LOCUS       NM_001291978            3556 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens NOP14 nucleolar protein (NOP14), transcript variant 1,
            mRNA.
ACCESSION   NM_001291978 XM_006713929
VERSION     NM_001291978.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3556)
  AUTHORS   Yan,X., Kuang,B.H., Ma,S., Wang,R., Lin,J., Zeng,Y.X., Xie,X. and
            Feng,L.
  TITLE     NOP14-mediated ribosome biogenesis is required for mTORC2
            activation and predicts rapamycin sensitivity
  JOURNAL   J Biol Chem 300 (3), 105681 (2024)
   PUBMED   38272224
  REMARK    GeneRIF: NOP14-mediated ribosome biogenesis is required for mTORC2
            activation and predicts rapamycin sensitivity.
REFERENCE   2  (bases 1 to 3556)
  AUTHORS   Lu,C., Liao,W., Huang,Y., Huang,Y. and Luo,Y.
  TITLE     Increased expression of NOP14 is associated with improved prognosis
            due to immune regulation in colorectal cancer
  JOURNAL   BMC Gastroenterol 22 (1), 207 (2022)
   PUBMED   35473611
  REMARK    GeneRIF: Increased expression of NOP14 is associated with improved
            prognosis due to immune regulation in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3556)
  AUTHORS   Zhu,X., Jia,W., Yan,Y., Huang,Y. and Wang,B.
  TITLE     NOP14 regulates the growth, migration, and invasion of colorectal
            cancer cells by modulating the NRIP1/GSK-3beta/beta-catenin
            signaling pathway
  JOURNAL   Eur J Histochem 65 (3), 3246 (2021)
   PUBMED   34218653
  REMARK    GeneRIF: NOP14 regulates the growth, migration, and invasion of
            colorectal cancer cells by modulating the
            NRIP1/GSK-3beta/beta-catenin signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3556)
  AUTHORS   Ying,Y., Li,J., Xie,H., Yan,H., Jin,K., He,L., Ma,X., Wu,J., Xu,X.,
            Fang,J., Wang,X., Zheng,X., Liu,B. and Xie,L.
  TITLE     CCND1, NOP14 and DNMT3B are involved in miR-502-5p-mediated
            inhibition of cell migration and proliferation in bladder cancer
  JOURNAL   Cell Prolif 53 (2), e12751 (2020)
   PUBMED   31971654
  REMARK    GeneRIF: CCND1, DNMT3B and NOP14 were identified as direct targets
            of miR-502-5p.
REFERENCE   5  (bases 1 to 3556)
  AUTHORS   Suzuki,T., Behnam,M., Ronasian,F., Salehi,M., Shiina,M.,
            Koshimizu,E., Fujita,A., Sekiguchi,F., Miyatake,S., Mizuguchi,T.,
            Nakashima,M., Ogata,K., Takeda,S., Matsumoto,N. and Miyake,N.
  TITLE     A homozygous NOP14 variant is likely to cause recurrent pregnancy
            loss
  JOURNAL   J Hum Genet 63 (4), 425-430 (2018)
   PUBMED   29440706
  REMARK    GeneRIF: we identified an identical homozygous NOP14 variant as a
            possible contributing factor for RPL in two Iranian families.
REFERENCE   6  (bases 1 to 3556)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 3556)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   8  (bases 1 to 3556)
  AUTHORS   Liu,P.C. and Thiele,D.J.
  TITLE     Novel stress-responsive genes EMG1 and NOP14 encode conserved,
            interacting proteins required for 40S ribosome biogenesis
  JOURNAL   Mol Biol Cell 12 (11), 3644-3657 (2001)
   PUBMED   11694595
REFERENCE   9  (bases 1 to 3556)
  AUTHORS   Hadano,S., Ishida,Y. and Ikeda,J.E.
  TITLE     The primary structure and genomic organization of five novel
            transcripts located close to the Huntington's disease gene on human
            chromosome 4p16.3
  JOURNAL   DNA Res 5 (3), 177-186 (1998)
   PUBMED   9734812
REFERENCE   10 (bases 1 to 3556)
  AUTHORS   Pribill,I., Barnes,G.T., Chen,J., Church,D., Buckler,A.,
            Baxendale,S., Bates,G.P., Lehrach,H., Gusella,M.J., Duyao,M.P.,
            Ambrose,C.M., Gusella,J.F. and MacDonald,M.E.
  TITLE     Exon trapping and sequence-based methods of gene finding in
            transcript mapping of human 4p16.3
  JOURNAL   Somat Cell Mol Genet 23 (6), 413-427 (1997)
   PUBMED   9661704
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK292939.1 and AK025692.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001291978.1.
            
            Summary: This gene encodes a protein that plays a role in pre-18s
            rRNA processing and small ribosomal subunit assembly. The encoded
            protein may be involved in the regulation of pancreatic cancer cell
            proliferation and migration. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, May 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1 and 2
            encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.255156.1,
                                           SRR1803614.141448.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000416614.7/ ENSP00000405068.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1225              AK292939.1         101-1325
            1226-3556           AK025692.1         191-2521
FEATURES             Location/Qualifiers
     source          1..3556
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..3556
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /note="NOP14 nucleolar protein"
                     /db_xref="GeneID:8602"
                     /db_xref="HGNC:HGNC:16821"
                     /db_xref="MIM:611526"
     exon            1..282
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..2661
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable nucleolar complex protein 14; NOP14 nucleolar
                     protein homolog"
                     /codon_start=1
                     /product="nucleolar protein 14 isoform 1"
                     /protein_id="NP_001278907.1"
                     /db_xref="CCDS:CCDS33945.1"
                     /db_xref="GeneID:8602"
                     /db_xref="HGNC:HGNC:16821"
                     /db_xref="MIM:611526"
                     /translation="MAKAKKVGARRKASGAPAGARGGPAKANSNPFEVKVNRQKFQIL
                     GRKTRHDVGLPGVSRARALRKRTQTLLKEYKERDKSNVFRDKRFGEYNSNMSPEEKMM
                     KRFALEQQRHHEKKSIYNLNEDEELTHYGQSLADIEKHNDIVDSDSDAEDRGTLSAEL
                     TAAHFGGGGGLLHKKTQQEGEEREKPKSRKELIEELIAKSKQEKRERQAQREDALELT
                     EKLDQDWKEIQTLLSHKTPKSENRDKKEKPKPDAYDMMVRELGFEMKAQPSNRMKTEA
                     ELAKEEQEHLRKLEAERLRRMLGKDEDENVKKPKHMSADDLNDGFVLDKDDRRLLSYK
                     DGKMNVEEDVQEEQSKEASDPESNEEEGDSSGGEDTEESDSPDSHLDLESNVESEEEN
                     EKPAKEQRQTPGKGLISGKERAGKATRDELPYTFAAPESYEELRSLLLGRSMEEQLLV
                     VERIQKCNHPSLAEGNKAKLEKLFGFLLEYVGDLATDDPPDLTVIDKLVVHLYHLCQM
                     FPESASDAIKFVLRDAMHEMEEMIETKGRAALPGLDVLIYLKITGLLFPTSDFWHPVV
                     TPALVCLSQLLTKCPILSLQDVVKGLFVCCLFLEYVALSQRFIPELINFLLGILYIAT
                     PNKASQGSTLVHPFRALGKNSELLVVSAREDVATWQQSSLSLRWASRLRAPTSTEANH
                     IRLSCLAVGLALLKRCVLMYGSLPSFHAIMGPLQALLTDHLADCSHPQELQELCQSTL
                     TEMESQKQLCRPLTCEKSKPVPLKLFTPRLVKVLEFGRKQGSSKEEQERKRLIHKHKR
                     EFKGAVREIRKDNQFLARMQLSEIMERDAERKRKVKQLFNSLATQEGEWKALKRKKFK
                     K"
     exon            283..417
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            418..559
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            560..699
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            700..834
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            835..957
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1089
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1369
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1500
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1586
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1722
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1824
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1978
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2138
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2286
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2405
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2561
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..3556
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3362..3367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /note="hexamer: AATGAA"
     polyA_site      3379
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /note="major polyA site"
     regulatory      3546..3551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /note="hexamer: TATAAA"
     polyA_site      3556
                     /gene="NOP14"
                     /gene_synonym="C4orf9; NOL14; RES4-25; RES425; UTP2"
                     /note="major polyA site"
ORIGIN      
        1 ggttccgcgg cccggcacgt gtcttagggt agcgcgcgcc tgtctctctt cgggtctcgg
       61 gcccttgggc gcagcggggc gcgcgccatg gcgaaggcga agaaggtcgg ggcgcgaagg
      121 aaggcctccg gggcgccggc gggagcgcga gggggcccgg cgaaggccaa ctccaatccg
      181 ttcgaggtga aagttaacag gcagaagttc cagatcctgg gccggaagac gcgccacgac
      241 gtgggactgc ccggggtgtc tcgcgcacgg gccctcagga agcgtacaca gactttacta
      301 aaagagtaca aagaaaggga taaatccaat gtattcagag ataaacgctt cggagaatac
      361 aacagcaaca tgagccccga ggagaagatg atgaagaggt ttgctctgga acagcagcga
      421 catcatgaga aaaaaagcat ctacaatcta aatgaagatg aagaattgac tcattatggc
      481 cagtctttgg cagacatcga gaagcataat gacattgtgg acagtgacag cgatgctgag
      541 gatcgaggaa cgttgtctgc tgagctgact gctgcccact ttggaggagg cggtgggctc
      601 cttcacaaga agactcaaca ggaaggcgag gagcgggaga aaccgaagtc ccggaaagag
      661 ctgattgaag agctcattgc caagtcaaaa caagagaaga gggagagaca agctcaacga
      721 gaagatgccc tcgagctcac ggagaagcta gaccaagact ggaaagaaat tcagactctc
      781 ctgtcccaca aaactcccaa gtcagagaac agagacaaaa aggaaaaacc caagcccgat
      841 gcatatgaca tgatggttcg cgagcttggc tttgaaatga aggcgcagcc ctctaacagg
      901 atgaagacgg aggcagaatt ggcaaaggaa gagcaggagc acctcaggaa gctggaggct
      961 gagagacttc gaagaatgct tggaaaggat gaggatgaaa atgttaagaa accaaaacat
     1021 atgtcagcag atgatctgaa tgatggcttc gtgctagata aagatgacag gcgtttgctt
     1081 tcctacaaag atggaaagat gaatgtcgag gaagatgtcc aggaagagca aagcaaggaa
     1141 gccagtgacc ctgagagcaa cgaggaagaa ggtgacagtt caggcgggga ggacacagag
     1201 gagagcgaca gcccagatag ccacttggac ctggaatcca acgtggagag tgaggaagaa
     1261 aacgagaagc cagcaaaaga gcagaggcag actcctggga aagggttgat aagcggcaag
     1321 gaaagagctg gaaaagctac cagagacgag ctgccctaca cgttcgcagc ccctgaatcc
     1381 tatgaggaac tgagatctct gttgttagga agatcgatgg aagagcagct tttggtggtg
     1441 gagagaattc agaagtgcaa ccacccgagt ctcgcagaag gaaacaaagc aaaattagaa
     1501 aaactgtttg gctttctttt ggaatacgtt ggcgatttgg ctacagatga cccaccagac
     1561 ctcacagtca ttgataagtt ggttgtgcac ttatatcatc tttgccagat gtttcctgaa
     1621 tctgcaagtg acgctatcaa atttgttctc cgagatgcga tgcatgagat ggaagaaatg
     1681 attgagacca aaggccgggc ggcattgcca gggttggatg tgctcattta tttgaaaatc
     1741 actgggctgc tatttccaac ttccgacttc tggcacccag tggtgacccc tgccctcgtg
     1801 tgcctcagtc agctgctcac caagtgcccc atcctgtccc tccaggacgt ggtgaagggc
     1861 ctgttcgtgt gctgcctgtt cctggagtat gtggctttgt cccagaggtt tatacctgag
     1921 cttattaatt ttcttcttgg gattctttac atagcaactc caaacaaagc aagccaaggt
     1981 tccactctgg tgcacccttt cagagcgctt gggaagaact cggaactgct cgtggtgtct
     2041 gctagagagg atgtggccac gtggcagcag agcagcctct ccctccgctg ggcgagtaga
     2101 ctgagggccc caacttcgac agaggccaat cacatccgac tgtcctgcct ggctgtgggc
     2161 ctggccctgc tgaagcgctg cgtgctcatg tacgggtccc tgccatcctt ccacgccatc
     2221 atggggcctc tccaagccct cctcacggat cacctggcgg actgcagcca cccgcaggag
     2281 ctccaggagc tgtgtcagag cacactgacc gaaatggaaa gccagaagca gctctgccgg
     2341 ccgctgacct gtgagaagag caagcctgtc ccactgaagc ttttcacacc ccggctggtc
     2401 aaagtcctcg agtttggaag aaaacaaggc agtagtaagg aggaacagga aaggaagagg
     2461 ctgatccaca aacacaagcg tgaatttaaa ggggccgttc gagaaatccg caaggacaat
     2521 cagttcctgg cgaggatgca actctcagaa atcatggaac gggatgcgga aagaaagcgg
     2581 aaagtaaagc agctttttaa cagcctggct acacaggaag gcgaatggaa ggctctgaag
     2641 aggaaaaagt tcaaaaaata aattacattt tataaataag gcaaggaact ggacattacc
     2701 tcacatctgc aattccaacc ctctgggagg ccaaggcagg aagattgctt cagcccagga
     2761 gttcgagacc agcctgggca acacaggaag accccgtctc taccaaaaaa acataaaaat
     2821 tagccaagtg tggtggcacg cacctgtagt cccaactact cgggaggctg aagcaggagg
     2881 actgcttgag ctgagtccaa ggttacagtg agccgtgatt gagccactgc actccagcct
     2941 cggccacagt gcaagactgt gtcgcttaaa aaaaaatttt tttttttgag acggagtttt
     3001 gctcttgttg cccaggctgg agtgcaatgg cacaacctcc acctcctggg ttcaagcgat
     3061 tctcctgcct cagcctcccg agtagctggg attacagaca tgtgccacca cgcccagcta
     3121 attttgtatt tttagtagag acggggtttc tccatgttgg tcaggctggt ctcgaattcc
     3181 cgacctcagg taatccacct gccttggccc cccaattata ggtgtgagcc acagcaccca
     3241 gccaaaaaag taattttttt tagagtaata atgctataat gttggtgtga ttccaacctc
     3301 cagctccccc cacccgctgc ctgcggtttt gtttctgtta aaacgtcacc tgatgaaata
     3361 gaatgaatcc tgaaatgcac ctctgggatc gggaatggtc tgtgtgttat cagctgcgac
     3421 tggttcactg cgtctggaca agcctcatgg ggactgggga ttctggccag tgtaatttct
     3481 gtcaaccacg gacgtttgcc ttcatgtgta gaatttactg ttgttatgca aattatattt
     3541 tcaattataa atgaaa
//
