LOCUS       NM_001039724            2075 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens nitric oxide synthase trafficking (NOSTRIN),
            transcript variant 2, mRNA.
ACCESSION   NM_001039724
VERSION     NM_001039724.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2075)
  AUTHORS   Paul,M., Gope,T.K., Das,P. and Ain,R.
  TITLE     Nitric-Oxide Synthase trafficking inducer (NOSTRIN) is an emerging
            negative regulator of colon cancer progression
  JOURNAL   BMC Cancer 22 (1), 594 (2022)
   PUBMED   35642021
  REMARK    GeneRIF: Nitric-Oxide Synthase trafficking inducer (NOSTRIN) is an
            emerging negative regulator of colon cancer progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2075)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2075)
  AUTHORS   Poupon,D., Hummel,T., Haehner,A., Welge-Luessen,A. and Frasnelli,J.
  TITLE     Nostril Differences in the Olfactory Performance in Health and
            Disease
  JOURNAL   Chem Senses 42 (8), 625-634 (2017)
   PUBMED   28981819
  REMARK    GeneRIF: The suggest that scores obtained with the worst nostril
            are the most efficient in detecting an olfactory disorder.
REFERENCE   4  (bases 1 to 2075)
  AUTHORS   Wang,J., Yang,S., He,P., Schetter,A.J., Gaedcke,J., Ghadimi,B.M.,
            Ried,T., Yfantis,H.G., Lee,D.H., Gaida,M.M., Hanna,N.,
            Alexander,H.R. and Hussain,S.P.
  TITLE     Endothelial Nitric Oxide Synthase Traffic Inducer (NOSTRIN) is a
            Negative Regulator of Disease Aggressiveness in Pancreatic Cancer
  JOURNAL   Clin Cancer Res 22 (24), 5992-6001 (2016)
   PUBMED   27401251
  REMARK    GeneRIF: NOSTRIN inhibited production of nitric oxide (NO) by
            suppressing the activation of endothelial nitric oxide synthase
            (eNOS).
REFERENCE   5  (bases 1 to 2075)
  AUTHORS   Lopez,S., Buil,A., Souto,J.C., Casademont,J., Martinez-Perez,A.,
            Almasy,L. and Soria,J.M.
  TITLE     A genome-wide association study in the genetic analysis of
            idiopathic thrombophilia project suggests sex-specific regulation
            of mitochondrial DNA levels
  JOURNAL   Mitochondrion 18, 34-40 (2014)
   PUBMED   25240745
REFERENCE   6  (bases 1 to 2075)
  AUTHORS   Schilling,K., Opitz,N., Wiesenthal,A., Oess,S., Tikkanen,R.,
            Muller-Esterl,W. and Icking,A.
  TITLE     Translocation of endothelial nitric-oxide synthase involves a
            ternary complex with caveolin-1 and NOSTRIN
  JOURNAL   Mol Biol Cell 17 (9), 3870-3880 (2006)
   PUBMED   16807357
  REMARK    GeneRIF: A ternary complex between NOSTRIN, caveolin-1, and eNOS
            mediates translocation of eNOS, with important implications for the
            activity and availability of eNOS in the cell.
REFERENCE   7  (bases 1 to 2075)
  AUTHORS   Oess,S., Icking,A., Fulton,D., Govers,R. and Muller-Esterl,W.
  TITLE     Subcellular targeting and trafficking of nitric oxide synthases
  JOURNAL   Biochem J 396 (3), 401-409 (2006)
   PUBMED   16722822
  REMARK    Review article
REFERENCE   8  (bases 1 to 2075)
  AUTHORS   Icking,A., Matt,S., Opitz,N., Wiesenthal,A., Muller-Esterl,W. and
            Schilling,K.
  TITLE     NOSTRIN functions as a homotrimeric adaptor protein facilitating
            internalization of eNOS
  JOURNAL   J Cell Sci 118 (Pt 21), 5059-5069 (2005)
   PUBMED   16234328
  REMARK    GeneRIF: NOSTRIN may facilitate endocytosis of endothelial nitric
            oxide synthase by coordinating the function of dynamin and the
            actin nucleation promoting factor N-WASP.
REFERENCE   9  (bases 1 to 2075)
  AUTHORS   Choi,Y.J., Cho,S.Y., Kim,H.W., Kim,J.A., Bae,S.H. and Park,S.S.
  TITLE     Cloning and characterization of mouse disabled 2 interacting
            protein 2, a mouse orthologue of human NOSTRIN
  JOURNAL   Biochem Biophys Res Commun 326 (3), 594-599 (2005)
   PUBMED   15596140
REFERENCE   10 (bases 1 to 2075)
  AUTHORS   Zimmermann,K., Opitz,N., Dedio,J., Renne,C., Muller-Esterl,W. and
            Oess,S.
  TITLE     NOSTRIN: a protein modulating nitric oxide release and subcellular
            distribution of endothelial nitric oxide synthase
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 17167-17172 (2002)
   PUBMED   12446846
  REMARK    GeneRIF: NOSTRIN modulates nitric oxide release and subcellular
            distribution of endothelial nitric oxide synthase.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP334580.1, BC093072.1, BF114987.1, BQ899074.1 and AC069137.6.
            
            On Feb 27, 2020 this sequence version replaced NM_001039724.3.
            
            Summary: Nitric oxide (NO) is a potent mediator in biologic
            processes such as neurotransmission, inflammatory response, and
            vascular homeostasis. NOSTRIN binds the enzyme responsible for NO
            production, endothelial NO synthase (ENOS; MIM 163729), and
            triggers the translocation of ENOS from the plasma membrane to
            vesicle-like subcellular structures, thereby attenuating
            ENOS-dependent NO production.[supplied by OMIM, Apr 2004].
            
            Transcript Variant: This variant is a dominant transcript and
            encodes a 506aa protein (isoform 2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002203.2, BC093072.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317647.12/ ENSP00000318921.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BP334580.1         48-53
            7-1427              BC093072.1         1-1421
            1428-1631           BF114987.1         1-204               c
            1632-1900           BQ899074.1         368-636
            1901-2075           AC069137.6         34978-35152
FEATURES             Location/Qualifiers
     source          1..2075
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.3"
     gene            1..2075
                     /gene="NOSTRIN"
                     /gene_synonym="DaIP2"
                     /note="nitric oxide synthase trafficking"
                     /db_xref="GeneID:115677"
                     /db_xref="HGNC:HGNC:20203"
                     /db_xref="MIM:607496"
     exon            1..37
                     /gene="NOSTRIN"
                     /gene_synonym="DaIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1531
                     /gene="NOSTRIN"
                     /gene_synonym="DaIP2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ortholog of mouse disabled 2 interacting proein 2;
                     endothelial nitric oxide synthase traffic inducer; ENOS
                     traffic inducer; BM247 homolog; eNOS-trafficking inducer;
                     nitric oxide synthase trafficker"
                     /codon_start=1
                     /product="nostrin isoform 2"
                     /protein_id="NP_001034813.2"
                     /db_xref="CCDS:CCDS42771.1"
                     /db_xref="GeneID:115677"
                     /db_xref="HGNC:HGNC:20203"
                     /db_xref="MIM:607496"
                     /translation="MRDPLTDCPYNKVYKNLKEFSQNGENFCKQVTSVLQQRANLEIS
                     YAKGLQKLASKLSKALQNTRKSCVSSAWAWASEGMKSTADLHQKLGKAIELEAIKPTY
                     QVLNVQEKKRKSLDNEVEKTANLVISNWNQQIKAKKKLMVSTKKHEALFQLVESSKQS
                     MTEKEKRKLLNKLTKSTEKLEKEDENYYQKNMAGYSTRLKWENTLENCYQSILELEKE
                     RIQLLCNNLNQYSQHISLFGQTLTTCHTQIHCAISKIDIEKDIQAVMEETAILSTENK
                     SEFLLTDYFEEDPNSAMDKERRKSLLKPKLLRLQRDIEKASKDKEGLERMLKTYSSTS
                     SFSDAKSQKDTAALMDENNLKLDLLEANSYKLSSMLAELEQRPQPSHPCSNSIFRWRE
                     KEHTHSYVKISRPFLMKRLENIVSKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQ
                     ARQDDELNLEKGDIVIIHEKKEGGWWFGSLNGKKGHFPAAYVEELPSNAGNTATKA"
     exon            38..123
                     /gene="NOSTRIN"
                     /gene_synonym="DaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            124..207
                     /gene="NOSTRIN"
                     /gene_synonym="DaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            208..270
                     /gene="NOSTRIN"
                     /gene_synonym="DaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            271..352
                     /gene="NOSTRIN"
                     /gene_synonym="DaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            353..415
                     /gene="NOSTRIN"
                     /gene_synonym="DaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            416..514
                     /gene="NOSTRIN"
                     /gene_synonym="DaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            515..640
                     /gene="NOSTRIN"
                     /gene_synonym="DaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            641..739
                     /gene="NOSTRIN"
                     /gene_synonym="DaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            740..865
                     /gene="NOSTRIN"
                     /gene_synonym="DaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            866..974
                     /gene="NOSTRIN"
                     /gene_synonym="DaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1063
                     /gene="NOSTRIN"
                     /gene_synonym="DaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1189
                     /gene="NOSTRIN"
                     /gene_synonym="DaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1304
                     /gene="NOSTRIN"
                     /gene_synonym="DaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1394
                     /gene="NOSTRIN"
                     /gene_synonym="DaIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..2075
                     /gene="NOSTRIN"
                     /gene_synonym="DaIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1596..1601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOSTRIN"
                     /gene_synonym="DaIP2"
                     /note="hexamer: AATAAA"
     polyA_site      1616
                     /gene="NOSTRIN"
                     /gene_synonym="DaIP2"
                     /note="major polyA site"
ORIGIN      
        1 acatttcaac atgagggacc cactgacaga ttgtccgtat aataaagtat acaagaacct
       61 aaaggagttt tctcaaaatg gagagaattt ctgcaaacag gtcacatctg ttcttcagca
      121 aagggcaaac ctggaaatta gctatgccaa aggacttcag aaactggcaa gcaagctgag
      181 caaagcatta cagaacacga gaaaaagttg tgttagcagt gcctgggcct gggcctcaga
      241 gggaatgaaa tccacagcgg acctgcatca aaaacttggc aaagcaattg aattggaagc
      301 aataaaaccg acttatcaag tcctaaatgt acaagagaag aagagaaaat cacttgacaa
      361 tgaagttgaa aagacagcaa atcttgtcat tagcaactgg aatcagcaaa ttaaggccaa
      421 gaagaaatta atggttagta ccaagaaaca tgaagcactt ttccagcttg tagaaagctc
      481 caagcaatct atgactgaga aggagaagcg gaagctcctc aataaactga caaaatcaac
      541 tgaaaagttg gaaaaggaag atgaaaatta ctaccaaaaa aacatggcgg gttattctac
      601 cagactgaaa tgggaaaaca cactagagaa ctgctaccag agcattctgg agctggagaa
      661 ggaaagaatt caacttttat gcaataactt aaaccagtac agccaacata tttctctttt
      721 tggccaaacc ctgaccacat gccacacgca gattcactgt gccatcagca agattgacat
      781 tgaaaaagat atccaggctg taatggaaga aactgcaatt ttatctacag aaaacaaatc
      841 tgagttcctg ttaacggatt actttgaaga agatcctaac agtgcaatgg ataaagagag
      901 acgaaagtct ttactaaaac caaaattatt gagactgcag agagacattg aaaaagcctc
      961 aaaagacaag gaaggcctgg aacgaatgct taaaacgtac tccagcacct cctccttctc
     1021 tgatgcaaag agccagaaag acacagcagc gttaatggat gagaacaatt tgaaactaga
     1081 ccttttggaa gcgaactcct acaaactgtc atcaatgtta gcagaacttg agcaaagacc
     1141 tcaacccagc catccttgta gtaattccat cttcaggtgg agggaaaagg agcatactca
     1201 tagctatgtg aaaatatctc ggcctttttt aatgaagaga ttagagaata ttgtgagcaa
     1261 ggcatcttct ggtgggcaga gcaatccagg ttcttcaact ccagcccctg gtgcagccca
     1321 gctcagcagc agactttgca aggccttgta ttcttttcaa gccaggcaag atgatgagtt
     1381 gaatttggaa aagggtgaca ttgtgattat acacgagaaa aaagaaggag gatggtggtt
     1441 tggatctttg aatgggaaaa aaggccattt tcctgccgct tatgtggagg agttaccttc
     1501 aaatgctggc aacacagcta caaaggcata aaacaagact ctgaacatac taccttcaca
     1561 ctcggtaatc aacaatacag tgtggttcaa ataagaataa agtgctctta cctttacatg
     1621 tttttctttt gaaatggatg gagttctacc tgcatgtcac agcactttgc attcatgatt
     1681 attagcttga aacagtcaga aaaaagatgg atgggtggag acagacaagg aagaggctcc
     1741 ttggttccta gaggagtttc caaattctag gagaccctag agatgatcca gtataacccc
     1801 tggtgtcaca gaaacagacg gagtccaagg tgggttcagc tgcttgcctg aagtcagagt
     1861 tatctggtag acaacagcag tgggacttag atgtcttttt cctctggatt tgggtggcaa
     1921 cagaacacag caggcctatg agggggtcaa gcagagcctg ggagatgagg aacacagatc
     1981 aattccaaga agagagacag gcaatcaaga caccaatgag atcaacccaa attaggggat
     2041 ggtaggatat ctctgacaaa cccacagcca atatc
//
