
            PMID: 1303292]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB290699.1, BC071562.1,
            AF315356.1 and AL133036.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_024408.3.
            
            Summary: This gene encodes a member of the Notch family. Members of
            this Type 1 transmembrane protein family share structural
            characteristics including an extracellular domain consisting of
            multiple epidermal growth factor-like (EGF) repeats, and an
            intracellular domain consisting of multiple, different domain
            types. Notch family members play a role in a variety of
            developmental processes by controlling cell fate decisions. The
            Notch signaling network is an evolutionarily conserved
            intercellular signaling pathway which regulates interactions
            between physically adjacent cells. In Drosophilia, notch
            interaction with its cell-bound ligands (delta, serrate)
            establishes an intercellular signaling pathway that plays a key
            role in development. Homologues of the notch-ligands have also been
            identified in human, but precise interactions between these ligands
            and the human notch homologues remain to be determined. This
            protein is cleaved in the trans-Golgi network, and presented on the
            cell surface as a heterodimer. This protein functions as a receptor
            for membrane bound ligands, and may play a role in vascular, renal
            and hepatic development. Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jan
            2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2645516.1,
                                           SRR11853559.2248.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256646.7/ ENSP00000256646.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DB290699.1         42-51
            11-2550             BC071562.1         1-2540
            2551-6413           AF315356.1         2307-6169
            6414-11425          AL133036.1         132-5143
FEATURES             Location/Qualifiers
     source          1..11425
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p12"
     gene            1..11425
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /note="notch receptor 2"
                     /db_xref="GeneID:4853"
                     /db_xref="HGNC:HGNC:7882"
                     /db_xref="MIM:600275"
     exon            1..329
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..7672
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; Notch homolog 2; notch 2"
                     /codon_start=1
                     /product="neurogenic locus notch homolog protein 2 isoform
                     1 preproprotein"
                     /protein_id="NP_077719.2"
                     /db_xref="CCDS:CCDS908.1"
                     /db_xref="GeneID:4853"
                     /db_xref="HGNC:HGNC:7882"
                     /db_xref="MIM:600275"
                     /translation="MPALRPALLWALLALWLCCAAPAHALQCRDGYEPCVNEGMCVTY
                     HNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQ
                     YSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCT
                     TVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYC
                     DSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCV
                     DGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDD
                     CSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDT
                     NPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAG
                     PRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQ
                     CVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVL
                     CEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCID
                     LVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNID
                     IDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSG
                     YKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDE
                     CASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFES
                     YTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDD
                     CLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYT
                     CKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECS
                     SHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCL
                     CPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYC
                     EEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCID
                     LVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCE
                     GDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCA
                     VASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGC
                     ASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARD
                     GVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLFDNF
                     ECQGNSKTCKYDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVL
                     MPPEQLLQDARSFLRALGTLLHTNLRIKRDSQGELMVYPYYGEKSAAMKKQRMTRRSL
                     PGEQEQEVAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASHAIQGTLSYPLVSVVS
                     ESLTPERTQLLYLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKR
                     REPVGQDAVGLKNLSVQVSEANLIGTGTSEHWVDDEGPQPKKVKAEDEALLSEEDDPI
                     DRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSS
                     DLSDEDEDAEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAG
                     ADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMNDGTTPLILAARLAVEG
                     MVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFL
                     AAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGT
                     VLTSALSPVICGPNRSFLSLKHTPMGKKSRRPSAKSTMPTSLPNLAKEAKDAKGSRRK
                     KSLSEKVQLSESSVTLSPVDSLESPHTYVSDTTSSPMITSPGILQASPNPMLATAAPP
                     APVHAQHALSFSNLHEMQPLAHGASTVLPSVSQLLSHHHIVSPGSGSAGSLSRLHPVP
                     VPADWMNRMEVNETQYNEMFGMVLAPAEGTHPGIAPQSRPPEGKHITTPREPLPPIVT
                     FQLIPKGSIAQPAGAPQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQQDGQ
                     VAQTILPAYHPFPASVGKYPTPPSQHSYASSNAAERTPSHSGHLQGEHPYLTPSPESP
                     DQWSSSSPHSASDWSDVTTSPTPGGAGGGQRGPGTHMSEPPHNNMQVYA"
     exon            330..411
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            412..671
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..1007
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1130
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1364
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1520
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1709
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1823
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1937
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2171
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2282
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2475
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2621
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2735
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2855
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..3008
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..3237
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3238..3439
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3440..3593
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3594..3778
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3779..3911
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            3912..4148
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4149..4261
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4262..4767
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            4768..5115
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            5116..5258
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            5259..5469
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            5470..5566
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            5567..5735
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            5736..6037
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            6038..6185
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            6186..6283
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     exon            6284..11425
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10900..10905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /note="hexamer: AATAAA"
     polyA_site      10923
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /note="major polyA site"
     regulatory      11328..11333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /note="hexamer: AATATA"
     regulatory      11345..11350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /note="hexamer: AATAAT"
     polyA_site      11349
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
     polyA_site      11364
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
     regulatory      11396..11401
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
                     /note="hexamer: TATAAA"
     polyA_site      11425
                     /gene="NOTCH2"
                     /gene_synonym="AGS2; HJCYS; hN2"
ORIGIN      
        1 aggctgcttc gttgcacacc cgagaaagtt tcagccaaac ttcgggcggc ggctgaggcg
       61 gcggccgagg agcggcggac tcggggcgcg gggagtcgag gcatttgcgc ctgggcttcg
      121 gagcgtagcg ccagggcctg agcctttgaa gcaggaggag gggaggagag agtggggctc
      181 ctctatcggg accccctccc catgtggatc tgcccaggcg gcggcggcgg cggcggagga
      241 ggaggcgacc gagaagatgc ccgccctgcg ccccgctctg ctgtgggcgc tgctggcgct
      301 ctggctgtgc tgcgcggccc ccgcgcatgc attgcagtgt cgagatggct atgaaccctg
      361 tgtaaatgaa ggaatgtgtg ttacctacca caatggcaca ggatactgca aatgtccaga
      421 aggcttcttg ggggaatatt gtcaacatcg agacccctgt gagaagaacc gctgccagaa
      481 tggtgggact tgtgtggccc aggccatgct ggggaaagcc acgtgccgat gtgcctcagg
      541 gtttacagga gaggactgcc agtactcaac atctcatcca tgctttgtgt ctcgaccctg
      601 cctgaatggc ggcacatgcc atatgctcag ccgggatacc tatgagtgca cctgtcaagt
      661 cgggtttaca ggtaaggagt gccaatggac ggatgcctgc ctgtctcatc cctgtgcaaa
      721 tggaagtacc tgtaccactg tggccaacca gttctcctgc aaatgcctca caggcttcac
      781 agggcagaaa tgtgagactg atgtcaatga gtgtgacatt ccaggacact gccagcatgg
      841 tggcacctgc ctcaacctgc ctggttccta ccagtgccag tgccctcagg gcttcacagg
      901 ccagtactgt gacagcctgt atgtgccctg tgcaccctca ccttgtgtca atggaggcac
      961 ctgtcggcag actggtgact tcacttttga gtgcaactgc cttccaggtt ttgaagggag
     1021 cacctgtgag aggaatattg atgactgccc taaccacagg tgtcagaatg gaggggtttg
     1081 tgtggatggg gtcaacactt acaactgccg ctgtccccca caatggacag gacagttctg
     1141 cacagaggat gtggatgaat gcctgctgca gcccaatgcc tgtcaaaatg ggggcacctg
     1201 tgccaaccgc aatggaggct atggctgtgt atgtgtcaac ggctggagtg gagatgactg
     1261 cagtgagaac attgatgatt gtgccttcgc ctcctgtact ccaggctcca cctgcatcga
     1321 ccgtgtggcc tccttctctt gcatgtgccc agaggggaag gcaggtctcc tgtgtcatct
     1381 ggatgatgca tgcatcagca atccttgcca caagggggca ctgtgtgaca ccaaccccct
     1441 aaatgggcaa tatatttgca cctgcccaca aggctacaaa ggggctgact gcacagaaga
     1501 tgtggatgaa tgtgccatgg ccaatagcaa tccttgtgag catgcaggaa aatgtgtgaa
     1561 cacggatggc gccttccact gtgagtgtct gaagggttat gcaggacctc gttgtgagat
     1621 ggacatcaat gagtgccatt cagacccctg ccagaatgat gctacctgtc tggataagat
     1681 tggaggcttc acatgtctgt gcatgccagg tttcaaaggt gtgcattgtg aattagaaat
     1741 aaatgaatgt cagagcaacc cttgtgtgaa caatgggcag tgtgtggata aagtcaatcg
     1801 tttccagtgc ctgtgtcctc ctggtttcac tgggccagtt tgccagattg atattgatga
     1861 ctgttccagt actccgtgtc tgaatggggc aaagtgtatc gatcacccga atggctatga
     1921 atgccagtgt gccacaggtt tcactggtgt gttgtgtgag gagaacattg acaactgtga
     1981 ccccgatcct tgccaccatg gtcagtgtca ggatggtatt gattcctaca cctgcatctg
     2041 caatcccggg tacatgggcg ccatctgcag tgaccagatt gatgaatgtt acagcagccc
     2101 ttgcctgaac gatggtcgct gcattgacct ggtcaatggc taccagtgca actgccagcc
     2161 aggcacgtca ggggttaatt gtgaaattaa ttttgatgac tgtgcaagta acccttgtat
     2221 ccatggaatc tgtatggatg gcattaatcg ctacagttgt gtctgctcac caggattcac
     2281 agggcagaga tgtaacattg acattgatga gtgtgcctcc aatccctgtc gcaagggtgc
     2341 aacatgtatc aacggtgtga atggtttccg ctgtatatgc cccgagggac cccatcaccc
     2401 cagctgctac tcacaggtga acgaatgcct gagcaatccc tgcatccatg gaaactgtac
     2461 tggaggtctc agtggatata agtgtctctg tgatgcaggc tgggttggca tcaactgtga
     2521 agtggacaaa aatgaatgcc tttcgaatcc atgccagaat ggaggaactt gtgacaatct
     2581 ggtgaatgga tacaggtgta cttgcaagaa gggctttaaa ggctataact gccaggtgaa
     2641 tattgatgaa tgtgcctcaa atccatgcct gaaccaagga acctgctttg atgacataag
     2701 tggctacact tgccactgtg tgctgccata cacaggcaag aattgtcaga cagtattggc
     2761 tccctgttcc ccaaaccctt gtgagaatgc tgctgtttgc aaagagtcac caaattttga
     2821 gagttatact tgcttgtgtg ctcctggctg gcaaggtcag cggtgtacca ttgacattga
     2881 cgagtgtatc tccaagccct gcatgaacca tggtctctgc cataacaccc agggcagcta
     2941 catgtgtgaa tgtccaccag gcttcagtgg tatggactgt gaggaggaca ttgatgactg
     3001 ccttgccaat ccttgccaga atggaggttc ctgtatggat ggagtgaata ctttctcctg
     3061 cctctgcctt ccgggtttca ctggggataa gtgccagaca gacatgaatg agtgtctgag
     3121 tgaaccctgt aagaatggag ggacctgctc tgactacgtc aacagttaca cttgcaagtg
     3181 ccaggcagga tttgatggag tccattgtga gaacaacatc aatgagtgca ctgagagctc
     3241 ctgtttcaat ggtggcacat gtgttgatgg gattaactcc ttctcttgct tgtgccctgt
     3301 gggtttcact ggatccttct gcctccatga gatcaatgaa tgcagctctc atccatgcct
     3361 gaatgaggga acgtgtgttg atggcctggg tacctaccgc tgcagctgcc ccctgggcta
     3421 cactgggaaa aactgtcaga ccctggtgaa tctctgcagt cggtctccat gtaaaaacaa
     3481 aggtacttgc gttcagaaaa aagcagagtc ccagtgccta tgtccatctg gatgggctgg
     3541 tgcctattgt gacgtgccca atgtctcttg tgacatagca gcctccagga gaggtgtgct
     3601 tgttgaacac ttgtgccagc actcaggtgt ctgcatcaat gctggcaaca cgcattactg
     3661 tcagtgcccc ctgggctata ctgggagcta ctgtgaggag caactcgatg agtgtgcgtc
     3721 caacccctgc cagcacgggg caacatgcag tgacttcatt ggtggataca gatgcgagtg
     3781 tgtcccaggc tatcagggtg tcaactgtga gtatgaagtg gatgagtgcc agaatcagcc
     3841 ctgccagaat ggaggcacct gtattgacct tgtgaaccat ttcaagtgct cttgcccacc
     3901 aggcactcgg ggcctactct gtgaagagaa cattgatgac tgtgcccggg gtccccattg
     3961 ccttaatggt ggtcagtgca tggataggat tggaggctac agttgtcgct gcttgcctgg
     4021 ctttgctggg gagcgttgtg agggagacat caacgagtgc ctctccaacc cctgcagctc
     4081 tgagggcagc ctggactgta tacagctcac caatgactac ctgtgtgttt gccgtagtgc
     4141 ctttactggc cggcactgtg aaaccttcgt cgatgtgtgt ccccagatgc cctgcctgaa
     4201 tggagggact tgtgctgtgg ccagtaacat gcctgatggt ttcatttgcc gttgtccccc
     4261 gggattttcc ggggcaaggt gccagagcag ctgtggacaa gtgaaatgta ggaaggggga
     4321 gcagtgtgtg cacaccgcct ctggaccccg ctgcttctgc cccagtcccc gggactgcga
     4381 gtcaggctgt gccagtagcc cctgccagca cgggggcagc tgccaccctc agcgccagcc
     4441 tccttattac tcctgccagt gtgccccacc attctcgggt agccgctgtg aactctacac
     4501 ggcacccccc agcacccctc ctgccacctg tctgagccag tattgtgccg acaaagctcg
     4561 ggatggcgtc tgtgatgagg cctgcaacag ccatgcctgc cagtgggatg ggggtgactg
     4621 ttctctcacc atggagaacc cctgggccaa ctgctcctcc ccacttccct gctgggatta
     4681 tatcaacaac cagtgtgatg agctgtgcaa cacggtcgag tgcctgtttg acaactttga
     4741 atgccagggg aacagcaaga catgcaagta tgacaaatac tgtgcagacc acttcaaaga
     4801 caaccactgt gaccaggggt gcaacagtga ggagtgtggt tgggatgggc tggactgtgc
     4861 tgctgaccaa cctgagaacc tggcagaagg taccctggtt attgtggtat tgatgccacc
     4921 tgaacaactg ctccaggatg ctcgcagctt cttgcgggca ctgggtaccc tgctccacac
     4981 caacctgcgc attaagcggg actcccaggg ggaactcatg gtgtacccct attatggtga
     5041 gaagtcagct gctatgaaga aacagaggat gacacgcaga tcccttcctg gtgaacaaga
     5101 acaggaggtg gctggctcta aagtctttct ggaaattgac aaccgccagt gtgttcaaga
     5161 ctcagaccac tgcttcaaga acacggatgc agcagcagct ctcctggcct ctcacgccat
     5221 acaggggacc ctgtcatacc ctcttgtgtc tgtcgtcagt gaatccctga ctccagaacg
     5281 cactcagctc ctctatctcc ttgctgttgc tgttgtcatc attctgttta ttattctgct
     5341 gggggtaatc atggcaaaac gaaagcgtaa gcatggctct ctctggctgc ctgaaggttt
     5401 cactcttcgc cgagatgcaa gcaatcacaa gcgtcgtgag ccagtgggac aggatgctgt
     5461 ggggctgaaa aatctctcag tgcaagtctc agaagctaac ctaattggta ctggaacaag
     5521 tgaacactgg gtcgatgatg aagggcccca gccaaagaaa gtaaaggctg aagatgaggc
     5581 cttactctca gaagaagatg accccattga tcgacggcca tggacacagc agcaccttga
     5641 agctgcagac atccgtagga caccatcgct ggctctcacc cctcctcagg cagagcagga
     5701 ggtggatgtg ttagatgtga atgtccgtgg cccagatggc tgcaccccat tgatgttggc
     5761 ttctctccga ggaggcagct cagatttgag tgatgaagat gaagatgcag aggactcttc
     5821 tgctaacatc atcacagact tggtctacca gggtgccagc ctccaggccc agacagaccg
     5881 gactggtgag atggccctgc accttgcagc ccgctactca cgggctgatg ctgccaagcg
     5941 tctcctggat gcaggtgcag atgccaatgc ccaggacaac atgggccgct gtccactcca
     6001 tgctgcagtg gcagctgatg cccaaggtgt cttccagatt ctgattcgca accgagtaac
     6061 tgatctagat gccaggatga atgatggtac tacacccctg atcctggctg cccgcctggc
     6121 tgtggaggga atggtggcag aactgatcaa ctgccaagcg gatgtgaatg cagtggatga
     6181 ccatggaaaa tctgctcttc actgggcagc tgctgtcaat aatgtggagg caactctttt
     6241 gttgttgaaa aatggggcca accgagacat gcaggacaac aaggaagaga cacctctgtt
     6301 tcttgctgcc cgggagggga gctatgaagc agccaagatc ctgttagacc attttgccaa
     6361 tcgagacatc acagaccata tggatcgtct tccccgggat gtggctcggg atcgcatgca
     6421 ccatgacatt gtgcgccttc tggatgaata caatgtgacc ccaagccctc caggcaccgt
     6481 gttgacttct gctctctcac ctgtcatctg tgggcccaac agatctttcc tcagcctgaa
     6541 gcacacccca atgggcaaga agtctagacg gcccagtgcc aagagtacca tgcctactag
     6601 cctccctaac cttgccaagg aggcaaagga tgccaagggt agtaggagga agaagtctct
     6661 gagtgagaag gtccaactgt ctgagagttc agtaacttta tcccctgttg attccctaga
     6721 atctcctcac acgtatgttt ccgacaccac atcctctcca atgattacat cccctgggat
     6781 cttacaggcc tcacccaacc ctatgttggc cactgccgcc cctcctgccc cagtccatgc
     6841 ccagcatgca ctatcttttt ctaaccttca tgaaatgcag cctttggcac atggggccag
     6901 cactgtgctt ccctcagtga gccagttgct atcccaccac cacattgtgt ctccaggcag
     6961 tggcagtgct ggaagcttga gtaggctcca tccagtccca gtcccagcag attggatgaa
     7021 ccgcatggag gtgaatgaga cccagtacaa tgagatgttt ggtatggtcc tggctccagc
     7081 tgagggcacc catcctggca tagctcccca gagcaggcca cctgaaggga agcacataac
     7141 cacccctcgg gagcccttgc cccccattgt gactttccag ctcatcccta aaggcagtat
     7201 tgcccaacca gcgggggctc cccagcctca gtccacctgc cctccagctg ttgcgggccc
     7261 cctgcccacc atgtaccaga ttccagaaat ggcccgtttg cccagtgtgg ctttccccac
     7321 tgccatgatg ccccagcagg acgggcaggt agctcagacc attctcccag cctatcatcc
     7381 tttcccagcc tctgtgggca agtaccccac acccccttca cagcacagtt atgcttcctc
     7441 aaatgctgct gagcgaacac ccagtcacag tggtcacctc cagggtgagc atccctacct
     7501 gacaccatcc ccagagtctc ctgaccagtg gtcaagttca tcaccccact ctgcttctga
     7561 ctggtcagat gtgaccacca gccctacccc tgggggtgct ggaggaggtc agcggggacc
     7621 tgggacacac atgtctgagc caccacacaa caacatgcag gtttatgcgt gagagagtcc
     7681 acctccagtg tagagacata actgactttt gtaaatgctg ctgaggaaca aatgaaggtc
     7741 atccgggaga gaaatgaaga aatctctgga gccagcttct agaggtagga aagagaagat
     7801 gttcttattc agataatgca agagaagcaa ttcgtcagtt tcactgggta tctgcaaggc
     7861 ttattgatta ttctaatcta ataagacaag tttgtggaaa tgcaagatga atacaagcct
     7921 tgggtccatg tttactctct tctatttgga gaataagatg gatgcttatt gaagcccaga
     7981 cattcttgca gcttggactg cattttaagc cctgcaggct tctgccatat ccatgagaag
     8041 attctacact agcgtcctgt tgggaattat gccctggaat tctgcctgaa ttgacctacg
     8101 catctcctcc tccttggaca ttcttttgtc ttcatttggt gcttttggtt ttgcacctct
     8161 ccgtgattgt agccctacca gcatgttata gggcaagacc tttgtgcttt tgatcattct
     8221 ggcccatgaa agcaactttg gtctcctttc ccctcctgtc ttcccggtat cccttggagt
     8281 ctcacaaggt ttactttggt atggttctca gcacaaacct ttcaagtatg ttgtttcttt
     8341 ggaaaatgga catactgtat tgtgttctcc tgcatatatc attcctggag agagaagggg
     8401 agaagaatac ttttcttcaa caaattttgg gggcaggaga tcccttcaag aggctgcacc
     8461 ttaatttttc ttgtctgtgt gcaggtcttc atataaactt taccaggaag aagggtgtga
     8521 gtttgttgtt tttctgtgta tgggcctggt cagtgtaaag ttttatcctt gatagtctag
     8581 ttactatgac cctccccact tttttaaaac cagaaaaagg tttggaatgt tggaatgacc
     8641 aagagacaag ttaactcgtg caagagccag ttacccaccc acaggtcccc ctacttcctg
     8701 ccaagcattc cattgactgc ctgtatggaa cacatttgtc ccagatctga gcattctagg
     8761 cctgtttcac tcactcaccc agcatatgaa actagtctta actgttgagc ctttcctttc
     8821 atatccacag aagacactgt ctcaaatgtt gtacccttgc catttaggac tgaactttcc
     8881 ttagcccaag ggacccagtg acagttgtct tccgtttgtc agatgatcag tctctactga
     8941 ttatcttgct gcttaaaggc ctgctcacca atctttcttt cacaccgtgt ggtccgtgtt
     9001 actggtatac ccagtatgtt ctcactgaag acatggactt tatatgttca agtgcaggaa
     9061 ttggaaagtt ggacttgttt tctatgatcc aaaacagccc tataagaagg ttggaaaagg
     9121 aggaactata tagcagcctt tgctattttc tgctaccatt tcttttcctc tgaagcggcc
     9181 atgacattcc ctttggcaac taacgtagaa actcaacaga acattttcct ttcctagagt
     9241 caccttttag atgataatgg acaactatag acttgctcat tgttcagact gattgcccct
     9301 cacctgaatc cactctctgt attcatgctc ttggcaattt ctttgacttt cttttaaggg
     9361 cagaagcatt ttagttaatt gtagataaag aatagttttc ttcctcttct ccttgggcca
     9421 gttaataatt ggtccatggc tacactgcaa cttccgtcca gtgctgtgat gcccatgaca
     9481 cctgcaaaat aagttctgcc tgggcatttt gtagatatta acaggtgaat tcccgactct
     9541 tttggtttga atgacagttc tcattccttc tatggctgca agtatgcatc agtgcttccc
     9601 acttacctga tttgtctgtc ggtggcccca tatggaaacc ctgcgtgtct gttggcataa
     9661 tagtttacaa atggtttttt cagtcctatc caaatttatt gaaccaacaa aaataattac
     9721 ttctgccctg agataagcag attaagtttg ttcattctct gctttattct ctccatgtgg
     9781 caacattctg tcagcctctt tcatagtgtg caaacatttt atcattctaa atggtgactc
     9841 tctgcccttg gacccattta ttattcacag atggggagaa cctatctgca tggacctctg
     9901 tggaccacag cgtacctgcc cctttctgcc ctcctgctcc agccccactt ctgaaagtat
     9961 cagctactga tccagccact ggatatttta tatcctccct tttccttaag cacaatgtca
    10021 gaccaaattg cttgtttctt tttcttggac tactttaatt tggatccttt gggtttggag
    10081 aaagggaatg tgaaagctgt cattacagac aacaggtttc agtgatgagg aggacaacac
    10141 tgcctttcaa actttttact gatctcttag attttaagaa ctcttgaatt gtgtggtatc
    10201 taataaaagg gaaggtaaga tggataatca ctttctcatt tgggttctga attggagact
    10261 cagtttttat gagacacatc ttttatgcca tgtatagatc ctcccctgct atttttggtt
    10321 tatttttatt gttataaatg ctttctttct ttgactcctc ttctgcctgc ctttggggat
    10381 aggttttttt gtttgtttat ttgcttcctc tgttttgttt taagcatcat tttcttatgt
    10441 gaggtgggga agggaaaggt atgagggaaa gagagtctga gaattaaaat attttagtat
    10501 aagcaattgg ctgtgatgct caaatccatt gcatcctctt attgaatttg ccaatttgta
    10561 atttttgcat aataaagaac caaaggtgta atgttttgtt gagaggtggt ttagggattt
    10621 tggccctaac caatacattg aatgtatgat gactatttgg gaggacacat ttatgtaccc
    10681 agaggccccc actaataagt ggtactatgg ttacttcctt gtgtacattt ctcttaaaag
    10741 tgatattata tctgtttgta tgagaaaccc agtaaccaat aaaatgaccg catattcctg
    10801 actaaacgta gtaaggaaaa tgcacacttt gtttttactt ttccgtttca ttctaaaggt
    10861 agttaagatg aaatttatat gaaagcattt ttatcacaaa ataaaaaagg tttgccaagc
    10921 tcagtggtgt tgtatttttt attttccaat actgcatcca tggcctggca gtgttacctc
    10981 atgatgtcat aatttgctga gagagcaaat tttcttttct ttctgaatcc cacaaagcct
    11041 agcaccaaac ttcttttttt cttcctttaa ttagatcata aataaatgat cctggggaaa
    11101 aagcatctgt caaataggaa acatcacaaa actgagcact cttctgtgca ctagccatag
    11161 ctggtgacaa acagatggtt gctcagggac aaggtgcctt ccaatggaaa tgcgaagtag
    11221 ttgctatagc aagaattggg aactgggata taagtcataa tattaattat gctgttatgt
    11281 aaatgattgg tttgtaacat tccttaagtg aaatttgtgt agaacttaat atacaggatt
    11341 ataaaataat attttgtgta taaatttgtt ataagttcac attcatacat ttatttataa
    11401 agtcagtgag atatttgaac atgaa
//
