LOCUS       NM_174913               6045 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens NOP9 nucleolar protein (NOP9), transcript variant 1,
            mRNA.
ACCESSION   NM_174913
VERSION     NM_174913.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6045)
  AUTHORS   Nudel,R., Simpson,N.H., Baird,G., O'Hare,A., Conti-Ramsden,G.,
            Bolton,P.F., Hennessy,E.R., Ring,S.M., Davey Smith,G., Francks,C.,
            Paracchini,S., Monaco,A.P., Fisher,S.E. and Newbury,D.F.
  CONSRTM   SLI Consortium
  TITLE     Genome-wide association analyses of child genotype effects and
            parent-of-origin effects in specific language impairment
  JOURNAL   Genes Brain Behav 13 (4), 418-429 (2014)
   PUBMED   24571439
REFERENCE   2  (bases 1 to 6045)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 6045)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 6045)
  AUTHORS   Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M.,
            Toyama,S., Usami,R., Ohtoko,K. and Kato,S.
  TITLE     Full-length transcriptome analysis of human retina-derived cell
            lines ARPE-19 and Y79 using the vector-capping method
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6662-6670 (2011)
   PUBMED   21697133
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6045)
  AUTHORS   Dong,S., Wang,Y., Cassidy-Amstutz,C., Lu,G., Bigler,R., Jezyk,M.R.,
            Li,C., Hall,T.M. and Wang,Z.
  TITLE     Specific and modular binding code for cytosine recognition in
            Pumilio/FBF (PUF) RNA-binding domains
  JOURNAL   J Biol Chem 286 (30), 26732-26742 (2011)
   PUBMED   21653694
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL096870.5, HY061279.1, AB095941.1 and BC015481.1.
            
            On Nov 22, 2018 this sequence version replaced NM_174913.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB095941.1, BX647311.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267425.8/ ENSP00000267425.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AL096870.5         90102-90105         c
            5-12                HY061279.1         3-10
            13-5517             AB095941.1         1-5505
            5518-6045           BC015481.1         1008-1535
FEATURES             Location/Qualifiers
     source          1..6045
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..6045
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
                     /note="NOP9 nucleolar protein"
                     /db_xref="GeneID:161424"
                     /db_xref="HGNC:HGNC:19826"
                     /db_xref="MIM:618308"
     exon            1..352
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2016
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pumilio domain-containing protein C14orf21; nucleolar
                     protein 9; NOP9 nucleolar protein homolog; hypothetical
                     protein HP08474"
                     /codon_start=1
                     /product="nucleolar protein 9 isoform 1"
                     /protein_id="NP_777573.1"
                     /db_xref="CCDS:CCDS9624.1"
                     /db_xref="GeneID:161424"
                     /db_xref="HGNC:HGNC:19826"
                     /db_xref="MIM:618308"
                     /translation="MGQGPRSPHKVGRRFPAGGKRGRGAKGSGRPLPGRKRQPWPPPD
                     GRSEPAPDSHPHLSPEALGYFRRALSALKEAPETGEERDLMVHNIMKEVETQALALST
                     NRTGSEMLQELLGFSPLKPLCRVWAALRSNLRTVACHRCGVHVLQSALLQLPRLLGSA
                     AEEEEEEEEDGKDGPTETLEELVLGLAAEVCDDFLVYCGDTHGSFVVRTLLQVLGGTI
                     LESERARPRGSQSSEAQKTPAQECKPADFEVPETFLNRLQDLSSSFLKDIAVFITDKI
                     SSFCLQVALQVLHRKLPQFCAHLCNAVIGYLSTRGSSVDGSPLLLFLRDQTSSRLLEQ
                     VLLVLEPPRLQSLFEEHLQGQLQTLAAHPIANFPLQRLLDAVTTPELLSPVFEELSPV
                     LEAVLAQGHPGVVIALVGACRRVGAYQAKVLQLLLEAFHCAEPSSRQVACVPLFATLM
                     AYEVYYGLTEEEGAVPAEHQVAMAAARALGDVTVLGSLLLQHLLHFSTPGLVLRSLGA
                     LTGPQLLSLAQSPAGSHVLDAILTSPSVTRKLRRRVLQNLKGQYVALACSRHGSRVLD
                     AIWSGAALRARKEIAAELGEQNQELIRDPFGHHVARNVALTTFLKRREAWEQQQGAVA
                     KRRRALNSILED"
     exon            353..802
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
                     /inference="alignment:Splign:2.1.0"
     exon            803..913
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1055
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1248
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1389
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1515
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1752
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1858
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..6045
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5094
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
                     /note="major polyA site"
     regulatory      6026..6031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
                     /note="hexamer: AATAAA"
     polyA_site      6045
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
ORIGIN      
        1 gcccgcgttt ctaaactttg tctggataag gcgcacgctt ggcgacgtcg aaggtccgtc
       61 cgcagttaag gaagcttttg cagccggaca ggtcgcgaag cacacatggg gcagggtccg
      121 cgctctccac acaaggtggg gcgccggttc ccagctggtg gcaaacgggg gcgcggggcc
      181 aaggggtcgg ggcgcccctt accaggccgt aagcggcaac cctggccgcc tccggatggg
      241 cgctcggagc cggctccaga ttcgcacccg cacctgagcc cggaagctct gggatatttc
      301 cgccgggcgc tgtcagcatt gaaagaggct cccgagactg gggaagaacg agatctgatg
      361 gtgcacaata taatgaagga agtagagact caggccctag ctttgtccac gaacaggact
      421 ggcagtgaga tgctgcagga actgttggga ttcagtccct tgaaaccgct ttgtcgcgtg
      481 tgggctgctc tgcgctctaa cttgcgcact gtggcctgtc accgatgcgg ggtccatgta
      541 ttacaaagtg ctttgctaca gctccctcga ttgctgggga gtgctgcaga ggaggaggag
      601 gaggaggagg aggatggaaa ggatggtccc acggagaccc tggaggagct ggtcctggga
      661 ctagccgctg aggtgtgtga tgattttctt gtctactgtg gagacacaca tggcagcttc
      721 gtggtcagaa ctctgcttca ggtgttagga gggactattc tggagtctga gagagccagg
      781 ccccgtggtt cccaatcatc tgaagcacag aagaccccag ctcaggaatg taagccagct
      841 gattttgaag tccctgaaac ctttttgaat cgccttcagg acctgagctc ctcctttctg
      901 aaggacattg cagtgtttat cactgataag atctccagct tctgtcttca agtggcttta
      961 caggttttac accgcaaact tccccagttt tgcgctcatc tctgcaatgc tgtgattggc
     1021 tacctgagta ctcgcggttc ctcagtagat ggcagtcccc tactgctatt tctccgagat
     1081 cagacgagtt ccagactcct ggagcaggtc ctgctggtgt tggagccccc aagactccag
     1141 agcctctttg aggagcactt gcaggggcag ctgcagaccc tggctgcaca tcccattgcc
     1201 aacttccctt tgcagcgctt actggatgca gtcactaccc ctgagctgct gtcccctgtg
     1261 tttgaggagc tgagccctgt cttggaagct gtattggccc agggccaccc aggggtagtc
     1321 attgccctgg tgggggcctg tcgcagagtt ggggcctacc aagccaaggt cctacagctc
     1381 ttgttggagg cattccactg tgcagagccc tcatcccggc aagtggcctg tgtgcctctc
     1441 tttgccactt tgatggctta tgaggtgtac tatggactga cggaggagga gggggcagtg
     1501 cctgcagagc accaggtggc aatggccgca gccagagcct tgggggatgt gacagtcctt
     1561 gggtctctac tgctccagca tctgctgcac ttctccactc ctggtcttgt acttcgaagt
     1621 ctgggtgcct tgacgggacc acagcttctg tcccttgccc aaagtcccgc tggctctcat
     1681 gtgctcgatg ccatcctgac cagcccctct gtgacgcgca agctgcgccg ccgtgtgctg
     1741 cagaacctaa agggacaata tgtggctctg gcctgtagtc gccatggcag ccgtgtgcta
     1801 gatgccatct ggagtggagc agccttgagg gcccggaagg aaattgctgc tgagcttggg
     1861 gagcagaacc aggagctgat aagagaccct ttcggccacc atgtggctcg aaatgtggcc
     1921 ttgactacct tcctaaagcg gcgagaggct tgggaacagc agcagggtgc ggtggccaag
     1981 cggaggcggg cattgaactc catacttgaa gactgaggct ttggatctgg gactgggtgt
     2041 tgatggggga gggcaaaatg gggtatccac cccatccctt tcctggttta aattggagtc
     2101 agaagtctta gtggtaaata tttgatattt ttattggaaa tgtttttgtt agtttgaggg
     2161 gaagggtatg aagacagatc tcaaggtaaa gtcagagagg gctgtcatca gtatgctggg
     2221 gagtttaggg acaggaggca ttggtagggg attagatgta gcagcagtca ggctgggatc
     2281 aagatgcctg ggggacatct tgatcttggc ctttcagggc aagtgggagg ccagaaaggt
     2341 ggctaggaaa gaacagcatt cttcaggtaa gggtatagac ttgggatgtg aggcgttatg
     2401 ctgaaaggtt ctgtcacgag gggatcagag gacagtgggg aaattgggtg ggttatctag
     2461 cctgtactgt ctgcaggtcc tgaaatttga tgctgtcata gtctttgcag tgggtcggtt
     2521 ggaatgattc tgggggcaga agctcagagc cccttagtag gaatggaggc ggcccttctg
     2581 ctgccactgc tcagccccct ccactgcatg acgaagggtg gaggaaattc ccagcaacat
     2641 atggcccagg ccttgcagca gtgtggaggt ccaacgaagg agctccctga atggcagaga
     2701 caagaggaaa tcagatgatt tggaaaactt gggaggaagc catcaagctg ggagatgagg
     2761 actttccaca agcaagagct aactaggggt aggtgggtgc aagaggacga attatgggga
     2821 ctatccaact gtaggggatg gggcagtatg acatgttgat ttctgacctg agtactttct
     2881 ttgggccaag tccttgaaag tcacaactca tagagtagag cccgtagaat gtggctttga
     2941 cattcaggct gccaaagagg tctcgagggt tttgcttgta cacgtcaaag gtgaatcggg
     3001 cgatgtcctt gctgtgcttg ggcctctccc gtcccaggcc atatgacagc actccactct
     3061 gtaggacacc cttgtcagtg cagtagatcc tcataccaga cacccaccac taatctccat
     3121 cagcactggg tcagaccctc cctcgcttgg actttctgtc cactgtgtga catccttgac
     3181 aattccacaa ctcctcctgc acctggtccc caggatcagg gttaagctag agaggaagcc
     3241 cgggaaagct ctaaaggaca ggcattggaa gcagccccag tataggcctc ttacccttgt
     3301 agggctccag ctctgaccag actgcaacac catcaggcac gtgtcatcct ccagcagctg
     3361 gaagaagtcc tcactgtcca ctgcagttcc atcctcctct agcaccaggg ttagcactcc
     3421 attcagcagt agggtctcca atgcctgccc aatggcaaga agcaagaagg gcaggtctta
     3481 tcccatgccc cttccctctt tagctgccca acatccatca gttggctcta gacattggtc
     3541 gatgtcccac tttgactttc cggcactttg atacctccta aaggttgcag ctctccgtgt
     3601 tcttcagttt ttgggggatc ctagctagag gctgaccttt ttcctctttg ctcctaccat
     3661 gtcattggca tctccccttg ctcccctcca agtcacttct ggtttggaat tggaaagcaa
     3721 gccaggttct cacgaagtcc acccttctgt cttatctaca atgctgcacc tcacttccca
     3781 caccctcaag agttctccag aagtgttttc agtaatagtg tttaaccttt ttgagtcctt
     3841 actctgtgcc aggtatgagg actttaccta cattatcctc ttactccttt caacaaccct
     3901 aggaggtgat gtattattat tgccttttta tagttgaaga aactgaggtt ttggtaggtt
     3961 gaacaacttc ccaaggtttg acaggcagga agtggcagaa tcagaatttg aacttgattt
     4021 gtcacacaaa tcacctttcc atactagctt ctgaattctg tccctcgaac tctccctatc
     4081 tcctgctaac ccctgctccc atagaaaagc tcactcggtg gaaaatgaac aaattgacca
     4141 gagctcatta ggcccactcc gctgctttta gccctcagag ggaggggcag ctgtgtgact
     4201 tcagccctct gctccatcat cacaagttgc cactgttgtg gagccccttg gctacccctg
     4261 ctataggaac cgaggaactt ggcctactta ctttggctag cagctcctgg cgggtggcag
     4321 ctgtcaggcc tttccggatg gtccgcttgt gatcacagac acggaaaggt cgctggggtg
     4381 gtggagctga ggtccagacc ctccgtccaa actccgagct tatattagat actgacctgg
     4441 tagttgagaa gaaaagtcaa gaaggggcga ggaggggctt ggtgagtgta aagggcatga
     4501 tgagggtaga gtggctagag ggctagggag ggagagatct aggtttatcg attagggatg
     4561 agggagagac catggagtgc aggtgggggc gggtggctca ggagcttgac aagcccactg
     4621 tggagtgggg agcaggagag gaaggggtac tggttagtct cctaggggct gagtggagta
     4681 ttgttgccct gcctatatcc cctaaaggtg gagggtagag cggagggtta gcagtcacct
     4741 gagtaagtca ctggggttca gagctgagag gtactccatg gtggaccgga gagttccttc
     4801 cctggaactt ctgggctggg tggttctctc ctgtgctggg gctttagtgg tgttttctgt
     4861 tacaaacctg ggatctcagc ccaggacaag gtgggaatga gtcaagcctg gactctggcc
     4921 cccctgcctg gccagtaaga agggcaaagt ccaaggggag ggatgaggga ggggccagat
     4981 ggggtcctgg aggaagaatt gcctggcaaa agccattgga gcttgtatgt gtgtctttgg
     5041 tgatgacatg tgttgtgagg gtagatggga accatgtaaa aggatgaaat gtgacttctg
     5101 gtgttttttt atttctatgg agggaatttc tggggacggt ttctggctct caggctctga
     5161 gaagctgcag tttatgagtg gctctgtgtg tgctgccacc tactggagaa gccataagct
     5221 gcagctttag gaaaagggaa cccggggcag agtgtgggga agtgggatgg cagcatggca
     5281 gggctttgga aaatgagagg tgagactgtg tccaggaagg gtgtaaggag aggatggatc
     5341 ctgatacatg gattcaggat cattagggtc ctgtctggga cactggcctt cctgcttacc
     5401 tgctctttcc ttcctccttg gtcggaggag gggctggctc actgctctgg cttcattttc
     5461 cagagctgcc tgctgcagtc acacttaggt catcttctct cacttttctc cttttgccga
     5521 ttagtggacg tgacagagat gtgaatgggg cagggatgtc ctttgatggc atcaagactt
     5581 tagcttctgg tgcgctgtgt cccagctctg atttcagttg cagccgtgat ggacagttgc
     5641 atggaagctg agactctcac tgacagtgaa accctcaaat gaacacaatc cctgctttcc
     5701 tgccaaggat ccttgtaggg tcccccagct tccccacttt ttttctgtgt cctgacaaag
     5761 aaacacagag taacttgatt gccctgtgac ctggccagtt gcatttcccc tgcaggcttg
     5821 agcccaagcc agagccttga aaaggtattc aggttgttgc ccaaaacact gaaaaaaact
     5881 ggccctggcc ctgaaccaaa taccttgaac cctcgtaaac tccataccct gacccccttg
     5941 ttttggatat acccaggtag aacaactctc tctcactgtc tgttgtgagg atacgctgta
     6001 gcccactcat taagtacatt ctcctaataa atgctttgga ctgat
//
