LOCUS       NP_056525                478 aa            linear   PRI 27-APR-2025
DEFINITION  ribosome biogenesis protein NOP53 [Homo sapiens].
ACCESSION   NP_056525
VERSION     NP_056525.2
DBSOURCE    REFSEQ: accession NM_015710.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 478)
  AUTHORS   Miyao,S., Saito,K., Oshima,R., Kawahara,K. and Nagahama,M.
  TITLE     MTR4 adaptor PICT1 functions in two distinct steps during pre-rRNA
            processing
  JOURNAL   Biochem Biophys Res Commun 637, 203-209 (2022)
   PUBMED   36403484
  REMARK    GeneRIF: MTR4 adaptor PICT1 functions in two distinct steps during
            pre-rRNA processing.
REFERENCE   2  (residues 1 to 478)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   3  (residues 1 to 478)
  AUTHORS   Wang,H., Zhao,J., Yang,J., Wan,S., Fu,Y., Wang,X., Zhou,T.,
            Zhang,Z. and Shen,J.
  TITLE     PICT1 is critical for regulating the Rps27a-Mdm2-p53 pathway by
            microtubule polymerization inhibitor against cervical cancer
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (10), 119084 (2021)
   PUBMED   34166715
  REMARK    GeneRIF: PICT1 is critical for regulating the Rps27a-Mdm2-p53
            pathway by microtubule polymerization inhibitor against cervical
            cancer.
REFERENCE   4  (residues 1 to 478)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (residues 1 to 478)
  AUTHORS   Camara-Quilez,M., Barreiro-Alonso,A., Vizoso-Vazquez,A.,
            Rodriguez-Belmonte,E., Quindos-Varela,M., Lamas-Maceiras,M. and
            Cerdan,M.E.
  TITLE     The HMGB1-2 Ovarian Cancer Interactome. The Role of HMGB Proteins
            and Their Interacting Partners MIEN1 and NOP53 in Ovary Cancer and
            Drug-Response
  JOURNAL   Cancers (Basel) 12 (9), 2435 (2020)
   PUBMED   32867128
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 478)
  AUTHORS   Yim,J.H., Kim,Y.J., Ko,J.H., Cho,Y.E., Kim,S.M., Kim,J.Y., Lee,S.
            and Park,J.H.
  TITLE     The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated
            cell death
  JOURNAL   Cell Death Differ 14 (11), 1872-1879 (2007)
   PUBMED   17657248
  REMARK    GeneRIF: results suggest that the induction of PTEN-modulated
            apoptosis is one of the putative mechanisms of tumor suppressive
            activity by GLTSCR2
REFERENCE   7  (residues 1 to 478)
  AUTHORS   Okahara,F., Itoh,K., Nakagawara,A., Murakami,M., Kanaho,Y. and
            Maehama,T.
  TITLE     Critical role of PICT-1, a tumor suppressor candidate, in
            phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic
            transformation
  JOURNAL   Mol Biol Cell 17 (11), 4888-4895 (2006)
   PUBMED   16971513
  REMARK    GeneRIF: These results suggest that PICT-1 plays a role in
            phosphatidylinositol 3,4,5-trisphosphate signals through
            controlling PTEN protein stability.
REFERENCE   8  (residues 1 to 478)
  AUTHORS   Okahara,F., Ikawa,H., Kanaho,Y. and Maehama,T.
  TITLE     Regulation of PTEN phosphorylation and stability by a tumor
            suppressor candidate protein
  JOURNAL   J Biol Chem 279 (44), 45300-45303 (2004)
   PUBMED   15355975
REFERENCE   9  (residues 1 to 478)
  AUTHORS   Smith,J.S., Tachibana,I., Pohl,U., Lee,H.K., Thanarajasingam,U.,
            Portier,B.P., Ueki,K., Ramaswamy,S., Billings,S.J.,
            Mohrenweiser,H.W., Louis,D.N. and Jenkins,R.B.
  TITLE     A transcript map of the chromosome 19q-arm glioma tumor suppressor
            region
  JOURNAL   Genomics 64 (1), 44-50 (2000)
   PUBMED   10708517
REFERENCE   10 (residues 1 to 478)
  AUTHORS   Bruni,R., Fineschi,B., Ogle,W.O. and Roizman,B.
  TITLE     A novel cellular protein, p60, interacting with both herpes simplex
            virus 1 regulatory proteins ICP22 and ICP0 is modified in a
            cell-type-specific manner and Is recruited to the nucleus after
            infection
  JOURNAL   J Virol 73 (5), 3810-3817 (1999)
   PUBMED   10196275
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX866974.1, BC004229.2 and BC006311.2.
            
            On Jun 11, 2009 this sequence version replaced NP_056525.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.813476.1,
                                           SRR3476690.594152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246802.10/ ENSP00000246802.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     Protein         1..478
                     /product="ribosome biogenesis protein NOP53"
                     /note="protein interacting with carboxyl terminus 1;
                     glioma tumor suppressor candidate region gene 2 protein;
                     p60"
                     /calculated_mol_wt=54258
     Region          1..51
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NZM5.2)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0007744|PubMed:22814378; propagated from
                     UniProtKB/Swiss-Prot (Q9NZM5.2)"
     Site            29
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9NZM5.2)"
     Region          48..445
                     /region_name="Nop53"
                     /note="Nop53 (60S ribosomal biogenesis); pfam07767"
                     /db_xref="CDD:462259"
     Site            93
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9NZM5.2)"
     Region          148..431
                     /region_name="Mediates interaction with CDKN2A/isoform
                     tumor suppressor ARF.
                     /evidence=ECO:0000269|PubMed:27323397"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NZM5.2)"
     Region          181..478
                     /region_name="Mediates interaction with NF2.
                     /evidence=ECO:0000269|PubMed:21167305"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NZM5.2)"
     Region          303..344
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NZM5.2)"
     Site            305
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8BK35; propagated from
                     UniProtKB/Swiss-Prot (Q9NZM5.2)"
     Region          342..386
                     /region_name="Mediates interaction with human herpesvirus
                     8 protein ORF16. /evidence=ECO:0000269|PubMed:20042497"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NZM5.2)"
     Region          347..395
                     /region_name="Nucleolar localization signal.
                     /evidence=ECO:0000269|PubMed:22292050"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NZM5.2)"
     Region          396..478
                     /region_name="Nucleolar localization signal.
                     /evidence=ECO:0000269|PubMed:22292050"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NZM5.2)"
     CDS             1..478
                     /gene="NOP53"
                     /gene_synonym="GLTSCR2; PICT-1; PICT1"
                     /coded_by="NM_015710.5:15..1451"
                     /db_xref="CCDS:CCDS12705.1"
                     /db_xref="GeneID:29997"
                     /db_xref="HGNC:HGNC:4333"
                     /db_xref="MIM:605691"
ORIGIN      
        1 maaggsgvgg krssksdads gflglrptsv dpalrrrrrg prnkkrgwrr laqeplglev
       61 dqfledvrlq ertsggllse apneklffvd tgskekgltk krtkvqkksl llkkplrvdl
      121 ilentskvpa pkdvlahqvp nakklrrkeq lweklakqge lprevrraqa rllnpsatra
      181 kpgpqdtver pfydlwasdn pldrplvgqd effleqtkkk gvkrparlht kpsqapavev
      241 apagasynps fedhqtllsa ahevelqrqk eaeklerqla lpateqaatq estfqelceg
      301 lleesdgege pgqgegpeag daevcptpar lattekkteq qrrrekavhr lrvqqaalra
      361 arlrhqelfr lrgikaqval rlaelarrqr rrqarreaea dkprrlgrlk yqapdidvql
      421 sseltdslrt lkpegnilrd rfksfqrrnm ieprerakfk rkykvklvek rafreiql
//
