LOCUS       NM_017617               9568 bp    mRNA    linear   PRI 26-NOV-2024
DEFINITION  Homo sapiens notch receptor 1 (NOTCH1), mRNA.
ACCESSION   NM_017617
VERSION     NM_017617.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9568)
  AUTHORS   Mora,P., Laisne,M., Bourguignon,C., Rouault,P., Jaspard-Vinassa,B.,
            Maitre,M., Gadeau,A.P., Renault,M.A., Horng,S., Couffinhal,T. and
            Chapouly,C.
  TITLE     Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation
            via the IL-6-STAT3 axis
  JOURNAL   J Neuroinflammation 21 (1), 258 (2024)
   PUBMED   39390606
  REMARK    GeneRIF: Astrocytic DLL4-NOTCH1 signaling pathway promotes
            neuroinflammation via the IL-6-STAT3 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9568)
  AUTHORS   Zhao,J., Williams,M.D., Hernandez,M., Kuang,G., Goldberg,H.,
            Fan,J., Ning,J., Ferrarotto,R. and Esmaeli,B.
  TITLE     Prognostic Impact of Notch1 Intracellular Domain, P63, and c-MYC in
            Lacrimal Gland Adenoid Cystic Carcinoma
  JOURNAL   Invest Ophthalmol Vis Sci 65 (11), 4 (2024)
   PUBMED   39230995
  REMARK    GeneRIF: Prognostic Impact of Notch1 Intracellular Domain, P63, and
            c-MYC in Lacrimal Gland Adenoid Cystic Carcinoma.
REFERENCE   3  (bases 1 to 9568)
  AUTHORS   Zhou,L., Yang,Y., Ye,Y., Qiao,Q., Mi,Y., Liu,H., Zheng,Y., Wang,Y.,
            Liu,M. and Zhou,Y.
  TITLE     Notch1 signaling pathway promotes growth and metastasis of gastric
            cancer via modulating CDH5
  JOURNAL   Aging (Albany NY) 16 (16), 11893-11903 (2024)
   PUBMED   39172098
  REMARK    GeneRIF: Notch1 signaling pathway promotes growth and metastasis of
            gastric cancer via modulating CDH5.
REFERENCE   4  (bases 1 to 9568)
  AUTHORS   Yamamoto,S., Schulze,K.L. and Bellen,H.J.
  TITLE     Introduction to Notch signaling
  JOURNAL   Methods Mol Biol 1187, 1-14 (2014)
   PUBMED   25053477
  REMARK    Review article
REFERENCE   5  (bases 1 to 9568)
  AUTHORS   Larsson,C., Lardelli,M., White,I. and Lendahl,U.
  TITLE     The human NOTCH1, 2, and 3 genes are located at chromosome
            positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of
            neoplasia-associated translocation
  JOURNAL   Genomics 24 (2), 253-258 (1994)
   PUBMED   7698746
REFERENCE   6  (bases 1 to 9568)
  AUTHORS   Milner,L.A., Kopan,R., Martin,D.I. and Bernstein,I.D.
  TITLE     A human homologue of the Drosophila developmental gene, Notch, is
            expressed in CD34+ hematopoietic precursors
  JOURNAL   Blood 83 (8), 2057-2062 (1994)
   PUBMED   7512837
REFERENCE   7  (bases 1 to 9568)
  AUTHORS   Lehman,A., Wuyts,W. and Patel,M.S.
  TITLE     Adams-Oliver Syndrome - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   27077170
REFERENCE   8  (bases 1 to 9568)
  AUTHORS   Milewicz,D.M. and Cecchi,A.C.
  TITLE     Heritable Thoracic Aortic Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301299
REFERENCE   9  (bases 1 to 9568)
  AUTHORS   Weinmaster,G., Roberts,V.J. and Lemke,G.
  TITLE     A homolog of Drosophila Notch expressed during mammalian
            development
  JOURNAL   Development 113 (1), 199-205 (1991)
   PUBMED   1764995
REFERENCE   10 (bases 1 to 9568)
  AUTHORS   Ellisen,L.W., Bird,J., West,D.C., Soreng,A.L., Reynolds,T.C.,
            Smith,S.D. and Sklar,J.
  TITLE     TAN-1, the human homolog of the Drosophila notch gene, is broken by
            chromosomal translocations in T lymphoblastic neoplasms
  JOURNAL   Cell 66 (4), 649-661 (1991)
   PUBMED   1831692
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354671.27, AF308602.1,
            AL592301.14, CN431067.1, DA324222.1, AB209873.1 and R42303.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 16, 2018 this sequence version replaced NM_017617.4.
            
            Summary: This gene encodes a member of the NOTCH family of
            proteins. Members of this Type I transmembrane protein family share
            structural characteristics including an extracellular domain
            consisting of multiple epidermal growth factor-like (EGF) repeats,
            and an intracellular domain consisting of multiple different domain
            types. Notch signaling is an evolutionarily conserved intercellular
            signaling pathway that regulates interactions between physically
            adjacent cells through binding of Notch family receptors to their
            cognate ligands. The encoded preproprotein is proteolytically
            processed in the trans-Golgi network to generate two polypeptide
            chains that heterodimerize to form the mature cell-surface
            receptor. This receptor plays a role in the development of numerous
            cell and tissue types. Mutations in this gene are associated with
            aortic valve disease, Adams-Oliver syndrome, T-cell acute
            lymphoblastic leukemia, chronic lymphocytic leukemia, and head and
            neck squamous cell carcinoma. [provided by RefSeq, Jan 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.1658475.1,
                                           SRR14038197.2460197.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651671.1/ ENSP00000498587.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               AL354671.27        29901-30162
            263-573             AF308602.1         1-311
            574-574             AL592301.14        167432-167432       c
            575-820             AF308602.1         313-558
            821-821             AL592301.14        166657-166657       c
            822-1106            AF308602.1         560-844
            1107-1113           CN431067.1         88-94
            1114-1332           AF308602.1         852-1070
            1333-1646           CN431067.1         314-627
            1647-1883           DA324222.1         28-264
            1884-9556           AB209873.1         159-7831
            9557-9568           R42303.1           17-28               c
FEATURES             Location/Qualifiers
     source          1..9568
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..9568
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /note="notch receptor 1"
                     /db_xref="GeneID:4851"
                     /db_xref="HGNC:HGNC:7881"
                     /db_xref="MIM:190198"
     exon            1..323
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..7930
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /note="translocation-associated notch protein TAN-1;
                     neurogenic locus notch homolog protein 1; Notch homolog 1,
                     translocation-associated; notch 1"
                     /codon_start=1
                     /product="neurogenic locus notch homolog protein 1
                     preproprotein"
                     /protein_id="NP_060087.3"
                     /db_xref="CCDS:CCDS43905.1"
                     /db_xref="GeneID:4851"
                     /db_xref="HGNC:HGNC:7881"
                     /db_xref="MIM:190198"
                     /translation="MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTE
                     ACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPL
                     DNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEA
                     SYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERP
                     YVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGV
                     NTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSE
                     NIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPV
                     NGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCE
                     IDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDK
                     INEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVD
                     IDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNA
                     YLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDEC
                     AGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLNGYKCD
                     CDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASN
                     PCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCV
                     CPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPN
                     PCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCP
                     AGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPC
                     LHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSG
                     WTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLV
                     DECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNT
                     YKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGE
                     RCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGG
                     TCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPF
                     TGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGA
                     GRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSL
                     QCWKYFSDGHCDSQCNSAGCLFDGFDCQRAEGQCNPLYDQYCKDHFSDGHCDQGCNSA
                     ECEWDGLDCAEHVPERLAAGTLVVVVLMPPEQLRNSSFHFLRELSRVLHTNVVFKRDA
                     HGQQMIFPYYGREEELRKHPIKRAAEGWAAPDALLGQVKASLLPGGSEGGRRRRELDP
                     MDVRGSIVYLEIDNRQCVQASSQCFQSATDVAAFLGALASLGSLNIPYKIEAVQSETV
                     EPPPPAQLHFMYVAAAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRR
                     EPLGEDSVGLKPLKNASDGALMDDNQNEWGDEDLETKKFRFEEPVVLPDLDDQTDHRQ
                     WTQQHLDAADLRMSAMAPTPPQGEVDADCMDVNVRGPDGFTPLMIASCSGGGLETGNS
                     EEEEDAPAVISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQD
                     NMGRTPLHAAVSADAQGVFQILIRNRATDLDARMHDGTTPLILAARLAVEGMLEDLIN
                     SHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNREETPLFLAAREGSY
                     ETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDEYNLVRSPQLHGAPLGGT
                     PTLSPPLCSPNGYLGSLKPGVQGKKVRKPSSKGLACGSKEAKDLKARRKKSQDGKGCL
                     LDSSGMLSPVDSLESPHGYLSDVASPPLLPSPFQQSPSVPLNHLPGMPDTHLGIGHLN
                     VAAKPEMAALGGGGRLAFETGPPRLSHLPVASGTSTVLGSSSGGALNFTVGGSTSLNG
                     QCEWLSRLQSGMVPNQYNPLRGSVAPGPLSTQAPSLQHGMVGPLHSSLAASALSQMMS
                     YQGLPSTRLATQPHLVQTQQVQPQNLQMQQQNLQPANIQQQQSLQPPPPPPQPHLGVS
                     SAASGHLGRSFLSGEPSQADVQPLGPSSLAVHTILPQESPALPTSLPSSLVPPVTAAQ
                     FLTPPSQHSYSSPVDNTPSHQLQVPEHPFLTPSPESPDQWSSSSPHSNVSDWSEGVSS
                     PPTSMQSQIARIPEAFK"
     exon            324..402
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..665
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            666..1004
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1127
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1361
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1517
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1703
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1817
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1931
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2165
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2276
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2469
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2615
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2729
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2849
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2850..3002
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3231
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3232..3433
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3434..3587
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3588..3772
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3773..3905
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3906..4163
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            4164..4276
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            4277..4848
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            4849..5280
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            5281..5429
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            5430..5646
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            5647..5734
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            5735..5900
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            5901..6196
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            6197..6344
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            6345..6442
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     exon            6443..9568
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9535..9540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /note="hexamer: AATAAA"
     polyA_site      9557
                     /gene="NOTCH1"
                     /gene_synonym="AOS5; AOVD1; hN1; TAN1"
                     /note="major polyA site"
ORIGIN      
        1 actagtgcct cggccgcggg agggagcgca agggcgcggg gcgcggggcg cgggcgcggg
       61 cgcgagcgca gcgaaggaac gagccgggcg cggagccggg cccgggggcc tgcgagagca
      121 cagcgccgcc agccagccgg ggaagagagg gcgggaccgt ccgccgccgc cccgggaccg
      181 tacgccgcgc gtgtgcgtcc cagccccgcc ggccagcgca ggaggccgcc gcccgggcgc
      241 agagggcagc cggtggggag gcatgccgcc gctcctggcg cccctgctct gcctggcgct
      301 gctgcccgcg ctcgccgcac gaggcccgcg atgctcccag cccggtgaga cctgcctgaa
      361 tggcgggaag tgtgaagcgg ccaatggcac ggaggcctgc gtctgtggcg gggccttcgt
      421 gggcccgcga tgccaggacc ccaacccgtg cctcagcacc ccctgcaaga acgccgggac
      481 atgccacgtg gtggaccgca gaggcgtggc agactatgcc tgcagctgtg ccctgggctt
      541 ctctgggccc ctctgcctga cacccctgga caatgcctgc ctcaccaacc cctgccgcaa
      601 cgggggcacc tgcgacctgc tcacgctgac ggagtacaag tgccgctgcc cgcccggctg
      661 gtcagggaaa tcgtgccagc aggctgaccc gtgcgcctcc aacccctgcg ccaacggtgg
      721 ccagtgcctg cccttcgagg cctcctacat ctgccactgc ccacccagct tccatggccc
      781 cacctgccgg caggatgtca acgagtgtgg ccagaagccc gggctttgcc gccacggagg
      841 cacctgccac aacgaggtcg gctcctaccg ctgcgtctgc cgcgccaccc acactggccc
      901 caactgcgag cggccctacg tgccctgcag cccctcgccc tgccagaacg ggggcacctg
      961 ccgccccacg ggcgacgtca cccacgagtg tgcctgcctg ccaggcttca ccggccagaa
     1021 ctgtgaggaa aatatcgacg attgtccagg aaacaactgc aagaacgggg gtgcctgtgt
     1081 ggacggcgtg aacacctaca actgccgctg cccgccagag tggacaggtc agtactgtac
     1141 cgaggatgtg gacgagtgcc agctgatgcc aaatgcctgc cagaacggcg ggacctgcca
     1201 caacacccac ggtggctaca actgcgtgtg tgtcaacggc tggactggtg aggactgcag
     1261 cgagaacatt gatgactgtg ccagcgccgc ctgcttccac ggcgccacct gccatgaccg
     1321 tgtggcctcc ttctactgcg agtgtcccca tggccgcaca ggtctgctgt gccacctcaa
     1381 cgacgcatgc atcagcaacc cctgtaacga gggctccaac tgcgacacca accctgtcaa
     1441 tggcaaggcc atctgcacct gcccctcggg gtacacgggc ccggcctgca gccaggacgt
     1501 ggatgagtgc tcgctgggtg ccaacccctg cgagcatgcg ggcaagtgca tcaacacgct
     1561 gggctccttc gagtgccagt gtctgcaggg ctacacgggc ccccgatgcg agatcgacgt
     1621 caacgagtgc gtctcgaacc cgtgccagaa cgacgccacc tgcctggacc agattgggga
     1681 gttccagtgc atctgcatgc ccggctacga gggtgtgcac tgcgaggtca acacagacga
     1741 gtgtgccagc agcccctgcc tgcacaatgg ccgctgcctg gacaagatca atgagttcca
     1801 gtgcgagtgc cccacgggct tcactgggca tctgtgccag tacgatgtgg acgagtgtgc
     1861 cagcaccccc tgcaagaatg gtgccaagtg cctggacgga cccaacactt acacctgtgt
     1921 gtgcacggaa gggtacacgg ggacgcactg cgaggtggac atcgatgagt gcgaccccga
     1981 cccctgccac tacggctcct gcaaggacgg cgtcgccacc ttcacctgcc tctgccgccc
     2041 aggctacacg ggccaccact gcgagaccaa catcaacgag tgctccagcc agccctgccg
     2101 ccacgggggc acctgccagg accgcgacaa cgcctacctc tgcttctgcc tgaaggggac
     2161 cacaggaccc aactgcgaga tcaacctgga tgactgtgcc agcagcccct gcgactcggg
     2221 cacctgtctg gacaagatcg atggctacga gtgtgcctgt gagccgggct acacagggag
     2281 catgtgtaac atcaacatcg atgagtgtgc gggcaacccc tgccacaacg ggggcacctg
     2341 cgaggacggc atcaatggct tcacctgccg ctgccccgag ggctaccacg accccacctg
     2401 cctgtctgag gtcaatgagt gcaacagcaa cccctgcgtc cacggggcct gccgggacag
     2461 cctcaacggg tacaagtgcg actgtgaccc tgggtggagt gggaccaact gtgacatcaa
     2521 caacaatgag tgtgaatcca acccttgtgt caacggcggc acctgcaaag acatgaccag
     2581 tggctacgtg tgcacctgcc gggagggctt cagcggtccc aactgccaga ccaacatcaa
     2641 cgagtgtgcg tccaacccat gtctgaacca gggcacgtgt attgacgacg ttgccgggta
     2701 caagtgcaac tgcctgctgc cctacacagg tgccacgtgt gaggtggtgc tggccccgtg
     2761 tgcccccagc ccctgcagaa acggcgggga gtgcaggcaa tccgaggact atgagagctt
     2821 ctcctgtgtc tgccccacgg gctggcaagg gcagacctgt gaggtcgaca tcaacgagtg
     2881 cgttctgagc ccgtgccggc acggcgcatc ctgccagaac acccacggcg gctaccgctg
     2941 ccactgccag gccggctaca gtgggcgcaa ctgcgagacc gacatcgacg actgccggcc
     3001 caacccgtgt cacaacgggg gctcctgcac agacggcatc aacacggcct tctgcgactg
     3061 cctgcccggc ttccggggca ctttctgtga ggaggacatc aacgagtgtg ccagtgaccc
     3121 ctgccgcaac ggggccaact gcacggactg cgtggacagc tacacgtgca cctgccccgc
     3181 aggcttcagc gggatccact gtgagaacaa cacgcctgac tgcacagaga gctcctgctt
     3241 caacggtggc acctgcgtgg acggcatcaa ctcgttcacc tgcctgtgtc cacccggctt
     3301 cacgggcagc tactgccagc acgatgtcaa tgagtgcgac tcacagccct gcctgcatgg
     3361 cggcacctgt caggacggct gcggctccta caggtgcacc tgcccccagg gctacactgg
     3421 ccccaactgc cagaaccttg tgcactggtg tgactcctcg ccctgcaaga acggcggcaa
     3481 atgctggcag acccacaccc agtaccgctg cgagtgcccc agcggctgga ccggccttta
     3541 ctgcgacgtg cccagcgtgt cctgtgaggt ggctgcgcag cgacaaggtg ttgacgttgc
     3601 ccgcctgtgc cagcatggag ggctctgtgt ggacgcgggc aacacgcacc actgccgctg
     3661 ccaggcgggc tacacaggca gctactgtga ggacctggtg gacgagtgct cacccagccc
     3721 ctgccagaac ggggccacct gcacggacta cctgggcggc tactcctgca agtgcgtggc
     3781 cggctaccac ggggtgaact gctctgagga gatcgacgag tgcctctccc acccctgcca
     3841 gaacgggggc acctgcctcg acctccccaa cacctacaag tgctcctgcc cacggggcac
     3901 tcagggtgtg cactgtgaga tcaacgtgga cgactgcaat ccccccgttg accccgtgtc
     3961 ccggagcccc aagtgcttta acaacggcac ctgcgtggac caggtgggcg gctacagctg
     4021 cacctgcccg ccgggcttcg tgggtgagcg ctgtgagggg gatgtcaacg agtgcctgtc
     4081 caatccctgc gacgcccgtg gcacccagaa ctgcgtgcag cgcgtcaatg acttccactg
     4141 cgagtgccgt gctggtcaca ccgggcgccg ctgcgagtcc gtcatcaatg gctgcaaagg
     4201 caagccctgc aagaatgggg gcacctgcgc cgtggcctcc aacaccgccc gcgggttcat
     4261 ctgcaagtgc cctgcgggct tcgagggcgc cacgtgtgag aatgacgctc gtacctgcgg
     4321 cagcctgcgc tgcctcaacg gcggcacatg catctccggc ccgcgcagcc ccacctgcct
     4381 gtgcctgggc cccttcacgg gccccgaatg ccagttcccg gccagcagcc cctgcctggg
     4441 cggcaacccc tgctacaacc aggggacctg tgagcccaca tccgagagcc ccttctaccg
     4501 ttgcctgtgc cccgccaaat tcaacgggct cttgtgccac atcctggact acagcttcgg
     4561 gggtggggcc gggcgcgaca tccccccgcc gctgatcgag gaggcgtgcg agctgcccga
     4621 gtgccaggag gacgcgggca acaaggtctg cagcctgcag tgcaacaacc acgcgtgcgg
     4681 ctgggacggc ggtgactgct ccctcaactt caatgacccc tggaagaact gcacgcagtc
     4741 tctgcagtgc tggaagtact tcagtgacgg ccactgtgac agccagtgca actcagccgg
     4801 ctgcctcttc gacggctttg actgccagcg tgcggaaggc cagtgcaacc ccctgtacga
     4861 ccagtactgc aaggaccact tcagcgacgg gcactgcgac cagggctgca acagcgcgga
     4921 gtgcgagtgg gacgggctgg actgtgcgga gcatgtaccc gagaggctgg cggccggcac
     4981 gctggtggtg gtggtgctga tgccgccgga gcagctgcgc aacagctcct tccacttcct
     5041 gcgggagctc agccgcgtgc tgcacaccaa cgtggtcttc aagcgtgacg cacacggcca
     5101 gcagatgatc ttcccctact acggccgcga ggaggagctg cgcaagcacc ccatcaagcg
     5161 tgccgccgag ggctgggccg cacctgacgc cctgctgggc caggtgaagg cctcgctgct
     5221 ccctggtggc agcgagggtg ggcggcggcg gagggagctg gaccccatgg acgtccgcgg
     5281 ctccatcgtc tacctggaga ttgacaaccg gcagtgtgtg caggcctcct cgcagtgctt
     5341 ccagagtgcc accgacgtgg ccgcattcct gggagcgctc gcctcgctgg gcagcctcaa
     5401 catcccctac aagatcgagg ccgtgcagag tgagaccgtg gagccgcccc cgccggcgca
     5461 gctgcacttc atgtacgtgg cggcggccgc ctttgtgctt ctgttcttcg tgggctgcgg
     5521 ggtgctgctg tcccgcaagc gccggcggca gcatggccag ctctggttcc ctgagggctt
     5581 caaagtgtct gaggccagca agaagaagcg gcgggagccc ctcggcgagg actccgtggg
     5641 cctcaagccc ctgaagaacg cttcagacgg tgccctcatg gacgacaacc agaatgagtg
     5701 gggggacgag gacctggaga ccaagaagtt ccggttcgag gagcccgtgg ttctgcctga
     5761 cctggacgac cagacagacc accggcagtg gactcagcag cacctggatg ccgctgacct
     5821 gcgcatgtct gccatggccc ccacaccgcc ccagggtgag gttgacgccg actgcatgga
     5881 cgtcaatgtc cgcgggcctg atggcttcac cccgctcatg atcgcctcct gcagcggggg
     5941 cggcctggag acgggcaaca gcgaggaaga ggaggacgcg ccggccgtca tctccgactt
     6001 catctaccag ggcgccagcc tgcacaacca gacagaccgc acgggcgaga ccgccttgca
     6061 cctggccgcc cgctactcac gctctgatgc cgccaagcgc ctgctggagg ccagcgcaga
     6121 tgccaacatc caggacaaca tgggccgcac cccgctgcat gcggctgtgt ctgccgacgc
     6181 acaaggtgtc ttccagatcc tgatccggaa ccgagccaca gacctggatg cccgcatgca
     6241 tgatggcacg acgccactga tcctggctgc ccgcctggcc gtggagggca tgctggagga
     6301 cctcatcaac tcacacgccg acgtcaacgc cgtagatgac ctgggcaagt ccgccctgca
     6361 ctgggccgcc gccgtgaaca atgtggatgc cgcagttgtg ctcctgaaga acggggctaa
     6421 caaagatatg cagaacaaca gggaggagac acccctgttt ctggccgccc gggagggcag
     6481 ctacgagacc gccaaggtgc tgctggacca ctttgccaac cgggacatca cggatcatat
     6541 ggaccgcctg ccgcgcgaca tcgcacagga gcgcatgcat cacgacatcg tgaggctgct
     6601 ggacgagtac aacctggtgc gcagcccgca gctgcacgga gccccgctgg ggggcacgcc
     6661 caccctgtcg cccccgctct gctcgcccaa cggctacctg ggcagcctca agcccggcgt
     6721 gcagggcaag aaggtccgca agcccagcag caaaggcctg gcctgtggaa gcaaggaggc
     6781 caaggacctc aaggcacgga ggaagaagtc ccaggacggc aagggctgcc tgctggacag
     6841 ctccggcatg ctctcgcccg tggactccct ggagtcaccc catggctacc tgtcagacgt
     6901 ggcctcgccg ccactgctgc cctccccgtt ccagcagtct ccgtccgtgc ccctcaacca
     6961 cctgcctggg atgcccgaca cccacctggg catcgggcac ctgaacgtgg cggccaagcc
     7021 cgagatggcg gcgctgggtg ggggcggccg gctggccttt gagactggcc cacctcgtct
     7081 ctcccacctg cctgtggcct ctggcaccag caccgtcctg ggctccagca gcggaggggc
     7141 cctgaatttc actgtgggcg ggtccaccag tttgaatggt caatgcgagt ggctgtcccg
     7201 gctgcagagc ggcatggtgc cgaaccaata caaccctctg cgggggagtg tggcaccagg
     7261 ccccctgagc acacaggccc cctccctgca gcatggcatg gtaggcccgc tgcacagtag
     7321 ccttgctgcc agcgccctgt cccagatgat gagctaccag ggcctgccca gcacccggct
     7381 ggccacccag cctcacctgg tgcagaccca gcaggtgcag ccacaaaact tacagatgca
     7441 gcagcagaac ctgcagccag caaacatcca gcagcagcaa agcctgcagc cgccaccacc
     7501 accaccacag ccgcaccttg gcgtgagctc agcagccagc ggccacctgg gccggagctt
     7561 cctgagtgga gagccgagcc aggcagacgt gcagccactg ggccccagca gcctggcggt
     7621 gcacactatt ctgccccagg agagccccgc cctgcccacg tcgctgccat cctcgctggt
     7681 cccacccgtg accgcagccc agttcctgac gcccccctcg cagcacagct actcctcgcc
     7741 tgtggacaac acccccagcc accagctaca ggtgcctgag caccccttcc tcaccccgtc
     7801 ccctgagtcc cctgaccagt ggtccagctc gtccccgcat tccaacgtct ccgactggtc
     7861 cgagggcgtc tccagccctc ccaccagcat gcagtcccag atcgcccgca ttccggaggc
     7921 cttcaagtaa acggcgcgcc ccacgagacc ccggcttcct ttcccaagcc ttcgggcgtc
     7981 tgtgtgcgct ctgtggatgc cagggccgac cagaggagcc tttttaaaac acatgttttt
     8041 atacaaaata agaacgagga ttttaatttt ttttagtatt tatttatgta cttttatttt
     8101 acacagaaac actgcctttt tatttatatg tactgtttta tctggcccca ggtagaaact
     8161 tttatctatt ctgagaaaac aagcaagttc tgagagccag ggttttccta cgtaggatga
     8221 aaagattctt ctgtgtttat aaaatataaa caaagattca tgatttataa atgccattta
     8281 tttattgatt ccttttttca aaatccaaaa agaaatgatg ttggagaagg gaagttgaac
     8341 gagcatagtc caaaaagctc ctggggcgtc caggccgcgc cctttccccg acgcccaccc
     8401 aaccccaagc cagcccggcc gctccaccag catcacctgc ctgttaggag aagctgcatc
     8461 cagaggcaaa cggaggcaaa gctggctcac cttccgcacg cggattaatt tgcatctgaa
     8521 ataggaaaca agtgaaagca tatgggttag atgttgccat gtgttttaga tggtttcttg
     8581 caagcatgct tgtgaaaatg tgttctcgga gtgtgtatgc caagagtgca cccatggtac
     8641 caatcatgaa tctttgtttc aggttcagta ttatgtagtt gttcgttggt tatacaagtt
     8701 cttggtccct ccagaaccac cccggccccc tgcccgttct tgaaatgtag gcatcatgca
     8761 tgtcaaacat gagatgtgtg gactgtggca cttgcctggg tcacacacgg aggcatccta
     8821 cccttttctg gggaaagaca ctgcctgggc tgaccccggt ggcggcccca gcacctcagc
     8881 ctgcacagtg tcccccaggt tccgaagaag atgctccagc aacacagcct gggccccagc
     8941 tcgcgggacc cgaccccccg tgggctcccg tgttttgtag gagacttgcc agagccgggc
     9001 acattgagct gtgcaacgcc gtgggctgcg tcctttggtc ctgtccccgc agccctggca
     9061 gggggcatgc ggtcgggcag gggctggagg gaggcggggg ctgcccttgg gccacccctc
     9121 ctagtttggg aggagcagat ttttgcaata ccaagtatag cctatggcag aaaaaatgtc
     9181 tgtaaatatg tttttaaagg tggattttgt ttaaaaaatc ttaatgaatg agtctgttgt
     9241 gtgtcatgcc agtgagggac gtcagacttg gctcagctcg gggagcctta gccgcccatg
     9301 cactggggac gctccgctgc cgtgccgcct gcactcctca gggcagcctc ccccggctct
     9361 acgggggccg cgtggtgcca tccccagggg gcatgaccag atgcgtccca agatgttgat
     9421 ttttactgtg ttttataaaa tagagtgtag tttacagaaa aagactttaa aagtgatcta
     9481 catgaggaac tgtagatgat gtattttttt catctttttt gttaactgat ttgcaataaa
     9541 aatgatactg atggtgatct ggcttcca
//
