LOCUS       NM_001270960            1232 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens nitric oxide synthase interacting protein (NOSIP),
            transcript variant 2, mRNA.
ACCESSION   NM_001270960
VERSION     NM_001270960.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1232)
  AUTHORS   Porschke,M., Rodriguez-Gonzalez,I., Parfentev,I., Urlaub,H. and
            Kehlenbach,R.H.
  TITLE     Transportin 1 is a major nuclear import receptor of the nitric
            oxide synthase interacting protein
  JOURNAL   J Biol Chem 299 (3), 102932 (2023)
   PUBMED   36690276
  REMARK    GeneRIF: Transportin 1 is a major nuclear import receptor of the
            nitric oxide synthase interacting protein.
REFERENCE   2  (bases 1 to 1232)
  AUTHORS   Sadaf,S., Nagarkoti,S., Awasthi,D., Singh,A.K., Srivastava,R.N.,
            Kumar,S., Barthwal,M.K. and Dikshit,M.
  TITLE     nNOS induction and NOSIP interaction impact granulopoiesis and
            neutrophil differentiation by modulating nitric oxide generation
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (7), 119018 (2021)
   PUBMED   33771575
  REMARK    GeneRIF: nNOS induction and NOSIP interaction impact granulopoiesis
            and neutrophil differentiation by modulating nitric oxide
            generation.
REFERENCE   3  (bases 1 to 1232)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1232)
  AUTHORS   Tomuschat,C., O'Donnell,A.M., Coyle,D., Dreher,N., Kelly,D. and
            Puri,P.
  TITLE     NOS-interacting protein (NOSIP) is increased in the colon of
            patients with Hirschsprungs's disease
  JOURNAL   J Pediatr Surg 52 (5), 772-777 (2017)
   PUBMED   28196663
  REMARK    GeneRIF: While NOSIP expression was increased in Hirschsprung's
            disease (HSCR) vs. non- HSCR patients, no significant difference
            was observed in patients with Hirschsprung's associated
            enterocolitis. The increased expression of NOSIP in the aganglionic
            and ganglionic bowel of HSCR may contribute to the development of
            enterocolitis by inhibiting local nitric oxide production in
            patients with Hirschsprung's disease.
REFERENCE   5  (bases 1 to 1232)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   6  (bases 1 to 1232)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 1232)
  AUTHORS   Michel,T. and Vanhoutte,P.M.
  TITLE     Cellular signaling and NO production
  JOURNAL   Pflugers Arch 459 (6), 807-816 (2010)
   PUBMED   20082095
  REMARK    Review article
REFERENCE   8  (bases 1 to 1232)
  AUTHORS   Schleicher,M., Brundin,F., Gross,S., Muller-Esterl,W. and Oess,S.
  TITLE     Cell cycle-regulated inactivation of endothelial NO synthase
            through NOSIP-dependent targeting to the cytoskeleton
  JOURNAL   Mol Cell Biol 25 (18), 8251-8258 (2005)
   PUBMED   16135813
  REMARK    GeneRIF: Endogenous NOSIP reduces the enzymatic capacity of eNOS,
            specifically in the G(2) phase of the cell cycle by targeting eNOS
            to the actin cytoskeleton.
REFERENCE   9  (bases 1 to 1232)
  AUTHORS   Dreyer,J., Schleicher,M., Tappe,A., Schilling,K., Kuner,T.,
            Kusumawidijaja,G., Muller-Esterl,W., Oess,S. and Kuner,R.
  TITLE     Nitric oxide synthase (NOS)-interacting protein interacts with
            neuronal NOS and regulates its distribution and activity
  JOURNAL   J Neurosci 24 (46), 10454-10465 (2004)
   PUBMED   15548660
REFERENCE   10 (bases 1 to 1232)
  AUTHORS   Dedio,J., Konig,P., Wohlfart,P., Schroeder,C., Kummer,W. and
            Muller-Esterl,W.
  TITLE     NOSIP, a novel modulator of endothelial nitric oxide synthase
            activity
  JOURNAL   FASEB J 15 (1), 79-89 (2001)
   PUBMED   11149895
  REMARK    GeneRIF: endothelial nitric oxide synthase (eNOS) interacting
            protein (NOSIP), modulator of eNOS activity by alteration of eNOS
            subcellular localisation; high expression levels in endothelial
            cells and vascularized tissue.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB470916.1, BC009299.2 and
            BE826708.1.
            
            On May 17, 2019 this sequence version replaced NM_001270960.1.
            
            Summary: The protein encoded by this gene may modulate the activity
            and localization of nitric oxide synthase (endothelial and
            neuronal) and thus nitric oxide production. Alternative splicing
            results in multiple transcript variants that encode the same
            protein. [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291535.1, SRR7410570.658081.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000596358.6/ ENSP00000470034.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DB470916.1         18-31
            15-989              BC009299.2         1-975
            990-1232            BE826708.1         86-328
FEATURES             Location/Qualifiers
     source          1..1232
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1232
                     /gene="NOSIP"
                     /gene_synonym="CGI-25"
                     /note="nitric oxide synthase interacting protein"
                     /db_xref="GeneID:51070"
                     /db_xref="HGNC:HGNC:17946"
                     /db_xref="MIM:616759"
     exon            1..42
                     /gene="NOSIP"
                     /gene_synonym="CGI-25"
                     /inference="alignment:Splign:2.1.0"
     exon            43..113
                     /gene="NOSIP"
                     /gene_synonym="CGI-25"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..949
                     /gene="NOSIP"
                     /gene_synonym="CGI-25"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 2;
                     eNOS-interacting protein; E3 ubiquitin-protein ligase
                     NOSIP; RING-type E3 ubiquitin transferase NOSIP"
                     /codon_start=1
                     /product="nitric oxide synthase-interacting protein
                     isoform 1"
                     /protein_id="NP_001257889.1"
                     /db_xref="CCDS:CCDS12772.1"
                     /db_xref="GeneID:51070"
                     /db_xref="HGNC:HGNC:17946"
                     /db_xref="MIM:616759"
                     /translation="MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNIRLSRDAVKDFD
                     CCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKKEIARQMKAYEKQRGTRREEQKEL
                     QRAASQDHVRGFLEKESAIVSRPLNPFTAKALSGTSPDDVQPGPSVGPPSKDKDKVLP
                     SFWIPSLTPEAKATKLEKPSRTVTCPMSGKPLRMSDLTPVHFTPLDSSVDRVGLITRS
                     ERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEKLIRKDMVDPVTGDKLTDRDIIVL
                     QRGGTGFAGSGVKLQAEKSRPVMQA"
     exon            114..219
                     /gene="NOSIP"
                     /gene_synonym="CGI-25"
                     /inference="alignment:Splign:2.1.0"
     exon            220..301
                     /gene="NOSIP"
                     /gene_synonym="CGI-25"
                     /inference="alignment:Splign:2.1.0"
     exon            302..461
                     /gene="NOSIP"
                     /gene_synonym="CGI-25"
                     /inference="alignment:Splign:2.1.0"
     exon            462..580
                     /gene="NOSIP"
                     /gene_synonym="CGI-25"
                     /inference="alignment:Splign:2.1.0"
     exon            581..768
                     /gene="NOSIP"
                     /gene_synonym="CGI-25"
                     /inference="alignment:Splign:2.1.0"
     exon            769..877
                     /gene="NOSIP"
                     /gene_synonym="CGI-25"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1232
                     /gene="NOSIP"
                     /gene_synonym="CGI-25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      967..972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOSIP"
                     /gene_synonym="CGI-25"
                     /note="hexamer: AATAAA"
     polyA_site      989
                     /gene="NOSIP"
                     /gene_synonym="CGI-25"
                     /note="major polyA site"
     regulatory      1132..1137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOSIP"
                     /gene_synonym="CGI-25"
                     /note="hexamer: AACAAA"
     polyA_site      1150
                     /gene="NOSIP"
                     /gene_synonym="CGI-25"
ORIGIN      
        1 acagttgaag aagcgaccga gggactggga gtcgttagtg aggatgacgc ggcatggcaa
       61 gaactgcacc gcaggggccg tctacaccta ccacgagaag aagaaggaca cagcggcctc
      121 gggctatggg acccagaaca ttcgactgag ccgggatgcc gtgaaggact tcgactgctg
      181 ttgtctctcc ctgcagcctt gccacgatcc tgttgtcacc ccagatggct acctgtatga
      241 gcgtgaggcc atcctggagt acattctgca ccagaagaag gagattgccc ggcagatgaa
      301 ggcctacgag aagcagcggg gcacccggcg cgaggagcag aaggagcttc agcgggcggc
      361 ctcgcaggac catgtgcggg gcttcctgga gaaggagtcg gctatcgtga gccggcccct
      421 caaccctttc acagccaagg ccctctcggg caccagccca gatgatgtcc aacctgggcc
      481 cagtgtgggt cctccaagta aggacaagga caaagtgctg cccagcttct ggatcccgtc
      541 gctgacgccc gaagccaagg ccaccaagct ggagaagccg tcccgcacgg tgacctgccc
      601 catgtcaggg aagcccctgc gcatgtcgga cctgacgccc gtgcacttca caccgctaga
      661 cagctccgtg gaccgcgtgg ggctcatcac ccgcagcgag cgctacgtgt gtgccgtgac
      721 ccgcgacagc ctgagcaacg ccaccccctg cgctgtgctg cggccctctg gggctgtggt
      781 caccctcgaa tgcgtggaga agctgattcg gaaggacatg gtggaccctg tgactggaga
      841 caaactcaca gaccgcgaca tcatcgtgct gcagcggggc ggtaccggct tcgcgggctc
      901 cggagtgaag ctgcaagcgg agaaatcacg gccggtgatg caggcctgag tgtgtgcggg
      961 agaccaaata aaccggcttg ggtgcgcaac gacgtggcgc cttcattcgc ggcgtgggcg
     1021 ccccggggac agggcaggcg aggatgcagg gccgtgcaaa cagtgctcct acagcgcacg
     1081 ctggagtttg aaagagcggg ctaagcatat tgaatgtggt ctcacattaa gaacaaaatc
     1141 tggccaggca cggtggctca cgcctgtaat cccagcactt tcggaggccg aggctagcgt
     1201 atcacttgag gtcaggagtt cgagaccagc ct
//
