LOCUS       NM_018648                507 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens NOP10 ribonucleoprotein (NOP10), mRNA.
ACCESSION   NM_018648
VERSION     NM_018648.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Cui,C., Liu,Y., Gerloff,D., Rohde,C., Pauli,C., Kohn,M., Misiak,D.,
            Oellerich,T., Schwartz,S., Schmidt,L.H., Wiewrodt,R., Marra,A.,
            Hillejan,L., Bartel,F., Wickenhauser,C., Huttelmaier,S.,
            Gollner,S., Zhou,F., Edemir,B. and Muller-Tidow,C.
  TITLE     NOP10 predicts lung cancer prognosis and its associated small
            nucleolar RNAs drive proliferation and migration
  JOURNAL   Oncogene 40 (5), 909-921 (2021)
   PUBMED   33288886
  REMARK    GeneRIF: NOP10 predicts lung cancer prognosis and its associated
            small nucleolar RNAs drive proliferation and migration.
REFERENCE   3  (bases 1 to 507)
  AUTHORS   Elsharawy,K.A., Althobiti,M., Mohammed,O.J., Aljohani,A.I.,
            Toss,M.S., Green,A.R. and Rakha,E.A.
  TITLE     Nucleolar protein 10 (NOP10) predicts poor prognosis in invasive
            breast cancer
  JOURNAL   Breast Cancer Res Treat 185 (3), 615-627 (2021)
   PUBMED   33161513
  REMARK    GeneRIF: Nucleolar protein 10 (NOP10) predicts poor prognosis in
            invasive breast cancer.
REFERENCE   4  (bases 1 to 507)
  AUTHORS   Ibanez-Cabellos,J.S., Seco-Cervera,M., Picher-Latorre,C.,
            Perez-Machado,G., Garcia-Gimenez,J.L. and Pallardo,F.V.
  TITLE     Acute depletion of telomerase components DKC1 and NOP10 induces
            oxidative stress and disrupts ribosomal biogenesis via NPM1 and
            activation of the P53 pathway
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1867 (12), 118845 (2020)
   PUBMED   32910990
  REMARK    GeneRIF: Acute depletion of telomerase components DKC1 and NOP10
            induces oxidative stress and disrupts ribosomal biogenesis via NPM1
            and activation of the P53 pathway.
REFERENCE   5  (bases 1 to 507)
  AUTHORS   Balogh,E., Chandler,J.C., Varga,M., Tahoun,M., Menyhard,D.K.,
            Schay,G., Goncalves,T., Hamar,R., Legradi,R., Szekeres,A.,
            Gribouval,O., Kleta,R., Stanescu,H., Bockenhauer,D., Kerti,A.,
            Williams,H., Kinsler,V., Di,W.L., Curtis,D., Kolatsi-Joannou,M.,
            Hammid,H., Szocs,A., Perczel,K., Maka,E., Toldi,G., Sava,F.,
            Arrondel,C., Kardos,M., Fintha,A., Hossain,A., D'Arco,F.,
            Kaliakatsos,M., Koeglmeier,J., Mifsud,W., Moosajee,M., Faro,A.,
            Javorszky,E., Rudas,G., Saied,M.H., Marzouk,S., Kelen,K., Gotze,J.,
            Reusz,G., Tulassay,T., Dragon,F., Mollet,G., Motameny,S.,
            Thiele,H., Dorval,G., Nurnberg,P., Perczel,A., Szabo,A.J.,
            Long,D.A., Tomita,K., Antignac,C., Waters,A.M. and Tory,K.
  TITLE     Pseudouridylation defect due to DKC1 and NOP10 mutations causes
            nephrotic syndrome with cataracts, hearing impairment, and
            enterocolitis
  JOURNAL   Proc Natl Acad Sci U S A 117 (26), 15137-15147 (2020)
   PUBMED   32554502
  REMARK    GeneRIF: Pseudouridylation defect due to DKC1 and NOP10 mutations
            causes nephrotic syndrome with cataracts, hearing impairment, and
            enterocolitis.
REFERENCE   6  (bases 1 to 507)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   7  (bases 1 to 507)
  AUTHORS   Wang,C. and Meier,U.T.
  TITLE     Architecture and assembly of mammalian H/ACA small nucleolar and
            telomerase ribonucleoproteins
  JOURNAL   EMBO J 23 (8), 1857-1867 (2004)
   PUBMED   15044956
REFERENCE   8  (bases 1 to 507)
  AUTHORS   Pogacic,V., Dragon,F. and Filipowicz,W.
  TITLE     Human H/ACA small nucleolar RNPs and telomerase share
            evolutionarily conserved proteins NHP2 and NOP10
  JOURNAL   Mol Cell Biol 20 (23), 9028-9040 (2000)
   PUBMED   11074001
REFERENCE   9  (bases 1 to 507)
  AUTHORS   Henras,A., Henry,Y., Bousquet-Antonelli,C., Noaillac-Depeyre,J.,
            Gelugne,J.P. and Caizergues-Ferrer,M.
  TITLE     Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs
  JOURNAL   EMBO J 17 (23), 7078-7090 (1998)
   PUBMED   9843512
REFERENCE   10 (bases 1 to 507)
  AUTHORS   Savage,S.A. and Niewisch,M.R.
  TITLE     Dyskeratosis Congenita and Related Telomere Biology Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301779
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ218536.1 and BM554889.1.
            
            On Dec 4, 2019 this sequence version replaced NM_018648.3.
            
            Summary: This gene is a member of the H/ACA snoRNPs (small
            nucleolar ribonucleoproteins) gene family. snoRNPs are involved in
            various aspects of rRNA processing and modification and have been
            classified into two families: C/D and H/ACA. The H/ACA snoRNPs also
            include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP
            proteins localize to the dense fibrillar components of nucleoli and
            to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production
            and rRNA pseudouridylation are impaired if any one of the four
            proteins is depleted. The four H/ACA snoRNP proteins are also
            components of the telomerase complex. This gene encodes a protein
            related to Saccharomyces cerevisiae Nop10p. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF129182.1, BU541623.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328848.6/ ENSP00000332198.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-287               BQ218536.1         42-328
            288-507             BM554889.1         254-473
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q14"
     gene            1..507
                     /gene="NOP10"
                     /gene_synonym="CHINE2; DKCB1; NOLA3; NOP10P; PFBMFT9"
                     /note="NOP10 ribonucleoprotein"
                     /db_xref="GeneID:55505"
                     /db_xref="HGNC:HGNC:14378"
                     /db_xref="MIM:606471"
     exon            1..117
                     /gene="NOP10"
                     /gene_synonym="CHINE2; DKCB1; NOLA3; NOP10P; PFBMFT9"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..258
                     /gene="NOP10"
                     /gene_synonym="CHINE2; DKCB1; NOLA3; NOP10P; PFBMFT9"
                     /note="homolog of yeast Nop10p; nucleolar protein family
                     A, member 3 (H/ACA small nucleolar RNPs); nucleolar
                     protein 10; snoRNP protein NOP10; nucleolar protein family
                     A member 3; NOP10 ribonucleoprotein homolog"
                     /codon_start=1
                     /product="H/ACA ribonucleoprotein complex subunit 3"
                     /protein_id="NP_061118.1"
                     /db_xref="CCDS:CCDS10037.1"
                     /db_xref="GeneID:55505"
                     /db_xref="HGNC:HGNC:14378"
                     /db_xref="MIM:606471"
                     /translation="MFLQYYLNEQGDRVYTLKKFDPMGQQTCSAHPARFSPDDKYSRH
                     RITIKKRFKVLMTQQPRPVL"
     exon            118..507
                     /gene="NOP10"
                     /gene_synonym="CHINE2; DKCB1; NOLA3; NOP10P; PFBMFT9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      489..494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NOP10"
                     /gene_synonym="CHINE2; DKCB1; NOLA3; NOP10P; PFBMFT9"
                     /note="hexamer: GATAAA"
     polyA_site      507
                     /gene="NOP10"
                     /gene_synonym="CHINE2; DKCB1; NOLA3; NOP10P; PFBMFT9"
                     /note="major polyA site"
ORIGIN      
        1 gtcgggcgga ccactgcaga ctgagcggtg gaccgaattg ggaccgctgg cttataagcg
       61 atcatgtttc tccagtatta cctcaacgag cagggagatc gagtctatac gctgaagaaa
      121 tttgacccga tgggacaaca gacctgctca gcccatcctg ctcggttctc cccagatgac
      181 aaatactctc gacaccgaat caccatcaag aaacgcttca aggtgctcat gacccagcaa
      241 ccgcgccctg tcctctgagg gtcccttaaa ctgatgtctt ttctgccacc tgttacccct
      301 cggagactcc gtaaccaaac tcttcggact gtgagccctg atgccttttt gccagccata
      361 ctctttggca tccagtctct cgtggcgatt gattatgctt gtgtgaggca atcatggtgg
      421 catcacccat aaagggaaca catttgactt ttttttctca tattttaaat tactacaaga
      481 ttattaaaga taaaatgatt tgaaaaa
//
