LOCUS       NM_015710               1504 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens NOP53 ribosome biogenesis factor (NOP53), mRNA.
ACCESSION   NM_015710
VERSION     NM_015710.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1504)
  AUTHORS   Miyao,S., Saito,K., Oshima,R., Kawahara,K. and Nagahama,M.
  TITLE     MTR4 adaptor PICT1 functions in two distinct steps during pre-rRNA
            processing
  JOURNAL   Biochem Biophys Res Commun 637, 203-209 (2022)
   PUBMED   36403484
  REMARK    GeneRIF: MTR4 adaptor PICT1 functions in two distinct steps during
            pre-rRNA processing.
REFERENCE   2  (bases 1 to 1504)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   3  (bases 1 to 1504)
  AUTHORS   Wang,H., Zhao,J., Yang,J., Wan,S., Fu,Y., Wang,X., Zhou,T.,
            Zhang,Z. and Shen,J.
  TITLE     PICT1 is critical for regulating the Rps27a-Mdm2-p53 pathway by
            microtubule polymerization inhibitor against cervical cancer
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (10), 119084 (2021)
   PUBMED   34166715
  REMARK    GeneRIF: PICT1 is critical for regulating the Rps27a-Mdm2-p53
            pathway by microtubule polymerization inhibitor against cervical
            cancer.
REFERENCE   4  (bases 1 to 1504)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1504)
  AUTHORS   Camara-Quilez,M., Barreiro-Alonso,A., Vizoso-Vazquez,A.,
            Rodriguez-Belmonte,E., Quindos-Varela,M., Lamas-Maceiras,M. and
            Cerdan,M.E.
  TITLE     The HMGB1-2 Ovarian Cancer Interactome. The Role of HMGB Proteins
            and Their Interacting Partners MIEN1 and NOP53 in Ovary Cancer and
            Drug-Response
  JOURNAL   Cancers (Basel) 12 (9), 2435 (2020)
   PUBMED   32867128
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1504)
  AUTHORS   Yim,J.H., Kim,Y.J., Ko,J.H., Cho,Y.E., Kim,S.M., Kim,J.Y., Lee,S.
            and Park,J.H.
  TITLE     The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated
            cell death
  JOURNAL   Cell Death Differ 14 (11), 1872-1879 (2007)
   PUBMED   17657248
  REMARK    GeneRIF: results suggest that the induction of PTEN-modulated
            apoptosis is one of the putative mechanisms of tumor suppressive
            activity by GLTSCR2
REFERENCE   7  (bases 1 to 1504)
  AUTHORS   Okahara,F., Itoh,K., Nakagawara,A., Murakami,M., Kanaho,Y. and
            Maehama,T.
  TITLE     Critical role of PICT-1, a tumor suppressor candidate, in
            phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic
            transformation
  JOURNAL   Mol Biol Cell 17 (11), 4888-4895 (2006)
   PUBMED   16971513
  REMARK    GeneRIF: These results suggest that PICT-1 plays a role in
            phosphatidylinositol 3,4,5-trisphosphate signals through
            controlling PTEN protein stability.
REFERENCE   8  (bases 1 to 1504)
  AUTHORS   Okahara,F., Ikawa,H., Kanaho,Y. and Maehama,T.
  TITLE     Regulation of PTEN phosphorylation and stability by a tumor
            suppressor candidate protein
  JOURNAL   J Biol Chem 279 (44), 45300-45303 (2004)
   PUBMED   15355975
REFERENCE   9  (bases 1 to 1504)
  AUTHORS   Smith,J.S., Tachibana,I., Pohl,U., Lee,H.K., Thanarajasingam,U.,
            Portier,B.P., Ueki,K., Ramaswamy,S., Billings,S.J.,
            Mohrenweiser,H.W., Louis,D.N. and Jenkins,R.B.
  TITLE     A transcript map of the chromosome 19q-arm glioma tumor suppressor
            region
  JOURNAL   Genomics 64 (1), 44-50 (2000)
   PUBMED   10708517
REFERENCE   10 (bases 1 to 1504)
  AUTHORS   Bruni,R., Fineschi,B., Ogle,W.O. and Roizman,B.
  TITLE     A novel cellular protein, p60, interacting with both herpes simplex
            virus 1 regulatory proteins ICP22 and ICP0 is modified in a
            cell-type-specific manner and Is recruited to the nucleus after
            infection
  JOURNAL   J Virol 73 (5), 3810-3817 (1999)
   PUBMED   10196275
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX866974.1, BC004229.2 and BC006311.2.
            
            On Nov 23, 2018 this sequence version replaced NM_015710.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.813476.1,
                                           SRR3476690.594152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246802.10/ ENSP00000246802.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                CX866974.1         11-40
            31-716              BC004229.2         1-686
            717-717             BC006311.2         709-709
            718-1504            BC004229.2         688-1474
FEATURES             Location/Qualifiers
     source          1..1504
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1504
                     /gene="NOP53"
                     /gene_synonym="GLTSCR2; PICT-1; PICT1"
                     /note="NOP53 ribosome biogenesis factor"
                     /db_xref="GeneID:29997"
                     /db_xref="HGNC:HGNC:4333"
                     /db_xref="MIM:605691"
     exon            1..238
                     /gene="NOP53"
                     /gene_synonym="GLTSCR2; PICT-1; PICT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1451
                     /gene="NOP53"
                     /gene_synonym="GLTSCR2; PICT-1; PICT1"
                     /note="protein interacting with carboxyl terminus 1;
                     glioma tumor suppressor candidate region gene 2 protein;
                     p60"
                     /codon_start=1
                     /product="ribosome biogenesis protein NOP53"
                     /protein_id="NP_056525.2"
                     /db_xref="CCDS:CCDS12705.1"
                     /db_xref="GeneID:29997"
                     /db_xref="HGNC:HGNC:4333"
                     /db_xref="MIM:605691"
                     /translation="MAAGGSGVGGKRSSKSDADSGFLGLRPTSVDPALRRRRRGPRNK
                     KRGWRRLAQEPLGLEVDQFLEDVRLQERTSGGLLSEAPNEKLFFVDTGSKEKGLTKKR
                     TKVQKKSLLLKKPLRVDLILENTSKVPAPKDVLAHQVPNAKKLRRKEQLWEKLAKQGE
                     LPREVRRAQARLLNPSATRAKPGPQDTVERPFYDLWASDNPLDRPLVGQDEFFLEQTK
                     KKGVKRPARLHTKPSQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEAEKLE
                     RQLALPATEQAATQESTFQELCEGLLEESDGEGEPGQGEGPEAGDAEVCPTPARLATT
                     EKKTEQQRRREKAVHRLRVQQAALRAARLRHQELFRLRGIKAQVALRLAELARRQRRR
                     QARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILRDRFKSFQRRNM
                     IEPRERAKFKRKYKVKLVEKRAFREIQL"
     exon            239..303
                     /gene="NOP53"
                     /gene_synonym="GLTSCR2; PICT-1; PICT1"
                     /inference="alignment:Splign:2.1.0"
     exon            304..412
                     /gene="NOP53"
                     /gene_synonym="GLTSCR2; PICT-1; PICT1"
                     /inference="alignment:Splign:2.1.0"
     exon            413..612
                     /gene="NOP53"
                     /gene_synonym="GLTSCR2; PICT-1; PICT1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..683
                     /gene="NOP53"
                     /gene_synonym="GLTSCR2; PICT-1; PICT1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..779
                     /gene="NOP53"
                     /gene_synonym="GLTSCR2; PICT-1; PICT1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..884
                     /gene="NOP53"
                     /gene_synonym="GLTSCR2; PICT-1; PICT1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1067
                     /gene="NOP53"
                     /gene_synonym="GLTSCR2; PICT-1; PICT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1243
                     /gene="NOP53"
                     /gene_synonym="GLTSCR2; PICT-1; PICT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1310
                     /gene="NOP53"
                     /gene_synonym="GLTSCR2; PICT-1; PICT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1387
                     /gene="NOP53"
                     /gene_synonym="GLTSCR2; PICT-1; PICT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1444
                     /gene="NOP53"
                     /gene_synonym="GLTSCR2; PICT-1; PICT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1504
                     /gene="NOP53"
                     /gene_synonym="GLTSCR2; PICT-1; PICT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1482..1487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOP53"
                     /gene_synonym="GLTSCR2; PICT-1; PICT1"
                     /note="hexamer: AATAAA"
     polyA_site      1504
                     /gene="NOP53"
                     /gene_synonym="GLTSCR2; PICT-1; PICT1"
                     /note="major polyA site"
ORIGIN      
        1 cttcctttga caagatggcg gcaggaggca gtggcgttgg tgggaagcgc agctcgaaaa
       61 gcgatgccga ttctggtttc ctggggctgc ggcccacttc ggtggaccca gcgctgaggc
      121 ggcggcggcg aggcccaaga aataagaagc ggggctggcg gcggcttgct caggagccgc
      181 tggggctgga ggttgaccag ttcctggaag acgtgcggct acaggagcgc acgagcggtg
      241 gcttgttgtc agaggcccca aatgaaaaac tcttcttcgt ggacactggc tccaaggaaa
      301 aagggctgac aaagaagaga accaaagtcc agaagaagtc actgcttctc aagaaacccc
      361 ttcgggttga cctcatcctc gagaacacat ccaaagtccc tgcccccaaa gacgtcctcg
      421 cccaccaggt ccccaacgcc aagaagctca ggcggaagga gcagctatgg gagaagctgg
      481 ccaagcaggg cgagctgccc cgggaggtgc gcagggccca ggcccggctc ctcaaccctt
      541 ctgcaacaag ggccaagccc gggccccagg acaccgtaga gcggcccttc tacgacctct
      601 gggcctcaga caaccccctg gacaggccgt tggttggcca ggatgagttt ttcctggagc
      661 agaccaagaa gaaaggagtg aagcggccag cacgcctgca caccaagccg tcccaggcac
      721 ccgccgtgga ggtggcgcct gccggagctt cctacaatcc atcctttgaa gaccaccaga
      781 ccctgctctc agcggcccac gaggtggagt tgcagcggca gaaggaggcg gagaagctgg
      841 agcggcagct ggccctgccc gccacggagc aggccgccac ccaggagtcc acattccagg
      901 agctgtgcga ggggctgctg gaggagtcgg atggtgaggg ggagccaggc cagggcgagg
      961 ggccggaggc tggggatgcc gaggtctgtc ccacgcccgc ccgcctggcc accacagaga
     1021 agaagacgga gcagcagcgg cggcgggaga aggctgtgca caggctgcgg gtacagcagg
     1081 ccgcgttgcg ggccgcccgg ctccggcacc aggagctgtt ccggctgcgc gggatcaagg
     1141 cccaggtggc cctgaggctg gcggagctgg cgcggcggca gaggcggcgg caggcgcggc
     1201 gggaggctga ggctgacaag ccccgaaggc tggggcggct caagtaccag gcacctgaca
     1261 tcgacgtgca gctgagctcg gagctgacag actcgctcag gaccctgaag cccgagggca
     1321 acatccttcg agaccggttc aagagcttcc agaggaggaa tatgatcgag cctcgagaga
     1381 gagccaagtt caaacgcaag tacaaggtga agctggtgga gaagcgggcg ttccgtgaga
     1441 tccagttgta gctgccatca gatgccggag actcgccctt caataaaaaa tctcttctag
     1501 ctga
//
