LOCUS       NM_000603               4366 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens nitric oxide synthase 3 (NOS3), transcript variant 1,
            mRNA.
ACCESSION   NM_000603
VERSION     NM_000603.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4366)
  AUTHORS   Sun,X., Moreno Caceres,S., Yegambaram,M., Lu,Q., Pokharel,M.D.,
            Boehme,J.T., Datar,S.A., Aggarwal,S., Wang,T., Fineman,J.R. and
            Black,S.M.
  TITLE     The mitochondrial redistribution of ENOS is regulated by AKT1 and
            dimer status
  JOURNAL   Nitric Oxide 152, 90-100 (2024)
   PUBMED   39332480
  REMARK    GeneRIF: The mitochondrial redistribution of ENOS is regulated by
            AKT1 and dimer status.
REFERENCE   2  (bases 1 to 4366)
  AUTHORS   Alkanli,N., Ay,A. and Cevik,G.
  TITLE     Investigation of the relationships between eNOS T786C, G894T,
            intron 4 VNTR (4a/b) gene variations and prostate cancer
            development and progression
  JOURNAL   Nitric Oxide 152, 69-77 (2024)
   PUBMED   39322022
  REMARK    GeneRIF: Investigation of the relationships between eNOS T786C,
            G894T, intron 4 VNTR (4a/b) gene variations and prostate cancer
            development and progression.
REFERENCE   3  (bases 1 to 4366)
  AUTHORS   Song,J., Wang,Y.L. and Chu,J.Q.
  TITLE     [Relationship of cerebrospinal fluid and serum levels of SIL-2R,
            eNOS, and CD93 with the progression and prognosis of viral
            encephalitis in children]
  JOURNAL   Zhongguo Dang Dai Er Ke Za Zhi 26 (10), 1072-1077 (2024)
   PUBMED   39467677
  REMARK    GeneRIF: [Relationship of cerebrospinal fluid and serum levels of
            SIL-2R, eNOS, and CD93 with the progression and prognosis of viral
            encephalitis in children].
REFERENCE   4  (bases 1 to 4366)
  AUTHORS   Zhang,X., Lin,G., Zhang,Q., Wu,H., Xu,W., Wang,Z., He,Z., Su,L.,
            Zhuang,Y. and Gong,A.
  TITLE     The rs3918188 and rs1799983 loci of eNOS gene are associated with
            susceptibility in patients with systemic lupus erythematosus in
            Northeast China
  JOURNAL   Sci Rep 14 (1), 20803 (2024)
   PUBMED   39242633
  REMARK    GeneRIF: The rs3918188 and rs1799983 loci of eNOS gene are
            associated with susceptibility in patients with systemic lupus
            erythematosus in Northeast China.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4366)
  AUTHORS   Sakaguchi,R., Takahashi,N., Yoshida,T., Ogawa,N., Ueda,Y.,
            Hamano,S., Yamaguchi,K., Sawamura,S., Yamamoto,S., Hara,Y.,
            Kawamoto,T., Suzuki,R., Nakao,A., Mori,M.X., Furukawa,T.,
            Shimizu,S., Inoue,R. and Mori,Y.
  TITLE     Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein
            assembly potentiates the positive feedback interaction between Ca2+
            and NO signals
  JOURNAL   J Biol Chem 300 (9), 107705 (2024)
   PUBMED   39178948
  REMARK    GeneRIF: Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS
            protein assembly potentiates the positive feedback interaction
            between Ca[2+] and NO signals.
REFERENCE   6  (bases 1 to 4366)
  AUTHORS   Huh,J.W., Ha,H.S., Kim,D.S. and Kim,H.S.
  TITLE     Placenta-restricted expression of LTR-derived NOS3
  JOURNAL   Placenta 29 (7), 602-608 (2008)
   PUBMED   18474398
  REMARK    GeneRIF: Integration event of an LTR10A element in the upstream
            region of NOS3 led to the generation of a placenta-specific
            alternative transcript.
REFERENCE   7  (bases 1 to 4366)
  AUTHORS   Janssens,S.P., Simouchi,A., Quertermous,T., Bloch,D.B. and
            Bloch,K.D.
  TITLE     Cloning and expression of a cDNA encoding human endothelium-derived
            relating factor/nitric oxide synthase
  JOURNAL   J Biol Chem 267 (31), 22694 (1992)
   PUBMED   1385404
  REMARK    Correction to:[J Biol Chem. 1992 Jul 25;267(21):14519-22.. PMID:
            1378832]
REFERENCE   8  (bases 1 to 4366)
  AUTHORS   Marsden,P.A., Schappert,K.T., Chen,H.S., Flowers,M., Sundell,C.L.,
            Wilcox,J.N., Lamas,S. and Michel,T.
  TITLE     Molecular cloning and characterization of human endothelial nitric
            oxide synthase
  JOURNAL   FEBS Lett 307 (3), 287-293 (1992)
   PUBMED   1379542
REFERENCE   9  (bases 1 to 4366)
  AUTHORS   Janssens,S.P., Shimouchi,A., Quertermous,T., Bloch,D.B. and
            Bloch,K.D.
  TITLE     Cloning and expression of a cDNA encoding human endothelium-derived
            relaxing factor/nitric oxide synthase
  JOURNAL   J Biol Chem 267 (21), 14519-14522 (1992)
   PUBMED   1378832
  REMARK    Erratum:[J Biol Chem. 1992 Nov 5;267(31):22694.. PMID: 1385404]
REFERENCE   10 (bases 1 to 4366)
  AUTHORS   Ros,M., Northup,J.K. and Malbon,C.C.
  TITLE     Adipocyte G-proteins and adenylate cyclase. Effects of
            adrenalectomy
  JOURNAL   Biochem J 257 (3), 737-744 (1989)
   PUBMED   2539094
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010973.7, DA859819.1,
            BC063294.1 and AI082109.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000603.4.
            
            Summary: Nitric oxide is a reactive free radical which acts as a
            biologic mediator in several processes, including neurotransmission
            and antimicrobial and antitumoral activities. Nitric oxide is
            synthesized from L-arginine by nitric oxide synthases. Variations
            in this gene are associated with susceptibility to coronary spasm.
            Alternative splicing and the use of alternative promoters results
            in multiple transcript variants. [provided by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). The 5' end of this
            transcript contains long terminal repeat (LTR) sequence, initiates
            from an LTR promoter and results in placenta-specific expression.
            (PMID: 18474398).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063294.1, SRR11853563.31246.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158188, SAMEA2162568
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297494.8/ ENSP00000297494.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC010973.7         7735-7773
            40-43               DA859819.1         1-4
            44-4363             BC063294.1         1-4320
            4364-4366           AI082109.1         19-21               c
FEATURES             Location/Qualifiers
     source          1..4366
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..4366
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /note="nitric oxide synthase 3"
                     /db_xref="GeneID:4846"
                     /db_xref="HGNC:HGNC:7876"
                     /db_xref="MIM:163729"
     exon            1..284
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            285..493
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..3947
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /EC_number="1.14.13.39"
                     /note="isoform 1 is encoded by transcript variant 1; cNOS;
                     EC-NOS; NOSIII; NOS type III; endothelial NOS;
                     constitutive NOS; nitric oxide synthase 3 (endothelial
                     cell)"
                     /codon_start=1
                     /product="nitric oxide synthase 3 isoform 1"
                     /protein_id="NP_000594.2"
                     /db_xref="CCDS:CCDS5912.1"
                     /db_xref="GeneID:4846"
                     /db_xref="HGNC:HGNC:7876"
                     /db_xref="MIM:163729"
                     /translation="MGNLKSVAQEPGPPCGLGLGLGLGLCGKQGPATPAPEPSRAPAS
                     LLPPAPEHSPPSSPLTQPPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGS
                     LVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAAT
                     GTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYA
                     TNRGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQ
                     HGWTPGNGRFDVLPLLLQAPDDPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALP
                     AVSNMLLEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSS
                     LWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVP
                     PISGSLTPVFHQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKTFKEVANAVKISAS
                     LMGTVMAKRVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETL
                     VLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSISCSDPLVS
                     SWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQL
                     GQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAARDIFSPKRSWKRQRYRLSAQ
                     AEGLQLLPGLIHVHRRKMFQATIRSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDH
                     IGVCPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPGGPPPGWVRDPRLPPCTLR
                     QALTFFLDITSPPSPQLLRLLSTLAEEPREQQELEALSQDPRRYEEWKWFRCPTLLEV
                     LEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVLAYRTQDGLGPLH
                     YGVCSTWLSQLKPGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPFRGFWQERLH
                     DIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSREPDNPKTYV
                     QDILRTELAAEVHRVLCLERGHMFVCGDVTMATNVLQTVQRILATEGDMELDEAGDVI
                     GVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDPPGSDTNSP"
     exon            494..605
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            606..754
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            755..917
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1009
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1151
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1291
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1466
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1568
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1763
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1837
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1982
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2087
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2155
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2272
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2447
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2580
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..2659
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2847
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..3020
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3231
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3232..3319
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3320..3441
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3442..3590
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3591..3785
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3786..4366
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4344..4349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /note="hexamer: ACTAAA"
     polyA_site      4366
                     /gene="NOS3"
                     /gene_synonym="ECNOS; eNOS"
                     /note="major polyA site"
ORIGIN      
        1 agttcggagc aggtgataga agctaggagg gggttgttta ctgaaactag gggcaaggag
       61 acgaagagaa catgaaagtt aaactttaag atgaagaaca aagctgaaca tactgatgca
      121 ttggatcttt ggagaggatc tcagaactca ttgtacttaa tttacaggct aaaaccttag
      181 aagaggaatt tattatatcc tacacaagac tccagggaag cacatggcct tggactgaag
      241 gctggcatct ggaagctgtc agccaccagc accttctgca gcaggaaaag gccagggctc
      301 tgctggagca ggcagcagag tggacgcaca gtaacatggg caacttgaag agcgtggccc
      361 aggagcctgg gccaccctgc ggcctggggc tggggctggg ccttgggctg tgcggcaagc
      421 agggcccagc caccccggcc cctgagccca gccgggcccc agcatcccta ctcccaccag
      481 cgccagaaca cagccccccg agctccccgc taacccagcc cccagagggg cccaagttcc
      541 ctcgtgtgaa gaactgggag gtggggagca tcacctatga caccctcagc gcccaggcgc
      601 agcaggatgg gccctgcacc ccaagacgct gcctgggctc cctggtattt ccacggaaac
      661 tacagggccg gccctccccc ggccccccgg cccctgagca gctgctgagt caggcccggg
      721 acttcatcaa ccagtactac agctccatta agaggagcgg ctcccaggcc cacgaacagc
      781 ggcttcaaga ggtggaagcc gaggtggcag ccacaggcac ctaccagctt agggagagcg
      841 agctggtgtt cggggctaag caggcctggc gcaacgctcc ccgctgcgtg ggccggatcc
      901 agtgggggaa gctgcaggtg ttcgatgccc gggactgcag gtctgcacag gaaatgttca
      961 cctacatctg caaccacatc aagtatgcca ccaaccgggg caaccttcgc tcggccatca
     1021 cagtgttccc gcagcgctgc cctggccgag gagacttccg aatctggaac agccagctgg
     1081 tgcgctacgc gggctaccgg cagcaggatg gctctgtgcg gggggaccca gccaacgtgg
     1141 agatcaccga gctctgcatt cagcacggct ggaccccagg aaacggtcgc ttcgacgtgc
     1201 tgcccctgct gctgcaggcc ccagatgatc ccccagaact cttccttctg ccccccgagc
     1261 tggtccttga ggtgcccctg gagcacccca cgctggagtg gtttgcagcc ctgggcctgc
     1321 gctggtacgc cctcccggca gtgtccaaca tgctgctgga aattgggggc ctggagttcc
     1381 ccgcagcccc cttcagtggc tggtacatga gcactgagat cggcacgagg aacctgtgtg
     1441 accctcaccg ctacaacatc ctggaggatg tggctgtctg catggacctg gatacccgga
     1501 ccacctcgtc cctgtggaaa gacaaggcag cagtggaaat caacgtggcc gtgctgcaca
     1561 gttaccagct agccaaagtc accatcgtgg accaccacgc cgccacggcc tctttcatga
     1621 agcacctgga gaatgagcag aaggccaggg ggggctgccc tgcagactgg gcctggatcg
     1681 tgccccccat ctcgggcagc ctcactcctg ttttccatca ggagatggtc aactatttcc
     1741 tgtccccggc cttccgctac cagccagacc cctggaaggg gagtgccgcc aagggcaccg
     1801 gcatcaccag gaagaagacc tttaaagaag tggccaacgc cgtgaagatc tccgcctcgc
     1861 tcatgggcac ggtgatggcg aagcgagtga aggcgacaat cctgtatggc tccgagaccg
     1921 gccgggccca gagctacgca cagcagctgg ggagactctt ccggaaggct tttgatcccc
     1981 gggtcctgtg tatggatgag tatgacgtgg tgtccctcga acacgagacg ctggtgctgg
     2041 tggtaaccag cacatttggg aatggggatc ccccggagaa tggagagagc tttgcagctg
     2101 ccctgatgga gatgtccggc ccctacaaca gctcccctcg gccggaacag cacaagagtt
     2161 ataagatccg cttcaacagc atctcctgct cagacccact ggtgtcctct tggcggcgga
     2221 agaggaagga gtccagtaac acagacagtg caggggccct gggcaccctc aggttctgtg
     2281 tgttcgggct cggctcccgg gcataccccc acttctgcgc ctttgctcgt gccgtggaca
     2341 cacggctgga ggaactgggc ggggagcggc tgctgcagct gggccagggc gacgagctgt
     2401 gcggccagga ggaggccttc cgaggctggg cccaggctgc cttccaggcc gcctgtgaga
     2461 ccttctgtgt gggagaggat gccaaggccg ccgcccgaga catcttcagc cccaaacgga
     2521 gctggaagcg ccagaggtac cggctgagcg cccaggccga gggcctgcag ttgctgccag
     2581 gtctgatcca cgtgcacagg cggaagatgt tccaggctac aatccgctca gtggaaaacc
     2641 tgcaaagcag caagtccacg agggccacca tcctggtgcg cctggacacc ggaggccagg
     2701 aggggctgca gtaccagccg ggggaccaca taggtgtctg cccgcccaac cggcccggcc
     2761 ttgtggaggc gctgctgagc cgcgtggagg acccgccggc gcccactgag cccgtggcag
     2821 tagagcagct ggagaagggc agccctggtg gccctccccc cggctgggtg cgggaccccc
     2881 ggctgccccc gtgcacgctg cgccaggctc tcaccttctt cctggacatc acctccccac
     2941 ccagccctca gctcttgcgg ctgctcagca ccttggcaga agagcccagg gaacagcagg
     3001 agctggaggc cctcagccag gatccccgac gctacgagga gtggaagtgg ttccgctgcc
     3061 ccacgctgct ggaggtgctg gagcagttcc cgtcggtggc gctgcctgcc ccactgctcc
     3121 tcacccagct gcctctgctc cagccccggt actactcagt cagctcggca cccagcaccc
     3181 acccaggaga gatccacctc actgtagctg tgctggcata caggactcag gatgggctgg
     3241 gccccctgca ctatggagtc tgctccacgt ggctaagcca gctcaagccc ggagaccctg
     3301 tgccctgctt catccggggg gctccctcct tccggctgcc acccgatccc agcttgccct
     3361 gcatcctggt gggtccaggc actggcattg cccccttccg gggattctgg caggagcggc
     3421 tgcatgacat tgagagcaaa gggctgcagc ccactcccat gactttggtg ttcggctgcc
     3481 gatgctccca acttgaccat ctctaccgcg acgaggtgca gaacgcccag cagcgcgggg
     3541 tgtttggccg agtcctcacc gccttctccc gggaacctga caaccccaag acctacgtgc
     3601 aggacatcct gaggacggag ctggctgcgg aggtgcaccg cgtgctgtgc ctcgagcggg
     3661 gccacatgtt tgtctgcggc gatgttacca tggcaaccaa cgtcctgcag accgtgcagc
     3721 gcatcctggc gacggagggc gacatggagc tggacgaggc cggcgacgtc atcggcgtgc
     3781 tgcgggatca gcaacgctac cacgaagaca ttttcgggct cacgctgcgc acccaggagg
     3841 tgacaagccg catacgcacc cagagctttt ccttgcagga gcgtcagttg cggggcgcag
     3901 tgccctgggc gttcgaccct cccggctcag acaccaacag cccctgagag ccgcctggct
     3961 ttcccttcca gttccgggag agcggctgcc cgactcaggt ccgcccgacc aggatcagcc
     4021 ccgctcctcc cctcttgagg tggtgccttc tcacatctgt ccagaggctg caaggattca
     4081 gcattattcc tccaggaagg agcaaaacgc ctcttttccc tctctaggcc tgttgcctcg
     4141 ggcctgggtc cgccttaatc tggaaggccc ctcccagcag cggtacccca gggcctactg
     4201 ccacccgctt cctgtttctt agtcgaatgt tagattcctc ttgcctctct caggagtatc
     4261 ttacctgtaa agtctaatct ctaaatcaag tatttattat tgaagattta ccataaggga
     4321 ctgtgccaga tgttaggaga actactaaag tgcctacccc agctca
//
