LOCUS       NM_016391                881 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens NOP16 nucleolar protein (NOP16), transcript variant 3,
            mRNA.
ACCESSION   NM_016391
VERSION     NM_016391.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 881)
  AUTHORS   Mu,S., Tian,Q. and Shen,L.
  TITLE     NOP16 promotes hepatocellular carcinoma progression and triggers
            EMT through the Keap1-Nrf2 signaling pathway
  JOURNAL   Technol Health Care 32 (4), 2463-2483 (2024)
   PUBMED   38251077
  REMARK    GeneRIF: NOP16 promotes hepatocellular carcinoma progression and
            triggers EMT through the Keap1-Nrf2 signaling pathway.
REFERENCE   2  (bases 1 to 881)
  AUTHORS   Yang,T., Sun,F., Zhang,C., Wang,Z., Yang,K., Xu,Y. and Liu,Q.
  TITLE     Elevated Expression of NOP16 as a Novel Prognostic Biomarker of
            Prostate Cancer
  JOURNAL   Ann Clin Lab Sci 53 (4), 587-597 (2023)
   PUBMED   37625836
  REMARK    GeneRIF: Elevated Expression of NOP16 as a Novel Prognostic
            Biomarker of Prostate Cancer.
REFERENCE   3  (bases 1 to 881)
  AUTHORS   Zhang,C., Wang,X.Y., Zhang,P., He,T.C., Han,J.H., Zhang,R., Lin,J.,
            Fan,J., Lu,L., Zhu,W.W., Jia,H.L., Zhang,J.B. and Chen,J.H.
  TITLE     Cancer-derived exosomal HSPC111 promotes colorectal cancer liver
            metastasis by reprogramming lipid metabolism in cancer-associated
            fibroblasts
  JOURNAL   Cell Death Dis 13 (1), 57 (2022)
   PUBMED   35027547
  REMARK    GeneRIF: Cancer-derived exosomal HSPC111 promotes colorectal cancer
            liver metastasis by reprogramming lipid metabolism in
            cancer-associated fibroblasts.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 881)
  AUTHORS   Zhang,C., Yin,C., Wang,L., Zhang,S., Qian,Y., Ma,J., Zhang,Z.,
            Xu,Y. and Liu,S.
  TITLE     HSPC111 governs breast cancer growth by regulating ribosomal
            biogenesis
  JOURNAL   Mol Cancer Res 12 (4), 583-594 (2014)
   PUBMED   24425784
  REMARK    GeneRIF: RNA 3'-phosphate cyclase (RTCD1/RTCA) interacted with
            HSPC111, and RTCD1 was involved in the HSPC111 multiprotein complex
            in regulating rRNA production and ribosomal biogenesis.
REFERENCE   5  (bases 1 to 881)
  AUTHORS   Butt,A.J., Sergio,C.M., Inman,C.K., Anderson,L.R., McNeil,C.M.,
            Russell,A.J., Nousch,M., Preiss,T., Biankin,A.V., Sutherland,R.L.
            and Musgrove,E.A.
  TITLE     The estrogen and c-Myc target gene HSPC111 is over-expressed in
            breast cancer and associated with poor patient outcome
  JOURNAL   Breast Cancer Res 10 (2), R28 (2008)
   PUBMED   18373870
  REMARK    GeneRIF: HSPC111 is an estrogen and c-Myc target gene that is
            over-expressed in breast cancer and is associated with an adverse
            patient outcome.
REFERENCE   6  (bases 1 to 881)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   7  (bases 1 to 881)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC019331.1 and AF161460.1.
            
            On Jun 2, 2019 this sequence version replaced NM_016391.7.
            
            Summary: This gene encodes a protein that is localized to the
            nucleolus. Expression of this gene is induced by estrogens and Myc
            protein and is a marker of poor patient survival in breast cancer.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (3) uses an alternate splice in
            the 3' coding region, which results in a frameshift, compared to
            variant 1. The resulting isoform (3) has a shorter and distinct
            C-terminus compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.109598.1,
                                           SRR5189661.163816.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000614830.5/ ENSP00000480832.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               BC019331.1         165-320
            157-881             AF161460.1         160-884
FEATURES             Location/Qualifiers
     source          1..881
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.2"
     gene            1..881
                     /gene="NOP16"
                     /gene_synonym="HSPC111; HSPC185"
                     /note="NOP16 nucleolar protein"
                     /db_xref="GeneID:51491"
                     /db_xref="HGNC:HGNC:26934"
                     /db_xref="MIM:612861"
     exon            1..166
                     /gene="NOP16"
                     /gene_synonym="HSPC111; HSPC185"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..596
                     /gene="NOP16"
                     /gene_synonym="HSPC111; HSPC185"
                     /note="isoform 3 is encoded by transcript variant 3; HBV
                     pre-S2 trans-regulated protein 3; nucleolar protein 16
                     homolog; hypothetical protein HSPC111; NOP16 nucleolar
                     protein homolog"
                     /codon_start=1
                     /product="nucleolar protein 16 isoform 3"
                     /protein_id="NP_057475.2"
                     /db_xref="CCDS:CCDS43403.1"
                     /db_xref="GeneID:51491"
                     /db_xref="HGNC:HGNC:26934"
                     /db_xref="MIM:612861"
                     /translation="MPKAKGKTRRQKFGYSVNRKRLNRNARRKAAPRIECSHIRHAWD
                     HAKSVRQNLAEMGLAVDPNRAVPLRKRKVKAMEVDIEERPKELVRKPYVLNDLEAEAS
                     LPEKKGNTLSRDLIDYVRYMVENHGEDYKAMARDEKNYYQDTPKQIRSKINVYKRFYP
                     AEWQDFLDSLQKRKMEVE"
     exon            167..275
                     /gene="NOP16"
                     /gene_synonym="HSPC111; HSPC185"
                     /inference="alignment:Splign:2.1.0"
     exon            276..345
                     /gene="NOP16"
                     /gene_synonym="HSPC111; HSPC185"
                     /inference="alignment:Splign:2.1.0"
     exon            346..452
                     /gene="NOP16"
                     /gene_synonym="HSPC111; HSPC185"
                     /inference="alignment:Splign:2.1.0"
     exon            453..881
                     /gene="NOP16"
                     /gene_synonym="HSPC111; HSPC185"
                     /inference="alignment:Splign:2.1.0"
     regulatory      862..867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOP16"
                     /gene_synonym="HSPC111; HSPC185"
                     /note="hexamer: AATAAA"
     polyA_site      881
                     /gene="NOP16"
                     /gene_synonym="HSPC111; HSPC185"
                     /note="major polyA site"
ORIGIN      
        1 acacgaggtc tgagagacag aggcagcgtg tttgagctgc tggtgcggtg gtcagcgcga
       61 tgcccaaggc caagggcaaa acccggaggc agaagtttgg ttacagtgtc aaccgaaagc
      121 gtctgaaccg gaatgctcga cggaaggcag cgccgcggat cgaatgctcc cacatccgac
      181 atgcctggga ccacgctaaa tcggtacggc agaacctggc cgagatgggg ttggctgtgg
      241 accccaacag ggcggtgccc ctccgtaaga gaaaggtgaa ggccatggag gtggacatag
      301 aggagaggcc taaagagctt gtacggaagc cctatgtgct gaatgacctg gaggcagaag
      361 ccagccttcc agaaaagaaa ggaaatactc tgtctcggga cctcattgac tatgtacgct
      421 acatggtaga gaaccacggg gaggactata aggccatggc ccgtgatgag aagaattact
      481 atcaagatac cccaaaacag attcggagta agatcaacgt ctataaacgc ttttacccag
      541 cagagtggca agacttcctc gattctttgc agaagaggaa gatggaggtg gagtgactgg
      601 tttacatcac agctgcccca ggctgaggcg tcccccggac cagtgaagct ggagccaggg
      661 tgtaaggcaa ggaggtgctg tgtggctcca gaggagctgg ccaggtccca tggaatcaga
      721 aggttacaca cacacgtgca cactccccgc tctggggaag gaactgttct cagaggctcc
      781 aatttatatt catctggggg ttcacggaaa agccagaacc tgctgttttc agggtgggtg
      841 atgtaaatat agtgtgtaca taataaagca aatatatttt a
//
