LOCUS       NM_015934               1994 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens NOP58 ribonucleoprotein (NOP58), mRNA.
ACCESSION   NM_015934
VERSION     NM_015934.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1994)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1994)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   3  (bases 1 to 1994)
  AUTHORS   Wang,J., Huang,R., Huang,Y., Chen,Y. and Chen,F.
  TITLE     Overexpression of NOP58 as a Prognostic Marker in Hepatocellular
            Carcinoma: A TCGA Data-Based Analysis
  JOURNAL   Adv Ther 38 (6), 3342-3361 (2021)
   PUBMED   34014550
  REMARK    GeneRIF: Overexpression of NOP58 as a Prognostic Marker in
            Hepatocellular Carcinoma: A TCGA Data-Based Analysis.
REFERENCE   4  (bases 1 to 1994)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1994)
  AUTHORS   Abel,Y., Paiva,A.C.F., Bizarro,J., Chagot,M.E., Santo,P.E.,
            Robert,M.C., Quinternet,M., Vandermoere,F., Sousa,P.M.F., Fort,P.,
            Charpentier,B., Manival,X., Bandeiras,T.M., Bertrand,E. and
            Verheggen,C.
  TITLE     NOPCHAP1 is a PAQosome cofactor that helps loading NOP58 on
            RUVBL1/2 during box C/D snoRNP biogenesis
  JOURNAL   Nucleic Acids Res 49 (2), 1094-1113 (2021)
   PUBMED   33367824
  REMARK    GeneRIF: NOPCHAP1 is a PAQosome cofactor that helps loading NOP58
            on RUVBL1/2 during box C/D snoRNP biogenesis.
REFERENCE   6  (bases 1 to 1994)
  AUTHORS   Verheggen,C., Lafontaine,D.L., Samarsky,D., Mouaikel,J.,
            Blanchard,J.M., Bordonne,R. and Bertrand,E.
  TITLE     Mammalian and yeast U3 snoRNPs are matured in specific and related
            nuclear compartments
  JOURNAL   EMBO J 21 (11), 2736-2745 (2002)
   PUBMED   12032086
  REMARK    GeneRIF: Mammalian and yeast U3 snoRNPs are matured in specific and
            related nuclear compartments.
REFERENCE   7  (bases 1 to 1994)
  AUTHORS   Nelson,S.A., Santora,K.E. and LaRochelle,W.J.
  TITLE     Isolation and characterization of a novel PDGF-induced human gene
  JOURNAL   Gene 253 (1), 87-93 (2000)
   PUBMED   10925205
REFERENCE   8  (bases 1 to 1994)
  AUTHORS   Yang,Y., Isaac,C., Wang,C., Dragon,F., Pogacic,V. and Meier,U.T.
  TITLE     Conserved composition of mammalian box H/ACA and box C/D small
            nucleolar ribonucleoprotein particles and their interaction with
            the common factor Nopp140
  JOURNAL   Mol Biol Cell 11 (2), 567-577 (2000)
   PUBMED   10679015
REFERENCE   9  (bases 1 to 1994)
  AUTHORS   Pintard,L., Kressler,D. and Lapeyre,B.
  TITLE     Spb1p is a yeast nucleolar protein associated with Nop1p and Nop58p
            that is able to bind S-adenosyl-L-methionine in vitro
  JOURNAL   Mol Cell Biol 20 (4), 1370-1381 (2000)
   PUBMED   10648622
REFERENCE   10 (bases 1 to 1994)
  AUTHORS   Lyman,S.K., Gerace,L. and Baserga,S.J.
  TITLE     Human Nop5/Nop58 is a component common to the box C/D small
            nucleolar ribonucleoproteins
  JOURNAL   RNA 5 (12), 1597-1604 (1999)
   PUBMED   10606270
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP245255.1 and BC032592.2.
            
            On Nov 22, 2018 this sequence version replaced NM_015934.4.
            
            Summary: The protein encoded by this gene is a core component of
            box C/D small nucleolar ribonucleoproteins. Some box C/D small
            nucleolar RNAs (snoRNAs), such as U3, U8, and U14, are dependent
            upon the encoded protein for their synthesis. This protein is
            SUMOylated, which is necessary for high affinity binding to
            snoRNAs. [provided by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.86755.1,
                                           SRR1660807.223343.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264279.10/ ENSP00000264279.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BP245255.1         48-76
            30-1994             BC032592.2         1-1965
FEATURES             Location/Qualifiers
     source          1..1994
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..1994
                     /gene="NOP58"
                     /gene_synonym="HSPC120; NOP5; NOP5/NOP58"
                     /note="NOP58 ribonucleoprotein"
                     /db_xref="GeneID:51602"
                     /db_xref="HGNC:HGNC:29926"
                     /db_xref="MIM:616742"
     exon            1..224
                     /gene="NOP58"
                     /gene_synonym="HSPC120; NOP5; NOP5/NOP58"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1769
                     /gene="NOP58"
                     /gene_synonym="HSPC120; NOP5; NOP5/NOP58"
                     /note="nucleolar protein NOP5/NOP58; nucleolar protein 5;
                     NOP58 ribonucleoprotein homolog"
                     /codon_start=1
                     /product="nucleolar protein 58"
                     /protein_id="NP_057018.1"
                     /db_xref="CCDS:CCDS2353.1"
                     /db_xref="GeneID:51602"
                     /db_xref="HGNC:HGNC:29926"
                     /db_xref="MIM:616742"
                     /translation="MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKL
                     KHFEKFQDTAEALAAFTALMEGKINKQLKKVLKKIVKEAHEPLAVADAKLGGVIKEKL
                     NLSCIHSPVVNELMRGIRSQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDT
                     MIVQAISLLDDLDKELNNYIMRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYA
                     SAKLSELLPEEVEAEVKAAAEISMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQ
                     NRMMAIAPNVTVMVGELVGARLIAHAGSLLNLAKHAASTVQILGAEKALFRALKSRRD
                     TPKYGLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLE
                     ARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDK
                     EDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCT
                     STAIASPEKKKKKKKKRENED"
     exon            225..301
                     /gene="NOP58"
                     /gene_synonym="HSPC120; NOP5; NOP5/NOP58"
                     /inference="alignment:Splign:2.1.0"
     exon            302..354
                     /gene="NOP58"
                     /gene_synonym="HSPC120; NOP5; NOP5/NOP58"
                     /inference="alignment:Splign:2.1.0"
     exon            355..476
                     /gene="NOP58"
                     /gene_synonym="HSPC120; NOP5; NOP5/NOP58"
                     /inference="alignment:Splign:2.1.0"
     exon            477..613
                     /gene="NOP58"
                     /gene_synonym="HSPC120; NOP5; NOP5/NOP58"
                     /inference="alignment:Splign:2.1.0"
     exon            614..678
                     /gene="NOP58"
                     /gene_synonym="HSPC120; NOP5; NOP5/NOP58"
                     /inference="alignment:Splign:2.1.0"
     exon            679..813
                     /gene="NOP58"
                     /gene_synonym="HSPC120; NOP5; NOP5/NOP58"
                     /inference="alignment:Splign:2.1.0"
     exon            814..959
                     /gene="NOP58"
                     /gene_synonym="HSPC120; NOP5; NOP5/NOP58"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1086
                     /gene="NOP58"
                     /gene_synonym="HSPC120; NOP5; NOP5/NOP58"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1250
                     /gene="NOP58"
                     /gene_synonym="HSPC120; NOP5; NOP5/NOP58"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1385
                     /gene="NOP58"
                     /gene_synonym="HSPC120; NOP5; NOP5/NOP58"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1447
                     /gene="NOP58"
                     /gene_synonym="HSPC120; NOP5; NOP5/NOP58"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1581
                     /gene="NOP58"
                     /gene_synonym="HSPC120; NOP5; NOP5/NOP58"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1718
                     /gene="NOP58"
                     /gene_synonym="HSPC120; NOP5; NOP5/NOP58"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1994
                     /gene="NOP58"
                     /gene_synonym="HSPC120; NOP5; NOP5/NOP58"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1971..1976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOP58"
                     /gene_synonym="HSPC120; NOP5; NOP5/NOP58"
                     /note="hexamer: AATAAA"
     polyA_site      1994
                     /gene="NOP58"
                     /gene_synonym="HSPC120; NOP5; NOP5/NOP58"
                     /note="major polyA site"
ORIGIN      
        1 ctagttccag tacagcgtgg agggtttagg cagcgtgttc tgattctttg cgggacggcg
       61 agcgcatttg tgctttgccc gccgcggcct aggaggcctt ttgaggccgc gtagtcggtg
      121 tttttgaact gactctacag cttctggcag gccgtgcggc gccctgaccc ggcctcacca
      181 tgttggtgct gtttgaaacg tctgtgggtt acgccatctt taaggttcta aatgagaaga
      241 aacttcaaga ggttgatagt ttatggaaag aatttgaaac tccagagaaa gcaaacaaaa
      301 tagtaaagct aaaacatttt gagaaatttc aggatacagc agaagcatta gcagcattca
      361 cagctctgat ggagggcaaa atcaataagc agctgaaaaa agttctgaag aaaatagtaa
      421 aagaagccca tgaaccgctg gcagtagctg atgctaaact aggaggggtc ataaaggaaa
      481 agctgaatct cagttgtatc catagtcctg ttgttaatga acttatgaga ggaattcgtt
      541 cacaaatgga tggattaatc cctggggtag aaccacgtga aatggcagct atgtgtcttg
      601 gattggctca cagcctgtct cgatatagat tgaagtttag cgctgataaa gtagacacaa
      661 tgattgttca ggcaatttcc ttgttagatg acttggataa agaactaaac aactacatta
      721 tgcgatgtag agaatggtat ggctggcatt tccctgaatt aggaaaaatt atttcagata
      781 atttaacata ctgcaagtgt ttacagaaag ttggcgatag gaagaactat gcctctgcca
      841 agctttctga gttgctgcca gaagaagttg aagcagaagt gaaagcagct gcagagatat
      901 caatgggaac agaggtttca gaagaagata tttgcaatat tctgcatctt tgcacccagg
      961 tgattgaaat ctctgaatat cgaacccagc tctatgaata tctacaaaat cgaatgatgg
     1021 ccattgcacc caatgttaca gtcatggttg gggaattagt tggagcacgg cttattgctc
     1081 atgcaggttc tcttttaaat ttggccaagc atgcagcttc taccgttcag attcttggag
     1141 ctgaaaaggc acttttcaga gccctcaaat ctagacggga tacccctaag tatggtctca
     1201 tttatcatgc ttcactcgtg ggccagacaa gtcccaaaca caaaggaaag atttctcgaa
     1261 tgctggcagc caaaaccgtt ttggctatcc gttatgatgc ttttggtgag gattcaagtt
     1321 ctgcaatggg agttgagaac agagccaaat tagaggccag gttgagaact ttggaagaca
     1381 gagggataag aaaaataagt ggaacaggaa aagcattagc aaaaacagaa aaatatgaac
     1441 acaaaagtga agtgaagact tacgatcctt ctggtgactc cacacttcca acctgttcta
     1501 aaaaacgcaa aatagaacag gtagataaag aggatgaaat tactgaaaag aaagccaaaa
     1561 aagccaagat taaagttaaa gttgaagaag aggaagaaga aaaagtggca gaagaagaag
     1621 aaacatctgt gaagaagaag aagaaaaggg gtaaaaagaa acacattaag gaagaaccac
     1681 tttctgagga agaaccatgt accagcacag caattgctag tccagagaaa aagaagaaaa
     1741 agaaaaaaaa gagagagaac gaggattaac agaaaggaat tacgattata tcacccggac
     1801 acacatcatg cttaagattc aactgggagc ataccaggga tgctctctaa cgtaatcaag
     1861 ggaaggttca gtaagacaaa gtgatttatc atctataact tcaaacctat ttgtcttgac
     1921 atcaactctg ttaaccttat gtcatcattt cttagagtct ttgatataca aataaaattt
     1981 tctttgtatt ttaa
//
